David LeMaster’s Post

#goldnanoparticles #colloidalgold #lateralflow The Fascinating Science Behind Gold Particles in Biomedical Applications Gold, a precious metal long prized for its beauty and durability, is undergoing a remarkable transformation in the world of medicine. Forget crowns and jewelry – scientists are now harnessing the unique properties of gold particles at the nanoscale (incredibly tiny, measured in billionths of a meter) to develop innovative biomedical applications. But what makes gold so special in this new realm? The key lies in its interaction with light. When light hits gold nanoparticles, it excites the metal's electrons, causing a collective oscillation known as surface plasmon resonance. This fancy term translates to some pretty cool abilities: Heat Generation: Gold nanoparticles can convert light energy into heat very efficiently. This property has applications in cancer treatment, where gold particles can be directed to tumors and then irradiated with lasers. The heat generated by the particles destroys cancer cells while leaving healthy tissues relatively unharmed. Light Scattering: Gold nanoparticles can scatter light with specific colors depending on their size and shape. This makes them ideal for creating contrast agents in medical imaging techniques like photothermal imaging and computed tomography (CT scans). By attaching these gold particles to molecules of interest, such as antibodies targeting specific diseases, doctors can gain a clearer picture of what's happening inside the body. Drug Delivery: Gold nanoparticles can be used as carriers for drugs. They can be designed to bind to specific molecules, allowing them to deliver their cargo directly to diseased cells and avoid healthy tissues. This targeted approach has the potential to reduce side effects and improve treatment efficacy. The science behind gold nanoparticles in biomedicine is still evolving, but the potential is vast. Researchers are exploring their use in: Gene Therapy: Gold nanoparticles could be used to deliver genetic material into cells, potentially paving the way for new treatments for genetic diseases. Antibacterial Treatments: Certain types of gold nanoparticles exhibit antibacterial properties, offering a potential weapon in the fight against antibiotic-resistant bacteria. Diagnostics: Gold nanoparticles can be used to develop highly sensitive biosensors for detecting diseases at early stages. The journey from a prized metal to a cutting-edge medical tool is a fascinating example of scientific ingenuity. As research continues, gold nanoparticles have the potential to revolutionize healthcare, offering more precise and effective treatments for a wide range of diseases.

💡 Don't miss the next Seminar at CIC nanoGUNE: 🔬 Advanced Imaging Techniques in in vivo models (Intravital Microscopy, Nuclear and Molecular Imaging).   The seminar will address advances in both intravital microscopy and preclinical nuclear (PET and SPECT) and molecular (MRI) imaging techniques, two fundamental approaches for biomedical research. Intravital microscopy allows real-time observation of cellular processes, such as cell movement and tumor progression, within living organisms. On the other hand, nuclear and molecular imaging techniques offer crucial anatomical and functional precision for studying diseases in areas such as oncology, cardiology, and neurosciences. Both technologies improve the understanding of complex biological processes and contribute significantly to translational research.   📅 Date: Monday 23 September 🕥 Time: 11:00 - 12:30 h 📍 Place: nanoGUNE   Speaker: Andrea Zapater, Ph.D. Product Specialist Bio.   Registration link: https://lnkd.in/dKh8XU9h Paralab Bio SL IVIM Technology Mediso Medical Imaging Systems

3D-printed sensors unveil embryonic development forces. Researchers at University College London have developed 3D-printed mechanical force sensors to measure the forces exerted during the development of chicken embryos. These sensors, attached to the spinal cord, quantify the forces necessary for proper neural tube formation. The study aims to improve understanding and prevention of spinal cord malformations like spina bifida, which affects 1 in 2,000 newborns in Europe annually. The technology has potential applications in studying human stem cells to understand and prevent conditions like spina bifida. Source: https://lnkd.in/drVZsxev #medical #healthcare #research #biomedical #3dprinting

https://lnkd.in/dBEjbBB4 Nanotechnology is a rapidly developing field with potential applications in medicine, communications, genomics, and robotics. Its unique self-ordering and assembly behaviors make it possible, and by understanding these processes, new approaches to enhancing human life will be developed. One of the greatest values of nanotechnology is its potential in developing new medical treatments, such as nanomedicine, which includes the development of nanoparticles, artificial receptors, DNA sequencing, drug delivery systems, gene therapy, and tissue engineering.

