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Olink Proteomics and SPT Labtech Unite to Enhance High-Throughput Proteomics and Sample Preparation Olink and SPT Labtech have announced the integration of Olink’s automated Explore HT high-throughput proteomics workflows with SPT Labtech’s Firefly liquid handling platform. Launched approximately a year ago, Olink's Explore HT platform leverages the Swedish company's multiplex PEA technology, capable of measuring over 5,300 proteins with just 2 µl of sample. This platform is specifically designed to advance protein biomarker discovery for drug development. The Firefly platform by UK-based SPT Labtech combines multiple functions pipetting, dispensing, incubating, and shaking into a single unit. Recently, an expansion was introduced to include an on-deck thermocycler and increased labware capacity. The Stratified Medicine Core Laboratory NGS Hub at the University of Cambridge will be the first to develop and implement Olink Explore protocols on the Firefly platform. #proteomics #sampleprep #biomarkers #drugdevelopment #labtech #automation #lifesciences #biotechnology #highthroughput #research #multiplexing #proteindiscovery #labautomation #genomics #cambridge #fireflyplatform #exploreht #ngs #medicalresearch #partnerships

📢[New publication! – SWATH #MassSpectrometry Strategy for Host Cell Protein Identification and Quantification in #mAb production] Host cell proteins (HCPs) are impurities produced during the manufacturing of #biotherapeutics, such as #monoclonalantibodies (mAbs). 🧫 Unfortunately, some HCPs can persist after #downstreamprocessing, negatively impacting the stability, efficacy, and safety of the final product. 🤝In a collaborative study, researchers from iBET - Instituto de Biologia Experimental e Tecnológica and Sanofi investigated the use of a mass spectrometry proteomics tool (#SWATH – Sequential Window Acquisition of all THeoretical fragment-ion spectra) to monitor and quantify HCP content during bioprocess development. Key highlights: ➡️SWATH-MS approach was developed for high-throughput HCP profiling ➡️Absolute or semi-absolute quantification of all identified HCPs was achieved. ➡️ Design space for two critical HCP clearance was assessed through a DoE study. ➡️ SWATH-MS method supported the characterization of a mAb purification platform. The SWATH-MS shows significant promise for HCP profiling, facilitating the optimization of bioprocessing strategies and ensuring the quality of biotherapeutic products. Read full article 🔗https://lnkd.in/d3rs7tFJ Congratulations to all the authors! 🎉 Sofia Carvalho Ludivine Profit Sushmitha Krishnan Ricardo A Gomes Bruno M. Alexandre Séverine Clavier Michael Hoffman Kevin Brower Patricia Gomes-Alves #mAbs #SWATH #massspectrometry #HCPquantification #purificationplatform #bioprocessdevelopment 

iBET - Instituto de Biologia Experimental e Tecnológica and Sanofi working together and proudly contributing to the development of analytics to detect and quantify host cell proteins in MAbs during Dowstream - adressing important challenges in Biopharma!

Genotyping Assay Market worth $37.1 billion by 2029 Download PDF Brochure:-https://lnkd.in/dNyqT5Nt The size of global genotyping assay market in terms of revenue was estimated to be worth $19.4 billion in 2024 and is poised to reach $37.1 billion by 2029, growing at a CAGR of 13.8% from 2024 to 2029. 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞 Thermo Fisher Scientific Illumina. Danaher Corporation QIAGEN Eurofins Scientific Finland Oy Wohlfahrtsstiftung der F. Hoffmann-La Roche AG Bio-Rad Laboratories, Merck KGaA, Darmstadt, Germany Agilent Technologies Revvity Standard BioTools PacBio GENEWIZ, Inc.. Luminex Oxford Nanopore Technologies GenScript Takara Bio Inc. New England Biolabs Tecan Genotypic Technology BGI Group Novogene Paragon Genomics, NeoGenomics Laboratories #genotyping #genomics #precisionmedicine #genetictesting #molecularbiology

