Winette van der Graaf’s Post

At Exact Sciences, our multi-cancer early detection (#MCED) program seeks to find more cancers early enough to make a difference. Sharing with the community just published in AACR Journals' Cancer Prevention Research, the long-term outcomes for patients with #MCED detected cancers. More than 4 years after diagnosis, half of these patients are alive and cancer-free, most received surgical treatment. Larger studies are needed to confirm and extend these findings which suggest that #MCED detection can enable successful cancer treatment. Thanks to colleagues at Geisinger and The Johns Hopkins University School of Medicine for this crucial collaboration with our group at Exact Sciences. #WeAreExact

🧬 It is estimated that every Australian has a 1 in 117 risk of being diagnosed with stomach (gastric) cancer by the age of 85. Today, we're spotlighting the incredible work of Dr. Annalisa Carli, a post-doctoral researcher @ONJCRI, who recently presented a fascinating seminar on her latest findings! ✨ Dr. Annalisa Carli's research delves deep into the role of a protein called DCLK1 in the progression of gastric cancer. She has discovered that DCLK1 plays a crucial role in how cancer cells migrate and invade other organs, a process that correlates with poor prognosis for patients. Excitingly, inhibiting DCLK1 can significantly reduce tumour size, invasion, and metastasis (spread) to other organs. Additionally, her team has found that DCLK1 is essential for the proper replication and division of cells, making it a key target for potential therapies. 🔬 Join us in applauding Dr. Carli's pioneering research that will pave the way for better treatments and outcomes for gastric cancer patients worldwide! 👏💖 La Trobe University #ONJCRI #Anticancer #GastricCancer #CancerResearch #Science #Innovation #Hope #CancerAwareness #Research #DCLK1 #Metastasis #CancerTherapy #Celebrate #LatrobeUni

🌟Insights into Metabolomics and Application in Colorectal Cancer Research🌟 Assistant Professor Jennifer Ose from the University of Utah Health, Department of Population Health, offered a compelling talk on "Metabolomics and its Application in Colorectal Cancer Research." This presentation was one of the highlights of the virtual event "Population Health and Cancer: The Power of Multi-Omics in Cohort Studies." Dr. Ose's discussion provided a deep insight into how metabolomics is revolutionizing our understanding of colorectal cancer. The talk provided not only profound comprehension but also showcased the potential for metabolomics to pave the way for important advancements in cancer research, diagnosis, and treatment strategies. For those interested in the intersection of population health and cancer research and missed the virtual event or want to rewatch, catch the full recording here: https://lnkd.in/dH5ks-et #Cancer #Research #Metabolomics #PopulationHealth

Thrilled to announce the publication of our research paper titled "Colonoscopy screening for colorectal cancer in Egypt: a nationwide cross-sectional study"! We delved into the landscape of colorectal cancer (CRC) screening in Egypt. Conducting a comprehensive survey across nine university hospitals involving around 1,500 participants, we aimed to assess compliance with CRC screening guidelines, knowledge levels, attitudes, and barriers. Surprisingly, less than 3% of participants were referred for CRC screening. Moreover, a mere 3.2% demonstrated good knowledge about CRC screening. However, more than 66% of participants showed a positive attitude towards the procedure. Financial burden and fear of results emerged as the predominant barriers. Our study underscored the urgent need for national-level interventions to bolster awareness and accessibility. Link: https://lnkd.in/dPQizKZe #SRPfellowship #ColorectalCancer #PublicHealth #ResearchImpact

Doctors Eunate Arana Arri and Mónica Saiz, researchers of the LUCIA EU Project, participated in the 1st Conference on Lung Cancer of the Basque Country (9-10 May 2024). During the conference, various topics were discussed regarding advances in the treatment of early stages of non-metastatic lung cancer. Dr. Eunate Arana, head of the Internationalization and Project Coordination Unit of the BIOBIZKAIA HEALTH RESEARCH INSTITUTE, presented the LUCIA EU project to the attendees, highlighting the importance of research in the identification of new risk factors and the establishment of a screening program that allows reducing the morbidity and mortality associated with this pathology; trying to validate new early detection diagnostic tests. Lung cancer has been trending in recent years with a significant increase in its incidence and prevalence, and also with an increasing incidence in non-smoking people. Dr. Mónica Saiz, pathologist at Cruces University Hospital, has highlighted the importance of early molecular diagnosis, focusing on the evaluation of the pathological response after neoadjuvant treatment. Numerous clinicians from osakidetza and other researchers from the LUCIA project also attended the event, such as Dr. Larraitz Garcia Echeberria, Unai Jimenez, Eider Azkona, Marian Sala, Marta Lázaro and Estíbaliz Montejo among others. #research #conference #spain #lungcancer #cancer #horizoneurope #horizonEU #riskfactors #screening #earlydetection IIS Biobizkaia

