HansaBioMed Life Sciences Ltd’s Post

A great example of the effective use of real-world data to optimize the usage of a well established treatment in fields that none would have suspected in the first place, such as a treatment for erectile dysfunction proving to act on decreasing neurotoxic protein levels in brain cells. There is still some controversy in the results interpretation but surely room for more encouraging research. #realworldevidence #realworlddata #alzheimersdisease

Technology Tuesday - Week 3 The Michael J. Fox Foundation's breakthrough in Parkinson's disease research introduces the "alpha-synuclein seeding amplification assay" (SAA), a test capable of detecting early signs of the disease with 90% specificity. This groundbreaking procedure identifies misfolded alpha-synuclein in spinal fluid, a key indicator of Parkinson's. The SAA test, integrated into drug trials, objectively identifies individuals with targeted biology, enhancing drug development accuracy. Remarkably, the SAA breakthrough originated from a large-scale observational study that utilized a scratch-and-sniff test, revealing a strong link between poor smell and Parkinson's, paving the way for a simple and accessible screening mechanism in 2024. #ParkinsonsResearch #MedicalBreakthrough #NeurologicalHealth #HealthInnovation #BiomedicalScience #AlphaSynuclein #SAAtest #EarlyDetection #HealthcareAdvancements #MJFFoundation #NeurodegenerativeDiseases #InnovativeHealthcare #HealthTech #MedicalDiscovery #ResearchMilestones #1872Consulting #TechTuesday #TechnologyTuesday https://lnkd.in/g2Nq58Nm

💡 Exciting advancements in the field of regulated cell death have opened up new avenues for treating complex diseases. A recent article in Nature Portfolio’s Cell Death Discovery explores groundbreaking treatments targeting regulated cell death, specifically ferroptosis and necroptosis, two pivotal cell death pathways implicated in various medical conditions.   🧬Acute kidney injury (AKI) affects 13 million people worldwide annually. By targeting regulated cell death and modulating specific molecules, it's possible to prevent extensive tissue damage and improve patient recovery, offering promising new therapies where traditional treatments have often fallen short.   🔬 At SeaBeLife, we focus on manipulating these cell death pathways to reduce inflammation and cellular damage caused by ferroptosis and necroptosis. Our research aims to provide significant improvements for patients suffering from various acute and orphan diseases, including Acute Liver Injury and Failure (ALI/ALF), ischemia-reperfusion injury, AKI, age-related macular degeneration (AMD), and neurodegenerative diseases.   👉 Learn more about regulated cell death: https://lnkd.in/dAC3JUeS   #Biotech #CellDeath #Innovation #Healthcare

Unlocking the Secrets of Cellular Communication: New Breakthrough Has Vast Medical Implications TOPICS:Cell BiologyCellsMolecular BiologyPaul Scherrer Institute By PAUL SCHERRER INSTITUTE JULY 3, 2024 "Adjacent cells freely exchange small molecules and ions with each other through channels made from proteins called connexins. Dysfunction in this important type of intercellular communication has been linked to a variety of diseases, including those of the heart and peripheral nervous system. Thus, connexins are important drug targets. Credit: Laura Canil" "Researchers have advanced their understanding of how drugs interact with connexin molecules. Connexins create channels that enable direct communication between adjacent cells. Dysfunctions in these channels play a role in neurological and cardiac disorders. This enhanced knowledge of drug binding and action on connexins could aid in developing treatments for these diseases."

https://lnkd.in/gJgXZgKf Mitochondrial dysfunction: mechanisms and advances in therapy

https://lnkd.in/dsHCAcFi). PRECAME Study: Preventing cardiovascular effects with metformin in obese patients ( Corpori Sano Biotechnology, Brasil 🇧🇷 2002 ): " Specific therapy, to live healthily " " The era of insulin resistance modulators, ability to alter the cellular regulatory circuit " " Drug that modulates mitochondrial, endothelial and DNA-telomere " " A new therapeutic approach in cardiovascular, metabolic and oncological " " Creating a scientific basis for an infinite possibility of future studies and research " " Through innovative medicines for public health and commited to bringing better health and a better future for patients, translating science and regenerative medicine into medicines that change human lives, as the main objective " " PRECAME Study and Walter's Metabolic Theory, improving the perspective and quality of life of patients " #science #ciencia #innovation #prevention #parkinsondisease #health #populationhealth #healthcare #publichealth #immunology #atherosclerosis #insulinresistance #cellculture #genetherapy #clinicaltrials #clinicalresearch #obesity #research

Pioneering early diagnosis of Alzheimer's disease through identification of amyloid-B oligomers in patients' cerebrospinal fluid, demonstrating potential for clinical application. #AlzheimersDisease #Chemistry #Diagnosis #FlurosecentProbes #CerebrospinalFluid #NatureCommunications https://lnkd.in/g_Qj9Hs3

Biomedical Sciences

🔬 Exciting Lancet Clinical Pictures Alert! 🔬 Delighted to share our recently published paper on an intriguing case: "Anti-GABAA Receptor Encephalitis 14 Months After Allogeneic Hematopoietic Stem-Cell Transplant for Acute Myeloid Leukemia." 🌐 Link to the paper: https://lnkd.in/dq3nawjV Our team delves into the rare occurrence of Anti-GABAA receptor encephalitis post-transplant, shedding light on potential challenges in diagnostic and the management of complications. 🧠 🔍 Key Takeaways: 1️⃣ Rapid Neurological Progression: Unusual myocloni escalation and super-refractory status epilepticus pose diagnostic and therapeutic challenges. 2️⃣ Transplant Association: Potential link between allogeneic stem cell transplants and GABAA receptor encephalitis warrants closer scrutiny in post-transplant patients. 3️⃣ Complex Management: Complex complications highlight the need for comprehensive post-transplant care strategies. 🤝 Collaborators: A massive shoutout to our remarkable team and dedicated clinical colleagues. 🌐 This case's success is a testament to the power of interdisciplinary USB-teamwork. From neurologists, radiologists, intensive care physicians and neurosurgeons to hematologists, every contribution played a pivotal role in steering this complex case towards a positive outcome. 🚀 #TeamUSB #Lancet #Clinicalpicture Urs Fisch Özgür Yaldizli

Stem cells directly into the heart to intervene within a month after the heart attack, and inject these cells hoping that they will help regenerate the tissue, reducing the scar area and regaining partial heart function. #worldhealth #publichealth #antiaging #aging #regenerativemedicne #medicine #cardiovasculardisease #hearthealth #heartdisease #celltherapy #clinicialtrials #clinicalresearch #health https://lnkd.in/euuk-qXE