I am thrilled to share that our work on FLiP–MS, a novel structural proteomics workflow for globally monitoring protein complex dynamics, has just been published! 🎉 In this research, we developed FLiP–MS, a cutting-edge method that probes changes in protein–protein interactions with high throughput and peptide-level structural resolution. By generating a library of peptide markers, FLiP–MS enables comprehensive monitoring of protein complex dynamics. Applying this approach to Saccharomyces cerevisiae, we uncovered links between Spt-Ada-Gcn5 acetyltransferase activity and the assembly state of several complexes, providing both global and molecular insights into cellular responses to DNA replication stress. A heartfelt thank you to all the amazing co-authors, but especially to Cathy Marulli for the incredible collaboration. Working alongside my fantastic co-first author was an absolute joy! We shared countless memorable moments, from brainstorming sessions to late-night data analyses. Even during the tough times without lab access due to the pandemic, we kept each other motivated and turned challenges into opportunities. Also, a big thank you to Paola Picotti for believing in us and encouraging us to pursue this high-risk project, even when the initial results weren't the most promising. Her unwavering support made this achievement possible. This journey has been a testament to teamwork, perseverance, and passion for science. Excited to see where this leads next! #Proteomics #TeamScience #PPI #ETHZ #PicottiLab #Gratitude Read the full article here https://lnkd.in/diUmT8Zm

Gearing up for #SLAS2024 in Boston on Feb. 3-7? Visit Eurofins Discovery at Booth 1253 to talk to our experts about exciting developments in #HTS, #Biophysics, #VirtualScreening, #ProteinDegradation, #SH2Domains & #Helicase projects.   Eurofins Discovery offers fully integrated solutions from concept to preclinical candidates, with expertise from chemistry through biology to address the unique challenges of drug discovery.   For detailed information and links to the event: https://lnkd.in/gZQg7WZ6 Attend our Exhibitor Tutorial on Monday, Feb. 5, 2-3 PM EST: ‘Eurofins Discovery Leading Innovation: From Protein Degradation to Echo® MS HTS, Two Recent Case Studies’ In this talk, we will discuss innovative therapeutic approaches with a first case study focusing on protein degraders design. A second case study will concentrate on label-free technological advances to drive High-throughput Screening (HTS) projects.   Key takeaways: + Learn how we design protein degrader strategies, including the visualization of ternary complex using biophysics + Gather valuable information on the optimization of screening cascades with reduced assay set-up time and enzyme consumption using the Echo® MS + Meet our experts in person and deepen your knowledge in hit finding from HTS to extended hit characterization #IntegratedDrugDiscovery #Eurofins

Single-Cell Analysis Market worth $6.9 billion by 2029 Download PDF Brochure:-https://lnkd.in/dEbQgmfU The single cell analysis market is expected to generate a revenue of USD 6.9 billion in 2029, with a revenue of USD 3.7 billion in 2024 to register a CAGR of 13.6%. Single Cell Analysis Market Dynamics -DRIVER: Technological advancements in single-cell analysis products -RESTRAINT: High cost of single-cell analysis products -OPPORTUNITY: High growth potential of single-cell sequencing -CHALLENGE: Technical challenges associated with single cell analysis Key players in the single-cell analysis market include Thermo Fisher Scientific  (US), Danaher Corporation (US), Merck Group (Germany), BD (US), Agilent Technologies, Inc. (US), QIAGEN (Netherlands), 10x Genomics (US), Illumina, Inc. (US), Bio-Rad Laboratories, (US), and many more ... #singlecellanalysis #singlecellsequencing #cellbiology #genomics #molecularbiology

