Munich Cluster for Systems Neurology (SyNergy)’s Post

Here's our most recent contribution to miniaturized wireless implantable technologies for fundamental biology studies of individual and social behaviors in small animals, published in the journal Neuron: Cell Press. This flexible electronic platform uses a high-bandwidth accelerometer that gently couples to the cardiovascular system for continuous quantitative monitoring of physiological processes and body movements in mouse models. Specifically, this battery-free system captures heart and respiratory rates, including variabilities in these quantities, along with physical activity, body orientation, temperature, and behavioral states. The relevance spans investigations of neural circuits under healthy and diseased conditions, effects of pharmaceutical treatments, and processes of disease progression and recovery. Demonstrated applications cover a wide range of pharmacological, locomotor, and acute and social stress tests, with unique insights into the coordination of physio-behavioral characteristics associated with normal and perturbed states. Let us know if you have interest in these systems for your research – we’ve already sent samples to numerous collaborators in neuroscience and physiology. Special thanks to Dr. Tony Banks for initiating this work, to Dr. Cameron Good and Prof. Sam Golden for leading the animal model studies, and to Dr. Wei Ouyang (former postdoctoral fellow, now on the faculty at Dartmouth College) for engineering contributions and project leadership. https://lnkd.in/gBxFtY36

Completed a module on the topic "Med platforms Matter: Materials science for cancer diagnostics and treatment", hosted by Cell Press through Researcher Academy, Elsevier. Med and Matter recognize that multiple driving technologies emerging in medicine are being developed on innovative and advanced materials platforms; these technologies exploit the behaviour of novel materials and phenomena, including biocompatible chemistries and mechanics, adaptive structures, transport properties, photo dynamics, and more. Simply put, the underlying platforms used for medicine matter. Here, it was focused that materials-based solutions for potential cancer treatment, diagnostics, and the next generation of personalized medicine. The webinar was presented by : Dr Natalie Artzi - talked about Engineering Therapeutic Immunity using Materials Dr Ali Khademhosseini - session about Engineering in Personalized Medicine Dr Wei Tao - presentation on Nanoscale Materials in Medicine: Training Drugs/Therapeutics to be Smarter

Dear Biomeds, 🧪Knowing about On-Chip Detection technology in Invitro test🩸 ▪️The in vitro test of the future is therefore one where cell and tissue activity is as close as possible to that inside the human body. Organ-on-a-chip technology achieves this through silicon devices upon which cells and tissue can grow. ▪️Silicon devices allow for using patient-specific biology and mutations, enabling more personalized medicine. As silicon devices can be mass produced, this will drastically speed up drug screening and development. ▪️Great progress is being made on brain-on-a-chip concepts that can help to decipher, and bring us closer to therapies for Neurodegenerative diseases such as Parkinson’s and Alzheimer’s – a research avenue that is being explored now. #organonchip #biochip #bioelectrode #biosensors #invitrotest #futuretechnology #bioscience #neurogenerative #siliconbaseddevice #bloodbrainbarrier #diagnostic #solution Dr S. ATHEENA MILAGI PANDIAN Rashika Murugan Sudherson M Sri Manoj Kumar Kriya Sakthi M Council of State Bioscience Associations (CSBA) Farcast Biosciences imec the Netherlands Popular Nanotechnology Biomedical & Medical Device OnChip Onchip Solutions - India

🦠Organ on a Chip Technology🔬 🤯Groundbreaking innovative research in On-Chip Detection🩸 🧠Organ-on-a-chip platform is built on our various in-house capabilities: ▪️Microfluidics to culture and control the cells on the chip. ▪️Multi-electrode arrays for high-throughput, multi-modal cell interfacing. ▪️Biosensors for measurement of the cell analytes. ▪️Lens-free imaging for visualization of structures and movements. ▪️Data analytics to find patterns in the wealth of information and make predictions. Major applications: ▪️A heart-on-a-chip, complete with a lens-free microscope to observe beating movements. ▪️Modeling of the Blood-Brain barrier. 🧪The in vitro test of the future is therefore one where cell and tissue activity is as close as possible to that inside the human body. Organ-on-a-chip technology achieves this through silicon devices upon which cells and tissue can grow. Silicon devices allow for using patient-specific biology and mutations, enabling more personalized medicine. 🫀Micropatterns on the chip are developed together with the relevant biology. High-density electrodes offer stimulation, such as for electroporation. And/or they read out activity on a single cell level.Even lens-free microscopes can be added to monitor movements. 🧠Great progress is being made on brain-on-a-chip concepts that can help to bring us closer to therapies for Neurodegenerative diseases such as Parkinson’s and Alzheimer’s – a research avenue that is being explored now. #organonachip #detection #measurement #biosensors #bloodbrainbarrier #neurodegenerative #futuretechnology #invitrotest #bioelectrode #bioscience RESEARCHER - ATHEENAPANDIAN VICE PRESIDENT - ATHEENAPANDIAN Atheenapandian_Researcher Atheenapandian_Researcher Kriya Sakthi Trainer_Atheenapandian

