Symeres’ Post

Stuck in a rut with your chemistry? Why not give #Symeres a call and see if our experienced and creative chemists cannot come up with a smart solution. Our team of expert chemists employs state-of-the-art techniques, such as cross-coupling and asymmetric #hydrogenation, to streamline the #synthesis of these complex molecules. This approach reduces time and costs, while increasing the yield of potential drug candidates. Additionally, our toolbox includes #parallelchemistry and #catalyst screening, which facilitate the rapid synthesis of analogues using the most suitable catalytic systems.

The versatile applications of spray drying have revolutionized the development and production of pharmaceuticals and biotechnology products. Read the blog from Michael Levis to learn more: https://lnkd.in/dVV7Fs3G

🔬 #𝗤𝘂𝗮𝗻𝘁𝗶𝘁𝗮𝘁𝗶𝘃𝗲 𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗨𝘀𝗶𝗻𝗴 #𝗥𝗮𝗺𝗮𝗻 #𝗦𝗽𝗲𝗰𝘁𝗿𝗼𝘀𝗰𝗼𝗽𝘆 𝗶𝗻 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 💊https://horiba.link/m1y Check out the Raman spectra of DayQuil™ and NyQuil™ collected with an immersion probe fiber-coupled to the MacroRAM™ Raman spectrometer. 📈🔍 While Raman spectroscopy is renowned for qualitative chemical analysis, did you know it can also excel in quantitative analysis? 🌟 Here’s how: Versatile Conditions: Effective for various solutes and solution mixtures. #Pharmaceutical Applications: Perfect for analyzing content uniformity in pharmaceuticals. With our advanced MacroRAM™ Raman spectrometer and immersion probe setup, we demonstrate how Raman spectroscopy can revolutionize quantitative analysis in pharmaceuticals. 🚀🔬

#Protein #Binding #Assays: By Technology (Equilibrium Dialysis, Affinity Electrophoresis, Ultrafiltration, Ultracentrifugation, Surface Plasmon Resonance, Others), By Product & Services (Instrument, Kits & Reagents, Services), By End-Users (Pharmaceutical & Biotechnology Companies, CROs, Consulting Firms, Others), and Region – Cumulative Growth Opportunities Analysis, Size, Share, Trends, and Industry Forecast Till 2030. By: Analytical Market Research Read More Info:https://lnkd.in/d5HpZTg7 Key Players: Merck KGaA, Darmstadt, Germany (Germany), Thermo Fisher Scientific (U.S.), GE (U.S.), Sovicell (Germany), Cyprotex (U.K.), BioDuro-Sundia. (U.S.), Beckman Coulter Diagnostics, (U.S.), Sartorius Stedim Biotech BIOOUTSOURCE LTD. (Germany), and Bio-Rad Laboratories, Inc. (U.S.). #marketgrowth #marketshare #marketsize #marketdemands #marketforecast #marketstretargy #marketanalysis #markettrends #market

Kudos to our researchers for their recent publication in the August issue of LCGC International! Chad Bastian, Alyssa McBurney, and Christopher Williams collaborated on the paper titled Rapid Quantitative Analysis of Ethylene Oxide and 1,4-Dioxane in Polymeric Excipients Using SIFT-MS. Their work showcases groundbreaking efforts in utilizing Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) for the analysis of volatile compounds in real-time, a significant advancement for continuous pharmaceuticals manufacturing. Dive into our comprehensive article here ➡️ <https://gag.gl/91WXU9> #LCGCInternational #SIFT-MS #continuouspharmamanufacturing #alcami

Advanced particle analysis revolutionises pharma development The CCDC - The Cambridge Crystallographic Data Centre) developed a suite of advanced informatics tools that enhance researchers' understanding of particle behaviour and surface properties in pharmaceutical manufacturing. These tools improve product formulation efficiency and reduce costs, showing significant benefits in various research studies. These innovations support formulators and particle engineers to make better informed decisions, advancing #pharmaceutical and fine #ChemicalManufacturing. Developed in collaboration with industry leaders like AstraZeneca and Pfizer, CSD-Particle tools promote a ‘digital first’ approach in drug development, minimising non-viable formulations and anticipating bottlenecks early on. https://lnkd.in/eTwD546m