🌟 Exciting Advances in Intracellular Protein Delivery! 🌟 In the quest for more effective therapeutic interventions, the development of advanced technologies for intracellular protein delivery has become essential, enabling precise targeting and enhanced efficacy in treating various diseases. Our clients at the University of Tartu Institute of Technology developed a groundbreaking method for efficient intracellular protein delivery using innovative bioconjugation methods! 🔬 The team designed a novel approach that binds a model protein, EGFP (Enhanced Green Fluorescent Protein), with a cell-penetrating peptide (CPP), NickFect 55, through a technique known as protein trans-splicing. This method allows for the covalent attachment of the CPP to the protein, enhancing its ability to cross cell membranes and deliver biological macromolecules effectively. 💡 Key Highlights: ·       The researchers confirmed successful protein trans-splicing with a split EGFP assay. ·       Developed a nanoentity binding EGFP and CPP NickFect 55 using protein trans-splicing ·       Employed Attune Nxt for flow cytometry analysis, which played a crucial role in the assesment of transfection efficacy and expression of split-EGFP assay plasmids; the assesment of the expression of the model-protein as well as the transduction efficacy of the nanoentity and its separate components. This research opens new avenues for future studies, including the exploration of different cargo proteins and in vivo applications. The newly developed method is a significant step forward in in the field of biotechnology and medicine, offering promising applications for targeted intracellular cargo delivery! We applaud all progress in personalized medicine and cancer therapy! 💚 The article is freely accessible here: https://lnkd.in/dAZaC2sK A short Estonian overview in available here: https://lnkd.in/dYnYteyQ Thermo Fisher Scientific products used: ·       Attune™ NxT Flow Cytometer ·       HEK293FT cells (catalog number: R70007) ·       8-well Nunc™ Lab-Tek™ ·       Cloning reagents #Biotechnology #ProteinDelivery #ResearchInnovation #Pharmaceutics #CellBiology #IntracellularDelivery #CPP #EGFP #Transfection #ScientificResearch #UniversityOfTartu #AttuneNxt University of Tartu University of Tartu, Institute of Technology Jekaterina Nebogatova

𝐌𝐢𝐜𝐫𝐨𝐑𝐍𝐀 𝐌𝐚𝐫𝐤𝐞𝐭 𝐖𝐨𝐫𝐭𝐡 $𝟒.𝟏𝟑 𝐁𝐢𝐥𝐥𝐢𝐨𝐧 𝐛𝐲 𝟐𝟎𝟑𝟏 (𝐂𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐏𝐃𝐅 𝐆𝐮𝐢𝐝𝐞) 𝐆𝐞𝐭 𝐅𝐫𝐞𝐞 𝐏𝐃𝐅 𝐆𝐮𝐢𝐝𝐞: https://lnkd.in/dYy3Gxmq The increasing prevalence of chronic diseases, advancements in molecular biology techniques, and growing research activities in the field of genomics are expected to drive the growth of the microRNA market. Additionally, the potential applications of microRNAs in diagnostics, therapeutics, and personalized medicine are likely to further boost market growth. With ongoing technological advancements and increasing investments in research and development, the microRNA market is poised for significant expansion in the coming years. By 2031, the market is projected to reach a value of $4.13 billion, representing a lucrative opportunity for key players in the industry. Major Players in MicroRNA Market QIAGEN Agilent Technologies BioGenex Bio-Rad Laboratories GeneCopoeia GenScript Horizon Discovery Illumina Merck Life Science NanoString Technologies, Inc. New England Biolabs Quantabio SISTEMIC SCOTLAND LIMITED Synlogic Thermo Fisher Scientific #MicroRNA #miRNA #GeneRegulation #Genomics #MolecularBiology #GeneticResearch #RNAi #Bioinformatics #GeneExpression #RNAResearch #Biotechnology #LifeSciences #GeneticTesting #MolecularDiagnostics #QIAGEN #AgilentTechnologies #BioGenex #BioRad #GeneCopoeia #GenScript #HorizonDiscovery #Illumina #MerckLifeScience #NanoStringTechnologies #NewEnglandBiolabs #Quantabio #SistemicScotland #Synlogic #ThermoFisherScientific

Is your research project stuck due to the lack of cutting-edge tools and expertise? At BioNome, we understand these pain points and are here to help. With advanced techniques like Molecular Docking, Protein Sequencing, and LC-MS Analysis, you can eliminate guesswork, reduce timelines, and get precise, actionable insights. Let BioNome help you overcome the challenges in your research journey! Reach out today to see how we can accelerate your project. Contact us at +91 9035259653. #BioNomeServices #ScientificSolutions #ResearchAndDevelopment #LifeSciences #PharmaceuticalResearch #DrugDiscovery #CustomSynthesis #BiotechnologyServices #AnalyticalServices #MolecularDocking #NextGenSequencing #Genomics #Proteomics #MicrobiologyResearch #Bioinformatics #ClinicalResearch #BiotechIndustry #STEMCareers #ResearchInnovation #BiotechSolutions #LabServices #ChemistryResearch #BiotechConsulting #AdvancedScience #CancerResearch #ScientificResearch #LabAnalysis #AcademicResearch #mscbiotechnology #mscbiochemistry #phdscholar #researchscholar #juniorresearchfellow #scientist #outsourcing #researchproject