Nanion Technologies

𝗔𝗰𝗰𝗲𝗹𝗲𝗿𝗮𝘁𝗶𝗻𝗴 𝗧𝗿𝗮𝗻𝘀𝗽𝗼𝗿𝘁𝗲𝗿 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝘄𝗶𝘁𝗵 𝗦𝗨𝗥𝗙𝗘²𝗥 𝗡𝟭! 🔬 Are you ready to revolutionize your transporter research? The SURFE²R N1 is purpose-built for measuring electrogenic transporters, offering unparalleled sensitivity, speed, and ease of use. Say goodbye to harsh radiolabeled compounds, and missed transporter currents due to their small amplitude. We’re excited to announce the SURFE²R N1 Research Grant 2024, dedicated to advancing innovative transporter research using the cutting-edge Solid Supported Membrane-based Electrophysiology (SSME). 🌟 Why Apply? The SURFE²R N1 empowers you with comprehensive functional characterization of electrogenic membrane transport in real-time. Recordings are possible from diverse membranes, including isolated membrane vesicles from native tissues or cultured cells, organellar membranes, and transporters reconstituted into proteoliposomes. 🌟Our promise? This grant offers a unique opportunity to explore electrogenic membrane transport with unparalleled sensitivity and temporal resolution. Receive a SURFE²R N1 for 6 months, complete with consumables and assay development support, free of charge. Applications will open soon—be the first to receive information about the grant. Register your interest! In the meantime, explore success stories from previous grant winners: https://ow.ly/3Lfj50S1Qfy #ResearchGrant #SURFE2RN1 #TransporterResearch #ScientificInnovation #Electrophysiology

George O. Okeyo, PhD is hiring! Field Application Scientist role in electrophysiology for automated patch clamp. Do you know anyone interested? Please share this post! #FAS #electrophysiology #ionchannels

If you're a researcher, scientist, or simply passionate about cardiac research, innoVitro's upcoming webinar is a must-attend event! Join the third edition of the LabINAR BREAK, where you will get insights into the crucial role of hiPSC-derived atrial and ventricular cardiomyocytes in preclinical drug discovery. 📅 Date & Time: September 19th at 4 PM CEST 🎤 Guest Speaker: Jamie Bhagwan from Axol Bioscience Ltd. What you will learn: ◾Explore how axoCells™ hiPSC-derived Atrial and Ventricular Cardiomyocytes show distinct contractility responses on the FLEXcyte 96 platform. ◾Get key insights include differences in beat rate, duration, and contractile force, along with chamber-specific effects of various compounds, such as GPCR agonists and K+ channel antagonists. 🔗 Learn more and register here: https://ow.ly/vPvc50T3WSi #Webinar #CardiacResearch #DrugDevelopment #iPSCCardiomyocytes #AtrialFibrillation #LabINARBREAK

𝗖𝗼𝗻𝘀𝘂𝗺𝗮𝗯𝗹𝗲𝘀 𝘁𝗮𝗶𝗹𝗼𝗿𝗲𝗱 𝗳𝗼𝗿 𝘆𝗼𝘂𝗿 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 The CardioExcyte 96 and FLEXcyte 96 systems are powerful tools designed to advance cardiac research by providing high-resolution data on cell contractility and electrophysiology. Whether you're investigating drug effects, cardiac safety, or disease models, these systems deliver the accuracy and efficiency your lab needs. The sensor plates for CardioExcyte 96 and FLEXcyte 96 are specifically designed to meet the demands of advanced cardiac studies. These sensor plates are essential for gaining deeper insights into cardiac function, physiology, and drug efficacy. With CardioExcyte 96 plates, you can simultaneously measure contractility and electrophysiology from the same cell population, providing a complete view of cardiac function. These plates are ideal for drug discovery, cardiac safety testing, and disease modeling. The FLEXcyte 96 plates are unique as they replicate the elasticity of human heart tissue, allowing you to culture iPSC-derived cardiomyocytes under conditions that closely mimic the human body. This creates a pro-maturation environment and ensures more accurate in vitro cardiac contractility measurements that truly reflect in vivo performance. Both CardioExcyte 96 and FLEXcyte 96 are designed to simplify your workflow, featuring automated data handling and analysis tools that help you move from experiment to results faster. Want to learn more about the sensor plates? Find more information in the flyer: https://ow.ly/JG1i50T307l #CellAnalytics #CardiacResearch #DrugDiscovery #CardioExcyte96 #FLEXcyte96

