International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health - IPC2025’s Post

Novel lifeforms in our microbiomes? Researchers at Stanford University and University of Toronto may have identified a new RNA-based microbial lifeform residing in the human microbiome. In this pre-print (not yet peer reviewed), the researchers describe a “previously unrecognised class of viroid-like element” which they have named “Obelisks”, after their predicted rod-like structure. Phylogenetic analyses couldn’t map the obelisk genomes to any known biological agents, suggesting that they are a distinct group, not previously described. The Obelisks were identified by analysing publicly available RNAseq datasets from the Integrative Human Microbiome Project, using a reference free approach to identify novel elements. Once defined, they went on to detect Obelisk-like elements in other human microbiome datasets estimating presence in ~10% of donors with global distribution. #viron #microbiome #obelisk #phylogenetics https://lnkd.in/gQD-s_XT

🥁 We are excited to announce our new "cutting-edge" Special Issue: "Computational Discovery Tools in #Genomics and Precision Medicine" lead by Dr. Felix Dietlein from Harvard Medical School. Biologically informed algorithms today, serve as essential engines propelling new biological insights and innovations. 🖥 💊 We welcome all manuscripts with a clear emphasis on biologically driven algorithms and data-driven approaches for novel biological and genomic discoveries. To read more, please click on the link below 👇 https://lnkd.in/g9S9rGwH #medicine #bioinformatics #biology #OpenAccess

Delighted to share a new article on the use of LC-MS/MS through DIA-SWATH on the ZenoTOF 7600 system (SCIEX) combined with electron activated dissociation (EAD) for metabolomics and lipidomics analyses in ecotoxicology. The journey has been extensive: mastering the instrument, optimising parameters, understanding fragmentation mechanisms, processing data, and all that follows. Yet, the results speak volumes: Zeno pulsing coupled with SWATH is a promising approach for comprehensive coverage of the metabolome and lipidome of an exotic organism. Meanwhile, EAD represents a revolution for in-depth structural characterisation of lipid species and metabolites, complemented by in-silico approaches like SIRIUS. Exciting prospects lie ahead for metabolomics and lipidomics through LC-DIA-MS/MS and compound annotation! A big thank you to the entire team at the Institut des Sciences Analytiques (especially Sophie Ayciriex, Valentina Calabrese, yohann clement, and Arnaud Salvador) and to our collaborators from the INRAE ecotoxicology team (Olivier Geffard, Arnaud Chaumot, and Davide Degli Esposti) for this extensive collaborative effort, their invaluable assistance, and all the discussions. Find out more about our open-access article here: https://lnkd.in/gSYEpjiM #Metabolomics #Lipidomics #ZenoTOF7600 #ElectronActivatedDissociation #SWATH #CompoundAnnotation #Chemometrics #MassSpectrometry Institut des Sciences Analytiques (ISA) - UMR 5280 INRAE Lyon-Grenoble Auvergne-Rhône-Alpes

Discovering the Unseen: Groundbreaking Research Unveils 'Obelisks' in the Human Microbiome In a stunning revelation that broadens the horizons of microbiome research, scientists have uncovered a novel component within the human gut and oral microbiome: tiny RNA structures, dubbed 'Obelisks.' These entities, even smaller than viruses, carry genetic information capable of being interpreted by cells, introducing sequences previously unknown to science. This fascinating discovery, initially shared on the bioRxiv preprint server on January 21 and awaiting peer review, unveils obelisks as flattened circles of RNA. These structures are theorized to fold into rod-like shapes, marking a significant departure from known biological forms. While reminiscent of 'viroids' discovered in the 1970s, obelisks present unique genetic sequences, suggesting a new category of information-carrying molecules. The significance of this discovery extends beyond the mere expansion of our genetic catalog. It prompts a reevaluation of the intricate balance within the human microbiome, comprising bacteria, fungi, and other microorganisms. The presence of obelisks in nearly 10% of sampled gut and oral microbiota from a global dataset underscores their potential impact on human health and disease. This research not only rekindles the joy of scientific discovery but also opens new avenues for understanding the dynamics of life itself. As scientists delve deeper into the nature and function of obelisks, we stand on the brink of unlocking secrets that could reshape our understanding of the microbial world and its influence on human health. For professionals in the fields of microbiology, biotechnology, and healthcare, this discovery represents a thrilling frontier of exploration. The implications for diagnostics, treatment, and our comprehension of life's origins are profound. Stay tuned for further updates as this research progresses towards peer review and beyond. The journey into the unknown continues, highlighting the endless potential for discovery within the world of science. #MicrobiomeResearch #ScientificDiscovery #InnovationInScience #Healthcare #Biotechnology https://lnkd.in/eeMYWYux

