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🧠💆♂️ Top 5 Cannabis Science Papers That Altered My Brain Chemistry The body of evidence supporting cannabis is growing rapidly: over 4,300 papers were published last year alone (averaging 12 a day), on a wide array of topics: 🏥 Clinical trials & observational studies 💊 Pharmacology and toxicology 🧬 Breeding and genomics 👩🌾 Agronomic methods ⚙️ New technologies ⚖️ Social outcomes 👨👨👧👧 Public health One year ago I began collecting news for the Cannamonitor brief, which has grown to >1500 subscribers since. Initially, I gathered a few papers that caught my eye, but I soon went full beast mode. Now, we process hundreds of scientific articles every month, retaining the top 25-50 for the brief. Here are 5 studies published in the last few years that have struck me the most: 👃 Aroma Impacts More than THC: The Nose Knows: Aroma, but Not THC Mediates the Subjective Effects of Smoked and Vaporized Cannabis Flower: https://lnkd.in/dEViX2HE ↳ The study highlights the importance of factors beyond cannabinoid content in determining the effects of cannabis, as shown by Ethan Russo, MD and colleagues. 🍃 Aroma is Not Driven by Terpenes: Minor, Nonterpenoid Volatile Compounds Drive the Aroma Differences of Exotic Cannabis: https://lnkd.in/dFV37bYd ↳ Aroma differences of cannabis are driven by minor sulfur compounds, as demonstrated by this study (and the series on specific smells that followed) sponsored by Abstrax Tech, Inc. 🥊 Entourage Effect Hits Harder than THC: Cannabis “Entourage Effect,” Not THC Potency, Responsible for Psychoactive Experience: https://lnkd.in/d9VrdTRM ↳ A novel encephalogram study conducted by PAX and Zentrela Inc. showed faster onset and greater psychoactive experience with full-spectrum live rosin vs distillate-based products. 🧬 Genetic Ancestry Reveals Domestication History: Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa: https://lnkd.in/dVYGBQnf ↳ Genomic study finds 4 clusters of cannabis genetic ancestry, suggesting domestication likely occurred 12,000 years ago in East Asia and not in Central or South Asia. 👬 Twin Study Dispels Psychiatric Risk Myth: Limited psychological and social effects of lifetime cannabis use frequency: Evidence from a 30-year community study of 4,078 twins: https://lnkd.in/daAWN6H7 ↳ A twin study found genetic confounding to be a significant factor in the association of cannabis use with psychiatric conditions, showing only a weak relationship with drug use disorders. Many other studies could have likely made it into this list. What are the most insightful papers that you have read? Let me know in the comments! 👍 PS: A special edition of the Brief is coming next week to celebrate 1 full year. Subscribe to make sure you won’t miss it! 📩https://lnkd.in/dBBsB9-Z