OLS OMNI Life Science’s Post

Hematopoietic Stem Cells (HSCs) are stem cells capable of replenishing blood and immune cells in the body. Since the establishment of high-purity isolation methods and identification of HSCs, regulating them has presented significant challenges. Among these challenges was the establishment of an ex-vivo HSCs expansion technique, a goal pursued by researchers.   In a recent webinar, Professor Satoshi Yamazaki from the University of Tokyo, Dr. Hans Jiro Becker from the University of Tsukuba, Meike Roskamp and Tsubasa Sano from BASF Pharma Solutions discussed key considerations for a robust culturing method using synthetic polymers, and the advancements in gene editing techniques derived from this technology!   If you missed the live event, you can view the recorded webinar on our Learning Center: https://lnkd.in/evAtkDHh #BASFPharmaSolutions #HSCs #SyntheticPolymer #Webinar

Are you working with EVs? Did you know that transmission electron microscopy (TEM) is a powerful tool for characterizing EVs? At QuTEM, we offer advanced nsTEM and cryoTEM analysis services, giving you detailed insights into exosomes and other EVs. Our services include: • Overall sample morphology  • Integrity assessment  • Aggregation analysis  • Particle classification based on internal structure and density Extracellular Vesicles (EVs) are emerging as key players in diagnostics and therapeutics, evolving from simple intercellular messengers to potential game-changers in medicine! These lipid bilayer-bound particles, ranging from 20-30 nanometers to 10 microns, carry a rich cargo of proteins, lipids, and nucleic acids, enabling the transfer of genetic material between cells. Thanks to recent technological advances, EV research is providing groundbreaking insights into cellular communication and disease mechanisms. Monitor the quality of EVs throughout the manufacturing process, whether for gene therapy, vaccine development, or drug delivery, our tailored analysis can help you explore the full potential of EVs! #EV #QuTEM #TEM #Technology 

🔬 Monitor the quality of EVs throughout the manufacturing process Extracellular Vesicles (EVs) are emerging as key players in diagnostics and therapeutics, evolving from simple intercellular messengers to potential game-changers in medicine! These lipid bilayer-bound particles, ranging from 20-30 nanometers to 10 microns, carry a rich cargo of proteins, lipids, and nucleic acids, enabling the transfer of genetic material between cells. Thanks to recent technological advances, EV research is providing groundbreaking insights into cellular communication and disease mechanisms. Did you know that transmission electron microscopy (TEM) is a powerful tool for characterizing EVs? At QuTEM, we offer advanced nsTEM and cryoTEM analysis services, giving you detailed insights into exosomes and other EVs. Our services include:  • Overall sample morphology  • Integrity assessment  • Aggregation analysis  • Particle classification based on internal structure and density Whether for gene therapy, vaccine development, or drug delivery, our tailored analysis can help you explore the full potential of EVs! #EV #QuTEM #TEM #Technology 

🧬  NTx Spotlight at ASGCT 2024: Advancing Genetic Medicines 🧬   Jessica Silva, a dedicated scientist at NanoVation Therapeutics, is gearing up to present our latest research at the American Society of Gene & Cell Therapy Annual Meeting. She will be diving into our sophisticated use of Long-Circulating Lipid Nanoparticles (LCLNP) for targeted delivery of nucleic acids — a key innovation in our genetic medicine toolbox.   📅 Date & Time: May 9, 2024, at 12:00 PM ET 🔍 Abstract #0032  🔬 Title: "Long-Circulating Lipid Nanoparticles (LCLNP) Effectively Deliver Nucleic Acids to Hematopoietic Stem and Progenitor Cells in the Bone Marrow"   This presentation will explore the forefront of LCLNP technology and its potential to transform genetic medicine. Jess’s insights are paving the way for innovative treatments targeting bone marrow cells, crucial in combating various diseases.   Don't miss the chance to see how NTx is shaping the landscape of advanced therapeutics.   #ASGCT2024  #InnovativeResearch #Biotech #genetherapy #RNA #Nucleicacid

We share this information with immense pleasure that StemBond Technologies will be exhibiting at the London Biotechnology Show. StemBond Technologies, a spin-out from the University of Cambridge, is a pioneering force in the cell and gene therapy sector. Our focus is on utilizing advanced materials science to revolutionize cell culture environments, particularly for T cells, Mesenchymal Stem Cells (MSCs), and Hematopoietic Stem Cells (HSCs). By addressing fundamental manufacturing challenges, we are unlocking new potentials in cell therapy efficacy and scalability. Our ground-breaking approach to manipulating the mechanical aspects of cell culture environments allows for the enhancement of cell growth and function. This innovative strategy is not only setting new standards in therapeutic cell production but also paving the way for broader applications in the field. We are committed to delivering solutions that will transform the landscape of cell-based therapies, ensuring better outcomes in clinical settings and a brighter future in regenerative medicine. Book your free visitor pass at https://lnkd.in/geed7HiH #lbs #lbs24 #londonbiotechnologyshow #biotechnology #innovation #bioinformatics #medtech #agriculture #bioengineering #innovation #lifesciences #bioenergy #genetics

