Sachs Associates’ Post

EvlaBio AG is a life science startup dedicated to the development of first-in-class therapeutics in the cardiovascular and cardiorenal space. The lead asset is a therapeutic monoclonal antibody (mAb) targeting the FGF23/FGFR4 pathway for the treatment of left ventricular hypertrophy (LVH) and heart failure with preserved ejection fraction (HFpEF) in the setting of chronic kidney disease (CKD). LVH and HFpEF occur in CKD patients as a consequence of FGF23/FGFR4 overdrive. Hence, blocking the FGF23/FGFR4 interaction has the potential to prevent cardiac hypertrophy and ameliorate heart failure in patients with CKD. The serviceable obtainable market of patients with LVH due to FGF23/FGFR4 overdrive ranges between 5 and 6 M in the seven major markets, representing a substantial commercial opportunity. Based on its underlying mechanism of action, the EvlaBio approach is expected to be hemodynamically neutral. This is a critical differentiating feature from currently available treatment options. With respect to modality, the EvlaBio will be the first biologic developed for this indication, and it has the potential to be a first in class and first in indication therapy. We also have a biomarker strategy leveraging specific features of target biology in place, ensuring effective clinical trial design. Meet EvlaBio @ #Sachs_BEF More Info @ https://lnkd.in/d7zEuKym #BigPharma #Dealmakers #PharmaIndustry #BiotechInEuropeForum #LifeSciences #Biotech #BioPharma #Partnering #Investment #Startups #Oncology #Neurology #Genomics #Immunotherapy #CNS #Autoimmune #Cardiovascular #BiotechIndustry #BioTechInvestment #Innovation #InvestmentForum #BiotechConference #EuropeanBiotech #SachsAutumnLifeSciencesWeek #SALSW

🔍 Exciting news in biotech investments! These investments show the growing potential in biometrics. Great to see advancements across different health areas, from mental health to cancer treatment 🇺🇸 Spyre Therapeutics | $180 million PIPE | monoclonal antibodies | preclinical in inflammatory bowel disease 🇺🇸 Engrail Therapeutics | $157 million series B | precision neuroscience | phase 2 in generalized anxiety disorder 🇨🇦 Cybin Inc | $150 million PIPE | mental healthcare | phase 2 in major depressive disorder 🇩🇪 Tubulis GmbH | €128 million ($138.75 million) series B2 | antibody drug conjugates | preclinical in multiple solid tumors 🇺🇸 Unicycive Therapeutics | $50 million PIPE | kidney disease treatments | phase 1 in hyperphosphatemia 🇬🇧 Relation | $35 million seed | multi omics for drug discovery | discovery in osteoporosis 🇸🇪 Asgard Therapeutics | €30 million ($32.53 million) series A | cancer immunotherapies | preclinical in cancer 🇬🇧 Mission Therapeutics | £25.2 million ($32 million) | deubiquitylating enzyme inhibitors | phase 2 in cardiac surgery-associated kidney injury 🇺🇸 Elicio Therapeutics | $6 million PIPE | immunotherapies | phase 2 in pancreatic ductal adenocarcinoma

Cancer Biomarkers Market worth USD 42.0 Billion | Growing at a CAGR of 11.3% Download PDF Brochure: https://lnkd.in/dgT6_KtE The size of global #cancer #biomarkers market in terms of revenue was estimated to be worth $24.5 billion in 2024 and is poised to reach $42.0 billion by 2029, growing at a CAGR of 11.3% from 2024 to 2029. 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: F. Hoffmann-La Roche Ltd. (Switzerland), Thermo Fisher Scientific Inc. (US), QIAGEN (Netherlands), Illumina, Inc. (US), Bio-Rad Laboratories, Inc. (US). 𝐎𝐭𝐡𝐞𝐫 𝐂𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐭𝐡𝐚𝐭 𝐚𝐫𝐞 𝐎𝐩𝐞𝐫𝐚𝐭𝐢𝐧𝐠 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐌𝐚𝐫𝐤𝐞𝐭 𝐆𝐥𝐨𝐛𝐚𝐥𝐥𝐲: Eureka Genomics New Path Molecular Research      QCDx Epify BV KeViRx, Inc. BioTether Sciences Inc.  BreakSight, Inc.      Exosome Sciences Inc InsideDNA Exosome Analytics  AnyGenes® EVIIVE Omnigene Medical Technologies Ltd Microgentas  Pure MHC, LLC Bioprognos Pace Diagnostics, Inc. Axaitech OncoSeer Diagnostics, Inc. Biosens Labs VarCT Diagnostics StoreMyTumor Avatrial PreCyte Inc NeuScience DKP Genomics, LLC BioMavericks Ymir Genomics OncoAssure Ltd Acuimmune Infiniplex Kurglab MD Healthcare Inc.   Cellgebra EviStat Angarus Therapeutics Fluidia Biosettia Inc. GenoDeep Gliotrack

