Nanion Technologies

𝗥𝗲𝗮𝗱𝘆 𝘁𝗼 𝗲𝗹𝗲𝘃𝗮𝘁𝗲 𝘆𝗼𝘂𝗿 𝘁𝗿𝗮𝗻𝘀𝗽𝗼𝗿𝘁𝗲𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵? 🚀 Imagine having access to a cutting-edge instrument that delivers unparalleled sensitivity, speed, and ease of use, transforming the way you approach electrogenic transporter and membrane pumps research. Our SURFE2R N1 does exactly that! This year, the SURFE2R N1 instrument grant is back: We are offering you the chance to use the 𝗦𝗨𝗥𝗙𝗘𝟮𝗥 𝗡𝟭 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗹𝗮𝗯 𝗳𝗼𝗿 𝘀𝗶𝘅 𝗺𝗼𝗻𝘁𝗵𝘀, 𝗰𝗼𝗺𝗽𝗹𝗲𝘁𝗲𝗹𝘆 𝗳𝗿𝗲𝗲 𝗼𝗳 𝗰𝗵𝗮𝗿𝗴𝗲, including consumables and full assay development support. No more dealing with harsh radiolabeled compounds or time-consuming protocols. This is your opportunity to advance your membrane transporter research. Apply now and be at the cutting edge of scientific discovery! 📅 Application deadline: September 30th, 2024 🔗 Learn more and apply: https://ow.ly/64oA50SCfkm #ResearchGrant #SURFE2RN1 #TransporterResearch #Electrophysiology #SSME #MembraneBiophysics

𝗘𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝘀𝗶𝗹𝗲𝗻𝘁 𝘁𝗿𝗮𝗻𝘀𝗹𝗼𝗰𝗮𝘁𝗶𝗼𝗻 𝗶𝗻 𝗻𝗮𝗻𝗼𝗽𝗼𝗿𝗲 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 Traditional nanopore studies often rely on detecting ionic currents to understand molecular passage. However, not all molecules leave an electrical trace, some pass through undetected, a phenomenon known as silent translocation. In a recent study, Daniel Burden et al. from Wheaton College investigated this process, focusing on the silent translocation of a Cyanine 5 derivative (sCy5a) through α-hemolysin (αHL) nanopores. By combining single-molecule fluorescence with single-channel electrical recordings, they confirmed that silent translocations do occur, even though they are infrequent. Their cutting-edge experimental setup used the Orbit mini bilayer recording device and MECA 4 OPTO-INV Fluorescence Microscopy Kit on an inverted microscope, allowing for simultaneous optical and electrical measurements in artificial lipid bilayers. This research challenges the assumption that molecular translocation always produces an electrical signal, suggesting that silent translocations could be more common than previously believed. Want to learn more about this topic? 🔗 Read the full article: https://ow.ly/i0z950Tg9C7 🔗 Learn more about simultaneous optical and electrical recordings: https://ow.ly/hJb150Tg9C5 🔗 Visit the Burden Lab: https://ow.ly/CcaQ50Tg9C6 #NanoporeResearch #LipidBilayers #Electrophysiology #SilentTranslocation #MECA #FluorescenceMicroscopy #MembraneBiophysics #Orbitmini

𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝗿𝗲𝗱 𝗯𝗹𝗼𝗼𝗱 𝗰𝗲𝗹𝗹𝘀: 𝗘𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝗽𝘀𝗲𝘂𝗱𝗼 𝗮𝗰𝘁𝗶𝗼𝗻 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹𝘀 Join Lars Kaestner, Professor at Saarland University, for an insightful talk in our upcoming webinar as he explores the phenomenon of pseudo action potentials (PAPs) in red blood cells (RBCs). 📅 When: September 19th, 2024, from 16:00-17:00 h CEST This talk combines innovative patch-clamp techniques with cutting-edge membrane potential and calcium imaging data to unravel the mysteries of PAPs. Don’t miss this chance to enhance your understanding of RBC physiology. Curious about the webinar? Learn more and save your spot here: https://ow.ly/NYvF50Te2Xq #Webinar #Electrophysiology #RedBloodCells #Erythrocytes #AutomatedPatchClamp #APC #IonChannels

