Sara Figuerola Santamonica’s Post

Excited to share my recent publication on induced spinal/cranial motor neurons (iSpMNs/iCrMNs) differential response to neurotoxic stress. Trying to identify factors responsible for these differences, we showed that stress-resistant iCrMNs show enrichment in proteostasis and neuronal function proteins. Notably, higher 26S proteasome activity and Ublcp1 levels contribute to stress resistance in iCrMNs. Grateful for the collaborative effort that brought these findings to light! #Neuroscience #Research #MotorNeurons #Proteomics

𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗡𝗲𝘂𝗿𝗼𝗻𝗮𝗹 𝗥𝗲𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 Researchers around 𝗠𝗮𝗴𝗱𝗮𝗹𝗲𝗻𝗮 𝗚ö𝘁𝘇 and 𝗚𝗶𝗮𝗰𝗼𝗺𝗼 𝗠𝗮𝘀𝘀𝗲𝗿𝗱𝗼𝘁𝘁𝗶 from #HelmholtzMunich have made strides in direct #neuronalReprogramming. This innovative approach transforms non-neuronal cells, specifically astrocytes, into functional neurons. 🧠 The results, published in Neuron Cell Press, offer hope for treating brain injuries and neurodegenerative diseases. 👉Read more: https://lnkd.in/dvTpCj9q #Neuroscience #Neuron #Proteostasis

New research showing that α-synuclein protein, a hallmark of Parkinson's disease, may be transferred from gut mucosal cells to the vagus nerve and dorsal motor nucleus. The study used newly engineered transgenic mice with restricted and inducible pathological human α-synuclein expression in intestinal epithelial cells, providing evidence for gut mucosal cells as a potential non-neuronal source of fibrillar α-synuclein protein. Check out the link to learn more. #ParkinsonsDisease #neuroscience #research

🧠 4 posters to check out at SfN this week My colleagues Jeroen, Shushant, Peter, and Debbie are in Chicago right now for the annual meeting of the Society for Neuroscience! Find them at booth 368 to see how Ncardia can help you de-risk drug discovery with iPSC-derived models. You can also learn more in these posters: 🔶 Evaluation of human induced pluripotent stem cell (hiPSC)-derived tri-culture as in vitro model for Alzheimer’s Disease Board B60; In-Person Presentation Time: Sun., Oct. 6, 1-2pm. 🔶 Cellular and Molecular Mechanisms of Tauopathies, Synucleinopathies, and Other Degenerative Diseases Board C7; In-Person Presentation Time: Tue., Oct. 8, 10-11am 🔶 Leveraging an hiPSC-derived 3D tri-culture model to accelerate neuronal maturation and induce microglial dysfunction in a model of tauopathy Board B134; In-Person Presentation Time: Tue., Oct. 8, 10-11am 🔶 Development of iPSC-based Parkinson’s disease model for drug discovery Board B139; In-Person Presentation Time:  Tue., Oct. 8, 4-5pm #sfn2024 #neuroscience #drugdiscovery #ipsc

New study introduces a screening method for identifying drugs that modulate the reactivity of astrocytes, cells implicated in neurodegeneration due to disease, injury, and aging. Histone deacetylase 3 (HDAC3) inhibitors were found to effectively reduce harmful astrocyte responses. The inhibitor RGFP966 specifically prevented the formation of reactive astrocytes and promoted neuroprotection in mouse models, highlighting the therapeutic potential of targeting astrocyte reactivity in neurodegenerative conditions. #Neurodegeneration #AstrocyteModulation #HDAC3Inhibitors #Neuroprotection #BiomedicalResearch #Neuroscience #TherapeuticStrategies https://lnkd.in/ei23Txdx

If you are attending Society for Neuroscience #SFN2024, drop by our booth or posters to see how iPSC derived models can de-risk your drug discovery program. Our SFN activities Booth 368 - come meet the Ncardia team; Peter Udall John Lamb Debbie D. Jeroen De Groot Posters - Evaluation of human induced pluripotent stem cell (hiPSC)-derived tri-culture as in vitro model for Alzheimer’s Disease Board B60; In-Person Presentation Time: Sun., Oct. 6 2024 1-2pm.   Cellular and Molecular Mechanisms of Tauopathies, Synucleinopathies, and Other Degenerative Diseases Board C7; In-Person Presentation Time: Tue., Oct. 8, 2024 10 - 11 a.m.   Leveraging a hiPSC derived 3D tri-culture model to accelerate neuronal maturation and induce microglial dysfunction in a model of tauopathy Board B134; In-Person Presentation Time: Tue., Oct. 8, 2024 10 - 11 a.m.   Development of iPSC-based Parkinson’s disease model for drug discovery Board B139; In-Person Presentation Time:  Tue., Oct. 8, 2024 4 - 5 p.m #SFN2024 #Neuroscience #Discovery

