Pharmaron Biologics (UK) Ltd’s Post

ELRIG Hosted Panel Discussion: 𝗕𝗲𝘆𝗼𝗻𝗱 𝘁𝗵𝗲 𝗟𝗮𝗯 – 𝗖𝗼𝗺𝗺𝗲𝗿𝗰𝗶𝗮𝗹 𝗖𝗮𝗿𝗲𝗲𝗿𝘀 𝗶𝗻 𝗟𝗶𝗳𝗲 𝗦𝗰𝗶𝗲𝗻𝗰𝗲. Our Early Career Professional Webinar is fast approaching, have you booked your slot yet? (21st February at 1pm – 2pm GMT) https://lnkd.in/emU6Ku8K This 𝗳𝗿𝗲𝗲-𝘁𝗼-𝗮𝘁𝘁𝗲𝗻𝗱 session is sure to be hugely valuable to anyone looking for their next career step, whether it be following on from study or moving from a lab role, it is important to know that there are Life Science commercial routes that can be considered to build a career outside of the lab. Join us to learn about commercial roles that enable you to stay in Life Science and use your knowledge and experience to add value to research and drug development communities. Our panellists are industry professionals representing a variety of commercial Life Science roles including. ·      Technical Sales Management ·      Business Development ·      Application Scientist ·      Product Management ·      Partnering The panel will share their personal experiences of moving into their chosen career paths and will explore the following questions and themes. ·      The variety of commercial roles available and what they entail. ·      What it is like to make the move ·      The rewards and challenges of the sector. ·      The different routes to take when moving from the lab or direct from study. ·      The skills and attributes needed to be successful in a commercial role. ·      Further qualifications and career advancement opportunities.   Who should attend? Undergraduate, Postgraduate, Post-Doctoral and other Early Career Professionals in science looking to learn more about careers in Life Science and roles outside of the lab. Book for free webinar 21st February at 1pm – 2pm GMT. ⬇️ Please share and tag anyone who might find this webinar useful. #ELRIG #ECP #CAREERWEBINAR Lisa Stott Mark Soave Chris Trevelyan Millie Fox Ph.D. Del Trezise Cassie Messenger

Recommended for those who are thinking of PhD as an option after undergraduate.

Offering for M.Sc Entrance CSIR-JRF-NET Life Sciences. Having offline and online options caters to a wider audience, accommodating different learning preferences and geographical constraints. Including recorded lectures is particularly helpful for students who may need to review concepts at their own pace or revisit certain topics for better understanding. Additionally, features like test series, study material, and doubt sessions provide a well-rounded learning experience, ensuring students have ample resources and support to excel in their preparation. With the batch starting on May 25, 2024, it gives prospective students a clear timeline to plan their enrollment and study schedule effectively. Overall, it sounds like a promising opportunity for those aspiring to pursue an M.Sc . in Life Sciences through CSIR-JRF-NET. Call Us: 9350172220, 9560671566, Inquiry: gyanbinduacademyonline@gmail.com Email:gyanbinduacademy@gmail.com Follow us @gyanbinduacademy into the future of life science and its impact on our world. #csirnetlifesciences More information: https://lnkd.in/guGhA9E2

Four months ago a neighbor gave an unusual graduation gift to one of her friends: a coaching session with me. He was applying to PhD programs in Biosciences, and he needed help with his personal statement. After our first meeting, he hired me back on his own dime. The results? Four interview invitations and four acceptance offers, including one from USC. And this despite a slow biotech market that created a more competitive PhD applicant pool than ever. A personal statement is more than a summary of your research interests. It is a story about why you are a good fit for a particular program. In a competitive market where high test scores are a dime a dozen, your story of how you might enrich a specific program has the power to tip the scales. I help you optimize the factors you can control in an otherwise mystifying application process. I'm offering a free workshop for medical students on Tuesday, March 26, at 12pm EST. There's still time to reserve a seat. https://lnkd.in/eZiU8z9F #medicalschool #personalstatement #writingcoach

