Synaptic Systems GmbH’s Post

🧠🔬 Mutations in the RARB gene lead to severe early-onset movement disorders, especially dystonia. RARB is essential for producing the retinoic acid receptor beta (RARb) protein, which regulates numerous genes in our body. One key target of RARb is the medium spiny neurons (MSNs) in the striatum, vital for motor control. With two types of MSNs, DiR enhances voluntary movement while D2R plays a role in inhibiting it. Understanding these pathways is crucial for advancing research and treatments! 💪✨ #RARB #MovementDisorders #Neuroscience

Within the intricate signaling networks governed by phosphatases and kinases, the protein PP2A takes center stage. B56δ, a regulatory subunit encoded by PPP2R5D gene, is a noteworthy player within the PP2A complex. It includes extensive intrinsically disordered regions (IDRs) that house a substrate-mimicking short linear motif (SLiM) and multiple crucial phosphorylation sites. What elevates the significance of PP2A's B56δ is the discovery that de novo missense mutations in PPP2R5D are associated with a spectrum of neurological manifestations. These mutations give rise to intellectual disabilities (ID), macrocephaly, Parkinsonism, and a broad range of neurological symptoms. Unraveling the complexities of PP2A sheds light on its pivotal role in maintaining neurological health and functioning. 🧬🔍 Here you can see a cryoEM structure of PP2A with B56δ subunit (orange) (PDB code: 8U89) Rendering by Gianluca Tomasello made with #proteinimager https://lnkd.in/dT4_aVwj #molecularart #PP2AProtein #neurologicaldisorders #neuroscience #structuralbiology #parkinsonsdisease #MolecularSignaling #scienceillustration #science

"(PP2A takes center stage )Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules like Akt, p53, c-Myc and β-catenin. It plays a critical role in cellular processes, such as cell proliferation, signal transduction and apoptosis. Structurally, it is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. PP2A undergoes post-translational modifications (i.e. phosphorylation and methylation), which in turn, regulates its enzymatic activity. Aberrant expression, mutations and somatic alterations of the PP2A scaffold and regulatory subunits have been observed in various human malignancies, including lung, breast, skin and colon cancer, highlighting its role as a ‘tumor suppressor’. This review is focused on the structural complexity of serine/threonine phosphatase PP2A and summarizes its expression pattern in cancer. Additionally, the PP2A interacting and regulatory proteins and substrates are also discussed. Finally, the mouse models developed to understand the biologi " To learn more about pp2a, you can read from this link pubmed : PMCID: PMC3665613NIHMSID: NIHMS456324PMID: 23454242

Within the intricate signaling networks governed by phosphatases and kinases, the protein PP2A takes center stage. B56δ, a regulatory subunit encoded by PPP2R5D gene, is a noteworthy player within the PP2A complex. It includes extensive intrinsically disordered regions (IDRs) that house a substrate-mimicking short linear motif (SLiM) and multiple crucial phosphorylation sites. What elevates the significance of PP2A's B56δ is the discovery that de novo missense mutations in PPP2R5D are associated with a spectrum of neurological manifestations. These mutations give rise to intellectual disabilities (ID), macrocephaly, Parkinsonism, and a broad range of neurological symptoms. Unraveling the complexities of PP2A sheds light on its pivotal role in maintaining neurological health and functioning. 🧬🔍 Here you can see a cryoEM structure of PP2A with B56δ subunit (orange) (PDB code: 8U89) Rendering by 3D Protein Imaging made with #proteinimager https://lnkd.in/damt2bWb #molecularart #PP2AProtein #neurologicaldisorders #neuroscience #structuralbiology #parkinsonsdisease #MolecularSignaling #scienceillustration #science

I am thrilled to announce that our review paper, titled " A review of the advanced, insight, and prospects of gene therapy for Alzheimer's disease: A novel target for therapeutic medicine" has been successfully published in the Gene journal ( Elsevier, Q2, IF:3.5). For those who wish to delve into the comprehensive details, the complete paper can be accessed through the following links: https://lnkd.in/d63ZG7qy The entire paper is available via this link until 4 May 2024. #genetherapy #alzheimersdisease #geneticmedicine #crisprcas9 #neurodegenerativediseases #neuroscience #neurology #alzheimersresearch #alzheimers

🧠 Exciting Breakthrough in Multiple Sclerosis Research- A New Mechanism to Regenerate Myelin? This groundbreaking discovery, published in Cell, highlights the potential of a novel protein function inhibitor, ESI1, to regenerate myelin and restore neurological function. 🔬 Key Insights: ESI1 targets gene silencing in oligodendrocytes, boosting myelin production. Successful preclinical tests in mice and human brain cells suggest potential for human trials! This approach could revolutionize MS treatment and extend to other neurodegenerative conditions. 💡 Implications for the future: Potential to reverse nerve damage in MS and similar disorders. Recovery from brain and spinal injuries. Opens possibilities for combating age-related cognitive decline. #MSresearch #Neuroscience #MedicalBreakthroughs #mutiplesclerosis #myelin #neurodegnerative #regenerativemedicine

#RettSyndromeresearch 🎥 Join the conversation on neurodevelopmental disorders and the MECP2 gene. MECP2 plays a critical role in neurodevelopment and neurological function, influencing gene transcription and synaptic connections. Mutations or duplications of the MECP2 gene are linked to severe neurodevelopmental disorders like Rett syndrome, causing issues in communication, learning, and coordination, especially in females.🧠 How do you think advancements in MECP2 research could shape future treatments for these disorders? Let’s explore this crucial topic together! #Neurodevelopment #MECP2 #GeneticResearch #Neuroscience #biotech #biotechnology #cyagen #HUGOGT #HUGOUS

🧬 #Epigenetics in Action: The rapidly advancing field of epigenetics reveals how environmental factors influence gene expression. Understanding Parkinson's Disease (PD) requires exploring how epigenetic modifications affect inflammation, synaptic plasticity, and neuroprotection, contributing to cognitive deficits. 🧠 🎯 How can advancements in epigenetic research pave the way for innovative therapies in Parkinson's Disease? Read Prof. Andre Surguchov et al's preprint and share your thoughts: https://lnkd.in/gziHqG7U #ParkinsonsDisease #CognitiveFunction #Neuroscience

New Neuroscience Article! Huntington’s disease (HD) is an inherited neurodegenerative disease caused by a CAG extension in exon 1 of the huntingtin gene. An extended polyglutamine tract in the huntingtin protein is developed due to the expanded alleles, resulting in intracellular signalling defects.Antisense Oligonucleotide (ASO) gene therapy is currently being pioneered to treat HD………… Read the rest of the article: https://lnkd.in/gma_icsT Written by: Maria K Neuroscience News British Neuroscience Association (BNA) Neuroscience, Surgery and Trauma Centre #neuroscience #huntington #huntingtondisease #genetherapy #disease

☑️ *READ DESCRIPTION BELOW:* DNA methylation, posttranslational histone modifications, and microRNAs are all major epigenetic processes that regulate gene expression. These pathways are found to be dysregulated in cancer. Phytocompounds have shown to modulate abnormal epigenetic modifications Khan A, Front Pharmacol. 2024 Mar 26;14:1273993. doi: 10.3389/fphar.2023.1273993. PMID: 38596245; PMCID: PMC11002180. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum