Sergi Segarra’s Post

The recent paper by Cassotta et al. highlights the growing need to move away from traditional models in #NutritionResearch and toward human-based methodologies. These innovative tools provide a more accurate representation of human biology, enhancing our understanding of nutritional pathophysiology and the evaluation of dietary compounds. Our work on a 3D in vitro model of the small intestinal barrier, cited in the paper, illustrates the potential of the MIVO platform to study molecule passage and nutrient effects under realistic conditions. As nutrition research advances, embracing these human-based models is essential for gaining deeper insights into human physiology, improving the assessment of novel food products, and developing more effective preventive and therapeutic strategies. #NAMs #OrganOnChip

This week is British Science week 2024 and the theme for this year is Time! The human gut microbiome undergoes changes in composition over time. The infant gut microbiome is colonised by Bifidobacterium, which can utilise the oligosaccharides present in human milk. The infant microbiome can be influenced by the following factors: delivery mode, diet, medication, and the environment. Image below - Bifidobacterium longum subsp. infantis on MRS agar #BSW24 #microbiology #microbiome

🔬 Excited to share our latest publication in the "International Journal of Molecular Sciences"! 📖 Title: Dietary High Salt Intake Exacerbates SGK1-Mediated T Cell Pathogenicity in L-NAME/High Salt-Induced Hypertension 🔗 Link: https://lnkd.in/eVS_aGhZ A big thank you to all the authors and everyone who contributed to this research. Interested in the impact of dietary salt on hypertension and T cell pathogenicity? Check out the full article here! #Research #Science #MolecularBiology #NewPublication n SN Dina Maal ki Hala Jar MDPI

Probiotic strain Bacillus coagulans VHBAX-04 isolated from human feces showed promising probiotic attributes in in vitro and in silico evaluations, including acid and gastric juice tolerance, resistance to bile salts, adhesion capabilities, and a favorable safety profile with no toxin genes. The study highlights the potential of Bacillus coagulans VHBAX-04 as a safe and effective probiotic option, suggesting its suitability for co-administration with antibiotics. Hashtags: #Probiotics #BacillusCoagulans #HumanMicrobiome #GutHealth #Biohacking Read more here: https://lnkd.in/dc8J6aD9 BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

𝐒𝐞𝐥𝐞𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐬𝐭𝐮𝐝𝐢𝐞𝐬 𝐨𝐧 𝐧𝐮𝐭𝐫𝐚𝐜𝐞𝐮𝐭𝐢𝐜𝐚𝐥 𝐢𝐧𝐠𝐫𝐞𝐝𝐢𝐞𝐧𝐭𝐬 𝐩𝐮𝐛𝐥𝐢𝐬𝐡𝐞𝐝 𝐢𝐧 𝐅𝐞𝐛𝐫𝐮𝐚𝐫𝐲. Each month, our subscriber to Supplements R&D Insight receive a scientific report presenting the best clinical studies published recently. Here, a selection of interesting studies on nutraceuticals published in February.   1. A new beneficial effect of #Levagen+® from GENCOR, with a study showing an improvement in memory in healthy young adults. ➡ https://lnkd.in/e2eJaTVn 2. An improvement in men’s fertility by using an antioxidant blend from Alfasigma. ➡ https://lnkd.in/emMhfVne   3. Vitamin C and #probiotics prevented upper respiratory tract infection in children ➡ https://lnkd.in/edKJHXWG   4. Lutein and zeaxanthin improved visual and cognitive performance in children, a study which used #Lutemax Kids from OmniActive Health Technologies ➡ https://lnkd.in/eH3pw4xJ   5. Still many studies on probiotics have been published, notably a study has shown the efficacy of B. animalis subsp. lactis XLTG11 for constipation in children, while another one reported the sleep-enhancing effect of B. longum 1714. ➡https://lnkd.in/e4823xU4 and https://lnkd.in/e5WZH9uk   Find all these studies and many more in Supplements R&D Insight. Contact Patricia PAUGAM, Juliette Michel or Valérie Le Dévéhat to book a demo.   #science #nutraceuticals #PEA #Probiotic #Nutraveris #FoodchainID

In a new review, investigators explore the link between age-related sarcopenia and gut microbiota alterations. Short-chain fatty acid metabolism, urolithin A, and bile acid production may be pivotal factors in the gut-muscle axis pathway. Supplementation with beneficial metabolite-associated microorganisms could enhance muscle function, mitigate muscle atrophy, and decelerate sarcopenia progression. Read the publication: https://lnkd.in/gfgqiYcM A high quality, clinically studied probiotic like Omni-Biotic can play a pivotal supportive role. Healthcare practitioners are welcome to request complimentary samples: omnibioticlife.com #aging #sarcopenia #gutmicrobiome

🐄🌾 The transition period in dairy cows, from dry-off through postpartum, is critical for their health and productivity. Major dietary changes impact rumen function, health and the cow’s overall well-being. Calving significantly influences digestion, with studies showing changes in rumen wall histology and gene expression. Support your herd by monitoring: - Feedbunk and water trough space, - Stocking density of the fresh cow pen, - Adjust the ration for proper moisture, energy density and particle length, - Feed a live yeast probiotic like S. cerevisiae CNCM I-1077 (LEVUCELL SC) to help support rumen function and improved cow performance Learn more practical transition cow management and nutrition tips here: https://bit.ly/3VI7Wbc

🔬🧫🧬  Chronic inflammation underlies the pathology of numerous human diseases, including rheumatoid arthritis and inflammatory bowel diseases (IBD). 👩⚕️ The resolution of inflammation is an active process that is facilitated by specialized pro-resolving mediators (SPM) and their intermediate lipid mediators (LM). These LM derive endogenously from omega-3 polyunsaturated fatty acids (n-3 PUFA) and confer their inflammation-resolving effects. 🧬 Importantly, LM biosynthesis is dysfunctional in various conditions, which may explain the inconclusive efficacy data from n-3 PUFA interventions. Here, we conceived a synbiotic strategy to improve n-3 PUFA conversion to LM through microbial metabolism. 👨🔬 In summary, we have developed and tested a novel synbiotic strategy that holds promise for enhancing inflammation medicine as well as nutritional therapies, as it allows for the self-sufficient production of pro-resolving LM. 🧫 SynΩ3 and similar compositions have widespread application and formulation capabilities, above all in the treatment or prevention of conditions related to chronic inflammation. 🎤 To find out more, meet Bodo Speckmann from Evonik Germany at the 17th IPC2024 in Prague, 18-21 June 2024 and... Hit the bell 🔔🔔🔔 to stay tuned on to International Scientific Conference on #Probiotics, #Prebiotics, #Gut #Microbiota and #Health - #IPC2024 and get updated on probiotic, prebiotic #science and #microbiota #research.

"Phytoene is a colourless carotenoid widely available from dietary sources and a precursor for the synthesis of other carotenoids. Although present at high concentrations across different tissues, phytoene is largely viewed as not having physiological activity." Here, Ángeles Morón-Ortiz, et al. "utilized the model organism C. elegans to show that phytoene is bioactive and has anti-ageing properties." "Supplementation with phytoene protects against oxidative damage and amyloid-β42 proteotoxicity (a major pathology of #AlzheimersDisease), and extends lifespan." They also "examined extracts from two microalgae, Chlorella sorokiniana and Dunaliella bardawil." "They showed that the extracts contain high levels of phytoene, and found that these phytoene-rich extracts have protective effects similar to pure phytoene." "These findings show that phytoene is a bioactive molecule with positive effects on #Ageing and Longevity and also suggests that phytoene-rich microalgae extracts can be utilized to produce foods or supplements that promote healthy ageing and prevent the development of chronic age-related diseases." Learn More in MDPI | #Antioxidants https://lnkd.in/dZyZR7kC Phytoene and Phytoene-Rich Microalgae Extracts Extend Lifespan in C. elegans and Protect against Amyloid-β Toxicity in an Alzheimer’s Disease Model - Angeles Moron Ortiz, Antonis Karamalegkos, Paula Mapelli Brahm, Marina Ezcurra and Antonio J. Meléndez Martínez, PhD Universidad de Sevilla University of Kent Neuroscience News https://lnkd.in/dVd9M3Jk

MS-Omics and CosmosID are proud to announce our support of a new study led by Cryptobiotix and Tate & Lyle and published in the International Journal of Food Sciences and Nutrition. This research investigates the specific effects of a broad range of low and no-calorie sweeteners on the human gut microbiota, highlighting the differential impact of tagatose, sorbitol, maltitol, stevia, acesulfame K and sucralose on microbial composition and activity Our collaborative effort highlights how different sweeteners can variably influence microbial composition and function. This study is a testament to the power of partnership in advancing our understanding of nutrition and gut health. https://hubs.ly/Q02j_-pw0 #GutHealth #NutritionScience #Cryptobiotix #CosmosID #MSOmics #CollaborativeResearch