Quorumetrix Studio

I'm very excited to share a companion video to the research article : "Organizing principles of astrocytic nanoarchitecture in the mouse cerebral cortex" published this month in Current Biology, from the labs of Keith Murai and Kaleem Siddiqi at McGill University. I'm very grateful to Chris Salmon for bringing me onto this project, and for providing invaluable direction and guidance throughout the production. The video provides a visual primer for the datasets and several key methods used in the study. It was truly an amazing experience to be involved with this project, and a particularly proud moment for me, as it is the first publication with Quorumetrix Studio as my affiliation. Check out the full article here: https://lnkd.in/guSc4yDq Primary Research Article Citation: Organizing principles of astrocytic nanoarchitecture in the mouse cerebral cortex Salmon et al., 2023, Current Biology 33, 1–16 March 13, 2023 a 2023 Elsevier Inc. https://lnkd.in/g5425YGi Authors: Christopher K. Salmon, Tabish A. Syed, J. Benjamin Kacerovsky, Nensi Alivodej, Alexandra L. Schober, Tyler F. W. Sloan, Michael T. Pratte, Michael P. Rosen, Miranda Green, Adario DasGupta, Shaurya Mehta, Affan Jilani, Yanan Wang, Hojatollah Vali, Craig A. Mandato, Kaleem Siddiqi*, and Keith K. Murai* Highlights: - High-resolution serial electron microscopy resolves astrocytic structural features - Computer vision methods are used to quantitatively understand nanoarchitectures - Astrocyte structure is hierarchical with hubs and specific organelle arrangements #scientificcommunication #datavisualization #3danimation #blender3d #astrocytes #neuroscience #quantitative #motiondesign

Discover the power of color jitter in data viz with Tyler Sloan's latest piece. Dive into how subtle shifts in color can enhance clarity and appeal, making dense datasets not just more visible, but visually stunning. https://lnkd.in/eXpCcPmF #DataViz #DataVisualization #DataDesign

I’m happy to release my  new portfolio film reel to showcase some of my favorite projects from over the past few years, I hope you’ll enjoy! https://lnkd.in/g-B7KzJk In this strange new world of fast-facts and generative creativity, I am old-school in my belief in the power of real data, and trusting one’s audience with information near to its rawest form. I’ve established Quorumetrix Studio to fill this niche. To communicate primary research data, visually.  To create content that is engaging to fellow scientists by virtue of its quantitative accuracy and attention to detail, all while being appreciated by the science-curious public for its visual appeal. And domes. I do domes. I’m always on the lookout for new clients and collaborators, for short and long-term projects, so please consider sharing and help me to reach those who need these visualization services, and remember Quorumetrix Studio for your next data-driven project! #motionGraphics  #dataviz #b3d #sciart #neuroscience #scicomm www.Quorumetrix.com https://lnkd.in/gQbSnucr

Happy to share a collection of videos that went into an article published today. A fascinating and stimulating collaboration with Kaleem Siddiqi's lab at McGill University and Minhaj Sirajuddin's lab at Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem) On the cover today in EMBO Journal: Using a combination of tissue clearing, micron volumetric imaging and computer vision, we built a 3D cardiomyocyte orientation reconstruction across mouse heart ventricular walls. See the feature from McGill: https://lnkd.in/gAHDh6Zi OR read the full paper: https://lnkd.in/gkJFUu_g

 I’m excited to share our latest #neuro #visualization. This project spanned many months, and grew in scope to beyond data #visualization to include #sonification. I hope you’ll sit back, put on your headphones, and enjoy a multi-sensory #neuroscience experience. In this video, we explore a compressed pattern of brain activity seen in all mammals, that is thought to underlie the creation and consolidation of memories.The Sharp Wave Ripples (SWRs) in the #hippocampus are the largest oscillation in the #brain, involving 10’s of thousands of #neurons. This is their story: Video description for "A Simian Symphony": #Neural probe recording from CA1 #hippocampus. #Sonification and #visualization driven by Local Field Potential (LFP) and Current Source Density (CSD). Single-unit spikes each associated different piano keys. CA1 unit ensembles during Sharp Wave Ripples (#SWRs). Spike-sorted units are visualized / sonified across 20 ripples, represented by 3D cell morphology of the #hippocampal #neuron type. Morph between anatomical layer to UMAP space. This video is the result of a fascinating collaboration between Quorumetrix Studio with Kari Hoffman's Perception Plasticity & Learning Lab and Diagnostic Biochips, Inc. What follows is a detailed description of what you're seeing in each scene: We start by zooming into the #brain, where we see a Diagnostic Biochips, Inc. DeepArray probe recording in the #hippocampus. We zoom in further to see the probe sites flickering with voltage changes around the neurons, the Local Field Potential (LFP). Original data is sampled at 30kHz, so we slow down. The audio #sonification is being driven by the LFP, and the background Current Source Density shows the flow of electrical charges between the cell layers. A multisensory experience of 'ripples' at 1/200th of their real speed. From the high-frequency #LFP data, a statistical technique  ‘spike sorting’ identified individual spiking neurons (‘units’). During the ripple, groups of neurons fire together as a #cellassembly , a unit of #neural computation. We introduce the spike sonification, where each unit is given a unique piano key. We then look at a sequence of individual Sharp Wave Ripples and their neuronal ensembles. The cell types of each unit are inferred from their depth and their spiking statistics, and are represented by their 3D neuron morphology. We’ve selected 20 ripples and measured by how many times each unit spikes during the ripple. Assemblies in the first 10 ripples are similar to each other, and those in the last 10 are similar to each other. For this sequence, the piano notes are assigned to units that had spikes in both sets of ripples. Units who spiked only in the first group were assigned the timbre of an acoustic bass, while the units who spiked only in the second group were assigned that of a marimba.