Pharmaron’s Post

Explore the latest episode of Pharmaron's #DMPK Insights: “It’s ‘All-go’ with Oligos: Challenges and Opportunities in LC-MS of Therapeutics.” Join experts Robert MacNeill, Professor Michael Bartlett and Dr. Guilherme (Gui) Guimaraes as they delve into the dynamic world of oligonucleotide LC-MS. Discover the key challenges, the critical importance of sensitivity in these assays, and the innovative analytical approaches and technologies being developed and used today. Don't miss this insightful discussion & listen to the podcast: https://lnkd.in/dYUSmmkd Learn more about Pharmaron DMPK services, here: https://lnkd.in/dCGMgYjK #DMPKinsights #Pharmaron #Podcast #Oligos

Take advantage of the expertise of our team, who prioritizes quality and precision at every step, to achieve maximum success rates in creating the custom cell lines you need. Learn more about how Pharmaron's innovative cell line engineering services can meet any research objective and drive your projects forward by clicking here: https://lnkd.in/ebsNS5P3 #CellLineEngineering #DrugDiscovery #Biotechnology #Pharmaron #CRISPR

Check out our colleague Robert MacNeill's latest #bioanalysis column on the nuanced, sometimes nuisance, nature of quantitative #lcms methodologies, particularly for complex modalities. Read here: https://lnkd.in/edFPDnQu Learn more about Pharmaron's comprehensive global small molecule bioanalysis capabilities, here: https://lnkd.in/e86aEcH6 #Pharmaron #drugdevelopment

This week, we had the pleasure of hosting Prof. Ian Fairlamb from the University of York, as part of the Invited Speaker Programme. Prof. Fairlamb discussed how to improve outcomes of palladium-catalysed reactions for discovery and process chemistry. We thank Prof. Fairlamb for his visit! Learn more about Pharmaron’s process chemistry services: https://buff.ly/3UCRUjo #processchemistry #drugdiscovery #chemistry #drugdevelopment #pharmaron

Join us for our next virtual chemistry lecture on Thursday, July 4, 2024, at 9:15 am (China Standard Time).     𝗦𝗲𝗹𝗲𝗰𝘁𝗶𝘃𝗲 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗣𝘆𝗿𝗶𝗱𝗶𝗻𝗲𝘀, 𝗗𝗶𝗮𝘇𝗶𝗻𝗲𝘀 𝗮𝗻𝗱 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹𝘀 𝘃𝗶𝗮 𝗨𝗻𝗰𝗼𝗻𝘃𝗲𝗻𝘁𝗶𝗼𝗻𝗮𝗹 𝗜𝗻𝘁𝗲𝗿𝗺𝗲𝗱𝗶𝗮𝘁𝗲𝘀 Prof. Andy McNally   Department of Chemistry Colorado State University    Register for the webinar: https://lnkd.in/dKdJXAdc     Pyridines and diazines are ubiquitous in pharmaceuticals and agrochemicals, yet there are limits in synthetic methods that can directly functionalize the C–H bonds in these structures. In this lecture, Prof. Andy McNally will show two distinct approaches, using phosphorus and ring-opened intermediates, that enable selective functionalization of these heterocycles into a range of valuable derivatives. A range of C–C and C–Heteroatom bond formations are viable, and the chemistry functions on structures typically encountered in drug discovery programs. Prof. McNally's lab has also performed mechanistic and computational studies of the regioselectivity of these reactions and the phosphorus ligand-coupling processes involved.

Pharmaron uses cell painting with subsequent data analysis with machine learning for a variety of applications to make this sensitive and powerful method available to our clients. Cell painting enables: •Phenotypic drug discovery •Target deconvolution •Analysis of signaling pathways and mechanism of action •Investigating drug resistance mechanisms The cells are screened via the high content imaging system Operetta and comprehensive data analysis is conducted by our adept bioinformaticians utilizing machine learning algorithms. Our fully automated, high-throughput assay and screening process is finely tuned to expedite cell painting applications with precision. To learn more about this fascinating technique and how we can support your drug discovery projects, please visit our website for more details and a case study showing a profiling study with 390 kinase inhibitors: https://lnkd.in/eg5vi7UB #pharmaron #drugdiscovery #cellpainting #machinelearning #highthroughputscreening #bioinformatics #morphologicalprofiling

As the final day of BOS Basel 2024 wraps up, we want to thank everyone for the great connections and insightful discussions we've had here in Switzerland. It has been a fantastic experience meeting industry experts and sharing our comprehensive drug substance and drug product services. Thank you to everyone who visited us at booth #36. We look forward to continuing these conversations and exploring new opportunities for collaboration. #BOSBasel #Pharmaron #LifeScience #CMC #Biologics #Radiolabelled

We're off to a great start at BOS Basel 2024 in Switzerland! It’s been great connecting with industry experts, and our team looks forward to meeting you tomorrow for Day 2. Stop by booth #36 to learn more about Pharmaron's fully integrated drug substance and drug product services. #Pharmaron #CDMO #BOSBasel #drugsubstance #drugproduct