A wonderful primer on RNA from the National Human Genome Research Institute. https://lnkd.in/eS-8AKPh
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Director of Bioinformatics | Cure Diseases with Data | Author of From Cell Line to Command Line | Data Science | Educator | Cloud Computing | Dana-Farber | MD Anderson | Join 32K followers on Twitter @tangming2005
Full resolution HLA and KIR genes annotation for human genome assemblies
Full resolution HLA and KIR genes annotation for human genome assemblies
biorxiv.org
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Understanding the intricate mechanisms behind sex-specific organ development holds immense potential for the life science industry, particularly pharma. Today’s blog delves into a study that sheds light on the genetic programs governing this complex biological process. Read more: https://lnkd.in/e2e9-wZ7 #geneexpression #sexual dimorphism #single cell RNA sequencing #single nucleus RNA sequencing #evolution
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ICYMI: Understanding the intricate mechanisms behind sex-specific organ development holds immense potential for the life science industry, particularly pharma. Last month's blog delves into a study that sheds light on the genetic programs governing this complex biological process. Read more: https://lnkd.in/e2e9-wZ7 #geneexpression #sexual dimorphism #single cell RNA sequencing #single nucleus RNA sequencing #evolution
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#biologyfacts Whole exome sequencing and whole genome sequencing are increasingly used in healthcare and research to identify genetic variations; both methods rely on new technologies that allow rapid sequencing of large amounts of DNA. These approaches are known as 👉 next-generation sequencing (or next-gene sequencing). Next-generation sequencing has sped up the process (taking only days to weeks to sequence a human genome) while reducing the cost. Know what GenScript can do for your research: https://ow.ly/kuea50PYSGy #Wholeexomesequencing #genomesequencing #geneediting #ngs #DNA Image from NGS
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B.Pharm, Ph.D., Assistant Professor - Lisbon Medical School, University of Lisbon. Senior Researcher - Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon.
R2 elements are non-long terminal repeat (non-LTR) retrotransposons that insert site-specifically into the host organism's 28S ribosomal RNA (rRNA) genes. To date these molecular parasites have been identified in arthropods, vertebrates, echinoderms, flatworms and hydra. Once a 28S gene is inserted it is no longer capable of producing functional rRNA; however, the ribosomal DNA locus itself is typically comprised of hundreds of genes. The “ecological landscape” for propagation of R2 elements is thus complex: the R2 element must produce enough copies to maintain itself, but overinsertion by R2 is detrimental to the host, so the elements must also contend with host mechanisms that suppress R2 replication. Originally discovered in 1977, many aspects of the biology of R2 retrotransposons have been deduced over subsequent years using silkmoths and fruitflies as model systems. As a retrotransposon, the R2 element reproduces itself through an RNA intermediate: the R2 RNA, which possesses a single ORF for the R2 protein as well as cis-regulatory signals necessary for insertion into the host genome. The R2 RNA is initially co-transcribed with host ribosomal RNA by RNA polymerase I and is processed out of this primary transcript utilizing an encoded self-cleaving ribozyme to free the 5′ end. The R2 RNA interacts with the R2 protein during insertion into the host genome. The mechanism by which the R2 element inserts has been well documented for Bombyx mori and proceeds via an ordered sequence of DNA cleavage and synthesis. Here you can see a recent cryoEM structure of the R2 with 5'ORF from Bombyx mori (PDB code: 8IBY) #molecularart ... #immolecular ... #retrotransposon ... #DNA ... #complex ... #bombyx ... #cryoem Structure rendered with #proteinimager and depicted with #corelphotopaint
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Clinical Trial Methodology Evaluator chez afmps - agence fédérale des médicaments et produits de santé
Nature. 2023 Aug 23 The complete sequence of a human Y chromosome. https://lnkd.in/eJmMFuuS "Here, the Telomere-to-Telomere (T2T) consortium presents the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference, showing the complete ampliconic structures of gene families TSPY, DAZ and RBMY; 41 additional protein-coding genes, mostly from the TSPY family; and an alternating pattern of human satellite 1 and 3 blocks in the heterochromatic Yq12 region." and Researchers assemble the first complete sequence of a human Y chromosome. NIH News Release. https://lnkd.in/e9bP22Jh
The complete sequence of a human Y chromosome - Nature
nature.com
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https://lnkd.in/gWSXzeDf 27 June https://lnkd.in/g-9SC5wM 26 June https://lnkd.in/gawCRagn 26 June https://lnkd.in/gY69Fhqg 19 June https://lnkd.in/gye_FiFz A technique that harnesses ‘jumping genes’ — mobile genetic sequences naturally found in bacteria that can cut, copy and paste themselves into genomes — could hold the key to redesigning DNA at will. Guided by an RNA molecule called a ‘bridge’ RNA or ‘seekRNA’, the system has been shown to edit genes in a bacterium and in test-tube reactions, but it is still unclear whether it can be adapted to work in human cells. If it can, it could be revolutionary, owing to its small size and its ability to make genetic changes that are thousands of bases long — much larger than is practical with the CRISPR — without breaking DNA.
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A bacterial version of reverse transcriptase reads RNA as a template to make completely new genes written in DNA. It will definitively change our way to look at the genome and read the transcriptome. doi: https://lnkd.in/eCiZ2tdx
Bizarre bacteria defy textbooks by writing new genes
nature.com
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R2 elements are non-long terminal repeat (non-LTR) retrotransposons that insert site-specifically into the host organism's 28S ribosomal RNA (rRNA) genes. To date these molecular parasites have been identified in arthropods, vertebrates, echinoderms, flatworms and hydra. Once a 28S gene is inserted it is no longer capable of producing functional rRNA; however, the ribosomal DNA locus itself is typically comprised of hundreds of genes. The “ecological landscape” for propagation of R2 elements is thus complex: the R2 element must produce enough copies to maintain itself, but overinsertion by R2 is detrimental to the host, so the elements must also contend with host mechanisms that suppress R2 replication. Originally discovered in 1977, many aspects of the biology of R2 retrotransposons have been deduced over subsequent years using silkmoths and fruitflies as model systems. As a retrotransposon, the R2 element reproduces itself through an RNA intermediate: the R2 RNA, which possesses a single ORF for the R2 protein as well as cis-regulatory signals necessary for insertion into the host genome. The R2 RNA is initially co-transcribed with host ribosomal RNA by RNA polymerase I and is processed out of this primary transcript utilizing an encoded self-cleaving ribozyme to free the 5′ end. The R2 RNA interacts with the R2 protein during insertion into the host genome. The mechanism by which the R2 element inserts has been well documented for Bombyx mori and proceeds via an ordered sequence of DNA cleavage and synthesis. Here you can see a recent cryoEM structure of the R2 with 5'ORF from Bombyx mori (PDB code: 8IBY) Rendering by Francisco J. Enguita made with #proteinimager https://lnkd.in/dw3MMWgy #molecularart #retrotransposon #DNA #complex #bombyx #cryoem
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