Who are some of the players looking to make a difference in the precision medicine space? 🎯 Precision medicine, which is a tailored treatment method taking into account an individual’s genetic makeup, environment and lifestyle, is being studied to potentially treat all kinds of diseases including cancer, metabolic diseases and neurological conditions. 🧬🔍 With a market value that is set to grow exponentially in the next few years, more and more biotechs are becoming immersed in the field. 📈 Read our latest article to discover seven precision medicine companies that you’ve got to watch out for! 👇 https://lnkd.in/dXbNVA6T #PrecisionMedicine #Biotech #Biopharma #Cancer #MetabolicDiseases #Neurodegeneration #BiotechStartups AC Immune | Alto Neuroscience | Biomea Fusion | Engine Biosciences | ReCode Therapeutics | Scorpion Therapeutics | SpringWorks Therapeutics | Novartis | Genoptix, Inc. | Pfizer | AstraZeneca | Amgen | Roche | Bristol Myers Squibb | BioNTech SE  

𝙀𝙢𝙚𝙧𝙜𝙞𝙣𝙜 𝙏𝙧𝙚𝙣𝙙𝙨 𝙞𝙣 𝙩𝙝𝙚 𝘽𝙧𝙖𝙞𝙣 𝙏𝙪𝙢𝙤𝙧 𝘿𝙞𝙖𝙜𝙣𝙤𝙨𝙞𝙨 & 𝙏𝙝𝙚𝙧𝙖𝙥𝙚𝙪𝙩𝙞𝙘𝙨 𝙈𝙖𝙧𝙠𝙚𝙩 𝙎𝙚𝙘𝙪𝙧𝙚 𝙖 𝙁𝙍𝙀𝙀 𝙎𝙖𝙢𝙥𝙡𝙚: https://lnkd.in/g6QwVu9V The 𝘽𝙧𝙖𝙞𝙣 𝙏𝙪𝙢𝙤𝙧 𝘿𝙞𝙖𝙜𝙣𝙤𝙨𝙞𝙨 & 𝙏𝙝𝙚𝙧𝙖𝙥𝙚𝙪𝙩𝙞𝙘𝙨 𝙈𝙖𝙧𝙠𝙚𝙩 is experiencing dynamic growth, fueled by advancements in medical technology and a deeper understanding of neuro-oncology. As we navigate through 2024, several key trends are shaping the landscape: 𝙄𝙣𝙣𝙤𝙫𝙖𝙩𝙞𝙫𝙚 𝘿𝙞𝙖𝙜𝙣𝙤𝙨𝙩𝙞𝙘 𝙏𝙤𝙤𝙡𝙨: Cutting-edge imaging technologies, such as advanced MRI and PET scans, are revolutionizing the early detection of brain tumors. These tools enhance accuracy, allowing for timely intervention and improved patient outcomes. 𝙏𝙖𝙧𝙜𝙚𝙩𝙚𝙙 𝙏𝙝𝙚𝙧𝙖𝙥𝙞𝙚𝙨 & 𝙋𝙧𝙚𝙘𝙞𝙨𝙞𝙤𝙣 𝙈𝙚𝙙𝙞𝙘𝙞𝙣𝙚: The shift towards personalized medicine is leading to the development of targeted therapies that address specific genetic mutations and molecular characteristics of brain tumors. This approach is significantly improving treatment efficacy and minimizing side effects. 𝙄𝙢𝙢𝙪𝙣𝙤𝙩𝙝𝙚𝙧𝙖𝙥𝙮 & 𝙉𝙤𝙫𝙚𝙡 𝙏𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩𝙨: Emerging therapies, including immunotherapy and gene editing techniques, are showing promise in treating brain tumors that were previously considered resistant to conventional methods. These innovative treatments offer new hope for patients. 𝙆𝙚𝙮 𝙋𝙡𝙖𝙮𝙚𝙧𝙨: The brain tumor diagnosis & therapeutics industry comprises of various key market players such as Pfizer, Amgen, AstraZeneca, Bristol Myers Squibb, Johnson & Johnson, Novartis, Karyopharm Therapeutics Inc., Canon Medical Systems Corporation, Lantern Pharma Inc. (Nasdaq: LTRN), and others. 𝘼𝙘𝙘𝙚𝙨𝙨 𝙁𝙪𝙡𝙡 𝙍𝙚𝙥𝙤𝙧𝙩: https://lnkd.in/gGz6zwUT As we move forward, collaboration between researchers, clinicians, and industry leaders will be crucial in advancing treatments and improving patient care. Let’s continue to support innovation and drive progress in this vital field! #braintumor #neurooncology #medicalinnovation #healthcare #precisionmedicine #immunotherapy #markettrends #marketresearch #globalindustry