Just finished my cofee break while reading Nature Communications and found this interesting paper : "Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles "☕ The Synthesis 👩🔬 : This paper presents a novel method for synthesizing chiral 1,2,3-triazoles via an highly enantioselective copper-catalyzed azidation/click cascade reaction. The use of a copper catalyst is particularly noteworthy as it facilitates the azidation and click reactions in a single, streamlined process. Why It's Interesting 🧠 : This method stands out because it not only simplifies the synthesis process but also achieves high enantioselectivity. This innovative approach could potentially lead to more efficient production of chiral drugs, reducing costs and improving accessibility. At Nuvisan, our dedicated Process Chemists leverage advanced synthesis techniques like the one highlighted in this publication. If you're interested in learning more about our capabilities or discussing potential collaborations, feel free to reach out! #Chemistry #OrganicChemistry #Triazoles #CopperCatalysis #DrugDevelopment #Pharmaceuticals #Nuvisan

💊 What does the future of pharma synthesis look like? Check out this recent publication which explores a novel method for synthesizing (3R)-quinuclidinol, a chiral building block in pharmaceutical products, using the integration of advanced catalysis. Together, Hydregen and AM Technology compare biocatalytic hydrogenation and metal-catalysed hydrogenation for ketone to chiral alcohol conversion, using the Coflore ACR. The use of a dynamically mixed flow reactor, precise temperature and flow rates enhanced the reaction's stability and scalability. Together, Hydregen and AM Technology leveraged the advantages of continuous flow chemistry and biocatalysis for sustainable manufacturing processes. 💡⚛️ Our publication shows promise of a scalable and efficient production of (3R)-quinuclidinol. View here > https://bit.ly/3PUOw1 #sustainability #pharmaceuticalindustry #pahrmaceuticalmanufacturing

Late Stage Saturation (LSS) vs Late Stage Functionalization (LSF) Converting aromatic molecules into saturated analogs with a higher fraction of sp3 carbons holds promise for enhancing their medicinal properties. This study demonstrates the feasibility of saturating aromatic and heteroaromatic drugs through mild rhodium-catalyzed hydrogenation, acid-mediated reduction, or photocatalyzed-hydrogenation techniques. By transforming sp2 carbon atoms into sp3 carbon atoms, can create saturated molecules with improved medicinal characteristics. Notably, the rhodium-catalyzed approach accommodates traces of dimethyl sulfoxide (DMSO) or water, enabling the reformulation of pharmaceutical compound collections stored in wet DMSO for chemical synthesis. Exemplified through the late-stage saturation (LSS) of 768 complex and densely functionalized small-molecule drugs, showcasing the transformative potential of these techniques in drug development. Great work Dr. Frank Glorius Dr. Tim Cernak and the team. #SaturatedMedicines #FunctionalizationVersusSaturation #RhodiumCatalyzedChemistry #DrugDevelopmentMethods #LateStageTransformation #MedicinalChemistry #PharmaceuticalInnovation #Sp3CarbonConversion #TransformativeDrugResearch #ChemicalSynthesisTechniques #NCATS #NIH #JACS

Really excellent collaboration to get to this result! Kudos to our researchers for their publication in the August issue of LCGC International! Chad Bastian, Alyssa McBurney, and Christopher Williams collaborated on the paper titled Rapid Quantitative Analysis of Ethylene Oxide and 1,4-Dioxane in Polymeric Excipients Using SIFT-MS. Their work showcases cutting-edge advancements in utilizing Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) for the analysis of volatile compounds in real-time, significantly benefiting continuous manufacturing in the pharmaceutical sector. Dive into the full article here ➡️ <https://gag.gl/91WXU9> #LCGCInternational #SIFT-MS #continuouspharmamanufacturing #alcami