🚀 Revolutionize your transfection with Lonza’s 4D Nucleofector® Technology! 🧬 🔎Are you looking for a highly efficient and versatile solution for transfecting hard-to-transfect cells? Lonza’s 4D Nucleofector® Technology offers superior performance over traditional electroporation and other non-viral methods. 💡Key benefits: ✅Superior performance: Achieve up to 90% efficiency for plasmid DNA and 99% for oligonucleotides, like siRNA. ✅Versatile Substrate Range: Transfect a wide range of substrates including DNA, mRNA, RNPs, miRNA, siRNA, peptides or proteins. ✅Maximum Flexibility: Effective for primary cells, stem cells, neurons, cell lines as well as cells in adherence with 750+ cell-type specific protocols. ✅Cell Viability: Ensure excellent cell viability. ✅Unmatched Scalability: Various Units designed for low to high-throughput transfections. 💪Backed by sterile Nucleocuvette® vessels, 4D Nucleofector® Technology empowers groundbreaking research in Gene Therapy, CAR-T generation, genome editing via CRISPR, iPSCs transfection, among many others. 🚀 🔗Follow the link to learn more: https://rb.gy/zz4jbh #Lonza #Transfection #4DNucleofector #Nucleofection #Bioanalytica #BioSciences #CRISPR #GeneTherapy #CART #iPSCs

🌐 Exploring Nanoparticles with 𝗰𝗿𝘆𝗼𝗧𝗘𝗠 🕵️♂️ Gain a comprehensive insight into your samples through the utilization of QuTEM’s Cryogenic Transmission Electron Microscopy (cryoTEM). Explore size distributions, circularity, integrity, lamellarity, membrane thickness, and particle internal structures with precision. This technique is particularly useful in studying the efficiency of genomic materials packaged in the capsids. Let our experts dive deeper into the details of these structures to enhance your understanding, especially in life sciences, gene therapy, vaccines, and drug delivery research. Please contact info@qutem.com to learn more. #QuTEM #lifesciences #genetherapy #vaccines #drugdelivery

🚀 Revolutionizing Cell Preservation! Join Andrew Hamann, PhD tomorrow at ISCT, International Society for Cell & Gene Therapy, to see Poster #75 - "Cryoprotectant additives, including rHSA, improve iNK and iT cell health and viability during cryopreservation." This work highlights a significant advancement in cryopreservation techniques, showing that the addition of recombinant human serum albumin (rHSA) and other cryoprotectants can greatly enhance the health and viability of iNK and iT cells during the freezing process. Notably, rHSA not only improved cell health in a dose-dependent manner but also showed even greater effects when combined with other additives. Key Takeaways: rHSA as a critical additive: It significantly enhances cell health without the risks of human-derived albumin. Combinations may be best: The study suggests that using a combination of cryoprotectants yields even better results, opening new avenues for research and application. #Cryopreservation #CellTherapy #Biotechnology

Inducible pluripotent stem cells (iPSCs) have the potential to differentiate into any cell type in the body, providing selective control for tissue formation. The impact of iPSC-based technology has been creating numerous advances in the fields of regenerative medicine; cell and gene therapies; as well as related fields such as cellular agriculture.   iPSCs require scalable and translatable cell expansion platforms which address the challenges faced by microcarrier and aggregate based culture approaches – critical for enabling future discovery and manufacturing. CellRev aims to provide solutions to these challenges.   In March 2024, CellRev and Getinge launched the Livit ACE (link below), a disruptive adherent cell expansion platform powered by Continuase™. https://lnkd.in/eCMb3U3z   We are already working on a biomanufacturing solution for human iPSCs on the Livit ACE platform. Interested in our bioprocess capability, protocol development or how to integrate our proprietary media additives into your existing workflows? Contact us on enquiry@cellrev.co.uk to discuss #hiPSCs #celltherapy #regenerativemedicine

Focus on #stemcells #research with Bio-protocol! (Series3_Post10) https://lnkd.in/dG-KVPpJ A reliable transgene-free protocol for generating human skeletal muscle stem cells from hiPSCs. The two-step process includes: 🔹 Differentiation of hiPSCs into myocytes (iMyoblasts, characterized as PAX3+/MyoD1+ myogenic stem cells) using small molecules. 🔹 Activation and expansion of undifferentiated reserve cells with growth factor-rich medium to establish cell lines. This robust method has been applied to model Facioscapulohumeral Muscular Dystrophy and Limb-Girdle Muscular Dystrophies, enabling efficient gene editing. Work by Dongsheng Guo, Katelyn Daman, Danielle Fernandes Durso, Jing Yan and Charles Emerson at UMass Chan Medical School. Follow Bio-protocol to stay updated on the latest advancements in life-science research.