Renal Disease Research Institute’s Post

May is Lyme Disease awareness month 💚 The title of this case report underscores our team’s “why”. “Bartonella- and Borrelia-Related Disease Presenting as a Neurological Condition Revealing the Need for Better Diagnostics” The authors go on to say: “The patient described in this report experienced continuous pain in both hips and degradation that went undiagnosed because her symptoms were attributed to possible MS or ALS, even though Bartonella and Borrelia have previously been detected in the bones and joints from patients with extensive hip involvement requiring joint replacement. At the time we began testing, the patient appeared asymptomatic for an infectious disease because she was afebrile. Similarly, lack of a fever has been noted to contribute to the delayed diagnosis of Bartonella spp. infection in a subset of endocarditis cases.” Our interdisciplinary team wants to know how many cases of neurologic and psychiatric diseases are being driven by treatable #infections that may evade detection and go untreated (including Lyme aka Borrelia and co-infections like #bartonella). 🦠 🧫 🧠 We feel that an important step toward diagnosing and treating this subset is refinement of detection methods. WE NEED BETTER TESTS…that patients can ACCESS. 🔬 While we are the The Alzheimer's Pathobiome Initiative (AlzPI), our refinement of these microbe testing methods can be applied to the diagnosis of many infection-associated #chronic diseases including the ones referenced in this case report. #PatientCenteredResearch #ChronicInfections #StealthInfections https://lnkd.in/dHPT7en2

In a recent randomized trial published in JAMA, researchers explored the potential benefits of acetaminophen in sepsis management. The study involved 447 patients with sepsis accompanied by respiratory or circulatory organ failure and compared the outcomes of patients receiving acetaminophen (1 gram every six hours for five days) to those receiving a placebo. The findings revealed no significant difference in the number of days patients were alive and free of organ support between the acetaminophen and placebo groups. Interestingly, the incidence of acute respiratory distress syndrome (ARDS) was notably lower in the acetaminophen group (2% compared to 9%). These preliminary results are promising; however, further research is required to establish the routine use of acetaminophen in patients with sepsis and organ dysfunction. #SepsisResearch #CriticalCare #MedicalResearch #Acetaminophen #ClinicalTrials #JAMAPublication #OrganFailure

New research award 🎉 Dr Mark Dockrell from Epsom and St Helier University Hospitals NHS Trust has been awarded a PhD studentship of £86,000 to investigate why sodium glucose transporter 2 (SGLT2) inhibitors have shown unexpected improvements in people with diabetic kidney disease.  Did you know that around 1 in 3 people with diabetes also have diabetic kidney disease? The newly approved SGLT2 inhibitors has recently been approved for type 2 diabetes and has a positive effect of reducing kidney disease progression in patients, but we’re not sure how or why! So far, Mark and the team have identified potential explanations using human kidney cells and how SGLT2 inhibitors may interfere with signalling pathways that cause scarring in the kidney. Unfortunately, this cannot be given to patients with T1 diabetes, but if we can understand why it is causing improvements this can be applied to develop specific treatment without added side effects. Are you a patient of diabetes and kidney disease? Comment below. 🗣️ You can read the full story on our website 👇 https://bit.ly/3T6p8qO #kidneydisease #kidney #kidneyhealth #TeamKidney #kidneyawareness #newresearch

🏅 We welcome you to read this #editorschoice #article by Marta Szandruk-Bender et al. The Risk of Developing Alzheimer’s Disease and Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Meta-Analysis 🏥 Wroclaw Medical University 👉 Full text: https://lnkd.in/dc4Q8bSR #clinical #medicine #openaccess #alzheimersdisease #neurodegenerativediseases #gutbrainaxis 📑 This article belongs to the Special Issue Prevention of Alzheimer's Disease: The Impact of Modifiable Risk Factors

There is a clinical trial being conducted in the US called Calyx, A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy. This study is open to patients from any location who meet certain criteria (some of which may be flexible), full details of which can be found here. Key points about the trial: For adult (over 18 years old) males with AMN or ALD. All costs for travelling to the US are covered for participant and one carer. Should a trial site open in your country of residence, participants will be able to move to this trial site. To understand more about the context of this trial you may be interested in this article published in Brain, June 2024. Leriglitazone halts disease progression in adult patients with early cerebral adrenoleukodystrophy. If you or a loved one would like to be considered for this trial please contact your consultant who can refer you. If your consultant is not familiar with the trial they can email info@minoryx.com for further information. You can also email Alex TLC if you’d like to discuss any aspects of this information info@alextlc.org. #Aldhope #alextlc #Adrenoleukodystrophy #adrenomyeloneuropathy