💸 𝐌&𝐀 𝐭𝐫𝐞𝐧𝐝𝐬 𝐢𝐧 𝐛𝐢𝐨𝐭𝐞𝐜𝐡 𝐢𝐧 2023 While 2023 was tough on the biotech and pharma sector, it witnessed a surge of M&As and IPOs. The investments focused on best-in-class rather than first-in-class approaches, concentrating on clinical-stage assets with 'de-risked' biology. Obesity, immunology, oncology, and neurology are the therapeutic areas that experienced the highest investments and developments, as these therapeutic areas are expected to see significant market growth in the coming years. Credits: Aimee Raleigh Atlas Venture More info: https://lnkd.in/dqu-2n39 #mergersandacquisitions #biotech #pharma #vc #venturecapital #innovation #womeninbusiness #drjojo

𝗡𝗮𝗻𝗼 𝗧𝗵𝗲𝗿𝗮𝗽𝘆 𝗠𝗮𝗿𝗸𝗲𝘁 𝟮𝟬𝟮𝟰-𝟮𝟬𝟯𝟬. 𝗚𝗹𝗼𝗯𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗥𝗲𝗽𝗼𝗿𝘁 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲: https://lnkd.in/dC44Wq7P Nanotherapy, a pivotal branch of nanomedicine, utilizes nanoparticles to precisely deliver drugs to specific targets within the body, a process known as targeting. Primarily focused on cancer therapy, nanotherapy addresses a key challenge of conventional methods by minimizing systemic distribution of drugs, thereby reducing collateral damage to healthy cells and enhancing treatment efficacy. Unlike traditional chemotherapy, which affects both healthy and cancerous cells indiscriminately, nanotherapy, also termed targeted therapy, aims to selectively deliver therapeutic molecules to affected cells, offering promising avenues for cancer treatment while minimizing adverse effects on healthy tissues. 𝗧𝗼 𝗞𝗻𝗼𝘄 𝗗𝗲𝗺𝗮𝗻𝗱 𝗼𝗳 𝟯𝗗 𝗖𝗲𝗹𝗹 𝗖𝘂𝗹𝘁𝘂𝗿𝗲 𝗦𝗰𝗮𝗳𝗳𝗼𝗹𝗱 𝗠𝗮𝗿𝗸𝗲𝘁 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙: https://lnkd.in/dC44Wq7P *𝗕𝘆 𝗧𝘆𝗽𝗲: Nano Electronic Biosensor, Molecular Nanotechnology, Implantable Cardioverter-Defibrillators *𝗕𝘆 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻: Cardiovascular Disease, Cancer Therapy, Diabetes Treatment, Rheumatoid Arthritis, Others *𝗕𝘆 𝗥𝗲𝗴𝗶𝗼𝗻: North America, Europe, Asia-Pacific, South America, Middle East & Africa *𝗕𝘆 𝗞𝗲𝘆 𝗣𝗹𝗮𝘆𝗲𝗿𝘀: Nanoprobes, Inc., Nanospectra Biosciences, Parvus Therapeutics Inc, Smith+Nephew, Selecta Biosciences, Sirnaomics, Tarveda Therapeutics, Sirnaomics #NanoTherapy #TargetedTherapy #Nanomedicine #CancerTreatment #DrugDelivery #Nanoparticles #PrecisionMedicine #NanoDrugDelivery #TherapeuticNanotechnology #InnovativeMedicine

Adoram Therapeutics, a University of Geneva spin-off, is developing next-generation (allosteric) small molecule drugs, which are safer and more effective than conventional (orthosteric) small molecules. We have developed an allosteric screening platform to efficiently identify positive or negative modulators of GPCR drug targets. We are securing investments to progress two preclinical stage assets towards human trials, and to expand our pipeline. Meet Adoram Therapeutics @ #Sachs_ELSF More Info @ https://lnkd.in/dQWhKYkV #ELSF2024 #LifeSciences #Biotech #BioPharma #Partnering #Investment #Startups #RisingStars #Oncology #Neurology #Genomics #Immunotherapy #CNS #Autoimmune #Cardiovascular #BiotechIndustry #BioTechInvestment #Innovation #InvestmentForum #SachsSpringLifeSciencesWeek #SSLSW

2024 Life Science #IPOs! Key drivers include: Later stage assets and #clinical #trial results. Multiple early stage assets with #platform technology TA Focus: #Oncology / #cancer, #Neuro/ #CNS; #Inflammation/ #Immunology TM focus #smallmolecules, #biologics, #genetherapy, and #celltherapy. The median #IPO is $110M with a high of $380M. #funding #publicofferings #biotech #biopharma Kyverna Therapeutics; CG Oncology; Contineum Therapeutics; Boundless Bio; Chromocell Corporation; Metagenomi; Telomir Pharmaceuticals, Inc.; Alto Neuroscience; Fractyl Health; Autonomix Medical; ArriVent Biopharma #ai #datascience #machinelearning #ML #VC #biopharma #biotech #CFO #ipos