The rapid advancement of sequencing technology has led to the emergence of various omics fields, from DNA and RNA to trending metabolomics, each offering unique research systems. These omics are interconnected like a river: genomics at the upstream defines fundamental properties, while downstream factors like epigenetics, transcription, translation, and environmental influences shape phenotypes. Sometimes, single-omics data fail to elucidate complex physiological mechanisms fully. Integrative multi-omics analysis can uncover potential regulatory networks within organisms, providing more substantial evidence for biological processes.    In March 2024, our client made a significant contribution to the field of omics technology by publishing a research achievement in the international academic journal Horticulture Research. The publication, titled: “Chromosome-scale genome, together with transcriptome and metabolome, provides insights into the evolution and anthocyanin biosynthesis of Rubus rosaefolius Sm. (Rosaceae),” Utilized genomics, transcriptomics, and metabolomics to elucidate the evolutionary mechanisms and anthocyanin synthesis in the Rosaceae family.   #BMKGENE provided comprehensive services for genome, transcriptome, and wide-target metabolome detection and analysis for this research. #Omics #Genomics #Metabolomics #Bioinformatics

Meet us in Mosbach (GER) and challenge our expertise in ⭐Microbiome Analysis Tools and Sequencing Services⭐ Explore with us the complex interactions between the microbiome, pathogens, and the immune system that can impact health and disease states. The Mosbacher Kolloquium is the traditional spring meeting of the German Society for Biochemistry and Molecular Biology (GBM - Gesellschaft für Biochemie und Molekularbiologie e.V.). The meeting is held annually in Mosbach, which provides a picturesque setting for scientific discussions over the latest scientific discoveries and emerging topics. #mosbacherkolloquium #molekularbiologie #biochemie #zymoresearcheurope #Mikrobiom #microbiomics

In the world of molecular biology, we're not just studying cells and DNA—we're unlocking life's hidden codes. 🧬🔍 Every experiment is a step towards personalized medicine🧬, more accurate diagnostics🔍, nd a deeper understanding of the diseases we aim to cure 🩺. It's not just science; it's a mission to transform healthcare from the inside out 🌐💡 #MolecularBiology #PersonalizedMedicine #HealthcareInnovation #MedicalResearch #Diagnostics #LifeSciences #Biotechnology #LabScience #HealthcareTransformation #Genomics #ScientificResearch #PrecisionMedicine

