Allen Institute for Neural Dynamics’ Post

⚡ Are you fascinated by the intricate workings of cells and the mysteries of neural activity? If so, we have an exciting opportunity for you to dive into the field of #electrophysiology and unleash your scientific curiosity!   On the page below, you'll find a treasure trove of information about electrophysiology and the #patchclamp technique. Gain a deeper understanding of how current and voltage changes across cell membranes drive cellular functions and contribute to neurological diseases. Learn about the essential components of an electrophysiology lab setup, including environment, optics, mechanics, and electronics. Understand how our #axon instrument portfolio, featuring amplifiers, digitizers, software, and accessories, provides a comprehensive solution for patch-clamping experiments of all scales.   We have curated a collection of resources, including webinars, customer stories, and application notes, to further enhance your knowledge and expertise in the field of electrophysiology. Click below to learn more! #neuroscience #neuron #neurodegenerative #actionpotential

⚡ Are you fascinated by the intricate workings of cells and the mysteries of neural activity? If so, we have an exciting opportunity for you to dive into the field of #electrophysiology and unleash your scientific curiosity!   On the page below, you'll find a treasure trove of information about electrophysiology and the #patchclamp technique. Gain a deeper understanding of how current and voltage changes across cell membranes drive cellular functions and contribute to neurological diseases. Learn about the essential components of an electrophysiology lab setup, including environment, optics, mechanics, and electronics. Understand how our #axon instrument portfolio, featuring amplifiers, digitizers, software, and accessories, provides a comprehensive solution for patch-clamping experiments of all scales.   We have curated a collection of resources, including webinars, customer stories, and application notes, to further enhance your knowledge and expertise in the field of electrophysiology. Click below to learn more! #neuroscience #actionpotential #neurodegenerative

Electrophysiological recording with glass electrodes is one of the best techniques to measure #membranepotential dynamics and ionic currents of voltage-gated channels in neurons. However, artifactual variability of the biophysical state variables that determine recording quality can be caused by insufficient affinity between the electrode and cell membrane during the recording. In this study, Angelica Jameson et al. utilized membrane-coated glass electrodes for the purpose of reducing artifactual variabilities delivered by technical difficulties of Drosophila #electrophysiology. The results indicate that membrane-coated glass electrodes reduce the variability of biophysical parameters and eliminate artifactual noise components. This innovation holds the potential for reliable recordings in challenging model systems such as Drosophila central #neurons and represents a step towards optimizing intracellular electrophysiology in such contexts. Read the article: https://bit.ly/4bl9kHg Learn more about the the patch-clamp systems used for this experiment: https://bit.ly/3QNCvuo

Need more contrast in your images? Download our #LabHacks Poster 'A guide to Differential Interference Contrast (DIC)' which will guide you through the steps to set up this technique on your upright #microscope. https://buff.ly/3U1KfLF #patchclamp #electrophysiology

Did you know we offer free #lab consultations? Whether you are starting a new lab or want to ensure you have the right equipment for your experiments, we can help optimise your lab through a free consultation. Learn more: https://buff.ly/3rrSYuf #electrophysiology #multiphoton #science

𝗖𝗲𝗹𝗲𝗯𝗿𝗮𝘁𝗶𝗻𝗴 𝟮𝟬 𝗬𝗲𝗮𝗿𝘀 𝗼𝗳 𝗣𝗼𝗿𝘁-𝗮-𝗣𝗮𝘁𝗰𝗵 🎉 The Port-a-Patch is a turn-key miniaturized patch clamp system enabling the user to rapidly generate high quality data, regardless of experience. In 2023, we marked the 20th anniversary of our first product in the market: the 𝗣𝗼𝗿𝘁-𝗮-𝗣𝗮𝘁𝗰𝗵. This innovative device was the first to provide high-fidelity Giga seals on a chip to perform semi-automated patch clamp experiments. To honor this achievement, we interviewed our CEO, Niels Fertig, who shared his vision and insights on how the Port-a-Patch revolutionized the field of electrophysiology and opened new possibilities for research and discovery. Cheers to 20 years of Port-a-Patch! 🥂 Read the interview here: https://ow.ly/LBWw50Ql6OM? Learn more about Port-a-Patch: https://lnkd.in/dV-pXz5q #PortaPatch #PatchClamp #Interview #TeamNanion #Innovation #Electrophysiology #IonChannels #APC #CellAnalytics #MembraneBiophysics

Research suggests the human brain consists of about 86 billion neurons. Each neuron forms connections to other neurons, which could add up to 1 quadrillion (1,000 trillion) connections. Over time, these neurons can combine, increasing storage capacity. Brain information travels up to an impressive 268 miles per hour with the help of these connections. There are four types of neurons:  Sensory: Sensory neurons deliver electrical signals from the outer parts of the body — the glands, muscles, and skin — into the CNS. Motor: Motor neurons carry signals from the CNS to the outside parts of the body. Receptors: Receptor neurons sense the environment (light, sound, touch, and chemicals) around you and convert it into electrochemical energy that is sent by sensory neurons.  Interneurons: Interneurons sends messages from one neuron to another. #neuron #Humanbrain #Controlandcoordination #Medical #Biology

Wi-Fi for neurons: first map of wireless nerve signals unveiled in worms. Studies find a densely connected network of neurons that communicate over long distances, rather than across synapses. This changes the long held idea that the nervous system passes messages from one nerve cell to another only through synapses, the points where the cells link up end to end. Biological mechanisms to support this 'wireless' connection are intriguing. What do you think? https://lnkd.in/gffrBCVv

In a new Brain Stimulation journal publication with Forouzan Farahani Niranjan Khadka Lucas Parra, Mihály Vöröslakos. Using Neuropixels 284 channels probes in-vivo rat model of transcranial electrical stimulation (tES). We show 0.35 V/m electric fields (like 1 mA tDCS/tACS) change neuronal firing rate. That is: currents used in tDCS and tACS produce electric field in the brain sufficient to change firing. I would say - not surprising but an important and rigorous direct verification. https://lnkd.in/e7T3VkMv

As the Editor's Summary tells us, "a complete understanding of the human brain begins with elucidation of its structural properties at a subcellular level". And so, here it is! https://lnkd.in/ePVmak2r