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🎓 Scientific Highlight of the Week 🎓 We are thrilled to share insights from a groundbreaking study titled "Magnetically guided adeno-associated virus delivery for the spatially targeted transduction of retina in eyes." Adeno-associated viruses (AAV) are extensively researched for gene therapy applications, particularly in treating retinal diseases. A significant challenge in developing retinal gene therapies lies in controlling the specificity and delivery of AAV to selected areas of the retina. This study aimed to demonstrate that magnetic nanoparticles can be used to transport different AAVs across the retina and modulate the selective transduction of specific retinal layers or photoreceptor cells in ex vivo porcine retinal explants and whole eyes. Researchers brought the viruses close to the target cell layer and controlled their interaction time to trigger transduction. They showed that this magnetically guided approach for transporting AAV to selected areas and layers of the retina does not require specific system optimization. This innovative approach allows for controlled AAV transport and selective transduction of cellular systems. Researchers believe this technology can be applied to various other tissues or organs to selectively deliver genes of interest. Our product, FluoMag-V, played a pivotal role in this research. These fluorescently labeled magnetic nanoparticles are designed for magnetofection applications. This technology uses magnetic fields to magnetize nanoparticles in solution, forming a strong gradient to attract them and cover the entire plate surface (e.g., in vitro use). FluoMag-V is a formulation of magnetic nanoparticles aimed at enhancing the infection and transduction capabilities of viruses. 📚 Explore the full article ➡ https://bit.ly/4foSDgv 🔍 Explore more publications in our Citation Database ➡ https://bit.ly/49qRYah 🛒 Learn more about our FluoMag-V ➡ https://bit.ly/3A99NyE Congratulations to the researchers for this remarkable achievement! 🧬🔬 Seungkuk Ahn Oliver Siontas Janis Koester Jacek Krol Sascha Fauser Daniel J. Müller #ScientificResearch #Biotechnology #Innovation #GeneTherapy #Magnetofection

Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics | The EMBO Journal

Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics | The EMBO Journal

embopress.org

Oliver Siontas

Visiting Researcher at BDR RIKEN I MSc Biotechnology, ETH Zürich

2mo

Well said! Thank you very much for appreciating our work. It’s an honor.

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