Nitin Mahajan’s Post

📣 We are thrilled to announce our participation in the leading Spanish Hepatology Congress, by Asociación Española del Estudio del Hígado, where we have presented an original scientific poster.  🆕 This new research is the result of our R&D team, focused on developing an improved culture model using human precision-cut liver slices (hPCLS) to investigate the phenotype and functionality of the hepatic sinusoid in the context of chronic liver disease. By using our patent-protected chip with microfluidics, we are able to culture hPCLS with: ✔ Extended half-life, up to 7 days. ✔ Enhanced structural and functional integrity of the tissue. ✔ Prevention of the loss of the sinusoidal cell phenotype. This model represents a new research tool that brings us closer to clinical applications compared to traditional models 🚀  #AEEH2024 #Liver #Sinusoid #Hepatology #Cirrhosis #ACLD #PCLS #3Dmodel #Scientificinnovation

Clinicians with an interest in thrombophilia: Attend our next NBCA Journal Club session! The NBCA Journal Club highlights groundbreaking research in thrombosis and thrombophilia and features a manuscript author as part of the discussion. Our next session convenes June 18, 2024 from 2-3 p.m. ET to discuss, Antithrombin Therapy: Current State and Future Outlook, published in Clinical and Applied Thrombosis/Hemostasis in 2023. The paper’s author, George M. Rodgers, III, MD, PhD, Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah School of Medicine, will join us to discuss his research. The session’s learning objectives: - Understand the genetic and acquired factors contributing to antithrombin (AT) deficiency and its implications. - Explore current treatment strategies for managing AT deficiency. - Identify specific patient populations and use cases where AT therapy may be considered and evaluate its potential benefits. - Investigate advancements and future directions in research, diagnosis, and treatment approaches for AT deficiency to enhance clinical outcomes and patient care. Register: bit.ly/NBCAJournalClub2024 #stoptheclot #nbcajounalclub #bloodclots #thrombophilia #thrombosis #antithrombintherapy #antithrombindeficiency #bloodcloteducation #continuingeducation

🔬 Exciting News! 📚 Thrilled to announce that a research paper from our group in IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna has been accepted by the Journal of Clinical Medicine (JCM) MDPI 🎉📄 💥 AUTOIMMUNE POLYENDOCRINE SYNDROMES IN ADULT ITALIAN CELIAC DISEASE PATIENTS💥 In this study, we delved into the prevalence of #autoimmune #polyendocrine syndromes in a cohort of patients with #celiac disease. Our findings emphasize the importance of a multidisciplinary management strategy for celiac patients, recognizing the intricate connections between different autoimmune conditions. 🔍 Understanding the "mosaic of autoimmunity" opens new avenues for comprehensive patient care and sheds light on the complex interplay of various autoimmune disorders within the same individual. 🤝 Grateful for the collaboration with fellow researchers and the support of our institution throughout this journey. Special thanks to the "Journal of Clinical Medicine" for providing a platform to share our insights. 📌 Looking forward to contributing more to the field of autoimmune research and advancing patient-centred approaches to healthcare. 💪🏼👩🔬👨⚕️ Free full text: https://lnkd.in/dMx2wDPu #Research #Autoimmunity #CeliacDisease #ClinicalMedicine #Healthcare #MedicalResearch #familyofautoimmunity #mosaicofautoimmunity

I am excited to announce the release of the latest scientific paper I had the privilege to contribute to, in collaboration with esteemed researchers from the University of East Anglia Medical School, under the guidance of Prof. Vass Vassiliou. 📄 Title: "Cost effectiveness analysis of drug coated balloon only angioplasty for de novo coronary artery disease" 🔗 Explore the full publication here: https://lnkd.in/eU45iQVs #uea #healtheconomics #cardiovasculardisease

🚨 Research Alert 🚨 I think it is important to share this pioneering study just published in the New England Journal of Medicine that demands our attention: "Microplastics and Nanoplastics in Atheromas and Cardiovascular Events." Conducted as a prospective, multicenter, observational study, it explored the presence of Microplastics and Nanoplastics - MNPs - in carotid artery plaque of patients undergoing carotid endarterectomy. Findings revealed a startling correlation: patients with MNPs in their arterial plaque showed a markedly higher risk of experiencing major cardiovascular events, such as myocardial infarction, stroke, or death, over a 34-month follow-up period. This research is among the first to directly link MNPs exposure to heightened cardiovascular risk in humans, building on previous preclinical studies that hinted at this alarming connection. The implications of these findings are profound, urging a reevaluation of our environmental policies and personal habits concerning plastic use and disposal. We should encourage innovation and adherence to sustainability principles to safeguard our health and the environment for future generations. #EnvironmentalHealth #CardiovascularResearch #Microplastics #Nanoplastics #NEJM #PublicHealthAwareness https://lnkd.in/dBqEcTR8