Call for Papers for Peptide Science https://lnkd.in/gFYhnH48 Fluorescent Peptides: Exploring the Luminous Language of Life Submission deadline: Friday, 31 January 2025 Submit at: https://lnkd.in/gnnSXufa Peptides, the miniature siblings of proteins, hold immense significance in biological processes, therapeutic development, and diagnostic applications. Their small size, structural diversity, and specificity make them excellent candidates for a variety of functions. When coupled with the dynamic field of fluorescence, peptides transform into powerful tools for imaging, sensing, and tracking biological phenomena with high specificity and sensitivity. The incorporation of fluorescent properties into peptides has opened a plethora of research avenues, allowing scientists to visualize and understand the intricate machinations of cellular and molecular systems. The aim of this special issue is to showcase the latest advancements, innovative methodologies, and cutting-edge research in the synthesis, characterization, and application of fluorescent peptides. We aim to provide a platform for researchers to share their insights, discuss challenges, and highlight the potential of these luminescent biomolecules in science and technology. Topics for this call for papers include but are not restricted to: Design of fluorescent peptides; Peptide self-assembly; Synthesis of fluorescent peptides; The fluorescence mechanism of peptides; Biophysical characterization of fluorescent peptides; Fluorescent peptide nanoparticles for bioimaging; Peptide fluorescence in high-throughput screening; Fluorescent peptides as probes for protein-protein interactions; Fluorescent peptides in neurobiological applications; Fluorescent peptides in drug discovery and development; Challenges and future perspectives in fluorescent peptide research. Guest Editor: Assoc. Prof. Jia Kong Shaanxi Normal University, China #Fluorescent #Peptides; #SelfAssembly; #StructureFunctionRelationship; #Biophysical Characterization; #Computational Design; #Biomedical Applications.

🔬 𝐃𝐫𝐢𝐯𝐢𝐧𝐠 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐈𝐧𝐧𝐨𝐯𝐚𝐭𝐢𝐨𝐧: 𝐓𝐡𝐞 𝐎𝐩𝐭𝐨𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 𝐂𝐚𝐧𝐧𝐮𝐥𝐚𝐞 𝐌𝐚𝐫𝐤𝐞𝐭 🔬 𝐂𝐥𝐢𝐜𝐤 𝐇𝐞𝐫𝐞, 𝐓𝐨 𝐆𝐞𝐭 𝐅𝐫𝐞𝐞 𝐒𝐚𝐦𝐩𝐥𝐞 𝐑𝐞𝐩𝐨𝐫𝐭 https://lnkd.in/d-VF-E8n The Optogenetics Cannulae Market is propelling cutting-edge research in neuroscience by enabling precise control of neural activity with light. These advanced tools are revolutionizing how researchers explore brain function, behavior, and neurological disorders, opening new avenues for therapeutic intervention. 🌟 Key Highlights: Precision Light Delivery: Optogenetics cannulae provide targeted light stimulation to specific neurons, allowing researchers to modulate brain activity with high accuracy. Critical Role in Research: These cannulae are essential for studying complex brain circuits and understanding disorders like Parkinson's, depression, anxiety, and epilepsy. Biocompatible Design: Made with biocompatible materials, optogenetics cannulae ensure long-term use in living tissues, enabling chronic studies in animal models. 📈 Market Dynamics: Rising Demand in Neuroscience: As optogenetics continues to expand, the demand for advanced optogenetic cannulae is growing, driven by research into brain function, behavior, and neural disorders. Technological Innovation: Continuous improvements in fiber optics, miniaturization, and light source integration are enhancing the functionality and application range of optogenetics tools. Cross-Disciplinary Impact: The market is benefiting from advancements across various fields, including neuroengineering, biophotonics, and genetic engineering, which are expanding the possibilities for neural modulation. #Company Prizmatix Ltd. Thorlabs Doric Lenses Inc. Ainnotech Scitech Korea Inc. Plexon Inc Hangzhou ORIGINOPTO Hangzhou Inper #Type • Ceramic • Stainless Steel • Others #Application • Hospital and Clinic • Laboratory • Other #Optogenetics #Neuroscience #Biotechnology #Neuroengineering #MedicalResearch #Innovation #HealthcareTechnology #LinkedInPost

