🔬 Exciting Insights from TIGEM Research! 🔬 This week, we delve into the groundbreaking research led by carmine Settembre at TIGEM. Carmine is an outstanding researcher and Full Professor in Histology and Embryology at the University of Naples “Federico II”. His remarkable achievements include the prestigious Ian Boyle award from the European Calcified Tissue Society (ECTS) and being elected as an EMBO Young Investigator. Carmine has secured grants like ERC StG, ERC PoC, ERC Consolidator from the European community for his cutting-edge work on autophagy roles in health and diseases. Carmine's focus lies in unraveling signaling pathways controlling selective autophagy and lysosome biogenesis in response to physiological stimulations. His ultimate goal is to design tailored therapeutic approaches for diseases marked by intracellular accumulation of toxic materials. Diseases like #mucopolysaccharidosis, #alpha1antitrypsin, and #OsteogenesisImperfecta fall within the purview of Settembre Carmine's studies. 📚 If you're keen to explore the role of lysosomes in orchestrating key cellular functions, don't miss the insightful review recently published in Nature Review Molecular Cell Biology. Carmine co-authored this piece with @Rushika perer Rushika M. Perera, an expert in autophagy-lysosome activation mechanisms at University of California, San Francisco. 🔗 Read the full review here: https://lnkd.in/dN6Xq23Q Stay tuned for more updates on cutting-edge research and scientific advancements! 🌐 #Science #Research #Autophagy #Lysosomes #HealthcareInnovation #Tigem #telethon
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I am pleased to announce that my latest paper has been published in eNeuro, the Society for Neuroscience (SfN)'s open-access, multidisciplinary journal (https://lnkd.in/geyjac3B). There is no greater feeling than reading a paper, developing an idea, designing an experiment, and then seeing that idea realized as a published paper, making an impact on science. A brief history of this paper: For several years, our lab faced persistent challenges in generating mature, pure motor neurons. Co-culturing motor neurons with astrocytes significantly prolonged their survival and enhanced functionality but posed limitations for biochemical studies due to the heterogeneous cell composition. After reading a paper on drug toxicity evaluation in a cancer cell line, I was inspired to develop an indirect co-culture system. We introduced an innovative culture insert method, physically separating astrocytes and motor neurons, to generate highly pure motor neurons for downstream assays. I appreciate my mentor, Dr. Baojin Ding, our Ph.D. student Masuma Akter here in LSU Health Shreveport, and our collaborator, Dr. Wu Xu at University of Louisiana at Lafayette. Read and Enjoy! https://lnkd.in/gJbhSX3r #neuroscience #molecularbiology #biochemistry #neurodegenerativedisease #ALS #cellbiology #motorneurons #universityoflouisiana
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📢 A New Tool: DNA Scaffolds + Acoustic Force Spectroscopy In recent work, researchers from the Adhesion and Inflammation Lab - LAI (INSERM U1067 | CNRS UMR 7333) Aix-Marseille University, in collaboration with the Marseille Cancer Research Center CRCM - Centre de Recherche en Cancérologie de Marseille ( CRCM, Aix-Marseille University / CNRS / INSERM / Institut Paoli-Calmettes) and the Institute of Biology of the École Normale Supérieure ( IBENS, ENS-PSL / CNRS / INSERM) presented a new method to study, on a single molecule, the breakdown of intermolecular bonds under the effect of a force. 📄 Reference: Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds, Yong Jian Wang, Claire Valotteau, Adrien Aimard, Lorenzo Villanueva, Dorota Kostrz, Maryne Follenfant, Terence Strick, Patrick Chames, Felix Rico, Charlie Gosse and Laurent Limozin, Biophysical Journal, published June 7, 2023. doi: https://lnkd.in/eaD8Ginf Open archive: https://lnkd.in/dKn-WNNz In Press: Centre national de la recherche scientifique 👉 https://lnkd.in/dnQZvEiy #ScienceNews #ProteinBonds #ResearchInnovation #Research #Tool #biology #biophysics #DNA #spectroscopy #AFS #Press #News #publication
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DP75 Digital Microscope Camera This camera merges brightfield and fluorescence imaging into one versatile tool, making your research smoother and more efficient. ✅ You can capture ultra-sharp images with minimal noise, thanks to its superior color reproduction and high-resolution capabilities. ✅ Its infrared imaging extends your vision beyond the visible, enabling detailed studies with multiple staining combinations up to 1000 nm. ✅ Advanced analysis features, from quantitative fluorescence intensity evaluation to precise overlay of images, will allow you to reach new heights. ✅ With AI-driven smart observation detection, achieving professional-quality results has never been easier. Want to learn more? Visit our website: https://lnkd.in/gxh7KQPR #LifeScience #microscopy #innovation #camera #Research #ImagingTechnology #ScienceInnovation #pathology #cytology #olympus #microscopy #lifescience #technology #education #evidentscientific #lecture #digitalisation #science #solution #neuroscience #brainresearch #drugdiscovery
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Biochemist | Molecular Biologist | Structural Biologist | Bioinformatics Scientist | Bioprocess Engineer