Multisite E2 Phosphorylation Anchors Specific E3 Partnership in Ubiquitylation, Rigidifies Assembly, and Facilitates Substrate Docking Ubiquitination, a cellular process crucial for various functions, relies on a dynamic dance between enzymes called E2 and E3. While the general steps are known, the specific rules governing E2-E3 partnerships remain a mystery, especially for the RING-family GID/CTLH E3s and their dedicated partner Ubc8/UBE2H. This partnership plays a vital role in diverse processes like yeast metabolism and human development. Unveiling the Exquisite Grip of Phosphorylation A recent study, using cutting-edge techniques like cryo-electron microscopy, sheds light on this enigmatic pairing. The researchers discovered a unique mechanism involving multisite phosphorylation of the E2 C-terminus. These phosphorylated sites, like tiny anchors, bind to specific "basic patches" on the E3, creating a remarkably stable and specific attachment. This contrasts with the dynamic, polyelectrostatic interactions seen in other ubiquitylation complexes. Beyond a Simple Grip: Rigidity and Substrate Shepherding This phosphorylated grip is more than just a handshake; it rigidifies the catalytic centers within the GID/CTLH E3, which constantly flexes as it interacts with substrates. This rigidity ensures efficient and precise transfer of the ubiquitin molecule to the target. Additionally, the anchored E2 helps guide substrates towards the ubiquitylation active sites, further streamlining the process. Evolutionary Tune-up Interestingly, the positions of these crucial phospho-dependent interactions remain remarkably conserved across different species, showcasing the importance of this mechanism in maintaining the GID/CTLH-Ubc8/UBE2H partnership throughout evolution. From Fundamentals to Applications: A Glimpse into the Future Understanding the details of E2-E3 partnerships like this one holds immense potential for future applications. For instance, manipulating the phosphorylation state of the E2 C-terminus could potentially be used to fine-tune ubiquitylation in specific contexts, potentially offering therapeutic avenues for diseases where this process goes awry. This research not only unveils the elegant language of protein interactions in ubiquitylation but also opens doors to exciting possibilities in manipulating these processes for therapeutic benefit, highlighting the power of basic scientific inquiry in paving the way for future medical advancements. 📝 Article, Open Access https://lnkd.in/eqxSQJRK 📷 EM Map Analysis https://lnkd.in/eX5rjBSZ 📎 Free Use and License https://lnkd.in/gpbw3cEg 📌 About EM Data Bank https://lnkd.in/ePU9n4kv Chrustowicz J, Sherpa D, Li J, Langlois CR, Papadopoulou EC, Vu DT, Hehl LA, Karayel O, Beier V, von Gronau S, Muller J, Prabu JR, Mann M, Kleiger G, Alpi AF, Schulman BA. Mol Cell (2023) #disease #research #structuralbiology #merize

🌟Shining Light on Quantum Dots🕵️♂️ 🪧The nanometer-sized semiconductor particles exhibit unique optical and electronic properties, making them invaluable in a variety of biomedical applications, from imaging to drug delivery. ▪️Quantum Dots: An Overview 🔄Quantum dots are tiny particles, typically ranging from 2 to 10 nanometers in diameter. 🔄They possess size-dependent optical properties due to quantum confinement, which allows them to emit light at specific wavelengths when excited. 🔄This tunable emission spectrum, along with their high brightness and photostability, makes QDs superior to traditional fluorescent dyes and organic molecules used in biomedical research. 💯Bioimaging with Quantum Dots 🔄One of the most promising applications of quantum dots is in bioimaging. Their bright and stable fluorescence allows for the creation of high-resolution images of biological tissues and cells. 🔄Quantum dots can be engineered to target specific cellular structures, enabling researchers to visualize complex biological processes in real-time. 🔄For instance, QDs conjugated with antibodies can bind to cancer markers, facilitating the early detection and diagnosis of tumors. 📍Recent advancements in QD technology have led to the development of near-infrared (NIR) emitting QDs, which penetrate deeper into tissues, providing clearer images with minimal background noise. 💯Quantum Dots in Targeted Drug Delivery 🔄Beyond imaging, quantum dots hold significant promise in the realm of targeted drug delivery. 🔄Due to their small size and surface modifiability, QDs can be designed to deliver therapeutic agents directly to diseased cells, minimizing side effects and enhancing treatment efficacy. By attaching specific ligands to their surface. RESEARCHER - ATHEENAPANDIAN Manoj_Atheenapandian_Researcher BioScience_Central VICE PRESIDENT - ATHEENAPANDIAN MOHAMMED SAHIL S-TRAINING OFFICER (TO)-ATHEENAPANDIAN Krithina - Trainer@Atheenapandian Dhanushya Biomedical Trainer ATHEENAPANDIAN PRIVATE LIMITED Aruna Biomedical Trainer ATHEENAPANDIAN PRIVATE LIMITED

