ME Association’s Post

#RSCPoster #RSCAnalytical #Quality rather than Quantity ! Studying the quality of lipoproteins is proving to be a captivating and crucial field in biomedical research. These molecules, often considered mere carriers of lipids in the body, are emerging as true indicators of cardiovascular and metabolic health. Analyzing not only the quantity but also the composition and characteristics of lipoproteins provides a novel window into the complexity of physiological and pathological processes. In a world where cardiovascular and metabolic diseases are increasingly prevalent, understanding the quality of lipoproteins could pave the way for new diagnostic and therapeutic strategies, promoting a personalized approach to medicine and enhancing the overall health of the population.

Our latest research uncovers the pivotal role of IL-18 in liver fibrosis. Discover how IL-18 impacts hepatic stellate cells (HSCs) and drives liver cirrhosis. This groundbreaking study sheds light on potential treatments for fibrosis. 👉 Read the full findings here: https://ow.ly/LYL150QCh1l #LiverHealth #Research #FibrosisTreatment #UCSD #UCSDHealth #UCSDACTRI

💖🔬 Happy Valentine's Day! Today, let's take a moment to appreciate the heart, not just metaphorically but scientifically too. 🔍 This image, captured by Prof. Lynn Roth's lab, depicts a high-magnification view of a mouse heart. In purple, you can see normal cardiac cells, while in blue, fibrotic scar tissue indicates myocardial infarction - truly, a visual representation of a broken heart. Prof. Lynn Roth's research group (within the #Physiopharmacology lab) aims to understand why blood vessels age and how this contributes to heart-related health problems. They are also exploring potential treatments to improve aging-related heart and blood vessel diseases. This could lead to new drugs or approaches to prevent ‘broken hearts’ 💔 and help people live healthier lives as they get older. Learn more about the Physiopharmacology lab here: https://lnkd.in/dn8afRm #PharmaceuticalSciences #Research #Heart #STEM #PhD #LetsShapeTheFuture Physiopharmacology Research Group

🔬 Investigating HO-1 Regulation: Insights from BACH1 Knockout Mice in Sepsis Raghavan Pillai Raju, from the Medical College of Georgia at Augusta University, USA, shared compelling findings at Redox Medicine 2024. His research explores how HO-1 regulation is altered in BACH1 knockout mice during sepsis, providing crucial insights into the complex interplay of oxidative stress and immune responses. #HO1Regulation #SepsisResearch #RedoxMedicine

【The Application of Analytical Techniques to Alpha-Synuclein in Parkinson’s Disease】 Full article: https://lnkd.in/gpnuC8cZ (Authored by Olatayo Adedayo Olahanmi, from Middle Tennessee State University, USA.) Alpha-synuclein is a small, soluble protein predominantly expressed in the brain, particularly in the presynaptic terminals of neurons. It is also a protein central to the pathophysiology of #Parkinsons_disease (PD). The study of alpha-synuclein and its pathological forms is crucial for understanding the etiology of PD and developing effective diagnostic and therapeutic strategies. This review paper explores the various analytical techniques used to study #alpha_synuclein in the context of Parkinson's disease and assesses the impact of these analytical #techniques on both the understanding and treatment of Parkinson's disease. 

Heart failure with preserved ejection fraction (HFpEF) is increasingly prevalent, often associated with cardiac amyloidosis 🫀 In their latest article, Elena Cavallone et al. review the crucial role of oxidative damage in the progression of this condition. The study highlights how reactive oxygen and nitrogen species lead to cardiomyocyte damage, hypertrophy, and fibrosis, perpetuating a cycle of inflammation and redox damage. Understanding these mechanisms opens doors to potential therapeutic strategies. Dive into the detailed analysis and future prospects in cardiac amyloidosis research: https://lnkd.in/eNwSiYb4 Università degli Studi di Torino #HeartFailure #MedicalResearch #OxidativeStress

On World Sickle Cell Day, we celebrate the groundbreaking achievements of the 2024 Shaw Laureates in Life Science and Medicine, Dr Swee Lay Thein and Dr Stuart Orkin.   Their pioneering work on the fetal to adult haemoglobin switch has led to effective genome-editing therapies for sickle cell anaemia and β-thalassemia. This innovative research brings new hope to millions worldwide affected by these devastating blood disorders.   #theshawprize #ShawPrize #LifeScienceandMedicine #GenomeEditing #SickleCellAnemia #SickleCellDisease #Thalassemia #ScientificAchievement #WorldSickleCellDay The National Institutes of Health National Heart, Lung, and Blood Institute Harvard Medical School

#InTheNews: After presenting new data from our Phase 2a #clinicaltrial of ENV-101, investigator Toby Maher, M.D., Ph.D., Professor of Medicine and Director of Interstitial Lung Disease at Keck School of Medicine of the University of Southern California discussed the findings with Healio.    In this article, hear Dr. Maher’s perspective on the tremendous need for idiopathic pulmonary fibrosis (#IPF) treatments that do more than slow the decline of lung function and why #pulmonologists are keeping a close eye on Endeavor’s ENV-101: https://bit.ly/3VrSNvr    #biotechnews #science #lungdisease 

Exciting news! 🎉 Our latest research on acute respiratory distress syndrome (ARDS) in a porcine model is now published in Biomedicines. 🫁 This study, in collaboration with the talented Dr. Yuan-Ming Tsai, sheds light on the intricate relationship between hypoxia and circulatory shock in ARDS. 🔬 We delve into the role of hypoxia-inducible factors (HIFs) and their impact on the cardiovascular system during ARDS. 🫀 Our findings highlight the potential of the hypotension prediction index (HPI) as an early warning tool for hypotension in ARDS patients. 🚨 Additionally, we observed significant changes in HIF-related metabolites, suggesting a metabolic reprogramming in response to hypoxia. 🧪 We believe this research will pave the way for more targeted and effective treatments for ARDS, ultimately improving patient outcomes. 💪 Check out the full article here: https://lnkd.in/gf_CxzME 📖 #ARDS #research #CriticalCare #MedTwitter #Science #Pulmonary

🚨 New Publication Alert 🚨 Our latest study in Scientific Reports (DOI: 10.1038/s41598-024-76066-w) explores how the NLRP3 inflammasome contributes to cardiac dysfunction during acute inflammation. Using LPS-induced models, we found: 🧬 NLRP3 activation drives pyroptosis but not apoptosis. ❤️ LPS exposure impairs LV relaxation and myocardial deformation without affecting global systolic function. 🧪 NLRP3 antagonism reduces pyroptotic markers, offering potential therapeutic insights. Proudly representing IMPRI: Tiiso Maluleke, Ashmeetha Manilall, Nandi Shezi, Sooraj Baijnath & Aletta Millen #Inflammation #CardiovascularResearch #NLRP3 #ScientificReports #IMPRI