NUVISAN The Science CRO’s Post

Ciao Roma! It's been a great start to the EFMC, with interesting talks on covalent drug discovery, beyond Ro5 and more, and the team is loving hearing the latest research and catching up with friends old and new. If you've not seem them yet, stop by booth #49 to say hello to Catherine and Patrik, or poster 491 to talk generative chemistry later today. EFMC - European Federation for Medicinal Chemistry and Chemical Biology #EMFCISMC24 #MedicinalChemistry

📯 We are at Frontiers in Medicinal Chemistry (FIMC) 2024 in Munich!   If you’re attending FIMC 2024, make a pitstop at Booth number 5 and have a chat with our experts Franz von Nussbaum, Felix Pape, Arun Narine and Robert R. A. Freund! 🔬 From hit-to-lead and lead optimization to scale-up, biotransformations, and physchem characterizations, our team of scientists helps turn your hit molecules into drugs. #medicinalchemistry #discoverychemistry #drugdiscovery #datascience

Following last week’s successful “4th EDELRIS Symposium on Affinity Selection – Mass Spectrometry”, we continue this week in another medicinal chemistry research setting. Edelris’ CSO Didier Roche, is present as an invited speaker at the “CCG, UGM & Conference” in Lyon. Here, Didier will explain more about the clever uses of Edelris’ Keymical Space of innovative synthetic NP-like and SP3-enriched topologies for the rational design of innovative target modulators. If you want to know more about our groundbreaking Keymical Space, do not hesitate to contact us! #medchem #molecularmodelling #chemicalbiology #innovation  

Check out my latest publication! In this work, we explore the use of photobiocatalysis for an enantioselective hydroamination reaction. This reaction can shorten the synthesis routes to chiral amine building blocks, molecules which have applications in pharmaceuticals, agrochemicals, and specialty chemicals. I’m thrilled to see this work finally published as it is my first, first-author publication of my PhD. More are yet to come soon!

Discover Novel Bioactive Compounds with Enamine’s Pseudo-Natural Products! Dive into the groundbreaking research on pseudo-natural products (PNPs) published in the RSC Medicinal Chemistry journal. This pivotal study, "Identification of Readily Available Pseudo-Natural Products," by Axel Pahl, Oleksandr Grygorenko, Ivan Kondratov, and Herbert Waldmann, reveals how Enamine’s extensive library of synthetic small molecules offers a treasure trove of structurally unique PNPs.  ▪ Vast Collection: Immediate access to diverse PNPs combining natural product fragments in novel ways; ▪ Advanced Tools: Utilized an improved NPFC tool to classify and analyze PNPs, revealing significant bioactivity potential; ▪ Efficient Discovery: Enamine’s library accelerates the discovery of novel chemotypes, providing a cost-effective alternative to traditional synthesis. Enamine’s PNPs can revolutionize drug discovery, enhancing the potential for finding new bioactive compounds and supporting innovative research. Read more https://lnkd.in/d4KSz6CU More about Enamine Compound Libraries https://lnkd.in/dbjfQaz8

The dedicated team at the Biomolecule Synthesis Laboratory (LSB / LNBio / CNPEM) is celebrating a significant milestone! We've recently completed the installation of a Liberty Blue 2.0 Automated Peptide Synthesizer, and their preliminary results are nothing short of remarkable. Since then, several synthesis tests have been carried out with excellent results. Their peptides have shown high yield and excellent degree of purity at ~ 80 to 95%. As a result, #LSB is now one of the few institutions in Brazil (and Latin America!) equipped for automated and optimized peptide synthesis and the only one equipped to synthesize #DNA, #RNA, and #Oligonucleotides. A huge congratulations to Thaíssa Engel and the entire team! Your dedication and expertise continue to push the boundaries of biomolecular research. Best of luck with your #research going forward. #PeptideSynthesis #Biotechnology #ScientificInnovation #AutomatedSynthesis #BiomolecularResearch #TeamSuccess #ResearchAndDevelopment #ScienceNews Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) Laboratório Nacional de Biociências (LNBio) LSB (Lean Scheduling Brazil)