Flow cytometry, invented in the 1950s, uses antibodies linked to fluorescent probes to detect cell surface and intracellular proteins. Although able to achieve single-cell sensitivity, the method is limited by the number of fluorophores that can be distinguished within the spectrum of fluorescent light. Now, a research collaboration led by the Wyss Institute at Harvard University has developed a method to significantly enhance the sensitivity of mass cytometry and image mass cytometry (IMC) using DNA nanotechnology. Applying a new signal amplification technology called “Amplification by Cyclic Extension” (ACE) to DNA barcodes linked to antibodies, they were able to amplify protein signals produced by antibody-bound metal isotopes more than 500-fold, and to simultaneously (and with high sensitivity) detect more than 30 different proteins. https://lnkd.in/e542ksdX

Today is the first step in a transformative journey to unlock the most in-demand skills in biochemistry. 🚀 Let me captivate your mind with a story of groundbreaking innovation: Imagine this: A young boy named Alex faced a devastating cancer diagnosis. Traditional treatments failed, and hope was slipping away. Then, a revolutionary breakthrough in Nanobiotechnology and AI in Medicine emerged. Researchers developed nanoparticles that targeted only cancer cells, guided by the precision of AI. Within months, Alex’s cancer was in remission. This is the power of merging nanotechnology with artificial intelligence. 🌟 🔬 Nanobiotechnology involves using nanoscale materials to solve biological challenges. From targeted drug delivery to advanced diagnostics, its potential is limitless. 💻 Artificial Intelligence (AI) amplifies these innovations by analyzing vast data, predicting outcomes, and designing efficient nanomaterials. The fusion of nanobiotechnology and AI is not just changing medicine—it’s creating a future where treatments are precise, effective, and personalized. If you’re driven by the pursuit of cutting-edge research and revolutionary applications, let’s connect and delve into these exciting advancements together! 🌐 Looking forward to learning and collaborating with you. #Biochemistry #Nanobiotechnology #AI #Medicine #Innovation #Networking #antibiotics #healthcare

Biomedical nanotechnology is dedicated to exploring nanoscience and nanotechnology for health wellness, with the ultimate goal of personalized health management. The applications of siRNA-nanoparticle complexes cover numerous diseases such as cancer and viral infection. They have the ability to detect cancer due to the permeable nature of the tumor's blood vessels, which allows the nanoparticles to penetrate and accumulate in the tumor due to their small size. Metal oxide nanoparticles, for example, which produce a high-contrast signal on magnetic resonance imaging (MRI) or computed tomography (CT), can be coated with antibodies specific to membrane receptors found on cancer cells. Once inside the body, this system selectively binds to cancer cells and illuminates them for the scanner. Similarly, gold particles can be used to improve light scattering for endoscopic techniques such as colonoscopy. In this way, nanotechnological strategies can allow the visualization of molecular markers that identify stages and types of cancer, allowing doctors to see molecules and cells not detected by conventional imaging techniques. Recent research has revealed that the use of nanorobots to administer antitumor drugs maintains the concentration of the drug at the site during treatment and minimizes the effects on adjacent healthy cells or tissues. References; EGOROV, E. et al. Robotics, microfluidics GRODZINSKI, P. et al. MAZZEO, A.; SANTOS, E. J. C. MOORE, J. A.; CHOW, J.C.L.

NEW BOOK to download for FREE Nanomedicine to Nanotechnology: from beaker to body Click here - https://lnkd.in/eNy-zjWj #OCP #nano #nanotechnology #nanomedicine