Bladder Cancer poses a significant and increasing threat to the Indian population. It's vital for both doctors and patients to be well-informed to ensure early detection and effective management. Research indicates that up to half of bladder cancer patients experience relapse post-bladder removal, with 70-90% of cases leading to distant metastasis and poor prognosis. Insights shared by Dr. Vineet Talwar, Director of the Department of Medical Oncology at RGCIRC, Delhi.  #bladdercancerindia #bladdercancer #uhapo #astellasindia #bladdercancerawareness Sampada Gosavi Stephen Head Neha Dwivedi CRSF - Cancer Research and Statistic Foundation Uhapo Sanjeev Sharma Vivek Sharma Akhil Kapoor Dr Trinanjan Basu Dr. Nandini Menon Dr. Shikha Sharma Urvashi Prasad Dr Puneet Ahluwalia

On May 22nd, the 'International Dialogue on Ovarian Cancer, from Bench to Bedside' congress brought together experts from the Sbarro Health Research Organization, Temple University College of Science and Technology and the Università degli Studi di Messina in a groundbreaking event! This hybrid congress, organized by myself, and Professor Alfredo Ercoli , bridged the gap between molecular research and clinical practice, fostering collaboration to improve ovarian cancer outcomes. Researchers shared the latest advancements, while clinicians discussed current treatment protocols and emphasized the vital feedback loop between the lab and the clinic. Professor Vincenzo Carnevale’s insights on how AI is revolutionizing cancer research were particularly noteworthy. Together, we are paving the way for innovative and effective cancer treatments. #OvarianCancerResearch #FromBenchToBedside #CancerTreatment #ResearchAndPractice #AIInMedicine

🔬 Saturday Science Spotlight: Unveiling the Complexity of Ovarian Cancer 🩺Dr Elena Denisenko from the Harry Perkins Institute of Medical Research working with teams from St John of God Subiaco Hospital, Curtin University, Clinipath Pathology, The University of Western Australia and Edith Cowan University (among others) recently published a study in Nature Portfolio that uses cutting-edge technologies, such as the Pawsey Supercomputing Research Centre infrastructure, to shed light on this complexity in ovarian cancer. 🔍 What They Found: The team identified various "subclones" or groups of cancer cells within tumours, each behaving differently and interacting uniquely with their surrounding environment. This discovery is crucial because it helps explain why some cancer treatments work for some patients but not for others. 🔗 Read more about this groundbreaking study here: https://lnkd.in/gS24ccN8 📈 Why is This Important? This study not only advances our understanding of ovarian cancer's complexity but also paves the way for more effective and individualised treatment approaches, offering hope for better management of this challenging disease. 🌟 #SaturdayScience #CancerResearch #OvarianCancer #Genomics #Healthcare

Angelina Jolie's case is one of the most recognized in genomic medicine. She had a strong family history of cancer. When she did BRCA testing, she found mutations that increased her risk of cancer. Breast cancer is topmost cancer affecting in Indian women. October is breast cancer awareness month. In our article in The Hindu, Dr. Anup Rawool and Vid Karmarkar, PhD, we discuss importance of and inequities in BRCA testing. What are your views about BRCA testing? Link to the article is in the comments below. #cancer #breastcancerawareness #breastcancer #publichealth #canseva #sahaj #pinkoctober #healthcare #genetictesting #genomics

Breast Cancer Awareness Month: The Power of BRCA Testing October is Breast Cancer Awareness Month, a crucial time to highlight the importance of early detection and prevention, especially through BRCA testing. As featured in a recent article by Dr. Anup Rawool and Vid Karmarkar, PhD in The Hindu, BRCA testing can be a game-changer in the fight against hereditary cancers. Angelina Jolie’s well-known story is a powerful example of the impact of genetic testing. With a strong family history of cancer, she opted for BRCA testing, which revealed mutations that significantly increased her risk. This knowledge empowered her to take proactive measures and reduce her risk through preventive surgery. In India, where breast cancer is the most prevalent cancer among women, such testing can be life-saving. However, equitable access to BRCA testing remains a challenge, with many high-risk individuals unable to afford the cost or unaware of the benefits. Addressing this requires a dual approach: Raising Awareness: Educating the public about the benefits of genetic testing and how it can guide personalized preventive care. Making Testing More Accessible: Reducing the cost of BRCA testing and ensuring availability, especially in underserved populations. As we observe #PinkOctober, let’s focus on making genetic testing accessible for all. Early detection can save lives, but only if the right tools are within reach for everyone, not just a few. Together, we can advocate for a future where every woman has the chance to understand her risks and take charge of her health. What are your thoughts on the role of genetic testing in cancer prevention? #BreastCancerAwareness #BRCA #GeneticTesting #PublicHealth #CancerPrevention #PinkOctober #HealthcareEquity #WomensHealth