Cryogenic Transmission Electron Microscopy (Cryo-TEM) has become more and more prevalent as a means to image the ultra structure of challenging biological and soft matter samples down to the low nm scale. The advent of new electron cameras and detectors has meant beam sensitive materials can now be visualised more reliably with reducing detrimental effects. Our spotlight on cryo-TEM imaging of liposomes explains more about howthe fantastic combination of a high performance camera and specialist sample preparation enables fantastic characterisation. #TEM #electronmicroscopy #liposomes #cryoem #imagingtechnology
✨ Does your business require TEM services? Check out our new Technique Spotlight and get in touch! ✨ Cryo-Transmission Electron Microscopy was used to assess the size and morphology of liposome formulations containing Vitamin C. Lipid liposomes are used to slow down the release of Vitamin C into the body. Cryo-TEM (at around -175C) is used to retain the native structure of the liposomes during imaging. Size analysis of the liposomes captured during imaging found the sample was non-homogeneous and this extends the release rate of the vitamin encapsulated within. Imaging was performed by Dr Julie Watts using the JEOL EUROPE 2100F Transmission Electron Microscope equipped with a Gatan Inc. 626 cryogenic holder. 📌Find out more about our commercial services below! 🌐https://lnkd.in/ewTiJr3Q ✉ nmcs@nottingham.ac.uk