In our recent study, we investigated the risk of adjacent-level fractures following interventions for osteoporotic vertebral compression fractures (VCFs). Through randomized controlled trials (RCTs), we aimed to compare the outcomes of vertebroplasty and kyphoplasty against the natural progression of the disease. Key Findings: - RCTs were conducted to evaluate the risk of adjacent-level fractures post-intervention. - Results indicated no significant difference in the incidence of adjacent compression fractures between patients who underwent vertebroplasty or kyphoplasty and those who followed the natural disease course. - This provides robust evidence that interventional treatments such as vertebroplasty and kyphoplasty do not elevate the risk of subsequent adjacent fractures. These findings are crucial for informing clinical decisions and reassuring both practitioners and patients regarding the safety of these common interventional treatments for VCFs. Our study underscores that opting for vertebroplasty or kyphoplasty does not compromise the structural integrity of adjacent vertebrae. • The link to our study: https://lnkd.in/d4qr-uFk #Osteoporosis #VertebralFractures #RCT #Vertebroplasty #Kyphoplasty #SpineHealth #ClinicalResearch

【Delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic】 Full article: https://lnkd.in/gq-PYTJb (Authored by Clarice Teixeira Silva Araújo, et al., from Universidade Federal do Espírito Santo (UFES) (Brazil), etc.) Acute ST-segment elevation #myocardial_infarction (STEMI) represents one of the most severe clinical presentations of atherosclerotic cardiovascular disease and is one of the leading causes of death worldwide. An increase in care delay for patients with STEMI may have affected clinical outcomes. This study analyzes the clinical profile, delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (#PPCI) in the state of Espírito Santo, Brazil, before and during the #COVID19 pandemic. #Coronary_Reperfusion 

🌟 **Unlocking the Hidden Challenges of Lyme Disease: A Public Health Concern** 🌟 Just read an enlightening piece on "Lyme Disease and Complications: The Hidden Public Health Problem You Need to Know" from Envita Medical Centers, and I believe it's a must-read for healthcare professionals. Here are some critical takeaways: 1. **Hidden Complications**: Neurological issues, chronic fatigue, fibromyalgia, and depression from Lyme disease are frequently misdiagnosed or overlooked. 2. **Chronic vs Post-Lyme**: Differentiating chronic Lyme disease from post-Lyme syndrome is crucial for effective treatment. 3. **Coinfections**: Babesiosis, ehrlichiosis, and bartonella can co-occur with Lyme, complicating diagnosis and treatment. 4. **Neurological Impact**: Significant cognitive/motor impairments with limited diagnostic tools. 5. **Biofilm Formation**: Lyme bacteria form biofilms, making them resistant to treatments. 6. **Immune Evasion**: The bacteria's evasion tactics lead to chronic infections. 7. **Cancer Link**: Chronic inflammation and immune suppression from Lyme may elevate cancer risks. 8. **Treatment Challenges**: Need for comprehensive treatment addressing coinfections and biofilms. 9. **Public Health Concern**: Misdiagnosis and inadequate treatment highlight the critical need for increased awareness. Let’s champion early detection, innovative treatments, and multi-disciplinary approaches to mitigate this growing public health issue. 🤝 What strategies are you implementing in your practice to tackle these complexities? Share your insights and join the conversation! 💬👇 #LymeDisease #PublicHealth #HealthcareInnovation #ChronicIllness #MedicalResearch

#HighlyCitedPapers   📝 Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study — Katarzyna Zdanowicz, Anna Bobrus-Chociej and Dariusz Marek Lebensztejn.   In this paper, the authors aimed to review the latest advances in knowledge of the role of #chemerin in the pathogenesis of various diseases from studies in pediatric patients.   Full text is available 👇 https://lnkd.in/dgZUztEW   #medicine #health #research #science

🎯 Paper Invitation on topic of "#Endothelial #Dysfunction and #Cardiovascular Diseases" For any questions or further information, please contact to <susie.sun@imrpress.com> Reviews in Cardiovascular Medicine looks forward to receiving your valuable contributions! #callforpapers #publishing #article #RCM