🌟 Exciting News for the Neuro Biomarkers and Biosignatures Community! We are thrilled to announce that the 1st round of abstract submissions is now open for the Neuro Biomarkers and Biosignatures (NBB) 2025 Conference! 🎉 📅 Event Dates: June 9-10, 2025 📍 Location: Rome, Italy This premier event will gather leading researchers, clinicians, and industry experts to explore the latest advancements in neuro biomarkers and biosignatures. If you’re working on groundbreaking research in this field, we invite you to share your insights with the global community. 🔍 Submission Details: Deadline for 1st Round Abstracts: November 11th Submit Your Abstract: https://lnkd.in/e-QB8d9h Conference Website:https://lnkd.in/ersRSzn9 Don’t miss this opportunity to present your work, network with peers, and contribute to the future of neuro biomarker research. We look forward to your innovative contributions and to seeing you in the Eternal City! #NeuroBiomarkers #Biosignatures #Neuroscience #NeurodegenerativeDiseases #Neuroimaging #GeneticMarkers #Proteomics #Neurogenetics #ClinicalDiagnostics #Neuroinflammation #AlzheimerDisease #ParkinsonDisease #MultipleSclerosis #BiomarkerDiscovery #BrainFunction #CognitiveDisorders #Neuroplasticity #NeuropsychiatricDisorders #BiomarkerValidation #BiomarkerProfiling #NeurochemicalMarkers #Neuroimmunology #Neurotoxicity #EarlyDetection #PersonalizedMedicine #DiseaseMechanisms #FunctionalMRI #Electrophysiology #MachineLearning #Neuroscience #Clinicaltrials 

Human neurons derived from induced-pluripotent stem cells (iPSCs) is a highly physiological and robust preparation that can be seamlessly integrated with electrophysiology to decipher mechanisms of action (MOA) and produce functional, predictive data. The benefits are substantial: 🔸 Empower your decision-making process with functional data obtained from human neurons. 🔸 Several disease models exist, with cells derived from patients and carrying specific mutations. 🔸 Various cell types are available and are suitable for use as both mono or co-cultures (ex. 75% Glutamatergic, 20% GABAergic and 5% Glial cells). For any queries or further information, don't hesitate to reach out to us at contact@ephyx-neuroscience.com. We look forward to hearing from you and exploring how we can contribute to your research. #Electrophysiology #DrugDiscovery #CNSResearch #DrugDevelopment #PreclinicalResearch #ResearchAndDevelopment #Neurophysiology #CentralNervousSystem #Neuroscience #CRO #Pharma #ContractResearch #MOA

🌟 Exciting News for the Neuro Biomarkers and Biosignatures Community! We are thrilled to announce that the abstract submissions is open for the Neuro Biomarkers and Biosignatures (NBB) 2025 Conference! 🎉 📅 Event Dates: June 9-10, 2025 📍 Location: Rome, Italy This premier event will gather leading researchers, clinicians, and industry experts to explore the latest advancements in neuro biomarkers and biosignatures. If you’re working on groundbreaking research in this field, we invite you to share your insights with the global community. 🔍 Submission Details: Deadline for 1st Round Abstracts: November 11th Submit Your Abstract: https://lnkd.in/e-QB8d9h Conference Website:https://lnkd.in/ersRSzn9 Don’t miss this opportunity to present your work, network with peers, and contribute to the future of neuro biomarker research. We look forward to your innovative contributions and to seeing you in the Eternal City! #NeuroBiomarkers #Biosignatures #Neuroscience #NeurodegenerativeDiseases #Neuroimaging #GeneticMarkers #Proteomics #Neurogenetics #ClinicalDiagnostics #Neuroinflammation #AlzheimerDisease #ParkinsonDisease #MultipleSclerosis #BiomarkerDiscovery #BrainFunction #CognitiveDisorders #Neuroplasticity #NeuropsychiatricDisorders #BiomarkerValidation #BiomarkerProfiling #NeurochemicalMarkers #Neuroimmunology #Neurotoxicity #EarlyDetection #PersonalizedMedicine #DiseaseMechanisms #FunctionalMRI #Electrophysiology #MachineLearning #Neuroscience #Clinicaltrials 

So now I´m thinking, how cool would it be to mix this methodology with the article in the previous publication and study the effects of gut microbiome on the CNS using brain organoids...