#goldnanoparticles #colloidalgold #lateralflow The Fascinating Science Behind Gold Particles in Biomedical Applications Gold, a precious metal long prized for its beauty and durability, is undergoing a remarkable transformation in the world of medicine. Forget crowns and jewelry – scientists are now harnessing the unique properties of gold particles at the nanoscale (incredibly tiny, measured in billionths of a meter) to develop innovative biomedical applications. But what makes gold so special in this new realm? The key lies in its interaction with light. When light hits gold nanoparticles, it excites the metal's electrons, causing a collective oscillation known as surface plasmon resonance. This fancy term translates to some pretty cool abilities: Heat Generation: Gold nanoparticles can convert light energy into heat very efficiently. This property has applications in cancer treatment, where gold particles can be directed to tumors and then irradiated with lasers. The heat generated by the particles destroys cancer cells while leaving healthy tissues relatively unharmed. Light Scattering: Gold nanoparticles can scatter light with specific colors depending on their size and shape. This makes them ideal for creating contrast agents in medical imaging techniques like photothermal imaging and computed tomography (CT scans). By attaching these gold particles to molecules of interest, such as antibodies targeting specific diseases, doctors can gain a clearer picture of what's happening inside the body. Drug Delivery: Gold nanoparticles can be used as carriers for drugs. They can be designed to bind to specific molecules, allowing them to deliver their cargo directly to diseased cells and avoid healthy tissues. This targeted approach has the potential to reduce side effects and improve treatment efficacy. The science behind gold nanoparticles in biomedicine is still evolving, but the potential is vast. Researchers are exploring their use in: Gene Therapy: Gold nanoparticles could be used to deliver genetic material into cells, potentially paving the way for new treatments for genetic diseases. Antibacterial Treatments: Certain types of gold nanoparticles exhibit antibacterial properties, offering a potential weapon in the fight against antibiotic-resistant bacteria. Diagnostics: Gold nanoparticles can be used to develop highly sensitive biosensors for detecting diseases at early stages. The journey from a prized metal to a cutting-edge medical tool is a fascinating example of scientific ingenuity. As research continues, gold nanoparticles have the potential to revolutionize healthcare, offering more precise and effective treatments for a wide range of diseases.

Researchers from Tianjin University and the Southern University of Science and Technology have developed a robot with an artificial brain made from human stem cells. This "brain-on-chip" technology combines a brain organoid with a neural interface chip, enabling the robot to learn tasks like avoiding obstacles and gripping objects. Described as "the world's first open-source brain-on-chip intelligent complex information interaction system," this research could pave the way for hybrid human-robot intelligence and brain-like computing. The team used low-intensity ultrasound treatment to improve organoid integration and growth, suggesting potential applications in treating neurodevelopmental disorders and repairing brain damage. Despite its promise, the technology still faces challenges such as low developmental maturity and insufficient nutrient supply in brain organoids. This development marks a significant advancement in brain-computer interface technology, an area where China aims to lead globally. Source: South China Morning Post

Unlock the future of drug discovery with RealBrain® microtissues! Join us for an enlightening webinar on 𝐒𝐞𝐩𝐭𝐞𝐦𝐛𝐞𝐫 𝟐𝟔𝐭𝐡 𝐚𝐭 𝟏:𝟑𝟎 𝐏𝐌 𝐂𝐄𝐓, where we explore how these cutting-edge 3D organotypic neural models are revolutionizing high-throughput screening. 𝐋𝐞𝐚𝐫𝐧 𝐚𝐛𝐨𝐮𝐭: ▪ The rapid maturation and scalability of 𝐑𝐞𝐚𝐥𝐁𝐫𝐚𝐢𝐧® 𝐦𝐨𝐝𝐞𝐥𝐬. ▪ Optical clarity for visualizing complex neural networks. ▪ Tessara's unique biomaterials that encapsulate neural stem cells into microtissues ready for assays in just three weeks. This session is perfect for pharmaceutical researchers, neuroscientists, and anyone passionate about innovative drug development. Don’t miss out on the insights from 𝐃𝐫. 𝐔𝐬𝐦𝐚𝐧 𝐀𝐬𝐡𝐫𝐚𝐟 𝐚𝐧𝐝 𝐃𝐫. 𝐌𝐚𝐫𝐤 𝐆𝐫𝐞𝐞𝐧𝐨𝐮𝐠𝐡! 𝐑𝐞𝐠𝐢𝐬𝐭𝐞𝐫 𝐧𝐨𝐰! https://lnkd.in/gNuaVGS4 #neuraldrugdiscovery #realbrain #biotechnology #pharmaceuticalresearch #3dmodels #innovation #webinar #drugdevelopment #neuroscience #highthroughputscreening #tessara #biomaterials #stemcells #opticalclarity #researchinnovation

3D-printed sensors unveil embryonic development forces. Researchers at University College London have developed 3D-printed mechanical force sensors to measure the forces exerted during the development of chicken embryos. These sensors, attached to the spinal cord, quantify the forces necessary for proper neural tube formation. The study aims to improve understanding and prevention of spinal cord malformations like spina bifida, which affects 1 in 2,000 newborns in Europe annually. The technology has potential applications in studying human stem cells to understand and prevent conditions like spina bifida. Source: https://lnkd.in/drVZsxev #medical #healthcare #research #biomedical #3dprinting