🔬Exciting news from the world of medical research! A recent study from the University of Miami Miller School of Medicine has made significant strides in understanding and potentially treating inflammatory joint diseases. Here’s what you need to know: The onset and progression of human inflammatory joint diseases are strongly linked to the activation of resident synovium/infrapatellar fat pad (IFP) pro-inflammatory and pain-transmitting signaling. This researchers hypothesize that the robust immunomodulatory effects of IFP-MSCs are largely exerted via their CD10-bound small extracellular vesicles (IFP-MSC sEVs), which they isolated and expanded in ELAREM™ HPL to assess their sEV miRNA cargo using multiplex methods. Through that, they found that CD10High and CD10Low sEVs possess distinct miRNA profiles. The study suggests that CD10High sEVs possess immunomodulatory miRNA attributes with strong chondroprotective/anabolic effects for articular cartilage in vivo. These results could serve as a foundation for sEV-based therapeutics for the resolution of detrimental aspects of immune-mediated inflammatory joint changes associated with conditions such as osteoarthritis. 1. Kouroupis, D., Kaplan, L. D., Huard, J. & Best, T. M. CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions. Cells 12, 1824 (2023). https://lnkd.in/e3DAV7ey #extracellularvesicles #exosomes #miRNA #humanplateletlysate #osteoarthritis #jointdisease #cartilage #stemcells #celltherapy #PLBS

🏥 Substantial new contribution by friends and former Johns Hopkins Medicine colleagues Bradley N. Reames & Aslam Ejaz to our special issue "Pancreatic Cancer: Recent Advances and Future Challenges" in the Journal of Clinical Medicine (JCM) MDPI (together with Lois Daamen & I.Q. Molenaar). 🎓 This systematic review examines the recurrence patterns after resection of non-invasive Pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN). The results highlight the need for both accurate post-operative risk-stratification and evidence-based surveillance strategies. Article link: https://lnkd.in/eFz-TFny.

Clinicians with an interest in thrombophilia: Attend our next NBCA Journal Club session! The NBCA Journal Club highlights groundbreaking research in thrombosis and thrombophilia and features a manuscript author as part of the discussion. Our next session convenes June 18, 2024 from 2-3 p.m. ET to discuss, "Antithrombin Therapy: Current State and Future Outlook," published in Clinical and Applied Thrombosis/Hemostasis in 2023. The paper’s author, George M. Rodgers, III, MD, PhD, Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah School of Medicine, will join us to discuss his research. The session’s learning objectives: - Understand the genetic and acquired factors contributing to antithrombin (AT) deficiency and its implications. - Explore current treatment strategies for managing AT deficiency. - Identify specific patient populations and use cases where AT therapy may be considered and evaluate its potential benefits. - Investigate advancements and future directions in research, diagnosis, and treatment approaches for AT deficiency to enhance clinical outcomes and patient care. Register: bit.ly/NBCAJournalClub2024 #stoptheclot #nbcajounalclub #bloodclots #thrombophilia #thrombosis #antithrombintherapy #antithrombindeficiency #bloodcloteducation #continuingeducation

A study in Science Translational Medicine reveals that the risk of prolonged severe COVID-19 varies among immunosuppressed individuals. The research, led by Yijia Li, M.D., from Harvard Medical School, emphasizes the importance of understanding immune defects influencing persistent COVID-19 across various immunosuppressive conditions. #COVID19Research #Immunocompromised #SARSCoV2 #HealthStudy #Immunosuppression #MedicalResearch

Hematological malignancies impact millions worldwide, including a significant number in the U.S. The complexity and varied nature of these diseases make traditional approaches to Real-World Data (RWD) analysis challenging. ConcertAI stands as a leader in RWD, collaborating with foremost experts in hematological testing and interpretation. Our mission is to develop pivotal reference data sets for hematological research. We are at the forefront of redefining solutions for hematological clinical trials, moving beyond conventional methods to provide more insightful and effective strategies. Looking for sophisticated solutions in hematological research or more effective strategies for your clinical trials? ConcertAI is your go-to partner. Visit us at ASH this year to learn how we're reshaping the world of hematological research and clinical trials. Together, let's advance our understanding and treatment approaches! https://lnkd.in/ghVuCf2T #Hematology #RWD #ClinicalTrials #Innovation #ConcertAI American Society of Hematology