This week, I am in Rome at the XXVIII European Federation of Medicinal Chemistry-International Symposium on Medicinal Chemistry (EFMC-ISMC) with Anders Johansson. This afternoon Anders has been presenting on one of our small molecule candidate drugs in the 1st time disclosure session. The title of the presentation was "Inhibition of the NLRP3 Inflammasome is a Promising Concept to Treat a Variety of Inflammatory Diseases". This is the largest European symposium in medicinal chemistry, chemical biology and drug discovery, bringing together over a 1300 participants from industry and academia. EFMC - European Federation for Medicinal Chemistry and Chemical Biology. #EFMCISMC #MedicinalChemistry #InflammatoryDiseases

Did you miss any of our July news and highlights? Here is a comprehensive summary of our posts for this month: https://lnkd.in/e4yDc5Ha! ✅ News & Collaborations: 1. Rita Gaidar and Anna Kapeliukha were pleased to attend the 58th International Conference on Medicinal Chemistry (#RICT 2024) in Bordeaux! 2. A new tool from MolSoft LLC for fast conformer generation is now available at Chemspace! 3. Chemspace offers Deubiquitinating enzymes from Biortus to facilitate new drug development! 4. Now all hot offers are in one place: https://lnkd.in/ezsPQrJk! 5. New page for promotional materials: https://lnkd.in/eUzmu_3x! ✅ #Meet_Chemspace_Team: Meet our Account Manager - Halina Hrodziuk! ✅Building Block and Screening Compound Sets: 1. 'Analogs to New Biological Tool Compound'– discover analogs for Ifebemtinib! 2. 'Building Blocks for Analogs'- check out our new post about Fosigotifator!  ✅'Biologics for Research' series:  Meet a new post about Orexin receptors! #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures

Interested in Synthesis of Sugar-Derived Heterocycles via Multicomponent Reactions, then read this detail review highlighting the growing utility of multicomponent reactions (MCRs) for the synthesis of diverse sugar-derived heterocyclic compounds. Divya Mathur and co authors provide an in-depth look at how sugars can be leveraged in a range of MCR methodologies. Key MCR approaches covered include the Passerini, Ugi, Petasis, Prins-Ritter, Mannich, and Hantzsch reactions, among others. The review showcases how the combination of sugars with diverse reactants can generate extensive libraries of glycoconjugate structures with potential biomedical applications. This work underscores the power of MCRs as efficient tools for diversity-oriented synthesis, harnessing the unique properties of sugars. The review is a must-read for synthetic and medicinal chemists interested in innovative approaches to accessing complex heterocyclic scaffolds. #ChemistryResearch #OrganicChemistry #SynthesisChemistry #Multicomponent_Reactions #SugarChemistry #HeterocyclicCompounds #DiversityOrientedSynthesis #DrugDiscovery SYNTHESIS Journal

Spotlight on our NanoVator: Marco Ciufolini: A Pioneer in Synthetic Organic Chemistry   Marco Ciufolini, Co-Founder and VP, Chemistry at NTx, has an illustrious career spanning over three decades in academia and pharmaceutical industry. With a BS from Spring Hill College, a PhD from the University of Michigan, and a PostDoc at Yale, Marco has significantly contributed to the development of commercial pharmaceuticals, including Onpattro® and Masitinib®. Now, at NanoVation, he leads our innovative chemistry efforts.    🏆 Achievements Invented D-Lin-KC2-DMA for nucleic acid delivery Developed Masitinib®, now in phase III clinical trials  Authored over 160 technical papers and 48 patents    🎵 Beyond the Lab Marco enjoys history, philosophy, and classical music, both orchestral and operatic. He is an avid user of YouTube and supporter of Wikipedia, both of which provide him with ample material to keep him intellectually stimulated.    🔬Fun Fact Marco became interested in chemistry at age 7 and received his first chemistry set at 8. The rest is history...   #Chemistry #Pharmaceuticals #Innovation #NanoVationTherapeutics #NanoVators  #RNA #Nucleicacid #LNP