I recently had the opportunity to represent AmberGen and present a poster at the American Society For Mass Spectrometry (ASMS) annual meeting this month. The poster reports a workflow we call 'Cyclic MALDI-IHC’. AmberGen’s Miralys™ MALDI-HiPlex-IHC is used to simultaneously image hundreds of intact proteins on a tissue section, tissue microarray, or single cells. The Cyclic MALDI-IHC workflow consists of reusing the same tissue section for successive imaging: (i) with the same panel of probes resulting in nearly identical images across cycles demonstrating this is a non-destructive workflow; (ii) with the same panel of probes at higher spatial resolution to image specific regions of interest; (iii) or image even with a completely different panel of probes to obtain additional biological information from precious samples. While this poster demonstrates successive cycles of MALDI-IHC, it also opens the doors for other multiomic and multimodal workflows (e.g., lipids, small molecules, drugs, transcripts) on the same tissue section. If you would like to learn more, contact us at AmberGen.com (info@ambergen.com). I am very grateful for the guidance of the scientific team at AmberGen including Prof. Kenneth Rothschild, Dr. Mark Lim, and Dr. Gargey Yagnik as well as our CEO, John Gillespie! #ASMS #MSI #spatialbiology #neuroscience #multiomic #multimodal #proteomics
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🔬 Mark your calendars for our upcoming Science Matters seminar! 🗓️ Join us on Wednesday, April 17th, as we delve into research examining stem cell-derived "brain organoids" with Dr. Alysson Muotri from UC San Diego. Discover the latest in disease modeling, brain evolution, and bioengineering applications. Dr. Muotri will speak on the technology's limitations and implications in this live-only session. Don't miss out - register now for free! https://lnkd.in/guDmrrgP #Bioengineering #GeneticsResearch #Neurodevelopment #ScienceMatters
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Witness the remarkable meeting point of the fallopian tube and the uterus - the isthmus, brought to you by Dr. Kate O'Neill and Dr. Junhyong Kim from the University of Pennsylvania using PhenoCycler. It's truly egg-ceptional! Blue = nuclei Pink = epithelial cells Green = extracellular matrix Orange = T cells Teal = lymphatics Red = smooth muscle cells Learn how spatial biology can help you discover novel insights in human biology, spanning a continuum from discovery to clinical and translational research. https://bit.ly/44bI8Xw #tissuetuesday #spatialbiology #singlecell #immunooncology #HuBMAP
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Orexin receptors are proteins located on the surface of nerve cells in the brain and other tissues of the body that respond to orexin, also known as hypocretin. Orexin is a neuropeptide that plays a crucial role in regulating sleep, wakefulness, and feeding. There are two main types of orexin receptors, known as OX1 and OX2, which are members of the G protein-coupled receptor (GPCR) family. In this study, the homology structure of OXR1 was obtained using Modeller 10.4, based on the PDB model 6TO7. The CHARMM-GUI server was used to embed the receptor in a POPC bilayer membrane. The orexin 1 peptide was obtained from the PDB model 1CQ0. (PDB code: 1CQ0) Rendering by Prof. Caio Sena (@prof_caiosena) made with #proteinimager Try it here https://lnkd.in/dc8yQfy #OrexinReceptors #Neuropeptide #Hypocretin #SleepRegulation #Wakefulness #FeedingBehavior #GPCR #ProteinStructure #HomologyModeling #Modeller #Bioinformatics #Neuroscience #MolecularBiology #StructuralBiology #3DModeling #Research #Science #PDB #OXR1 #OX1 #OX2
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Orexin receptors are proteins located on the surface of nerve cells in the brain and other tissues of the body that respond to orexin, also known as hypocretin. Orexin is a neuropeptide that plays a crucial role in regulating sleep, wakefulness, and feeding. There are two main types of orexin receptors, known as OX1 and OX2, which are members of the G protein-coupled receptor (GPCR) family. In this study, the homology structure of OXR1 was obtained using Modeller 10.4, based on the PDB model 6TO7. The CHARMM-GUI server was used to embed the receptor in a POPC bilayer membrane. The orexin 1 peptide was obtained from the PDB model 1CQ0. (PDB code: 1CQ0) Rendering by Prof. Caio Sena (@prof_caiosena) made with #proteinimager Try it here https://lnkd.in/gBBUGYQ #OrexinReceptors #Neuropeptide #Hypocretin #SleepRegulation #Wakefulness #FeedingBehavior #GPCR #ProteinStructure #HomologyModeling #Modeller #Bioinformatics #Neuroscience #MolecularBiology #StructuralBiology #3DModeling #Research #Science #PDB #OXR1 #OX1 #OX2
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5 Years Master's Degree : Project Management and Innovation in Biotechnology (BIOTIN). In charge of the Communication in the association BIOTIN Corp.
I’m pleased to share with you my first contribution to a scientific article, published in Plos One, under the supervision of ABDEL✨ AOUACHERIA🐾 and Sophie Charrasse at CNRS | ISEM Montpellier. This article focuses on the semiotic phenotyping of mitochondrial network morphology in live human cells. https://lnkd.in/eBWex4Xy
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