𝐏𝐫𝐞𝐬𝐞𝐧𝐭𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐍𝐞𝐰 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐑𝐞𝐬𝐮𝐥𝐭𝐬 🗣️ DDEA Grant Recipient Virginia Díez has just presented her postdoc project 𝘝𝘢𝘳𝘪𝘢𝘯𝘵-𝘵𝘰-𝘧𝘶𝘯𝘤𝘵𝘪𝘰𝘯 𝘵𝘳𝘢𝘯𝘴𝘭𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘰𝘣𝘦𝘴𝘪𝘵𝘺-𝘢𝘴𝘴𝘰𝘤𝘪𝘢𝘵𝘦𝘥 𝘭𝘰𝘤𝘪 𝘵𝘩𝘳𝘰𝘶𝘨𝘩 𝘮𝘶𝘭𝘵𝘪-𝘰𝘮𝘪𝘤𝘴 𝘥𝘢𝘵𝘢 𝘪𝘯𝘵𝘦𝘨𝘳𝘢𝘵𝘪𝘰𝘯 at the Annual Variant to Function Symposium, organised by the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute of MIT and Harvard in Boston.   “𝘐𝘵 𝘸𝘢𝘴 𝘢 𝘱𝘭𝘦𝘢𝘴𝘶𝘳𝘦 𝘵𝘰 𝘣𝘦 𝘣𝘢𝘤𝘬 𝘵𝘰 𝘵𝘩𝘦 𝘉𝘳𝘰𝘢𝘥 𝘸𝘩𝘦𝘳𝘦 𝘐 𝘥𝘪𝘥 𝘢 3-𝘮𝘰𝘯𝘵𝘩 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘴𝘵𝘢𝘺 𝘭𝘢𝘴𝘵 𝘧𝘢𝘭𝘭 𝘵𝘰 𝘳𝘦𝘤𝘰𝘯𝘯𝘦𝘤𝘵 𝘸𝘪𝘵𝘩 𝘤𝘰𝘭𝘭𝘦𝘢𝘨𝘶𝘦𝘴, 𝘥𝘪𝘴𝘤𝘶𝘴𝘴 𝘷𝘢𝘳𝘪𝘢𝘯𝘵-𝘵𝘰-𝘧𝘶𝘯𝘤𝘵𝘪𝘰𝘯 𝘴𝘤𝘪𝘦𝘯𝘤𝘦 𝘢𝘯𝘥 𝘱𝘳𝘦𝘴𝘦𝘯𝘵 𝘯𝘦𝘸 𝘳𝘦𝘴𝘶𝘭𝘵𝘴 𝘰𝘧 𝘮𝘺 𝘱𝘰𝘴𝘵𝘥𝘰𝘤 𝘱𝘳𝘰𝘫𝘦𝘤𝘵” says Virginia Díez. Virginia Díez presented new genes discovered to be targeted by body mass index genetic variants. She also gave an update on tissue specificity of the genes, whose names are saved for an up-coming publication. 🤫 The postdoc project is being developed at the Novo Nordisk Foundation Center for Basic Metabolic Research and is funded by the Danish Diabetes and Endocrine Academy. Well done, Virginia! 👏🏽 We are looking forward to reading your publication. 𝐑𝐞𝐚𝐝 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐕𝐢𝐫𝐠𝐢𝐧𝐢𝐚'𝐬 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐩𝐫𝐨𝐣𝐞𝐜𝐭 𝐡𝐞𝐫𝐞: https://lnkd.in/dPFZZx64 #DDEA #Researcher #Postdoc #Presentation

📅 The next February 13th,10.00-12.00, we invite you to participate in our specialized event on Emerging OMICS Techniques in Medical Research, focusing on Metabolomics, Lipidomics, and Proteomics and their applications in health research 🔬   🌟 The event will feature insights from experts in the OMICS field:   ☑ Paolo Bonini (oloBion) will introduce how innovative techniques such as metabolomics, lipidomics, and proteomics are making significant strides in biomedical research. ☑ Jacob Folz (ETH Zürich) will share insights into the application of OMICS in non-invasive and longitudinal profiles, highlighting its role in understanding the microbiome and metabolome in physiology and diseases.   ☑ Raquel Cumeras (Universitat Rovira i Virgili) will showcase the application of metabolomics techniques in oncological research.   📍 The event will take place in Parc Científic de Barcelona (Sala Dolors Aleu). Don't miss the opportunity to explore these cases and interact with the experts and other attendees during our Coffee & Snack after the presentations ☕🍪   Register now at https://wkf.ms/3RTo1c7   #BCNHealthInnovationWeek #MedicalResearch #OMICTechniques

https://lnkd.in/grk97WrW I’m thrilled to share a recently published paper from my collaboration with Prof. Hiroshi Maeda at the University of Wisconsin, Madison. In this study, we explore a fascinating discovery about the evolutionary versatility of aminotransferases (ATs), an ancient enzyme family central to nitrogen metabolism across the tree of life. Our research revealed that ATs, unlike other core metabolic enzymes, exhibit broad substrate promiscuity. This characteristic allowed different taxa to recruit distinct nonorthologous ATs to carry out essential reactions, contributing to robust and diverse nitrogen metabolic networks. What’s especially intriguing is that these enzymes, despite diverging over a billion years, share common signatures of multisubstrate specificity using different nonconserved active site residues! This study provides critical insights into AT enzyme evolution and function, offering a foundation for understanding nitrogen metabolism across species. Looking forward to seeing how this knowledge will contribute to broader biochemical and metabolic research! This project was supported by the DOE Joint Genome Institute's DNA Synthesis Science Program as well as DOE BER's Genome Science Prgram. #NitrogenMetabolism #Aminotransferase #EvolutionaryBiology #TreeOfLife #Collaboration #ScientificResearch #EnzymeFunction