Three months ago, I was accepted into the iPREP program at Indiana University School of Medicine! 🎉 NIH iPREP (Post-Baccalaureate Research Education Program) is an immersive research and professional development program designed to prepare students from underrepresented communities for Ph.D. programs in biomedical sciences. It’s a space where curiosity meets opportunity, and where I get to dive deeper into the research that’s close to my heart—while learning what it truly means to be a scientist, advocate, and mentor. Since joining iPREP, I’ve had the absolute honor of working with Christopher Robinson, Ph.D. on a project focused on predicting CD8+ T cell epitopes in Coxsackievirus B3. 🔬💻 Yes, it’s as intense as it sounds, but the challenge has only sharpened my skills and deepened my drive to understanding the many mysteries of the immune system. I've realized iPREP has become more than research to me—it’s about growth, community, and finding your voice in science. From career development seminars to exploring my future in science policy and mentorship, I’m evolving in ways that are pushing me beyond the limits I once thought existed. To everyone who’s been part of my journey so far, thank you. The little kid in me who once dreamed of being a scientist is living that dream, and this is just the beginning. 🚀 #IPREP #Immunology #Bioinformatics #ScienceWithPurpose #MentorshipMatters #STEMJourney #RepresentationInSTEM #AutoimmuneResearch #PuzzleSolver

⭐ 🎒 Scholarship Notice for Student members of the Society of Cosmetic Chemists!! 🎒⭐ Get all the details on the scholarship package and how to apply the from the Society of Cosmetic Chemists, California Chapter below 👇 #cosmeticchemist #cosmeticchemist

Last week I was teaching in a summer school of the IBS German and Austrian-Swiss Region in Strobl at the beautiful Wolfgangsee. The theme of the summer school was “Time-to-Event Analysis”. Thanks again to the organizers for inviting me!   One of the topics I discussed was non-proportional hazards (NPH) in drug development. Of course much can be said about this topic, so this post can only be a start. Before discussing NPH it may be useful to think about why we actually assume *PH* when designing and analyzing trials. - Assuming PH allows summary of the treatment effect over time in *one number*, the hazard ratio (HR). - Assuming PH implies that the power of the logrank test only depends on alpha, power, and an assumed HR (and the randomization ratio). Nothing else! - The logrank test has maximal power against PH alternatives. - The canonical estimand corresponding to the logrank test is the HR, so that we naturally align hypothesis test and effect quantification. Now, if we anticipate NPH during trial design things get a bit more complicated: - The HR is time-varying, i.e. it is not obvious how to quantify the effect in one number. We typically have several aspects that need to be looked at, e.g. delayed effect or cure. - The logrank test remains valid in the sense that it always protects type I error. Under H0 there cannot be NPH! - However, the logrank test is not power optimal anymore. Other tests, e.g. weighted logrank or maxcombo, may offer better power *against specific alternatives*. They may have other issues though (choice if weight fubction, estimand corresponding to them unclear, T1E violation). - When designing a trial anticipating NPH the first question to ask is: How do we quantify the effect? HR still? Restricted mean survival time? Difference at milestone? Difference at a quantile? Accelerated failure time? A trial can be designed using each of these, but each has pro’s + con’s. - How does the hypothesis test relate to the effect measure of interest? - The power of a hypothesis test now depends on many more quantities than just alpha, power, and effect size, e.g. also on the value of survival functions, censoring distribution, etc. This implies that one needs to make quite precise assumptions when evaluating operating characteristics of a design – and that these are only accurate if these assumptions hold true in the actual data. - Trials are typically designed through simulations.   What do regulators say? - In Europe regulators have repeatedly stated that for them, it would be fine to run a logrank test and then potentially quantify the effect as appropriate. Having said that, I am not aware of a label precedence of such a decoupling of the hypothesis test and effect measure. - In the US, the FDA has clearly voiced a preference for the (unweighted) logrank test, see paper linked in comments. I am not aware of a comment or position with respect to the effect measure. #biostatistics #survival #estimand #drugdevelopment

Curious about career options beyond the bench? Join PBSS on May 30th for a free online workshop diving into the roles, attributes and paths into Project Management and Regulatory Affairs. It's been a lot of fun putting this together with Shichang Miao, Enas Mahmoud, and Dean Wilson at PBSS International as well as the knowledgable group of PM and Regulatory professionals who have walked the walk of career transitions themselves. First in a planned series! #careergrowth #findyourpath #keeplearning

Adoptibility to changing situations and requirements is the key........

I like how Elena Hoffer, PhD interpreted the graph image below. Being a subject matter expert does not mean a lot to people unless they learn what they can do with an expert of your caliber and type. In other words, degrees and experience “do not speak for themselves.” Those are just requirements and preferences; they get you to the door (the hiring manager or interview). It is still up to you as a subject matter expert to sell the benefits of your knowledge and the skills you have acquired through the journey. Remember this tip for your next interview!