Pufferfish poisoning poses a serious threat to human health, with numerous incidents reported worldwide. The toxicity of pufferfish is primarily attributed to tetrodotoxins (TTXs) and paralytic shellfish toxins (PSTs), both of which are potent blockers of voltage-gated sodium channels. However, the toxicity profiles of individual TTX analogues and the presence of PSTs in certain pufferfish species remain poorly understood, creating challenges for food safety management and risk assessment. Two recent papers from Monica Campàs' group address this critical issue by improving our understanding of these toxins in pufferfish. The authors utilized an automated patch clamp system (the Patchliner) to assess the effects of five TTX analogues and two PSTs – saxitoxin (STX) and its analogue decarbamoylsaxitoxin (dcSTX) – on voltage-gated sodium channels in Neuro-2a cells. From this data, they determined toxicity equivalency factors (TEFs) for the TTX and STX analogues, showing that all analogues were less toxic than TTX or STX, respectively. The authors also demonstrated that TEFs derived from APC experiments could be used as correction factors in LC−MS/MS data, making it easier to turn analytical data into useful toxicological insights. Importantly, although previous research had primarily associated pufferfish toxicity with TTX, these studies mark the first record of PSTs in Mediterranean pufferfish L. lagocephalus. The presence of STX and dcSTX in pufferfish, particularly in the liver, suggests a growing risk to seafood safety in this region. These studies offer new insights into the presence of PSTs in Mediterranean pufferfish and provide a novel approach for assessing the toxicity of TTX analogues. The successful application of automated patch clamp for toxicological assessment of TTX analogues and the establishment of TEFs offer valuable tools for translating analytical data into meaningful toxicological information. -- Find the two articles here: https://lnkd.in/gX-K_GGS and https://lnkd.in/gE_AtndZ Learn more about the Patchliner, the most versatile automated patch clamp system on the market: https://lnkd.in/eeVZfG4M   #toxins #hts #navs #ionchannels #toxicity

𝗟𝗼𝗼𝗸𝗶𝗻𝗴 𝘁𝗼 𝗰𝗮𝗽𝘁𝘂𝗿𝗲 𝘁𝗵𝗲 𝗯𝗶𝗼𝗽𝗵𝘆𝘀𝗶𝗰𝗮𝗹 𝗽𝗿𝗼𝗽𝗲𝗿𝘁𝗶𝗲𝘀 𝗼𝗳 𝗶𝗼𝗻 𝗰𝗵𝗮𝗻𝗻𝗲𝗹𝘀 𝗮𝘁 𝘁𝗵𝗲 𝘀𝗶𝗻𝗴𝗹𝗲-𝗰𝗵𝗮𝗻𝗻𝗲𝗹 𝗹𝗲𝘃𝗲𝗹? The Patchliner delivers the versatility and precision you need. This fully automated patch clamp system allows you to record from 4 or 8 cells simultaneously, offering gigaseal data quality and experimental freedom. Equipped with HEKA EPC10 amplifiers and borosilicate glass chips, the Patchliner ensures low-noise, high-resolution recordings. But what if you want to go deeper? 🤔 Using NPC-16 chips and fine-tuning suction, Patchliner allows you to explore single-channel currents with exceptional accuracy. Plus, you can easily switch between single-channel and whole-cell modes, unlocking more insights from your experiments. Ready to take your research further? Click here to learn more: https://ow.ly/AXeS50Tk8Bz #Patchliner #SingleChannels #IonChannels #Electrophysiology #PatchClamp #APC

𝗛𝗼𝘄 𝗮𝗿𝗲 𝗰𝗵𝗮𝗻𝗻𝗲𝗹𝗼𝗽𝗮𝘁𝗵𝗶𝗲𝘀 𝘀𝗵𝗮𝗽𝗶𝗻𝗴 𝘁𝗵𝗲 𝗳𝘂𝘁𝘂𝗿𝗲 𝗼𝗳 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆? Did you know that over 1,300 human syndromes are now linked to mutations in ion channel genes that play a key role in disease development, also know as channelopathies? In his latest blog, Marc Rogers dives deep into this rapidly growing field and how genetic screening is uncovering more of these critical mutations. He also reveals how high-throughput automated patch clamp (APC) is revolutionizing the way we study these ion channels, allowing for faster, more accurate characterization that’s essential for developing targeted therapies. Curious to learn how this cutting-edge technology is transforming drug discovery and precision medicine? The blog covers: ◾ Key case studies on cardiac and neuronal ion channels ◾ Comparisons between APC and other methods like in silico modeling ◾ How APC is bridging the gap between genetic findings and real-world clinical outcomes This is your chance to explore the latest breakthroughs in channelopathy research! 🔗 Don’t miss out! Register to unlock the full blog here: https://ow.ly/zk9M50SVQZP #Channelopathies #IonChannels #DrugDiscovery #GeneticScreening #APC #PrecisionMedicine

