🎙️Check out our discussion with Mayukh Sukhatme, MD, President and CIO of Roivant Sciences, about their recent dealmaking and their drug discovery and development philosophy! https://ow.ly/55zJ50PykeY
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⚫️ Now at ASCRO, Uppsala: Martin Bergstrand explains the possibilities of Model Informed Drug Development, how it can reduce time to market, cost, size of study population and increase probability of success in dose selection, formulation and route of administration among other things, to an engaged audience from different Clinical Research Organizations, (CRO). 🟠 And a tip: There are still (very) few seats left to a workshop on the topic, “An introduction to probabilistic decision support in drug development”, in Rome during PAGE, led by Martin, our CEO Peter Milligan, Chief statistician Richard Anziano and Senior Consultant Giovanni Smania. #cro #lifesciences #biosimulation #biotech
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Following recent news from Charles River Laboratories, regarding their continued investment into their Alternative Methods Advancement Project (AMAP), to reduce reliance on animal testing - we are thrilled to share a collaborative #genotoxicity publication between CRL, CN Bio and TwinStrand Biosciences. The publication demonstrates that Liver-on-a-chip is a promising tool for genotoxicity assessment. Click the link to learn more & congrats to all involved! #animalalternatives #organonchip #microphysiologicalsystem
I'm very excited to share our recent publication using our PhysioMimix platform to develop a genotoxicity application as a fantastic collaboration between CN Bio , Charles River Laboratories and TwinStrand Biosciences https://lnkd.in/eT6AdJyY It was a pleasure working with Benjamin Kopp , Annie Hamel , Thalita Boldrin Zanoni, PhD and the rest of the team at Charles River and TwinStrand. And a huge thanks to Raul Silva and Caitlin Rore who did most of the actual hard work at CN Bio and Tomasz Kostrzewski and Emily Richardson for their support. #OrganOnAChip #Genotox #NAM #MPS
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Digital Chemistry Expert at MilliporeSigma | Enhancing Lab Productivity & Workflow Automation with AI/ML Solutions
Stop screening & start synthesizing by leveraging the power of SYNTHIA™ retrosynthesis from MilliporeSigma. Register for your free SYNTHIA™ Lite trial access > https://lnkd.in/dZ_EjE39 Quickly find & easily navigate innovative and novel pathways for novel and published target molecules. #retrosynthesis #drugdiscovery #organicchemistry #medicinalchemistry
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Are you interested in the drug discovery life cycle and the role of single cell analysis? Watch Jessica Hall, Field application Scientist here at Sphere Fluidics, outlining the process along side the traditional methods vs the picodroplet approach in our first Teach me in 10 video! Watch on demand here: https://lnkd.in/e8G7Jhpm #DrugDiscovery #DrugDevelopment #SingleCellAnalysis #Microfluidics #LabAutomation
📣 We have a new Teach Me in 10 episode out now! We are delighted to be joined by Jessica Hall, a Field Application Scientist at Sphere Fluidics Limited, to explore single-cell analysis and screening in drug discovery. In the episode, Jessica will outline the drug discovery lifecycle and the role of single-cell analysis within it. Then, she will discuss the traditional methods vs the picodroplet approach and showcase a solution. Watch the full episode on-demand for FREE: https://lnkd.in/e8G7Jhpm #TMI10 #DrugDiscovery
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👋🏼 Hello toxicologists! We presented at #SOT2024 new data produced by our high-content screening system SydLab™ One for #DART The study highlights the strong advantages of SydLab™ One: 📊 Reproducible and accurate results thanks to standardized protocols 🧪 An automated dosing of chemicals with low liquid consumption 🚀 Multi-phenotypic readouts in real-time in full organisms 🔬 Fully automated high-content screening platform = unlocking #Celegans model as a new #NAMs technology for #EarlyTox SydLab™ One represents the first all-in-one C. elegans microfluidic #labdevice that contributes to the rapid identification of toxic compounds de-risking and accelerating the early stages of discovery pipelines. Missed our presentation? Download the poster here 🔗👉🏼 https://lnkd.in/eVDeJ5rz #toxicology #ReproTox #stressresponse #fluorescence #labtechnology #microfluidics #OoC #HCS #labautomation #AIanalysis
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A learning opportunity.
Join us at the Drug Discovery & Development Virtual Event Series 2024 on February 21st! We're excited to showcase how Picodroplets enable high throughput single cell screening and isolation in Senior Field Application Scientist, Romina Durigon’s webinar. Reserve your place: https://bit.ly/3HKdET7 #LRdrug #CellLineDevelopment #AntibodyDiscovery #SphereFluidicsLimited
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I got 27th place/ 1946 and won a silver medal in a kaggle competition!!! This competition on Kaggle invited participants to forecast the efficacy of potential new medicines. This competition aimed to accelerate drug discovery by enabling more precise predictions of drug outcomes based on chemical data. For our solution, we prepared 2 models, one for which the structure of the molecule is shared in the training set, and another for molecules with unseen structures. For the shared data, we enhanced accuracy by using a 1D CNN that treats SMILES as strings, incorporating residual connections and attention mechanisms. we used ChemBERTa, capable of transfer learning, and preserved generalization performance by freezing the first three layers during training to retain information from pre-trained molecules. This competition had a huge gap in molecular structure between the Public and Private leaderboards, making it a very "shaky" competition. Despite this, our team managed to create a highly robust model, achieved 8th on the Public and 27th on the private as well. Here is our solution. Any comments or questions are welcome! https://lnkd.in/gjhM5yBj
S_Kikuchi won a Silver Medal for placing 27th in NeurIPS 2024 - Predict New Medicines with BELKA
kaggle.com
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Cereno Scientific submits Clinical Trial Application (CTA) for first-in-human Phase I study with novel epigenetic HDACi drug candidate CS014 The CTA was submitted for a first in human Phase I study to primarily evaluate the safety and tolerability of CS014 in healthy volunteers. The design is a traditional single ascending and multiple ascending dose study for 1 week. Title of the study is “A first-in-human, open-label trial to investigate safety, tolerability, pharmacokinetics, and pharmacodynamics of CS014 in healthy volunteers after single and multiple administration”. Read the full press release here:
Read the full Press release
cerenoscientific.com
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Senior Field Applications Scientist at illumina. Improve human health by unlocking the African genome
Have you ever wondered how your unique genetic makeup influences your response to medications? Join this insightful webinar on Pharmacogenomics—an field that explores the interaction between genetics and drug response. Pharmacogenomics holds the key to personalized medicine, revolutionizing how we prescribe and tailor treatments to individual patients. By understanding genetic variations, healthcare providers can predict how individuals will respond to medications, leading to safer and more effective therapies. You don't want to miss this webinar. #Pharmacogenomics #NextBio #DNAtesting #PersonalizedMedicine #HealthcareInnovation #Workshop #Genetics #DrugResponse #LearningOpportunity
Join us on 5 June 2024 for a webinar hosted by Next Biosciences and Jeffrey Shaman, Chief Science Officer of Coriell Life Sciences. Jeffrey will do a deep dive into ‘DNA testing for more precise prescribing', and the webinar will kick off at 6pm. Attend the webinar and receive 1 Clinical CPD point if you are registered with the HPCSA. RSVP now to secure your spot: https://ow.ly/vFGA50REbUx Explore the wonders of pharmacogenomics testing: https://ow.ly/ofLO50REbWQ #OnlineWebinar #DNAtesting #pharmacogenomics #cpdaccredited
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