Max Planck Institute for the Science of Light’s Post

Breast magnetic resonance imaging (MRI) uses magnetic fields to create an image of the breasts. It’s used in breast cancer screening for some women at higher risk, such as those with inherited gene mutations linked to breast cancer or those who received radiation treatment to the chest area between ages 10-30. It’s not a recommended breast cancer screening test for women of average risk. Learn more about breast MRI, and view an interactive model of what a breast MRI may show: https://bit.ly/3y2JwRl

Animal models may not be transposable to humans, and in cancer research, this can compromise accuracy...😔 What if you had a tool that truly mimics human tumor environments? 💭 We are happy to present the SynTumor 3D Cancer Model from SynVivo, Inc! 🎉 This new chip reproduces realistic tumor environments, reaching a level of complexity close to that of the human body.  And thanks to its unique vascularised network design, you can get real insights into how drugs interact with tumor cells! Ready to accelerate your research? 😁 Check out the details and see how SynTumor can change your approach to cancer research: https://lnkd.in/eR4rPYqD 👩🔬👨🔬 #cancermodeling #drugscreening #microbiology

The gene-editing technology CRISPR shows early promise as a therapeutic strategy for the aggressive and difficult-to-treat brain cancer known as primary glioblastoma, according to findings of a new study from Gladstone Institutes. Using a novel technique they’ve dubbed “cancer shredding,” the researchers programmed CRISPR to zero-in on repeating DNA sequences present only in recurrent tumor cells—and then obliterate those cells by snipping away at them. Working with cell lines from a patient whose glioblastoma returned after prior treatments, the team used CRISPR to destroy the tumor cells while sparing healthy cells. Read more about the study: https://bit.ly/46xIB6X

Study 3D skin models for cancer research with ZEISS arivis We are glad to learn how arivis facilitated the study of 3D skin cancer models by providing advanced imaging analysis. Researchers used arivis software to analyze the spatial arrangement of their innovative 3D bio-printed skin cancer and normal skin constructs. These 3D models more accurately emulate the in vivo tumor microenvironment than traditional 2D cell cultures. Leveraging arivis for this type of 3D cell culture research can enhance insights into cancer biology and drug responses. https://lnkd.in/e9zSdVDN

Source: Frontiers in chemistry This study used ultrahigh resolution lipid mass spectrometry imaging to investigate the spatial distribution and alterations of lipids in ovarian tissues from mouse models of high-grade serous ovarian cancer. The researchers identified specific lipid biomarkers that could potentially be used for future diagnostic purposes. The study provides insights into the molecular level progression and metastasis mechanism of ovarian cancer.

New from Cell Chemical Biology: Arc Core Investigator and Stanford University Biochem Professor Lingyin Li explores the future of cancer therapy using cGAMP-STING 🧬 The Li lab works to investigate how the signaling molecule cGAMP is passed between different cell types to activate the STING pathway and how cancers escape detection through cGAMP degradation — which controls how immune cells are recruited to a tumor to fight cancer. The perspective piece from Dr. Li outlines the successes + setbacks of cGAMP analogs as STING agonists, as well as new strategies for boosting endogenous cGAMP-STING signaling for cancer therapy while avoiding toxic side effects.👇 https://lnkd.in/gaaD2ZME

Epigenetics play a significant role in cancer onset and spread, and scientists explore epigenetic regulators for their roles in carcinogenesis. In this webinar brought to you by The Scientist, Özgen Deniz and Christina Leslie will explore the role of epigenetic dysregulation in cancer and how epigenomics can help dissect the molecular pathology of cancer. Our speakers will look at repeatome epigenetic dysregulation in oncogenesis and how to analyze epigenomic data to characterize epigenomic mechanisms of cancer pathology and identify potential new targets for therapeutics. 📅 April 1, 2024 @ 10AM ET Register now: https://ow.ly/mnAV50QGOrN

Can we detect HER2 expression from a single tube of blood? As extracellular vesicles are increasingly employed to gain insights into tumor biology, oncosomes, tumor specific large extracellular vesicles, hold promise as complementary liquid biopsy analytes. Attend this webinar to discover a novel method for oncosome detection using the RareCyte CTC platform. Register here, https://lnkd.in/gi833GjU   Dr. Papp, CellCarta, will present findings from a proof-of-concept study that combine data from oncosomes, CTCs, and cfDNA analysis to identify metastatic breast cancer patients with elevated HER2 expression. Learn more about the RareCyte CTC platform, https://lnkd.in/gttHAdb6 CellCarta #PrecisionMedicine #circulatingtumorcells #LiquidBiopsy #RareCyte

Highlights from PCF’s 30th Annual Scientific Retreat PCF hosts an Annual Scientific Retreat to share the latest research findings, inspire collaboration, promote mentorship, and honor the newest awardees. Meeting sessions at the 30th Retreat addressed basic biology and genetics research, clinical trials, treatment resistance, and the future of AI in prostate cancer. Below are just a few examples of cutting-edge findings presented at the meeting. -A clinical trial suggests synergistic effects in combining treatments for advanced prostate cancer -A new test identifies deadly neuroendocrine prostate cancer, and may also be useful in lung cancer -AI has the potential to improve prostate cancer diagnosis and characterization -A large study of men of African ancestry reveals a complex and varied genetic profile

Excited to share our latest review, "The reckoning of chromosomal instability: past, present, future," featured in the special issue on "Aneuploidy and Chromosome Instability"! Working with Andrew Lynch and Mark Burkard on this review was truly rewarding. In our review, we explore the quantitative measures of chromosomal instability (CIN) in cancer. We highlight how technological advancements have transformed CIN quantification, providing enhanced accuracy and profound insights. #ChromosomalInstability #Aneuploidy #CIN