𝗟𝗼𝗼𝗸𝗶𝗻𝗴 𝘁𝗼 𝗰𝗼𝗺𝗯𝗶𝗻𝗲 𝗼𝗽𝘁𝗶𝗰𝗮𝗹 𝗮𝗻𝗱 𝗲𝗹𝗲𝗰𝘁𝗿𝗶𝗰𝗮𝗹 𝗿𝗲𝗮𝗱𝗼𝘂𝘁𝘀 𝗶𝗻 𝗼𝗻𝗲 𝗱𝗲𝘃𝗶𝗰𝗲? 💡 The MECA 4 OPTO-INV kit, a cutting-edge solution for researchers looking to perform simultaneous optical and electrical recordings in free-standing artificial lipid bilayers. Designed as an add-on for the Orbit mini platform, the MECA 4 OPTO-INV kit allows electrical recordings from four bilayers while integrating seamlessly with an inverse microscope. This setup provides a powerful way to study channels, biological nanopores, and molecule-membrane interactions. With four identical apertures, you can rapidly paint membranes and achieve high-resolution electrical and optical measurements, enhancing your experimental throughput and data quality. With the MECA 4 OPTO-INV kit, you can: 🟣 Monitor membrane conductance and capacitance while capturing high-resolution optical data. 🟣 Study channels and biological nanopores in reconstituted bilayers. 🟣 Explore molecular interactions with membranes in unprecedented detail. Want to learn how this kit can elevate your research? Check out our flyer or reach out to our team of scientists for personalized support! 🔗 Learn more: https://ow.ly/St2K50Tg8st? #LipidBilayers #OrbitMini #Biophysics #Nanopores #MECA #OpticalRecordings #MembraneScience

SLC6A1 Connect will host Nanion Technologies to discuss high performance electrophysiology in GAT1 Transporters. ✔ Automated Patch Clamp ✔ Membrane Biophysics ✔ Cell Analytics The presentation is relevant to academics, pharma and CROs working to understand the underlying disease of ion channel and transporter mutations. Abstract and registration information below. COMBINEDBrain Wadiche Labs Jacques Wadiche Linda Wadiche Michael Kavanaugh Jonathan Marvin Terry Jo Bichell Kirill Zavalin Sarah Poliquin Amber N. Freed #PatchClamp #IPSC #Neurons #GAT1 #SLC6A1 #IonChannels #Transporter

𝗔𝗱𝘃𝗮𝗻𝗰𝗶𝗻𝗴 𝗶𝗼𝗻 𝗰𝗵𝗮𝗻𝗻𝗲𝗹 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝘄𝗶𝘁𝗵 𝗹𝗶𝗽𝗶𝗱 𝗯𝗶𝗹𝗮𝘆𝗲𝗿 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 For decades, planar artificial lipid bilayers have been a reliable model for studying channel-forming pores and ion channels through voltage clamp electrophysiology. These chemically well-defined systems have led to countless breakthroughs in understanding membrane dynamics. A major innovation in this field is the Micro-Electrode Cavity Array (MECA) technology, integrated into the Orbit 16 TC and Orbit mini devices, and produced by our partner, Ionera. Unlike traditional methods, MECA technology significantly improves both the throughput and ease of use of lipid bilayer recordings by allowing parallel experiments. This advancement enables researchers to achieve higher efficiency and more accurate results, making lipid bilayer studies more accessible and scalable. Each MECA chip contains µm-sized micro-cavities, spanned by lipid bilayers and equipped with Ag/AgCl microelectrodes, ensuring high-resolution, low-noise recordings with minimal stray capacitance. Curious to learn more about the planar lipid bilayer technique? We've prepared some valuable resources for you to explore this fascinating method. 🔗 Learn more here: https://ow.ly/nglf50Tg6Tf #Electrophysiology #LipidBilayers #IonChannels #Biophysics #MEmebraneBiophysics #MECA #BLM

𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝗥𝗲𝘁𝘂𝗿𝗻𝘀 𝘁𝗼 𝗡𝗮𝗽𝗮 𝗖𝗮𝗹𝗶𝗳𝗼𝗿𝗻𝗶𝗮 𝗦𝗽𝗿𝗶𝗻𝗴 𝗼𝗳 𝟮𝟬𝟮𝟱 𝗚𝗲𝘁 𝘆𝗼𝘂𝗿 𝘁𝗶𝗰𝗸𝗲𝘁𝘀 𝗵𝗲𝗿𝗲: https://ow.ly/keCR50Thv8A 𝗔𝗽𝗿𝗶𝗹 𝟯𝟬 - 𝗠𝗮𝘆 𝟭, 𝟮𝟬𝟮𝟱 Join us for diverse scientific discussions, networking, and a little wine at the Meritage Resort & Spa 𝗦𝗽𝗲𝗮𝗸𝗲𝗿𝘀: Dr. Mustafa Djamgoz - Imperial College of London Dr. Adam Cohen - Quiver Bioscience Dr. Tamer Gamal El-Din - University Washington Dr. Filip Van Petegem - University of British Columbia Dr. Howard Young - University of Alberta Dr. Gerald Zamponi - University of Calgary Dr. Al George Jr. - Northwestern University Dr. Olive Burata - University of California San Francisco Dr. Terry Hébert - McGill University Dr. Hiro Furukawa - Cold Spring Harbor Laboratory Dr. Baron Chanda - Washington University in St Louis Dr. Brooke Ahern - US Army DEVCOM Dr. Heike Wulff - University of California Davis Dr. Dave Weaver - Vanderbilt University Dr. David Chiang - BWH Harvard Dr. John Graef - Sarepta Therapeutics Dr. Teresa Giraldez - Universidad de La Laguna More coming soon