Mia Chen’s Post

Caronic anhydride What is Caronic anhydride? Caronic anhydride (CAS NO.67911-21-1) is an intermediate for pharmaceuticals as Boceprevir and Paxlovid（nirmatrelvir and ritonavir）.  MF.: C7H8O3 CAS No: 67911-21-1 Chemical name: 6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione

DOTA PEG https://lnkd.in/gj4QuzGX DOTA PEG linkers are an important class of molecules widely used in pharmaceutical research and development. These linkers are composed of a DOTA chelator and a polyethylene glycol (PEG) chain. The DOTA moiety is used to bind to metal ions such as copper, gallium or lutetium, while the PEG chain provides stability and solubility to the resulting conjugate.

Harnessing strain-release driven reactivity of a chiral SuFEx reagent: Stereocontrolled access to sulfinamides, sulfonimidamides, and sulfoximines. The amine exchange can be done at either the S(IV) or S(VI) oxidation state, leading to diverse chemical space suitable for pharmaceuticals and organocatalysts. Over 70 examples highlight the broad functional group tolerance with an emphasis on complex pharmaceutical amines. Highly functionalized sulfonimidoyl ureas from a common precursor. https://lnkd.in/gfRKY-cz

Decarboxylative aminomethylation of aryl bromides with N-protected glycine as an aminomethyl source under nickel/photoredox-catalyzed conditions opens the gateway to primary benzylamines (ArCH2NH2), regarded as valuable building blocks for pharmaceuticals https://lnkd.in/d-uJxQ7j

𝗕𝗼𝗿𝗼𝗻-𝗖𝗼𝗻𝘁𝗮𝗶𝗻𝗶𝗻𝗴 𝗕𝘂𝗶𝗹𝗱𝗶𝗻𝗴 𝗕𝗹𝗼𝗰𝗸𝘀 𝗳𝗼𝗿 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵: 𝗕𝗲𝗻𝘇𝗼𝘅𝗮𝗯𝗼𝗿𝗼𝗹𝗲𝘀 Boronic acids are recognized as useful scaffolds for pharmaceutical compounds, due to their unique property to form a reversible covalent bond at the boron center with various nucleophilic functional groups. TCI can offer a wide range of benzoxaboroles with various functional groups on each benzene ring useful for further derivatizations and we also can provide custom synthesis of derivatives including bulk synthesis. 𝗟𝗲𝗮𝗿𝗻 𝗠𝗼𝗿𝗲: https://lnkd.in/gSfn7tGK #bulksynthesis #customsynthesis #pharmaceuticalcompounds #benzoxaboroles #medicinalresearch #boronicacids #researchchemicals #reagents

Metal-free synthesis of heterocycles is highly sought after in the pharmaceutical industry and more so when the heterocycle happens to be a "Pyridine" ring. A new method reports a radical 6-endo addition method for pyridine synthesis from cyclopropylamides and alkynes wherein various terminal and substituted alkynes can be inserted as C2 units into cyclopropylamides to synthesize versatile pyridines to suit the late-stage pyridine installation on complex molecules. The reaction is amenable to easily scale up with excellent functional group compatibility while avoiding the headache of eliminating the need to remove trace metal catalysts from the reaction. https://lnkd.in/gBYvDQex

🔬 We are excited to share our latest case study on Container Closure Integrity (CCI)  for autoinjectors with optically transparent windows. This study highlights our collaboration with Ionis Pharmaceuticals, Inc. to improve the reliability and safety of their autoinjector packaging. This case study demonstrates that a non-destructive CCI test method, based on headspace analysis, can be used to directly evaluate the CCI of a fully assembled autoinjector configuration when it has an optically transparent window. Read full case study here 👉 https://lnkd.in/eTb9VQaE #LighthouseInstruments #CCIT #Autoinjectors

I am delighted to share another published review article titled "Different Biological Activities and Structure Activities Studies of Acridine and Acridone Derivatives: An Updated Review" in the World Journal of Pharmaceutical Research. SJIF Impact Factor - 8.453 DOI: 10.20959/wjpr202416-33529

The Dangers of statins and modern pharmaceuticals! The beneficial effects of Estradiol and Testosterone on lipids - massively different than the synthetic drugs of modern pharmaceuticals!! https://lnkd.in/eASGfiSg

A solution for the coupling of troublesome heterocycles ?