Vadiraja Bhat, PhD.’s Post

Lambton Water Research Centre at Lambton College showcases two cutting-edge pieces of equipment: the Agilent Liquid Chromatography with Multiple Wavelength Detector (MWD) and Triple Quadrupole (TQ) Mass Spectrometer (MS), and the Agilent Time of Flight (TOF) LC/MS. 🔍 Agilent Liquid Chromatography with MWD & TQ MS: With its multiple wavelength detector and triple quadrupole mass spectrometer, we're equipped for sensitive, targeted quantification of compounds in any sample. From detecting per and polyfluorinated substances (PFAS) to pharmaceutical and personal care products in wastewater, this system is our go-to for confirmation of what's in the water. 🌊🔬 🌟 Agilent Time of Flight (TOF) LC/MS: Our TOF LC/MS allows us to capture a full spectrum of mass-to-charge ratios up to 20,000 in a single sample. This means we can screen unknown compounds and identify them with unparalleled accuracy.💡💧 📧 Connect with Our Team: Carlos Diaz LWC Coordinator - carlos.diazrangel@lambtoncollege.ca Learn more about our Lambton Water Centre here: https://lnkd.in/gb3HTrap #WaterResearch#ExpertiseInAction#LambtonWaterCentre#InnovateWithUs

Introducing High Throughput BioResolve Premier Columns for rapid analysis of large biomolecules. Reduce chromatography run-times by up to 5x and obtain vital information about monoclonal antibody critical quality attributes to make development decisions – fast. Learn more--> https://bit.ly/3VYuhTG

Celerion has been called the most automated bioanalytical laboratory in the industry. Our approach is the strategic incorporation and use of bioanalytical laboratory automation to achieve controlled and error-free assays with improved accuracy, efficiency, and throughput. Our bioanalytical laboratories are market leaders in the implementation of automation with over 25 automation instruments including Hamilton Stars, Tecan EVOs, and Caliper SciClone G3’s . There are many reasons we perform automation in bioanalytical laboratories including:   - Enhanced consistency - Quality improvement - Higher sample throughput  - Real-time sample verification - Increased versatility in workforce - Improve efficient and effective use of labor resources Learn more: https://lnkd.in/eunva39X   https://lnkd.in/eTzWgDwz #Bioanalytical #BiotechInnovation #AutomatedLabs #LabEfficiency #ResearchExcellence

Looking for a reliable partner for your pharmaceutical development needs? Seven Star Pharmaceutical Services (Seven Star) has got you covered. Our team specializes in CMC/solid-state chemistry research, crystallization process development, pre-formulation studies and formulation development studies. We also offer comprehensive routine and focused analytical testing services, ensuring accurate and timely results without any compromise on quality. Contact us to learn more about our services. https://lnkd.in/etWhi36 #chemistry #research #pharmaceutical #CMC #drugdevelopment #pharmaceuticaldevelopment #SolidStateChemistry #SaltScreening #CrystallizationScreening #CocrystalScreening #PolymorphScreening #preformulations #formulationdevelopment #MedicinalChemistry #SingleCrystalXrayDiffraction #materialsscience #analyticalresearch #materialsresearch #cdmo #CRO #contractresearch #drugdiscovery #api #crystalform #pharmaceuticaldevelopment 

Some nice work by Coombes et al, looking at ssDNA assay for product purity 🛎Overview: Coombes et al have developed a novel method using ion pair reversed phase HPLC assay for ssDNA re-generation post PCR for selective enhancement of ligands by exponential enrichment (SELEX). But SELEX experiments often result in low yields of ssDNA aptamers and the ability to generate high-quality ssDNA in high yields from the dsDNA PCR products. 🎯 Summary: Coombes et al IP RP HPLC assay demonstrating significant advantages over existing affinity chromatography and nuclease digestion methods, for the purification of ssDNA . #massspectrometry #massspec #nucleotides #dna #lcms #hplc #chemistry #science #sciencecommunication #scienceandtechnology

Native mass spectrometry (MS) has emerged as a widely used technique for the characterization of intact proteins and noncovalent protein complexes. In this study, they demonstrate a highly sensitive analytical flow LC/MS methodology for the analysis of native proteins and protein complexes. This workflow comprehends: - the AdvanceBio size exclusion chromatography (SEC) column for online sample separation - LC/MS analyses conducted on a 1290 Infinity II LC coupled with a 6545XT AdvanceBio LC/Q-TOF - Agilent MassHunter Acquisition (B.09.00) workstation software with the large molecule SWARM autotune. You can read the application note here: https://lnkd.in/d6FMQEiy

Learn how SAMDI Mass Spectrometry is disrupting small molecule drug discovery by rapidly generating high-quality data via label-free and high-throughput capabilities: https://bit.ly/3Tqxzh1

Waters Announces Seamless HPLC/UPLC Data Bridge for Light Scattering, Integrating Essential Instruments for Large Molecule Characterization

Automating At-Line Titer Measurement with a Novel Fit-For-Purpose Chromatographic Device Here, we describe a novel, compact device, the HaLCon analyzer, capable of rapid, automated at-line measurement of antibody titers from stirred bioreactors using an aseptic sampling device. Assay linearity and accuracy were evaluated over a measurement range of 0.1 to 6.5 g/L using a simulated cell culture titer curve spiked with bovine serum albumin (BSA) and human IgG. Manual and automated aseptic sampling measurements using the HaLCon analyzer compared very favorably with a commercial Protein A HPLC system. Excellent intra-assay precision (CV < 3%) was demonstrated for both off-line and at-line measurements with the HaLCon analyzer. Measurement results were also unaffected by BSA levels up to 2.5% (v/v). https://lnkd.in/gDbyjT_E #aspenalert #biotech #bioprocess

Sophisticated reaction monitoring and optimisation have never been easier. Kinetics is compelling with #ReactALL. This is a recipe for how to make formulation ideas come true. - A breakthrough concept 💡 - Scientists 👩🔬 👨🔬 - 5-10 mL of sample (ONLY) ⚗ - ReactALL - HPLC - Well written report 📄 It is never been easier. Technobis Crystallization Systems #chemistry #reactions #formulations #pharma #pharmaceuticals #laboratory #experiment #instrumentation #quantitative #particles #QC #QA