Promega Switzerland

Where can you meet our Team over the coming weeks? 👋 We look forward to connecting with you, helping you navigate our technologies and exploring how we can best support your research together. Scroll through to find out where you can find us in March and April ⬇️

Celebrating 20 years of the Maxwell® System! Trusted automated nucleic acid extraction—empowering scientific breakthroughs across the globe. ➡️ https://bit.ly/4kH0UiA #Maxwell20thCelebration #Promega #Genomics #NucleicAcidExtraction

Ever wondered what stutter is in genetic analysis? Stutter occurs when minor, extra peaks appear in DNA profiles, potentially complicating interpretation. But don't worry—there are ways to reduce it for clearer, more accurate results! Learn more about stutter and the latest innovations in reducing its impact in forensic and genetic identity work. Stay informed by signing up for updates today! https://bit.ly/3DZGsZx

Read this interesting article from Charlotte Sutter, PhD student at the University of Zurich (UZH) and student ambassador at the ISHI conference 2024, in Promega's latest PID newsletter! 🧬✍️ In her research at the intersection of epigenetics and forensic science, Charlotte explores how DNA methylation patterns can be harnessed for age estimation in various tissues. Learn more and discover her workflow below ⬇️ Congratulations Charlotte!

📌 The DNA Damage Response (DDR) pathway preserves genomic integrity by detecting and repairing DNA damage, ensuring proper replication, cell cycle progression, and apoptosis. DDR dysfunction contributes often to cancer by promoting genomic instability and uncontrolled growth. Given its central role in cell cycle progression and cell proliferation, the DDR pathway has become a significant target for anti-cancer therapeutics.  📌 Targeting DDR with inhibitors enhances cancer cell sensitivity to chemotherapy and radiotherapy, often leveraging synthetic lethality, as seen with PARP inhibitors in BRCA-mutant cancers. 📍 Promega Corporation offers a variety of assays and technologies to facilitate PARP/DDR pathway drug discovery. Discover how we adapted these assays to assess inhibitor binding to DDR proteins in complex with partners, DNA fragments, or metabolites, providing deeper insights into DDR-targeted therapeutics. 💡 Discover more: https://lnkd.in/eF8J4J5y #PARP #PARG #POLQ #NanoBRET #Targetengagement #Occupancy Promega Switzerland

Cut down on lab equipment costs and transform your data workflow with the MyGlo™ Reagent Reader. Learn how integrating #MyGlo with the ProNect™ Data Platform helps bypass the need for multiple analysis programs by providing comprehensive data analysis for Caspase-Glo® Assays. Reduce dependency on costly lab infrastructure and enjoy efficient, cost-effective research processes. Transform your data workflow now ➡️ https://bit.ly/4iqsZZI

The Efficiency of Gene Delivery through AAV can be challenged by preexisting patient immunity, dosage, tissue tropism. Neutralizing antibodies (NAbs) in serum can interfere with gene therapy, particularly when using viral vectors like AAV. Their removal require specialized procedures and have limitations. Detecting and quantifying these antibodies is therefore crucial for patient screening, monitoring immune responses and patient eligibility. A cell-based reporter such as Promega’s Transduction Inhibition Assay allows to measure AAV uptake of 11 AAV serotypes and it is suitable to determine tissue tropism in vivo. All of this with a simple and short (4-24 hours incubation) workflow. The assay is useful for 📌 quantifying Nab titer in human serum samples 📌 Early development, pre-clinical and clinical studies 📌 Screening AAV capsid variants to evade Nab 📌 Monitor Nab levels to optimize redosing and is suitable for early development, pre-clinical and clinical studies. You won’t find the assay on our catalogue! Contact @Réka.Nagy or @Anna.Lazzaro for more information

Thinking of getting a new microplate reader for your lab? 🧪 Choosing the right one can make all the difference. Have you considered the following factors? ➡️ Does it support the microplate formats you need, from 6-well to 384-well? ➡️ Can it detect the types of signal your assays rely on — Absorbance, Fluorescence, Luminescence, or BRET/FRET? ➡️ Performance is key: Sensitivity, low background, and minimal crosstalk ensure accurate and reliable results. ➡️ Don’t overlook automation features like shaking, temperature control, and injectors that can streamline your workflow. ➡️ Quality service and support, including training and instrument setup, can set you up for long-term success. Swipe through our guide to explore what matters most and discover how our GloMax® instruments can help your lab's workflows glow more! ✨

Your qPCR mix should work as hard as you do. 💪🧬 With GoTaq® Endure qPCR Master Mix and RT-qPCR System, you can amplify DNA from even the toughest samples like blood, soil, bacteria and viruses. Built to tolerate inhibitors like ethanol and heparin, this mix supports multiplexing and delivers reliable results without the need for extra purification. Explore our newest mix designed for challenging conditions ➡️ https://bit.ly/3XFj4am

Join us next Wednesday, 12 March 2025 for our expert-led forum 'Veterinary Diagnostics Simplified: Learn How to Automate High-Throughput Extraction'. 🩺🐶 Together, we will explore strategies for streamlining nucleic acid extraction in veterinary diagnostics and zoonotic disease monitoring. You will have a chance to engage directly with automation specialists, troubleshoot challenges and gain actionable insights to improve your lab’s efficiency. ⚙️ Learn about: ✔️ Core principles of magnetic bead-based nucleic acid extraction and liquid handling platforms ✔️ Best practices for automating workflows for veterinary science and animal health applications ✔️ Proven strategies to build, validate, and troubleshoot high-throughput extraction methods Register now ➡️ https://bit.ly/3F0jG3V 📆 Wed., 12 March 2025 🕓 4pm CET #nucleicacidextraction #automation #veterinaryscience #webinar #lifesciences #biotech