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Electrophysiological recording with glass electrodes is one of the best techniques to measure #membranepotential dynamics and ionic currents of voltage-gated channels in neurons. However, artifactual variability of the biophysical state variables that determine recording quality can be caused by insufficient affinity between the electrode and cell membrane during the recording. In this study, Angelica Jameson et al. utilized membrane-coated glass electrodes for the purpose of reducing artifactual variabilities delivered by technical difficulties of Drosophila #electrophysiology. The results indicate that membrane-coated glass electrodes reduce the variability of biophysical parameters and eliminate artifactual noise components. This innovation holds the potential for reliable recordings in challenging model systems such as Drosophila central #neurons and represents a step towards optimizing intracellular electrophysiology in such contexts. Read the article: https://bit.ly/4bl9kHg Learn more about the the patch-clamp systems used for this experiment: https://bit.ly/3QNCvuo

Membrane-coated glass electrodes for stable, low-noise electrophysiology recordings in Drosophila central neurons

Membrane-coated glass electrodes for stable, low-noise electrophysiology recordings in Drosophila central neurons

ncbi.nlm.nih.gov

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