Medicines Discovery Catapult’s Post

FLUIDDA is very excited to announce an important collaboration with the THREE LAKES FOUNDATION to investigate early predictors of progression of interstitial lung abnormalities (#ILA) using quantitative CT imaging. ILA, which may be an early sign of pulmonary fibrosis (#PF), is a common incidental finding on chest CT scans, but researchers have yet to determine why some patients progress while others remain stable. This cooperative endeavor, sponsored by the THREE LAKES FOUNDATION, will be undertaken in collaboration with investigators at Vanderbilt University Medical Center and Weill Cornell Medicine. We share Three Lakes Foundation’s commitment to improving time-to-diagnosis, quality of life, and outcomes for patients living with PF. #fibrosis #lunghealth #IPF

The Clinical Services In IR Task Force developed a three-stage system for clinical services infrastructure development. This system shall help create awareness of the fact that different levels of service provision can be offered and worked towards. IRs may also use this system to benchmark themselves and set personal goals for future developments in their centre and practice. The three levels of clinical services infrastructure are split into #inpatient and #outpatient. What is your current level? Where do you see yourself in three years from now? What helps you or holds you back? Leave a comment to share your experience! Learn more about the three-stage system here: https://t.ly/8EvkP Task force members: Prof. Dr. Andreas H. Mahnken, Alessandro Cannavale, Joo-Young Chun, Thierry De Baere, Rok Dezman, Stevo Duvnjak, Miltiadis (Miltos) Krokidis MD, PhD, EBIR-ES, FCIRSE, FRCR, FSIR, Maria Antonella Ruffino, MD, EBIR, FCIRSE, Anthony Ryan, José Urbano García #IRgoingClinical #interventionalradiology #IRad #ClinicalServicesInIR

🎉 I am proud to share our Cochrane systematic review, which consolidates all available information regarding the reliability of structural ultrasound examinations for detecting congenital anomalies in the first and second trimesters. This review of 53,000 research papers(!) is a significant milestone in prenatal diagnostics, enhancing our understanding and capabilities in early anomaly detection. We invite colleagues, healthcare professionals, and researchers to read our findings and consider the implications for clinical practice. Find out more about our insights and conclusions here: https://lnkd.in/e26GgN76 Many compliments to my coauthors for getting this laborious job done and having it (finally) published! Marieke Buijtendijk, Bo Bet, Mariska Leeflang, Harsha Shah, Tom Reuvekamp, Timothy Goring, Daniël Docter, Melanie Timmerman, Yousif Dawood, Malou Lugthart, Bente Berends, Jacqueline Limpens, Eva Pajkrt, Maurice van den Hoff Amsterdam UMC, Amsterdam UMC - Amsterdam Reproduction and Development For more information on our work, please visit 3Dhumandevelopment.com #CochraneReview #Ultrasound #PrenatalCare #MedicalResearch #HealthcareInnovation

Notice the use of UEA in this patient population. This can be used for both 2D enhanced echocardiography and stress echocardiography not just in adult patients, remember we can use this and SHOULD use this in pediatric patients. #pedsueas #UEAs #contrastecho #pedsecho

📢 Latest European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential B3 lesions! 🎯 📎https://lnkd.in/dxZnBw8U 🌟 Top clinical relevance  👨⚕️ by leading authorities in the field. 📣 selected highlight  🔍 Advances in radiological imaging and image-guided sampling are essential 4 the up2date diagnosis and management of B3 lesions. 🤝 A multidisciplinary team approach is crucial 🗣️ patient communication is key #BreastHealth #B3Lesions #EuropeanGuidelines #MedicalAdvancements #PatientCenteredCare ✨

𝗧𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺𝗶𝗻𝗴 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝘄𝗶𝘁𝗵 𝗖𝗮𝗿𝗱𝗶𝗼𝘀𝗶𝗴𝗵𝘁®-𝗦 𝗮𝗻𝗱 𝗖𝗮𝗿𝗱𝗶𝗼𝗘𝘅𝗰𝘆𝘁𝗲 𝟵𝟲 Animal models often fail to accurately predict how human heart cells respond to new compounds due to differences between species. This highlights the urgent need for better models in drug testing. With NEXEL´s Cardiosight®-S human heart cells and the CardioExcyte 96 system, you gain access to reliable data that replaces animal testing and enhances the accuracy of drug-induced heart function studies. Our latest application note showcases this powerful combination, offering detailed guidance on compound treatment, data acquisition, and analysis. Key insights: ◾ Simultaneous measurement of both ion channel activity (EFP) and contractility (IMP) ◾ Dose-dependent effects of Nifedipine on beat rate and contractile force ◾ Non-invasive, label-free monitoring for long-term, high-resolution data Want to bring greater precision and predictability to your cardiac research? 📊 Explore the application note for valuable insights. Read more here: https://ow.ly/Tgpo50TqHI2 #CardiacResearch #DrugDiscovery #hiPSC #Cardiomyocytes #CardioExcyte96 #CellAnalytics

CALCIO is a prospective, observational cohort study that is collecting real-world data on the use of intravascular lithotripsy (IVL) with the Shockwave Medical IVL system (Shockwave Medical, Inc.) to disrupt vascular calcifications in patients with chronic limb-threatening ischemia (CLTI). The study was initiated and is co-chaired by Dr. Raman uberoi, Prof. Peter Reimer and Prof. Christoph Binkert. CALCIO started patient enrolment on July 15, 2024, with the goal of recruiting 400 CLTI patients over the next two years. Learn more about CALCIO via CIRSE Insider! ➡️ https://t.ly/fkULP #CIRSEinsider #interventionalradiology Next Research

Learn about the importance of custom-windowing techniques in CT imaging to better assess calcium and improve decision-making for TCAR candidacy. Read the clinical guide: https://lnkd.in/g4_eU2Ez

Connect with Kathryn Bungartz when you are in Florence and learn more about how we can help you in your daily work. #ngs #medicine #cancer #diagnostics

A damaged gut barrier is linked to worse outcomes in #IBD patients. Cutting-edge endoscopic methods, such as probe-based confocal laser endomicroscopy (pCLE), have shown promise in evaluating real-time structural and functional barrier impairment at a cellular level, enabling the prediction of therapy responses and potential negative clinical results. Tools like #Cellvizio can assist with forecasting treatment responses and creating tailored care strategies. Click here to read more: https://hubs.ly/Q02KJ3c70 #functionalimaging Crohn's & Colitis Foundation