Giant unilamellar vesicles (GUVs) serve as model systems for studying membrane behavior, offering insights into processes such as membrane deformation, cargo transport, and vesicle fusion. However, achieving precise control over these processes in synthetic systems remains challenging. The ability to programmatically remodel lipid membranes and GUVs in a controlled and reversible manner is a significant hurdle in the field. Traditional approaches often lack the capacity to induce complex, dynamic changes in membrane structure that are critical for replicating biological functions such as vesicle fusion, fission, and cargo transport. A recent study introduces innovative 3D reconfigurable DNA origami pincers (DOPs) that can dynamically interact with and remodel lipid membranes in GUVs, which were generated using the Vesicle Prep Pro system. These DOPs are designed to control membrane morphology by adjusting their pinching angle, enabling the precise modulation of GUV shape and membrane dynamics. The DNA origami structures can oligomerize on the GUV membrane, forming complex cage-like assemblies that can capture, compartmentalize, and even detach lipid fragments. This oligomerization process is accompanied by membrane disruptions, enabling the passage of cargo across the membrane. The DOPs can be programmably reconfigured to induce specific deformations in the GUV membranes. By adjusting the pinching angle, the DOPs can transition GUVs from near-spherical to significantly deformed states, demonstrating a high level of control over membrane morphology. Upon oligomerization, the DOPs form structured cages on the GUV membrane, which not only remodel the membrane but also induce transient pores. These pores enable the controlled passage of molecules across the membrane. The study showcases the ability to reversibly remodel the GUV membranes by sequentially adjusting the DOP pinching angles. This highlights the potential for creating synthetic systems where membrane dynamics can be precisely programmed and controlled in real time. In conclusion, this study represents a significant advance in the field of lipid membrane and GUV research, demonstrating how DNA origami structures can be used to dynamically and reversibly manipulate membrane morphology and function. These findings are particularly relevant for the development of synthetic cells and advanced biomaterials, where the precise control of membrane dynamics is essential. The ability to engineer DNA-based nanostructures that can induce and control complex membrane behaviors opens new possibilities for studying membrane mechanics, drug delivery, and the creation of programmable vesicle-based systems. -- Find the full article here: https://lnkd.in/dUmPJJF2 Learn more about automated preparation of solvent-free GUVs: https://lnkd.in/ezTiY2FG   #GUVs #lipids #membrane #DNA #origami 

𝗡𝗮𝗻𝗶𝗼𝗻 𝗨𝘀𝗲𝗿 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 𝟮𝟬𝟮𝟰 - 𝗔𝗴𝗲𝗻𝗱𝗮 𝗶𝘀 𝗻𝗼𝘄 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲! Join us on October 22-23 at Nanion Technologies HQ in Munich for two days of insightful talks, interactive poster sessions, and instrument demos showcasing new applications and product highlights. We’ve got an exciting lineup of speakers from around the world, eager to share their latest research and innovations. Whether you're focused on assay development, advancing cardiac safety, exploring ion channels and membrane transporters, or diving into the latest trends in drug discovery, at our user meeting there's something for everyone: ✅ Engage with experts ✅ Explore cutting-edge applications ✅ See our products in action ✅ Build connections Curious about the speakers and sessions? Check out the full agenda and secure your spot today: https://ow.ly/E6g950T39ft #UserMeeting #NUM2024 #Event #APC #CellAnalytics #MembraneBiophysics #ScientificConference

Who said learning electrophysiology isn’t fun? Over the past few days, we had the pleasure of working with an incredibly talented group of students at the Cell Physiology Workshop in Liverpool. Artem from our team not only taught but also truly connected with the next generation of scientists, guiding them through hands-on sessions with some of the most advanced tools in #electrophysiology. From transporter assays and planar patch clamping to bilayer recordings and giant unilamellar vesicle electroformation, students explored a wide range of techniques—always with smiles, laughter, and endless curiosity. A huge thank you to everyone who made this workshop a success! Rich Rainbow, Jon Robbins, Sean Brennan, everyone... We’re proud to contribute to the education and development of future leaders in the field of electrophysiology. #ephys #ionchannels #transporters #guvs #bilayer University of Liverpool, University of Leicester

𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗵𝗶𝗣𝗦𝗖-𝗖𝗠 𝗺𝗮𝘁𝘂𝗿𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗧𝟯 𝗮𝗻𝗱 𝗗𝗲𝘅: 𝗔 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲𝘅 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 🫀✨ Are you working with hiPSC-derived cardiomyocytes (hiPSC-CMs) and looking to improve their maturation for applications in disease modeling, drug discovery, or cell therapy? We've got something exciting to share with you! In collaboration with Bayer, Fraunhofer IBMT, and Hamamatsu Photonics France, we've developed an application note that dives into how triiodothyronine (T3) and dexamethasone (Dex) can enhance the structural and functional maturation of hiPSC-CMs. Our study combines impedance/EFP and calcium imaging to track calcium transients and electrical activity in the same cells. The results are promising, T3 and Dex not only modulate the electrical activity but also improve calcium handling, crucial for the maturation of these cells. We also explored how the NSP-96 transparent plate can be used for multiple assays, allowing you to measure electrical activity, contractility, and calcium transients from the same cell population using the CardioExcyte 96 and FDSS/μCELL. This means more data from fewer cells and reduced variability. Curious to learn more? Check out the full application note here: https://ow.ly/bwVS50T1NC4 #Cardiomyocytes #hiPSC #StemCells #DrugDiscovery #CellAnalytics #CardioExcyte96

𝗕𝗲𝗰𝗼𝗺𝗶𝗻𝗴 𝗮 𝗖𝗥𝗢 𝗲𝘅𝗽𝗲𝗿𝘁 𝗳𝗼𝗿 𝗛𝘂𝗺𝗮𝗻-𝗕𝗮𝘀𝗲𝗱 𝗖𝗲𝗹𝗹 𝗔𝗻𝗮𝗹𝘆𝘁𝗶𝗰𝘀 Over the past six years, innoVitro has become a standout in human-based cell analytics as a leading Contract Research Organization (CRO). Their focus on human-based predictivity, supported by cutting-edge technology, allow them to offer a wide range of customized services essential for drug discovery. From preclinical safety assessments to toxicity evaluations and efficacy studies, they serve both the pharmaceutical and food supplement industries. From day one, innoVitro has closely partnered with Nanion. First to develop the FLEXcyte 96 system for cardiac contractility assessment, and then integrating other advanced technologies from Nanion, including the CardioExcyte 96 and live-cell analytics system AtlaZ. “The precise data analysis capabilities offered by Nanion Technologies’ platforms enable us to deliver the reliable and robust results necessary for informed decision-making by our customers. ” says Dr. Bettina Lickiss, BD and Scientific Communication Manager at innoVitro. Want to learn more about innoVitro and their experience with Nanion’s platforms? ➡ Find more in this case study: https://ow.ly/FUtm50T1Kjv #CellAnalytics #DrugDiscovery #CRO #PreclinicalResearch #Collaboration #AtlaZ #FLEXcyte96 #CardioExcyte96

Since my PhD days, I've always wanted to attend the renowned Plymouth Cell Physiology Workshop to learn from top electrophysiologists. This year, that dream came true! Well, not in Plymouth, but in its new home – Liverpool. And not as a student, but as part of the teaching team. And it was such a great experience! I feel honored to have shared knowledge on transporter assays and the nuances of bilayer recordings with everyone. It was fantastic to bring four of our instruments for practical courses on making GUVs, recording Nav1.5 currents, and forming 16 lipid bilayers at a time with Gramicidin A incorporation. A big shoutout to my "Fab Four" students, Karen, Serena, Paul, and Aishwarya, with whom I had the pleasure of spending most of my time during the practical courses. You guys are amazing – so talented, curious, sharp, and fun! Watching you work in the lab was a true delight. And of course, a huge thanks to Rich Rainbow, Jon Robbins, Sean Brennan, the entire teaching crew, and the sponsors for making this happen. I wish everyone a productive second week of the workshop and I’m already looking forward to the next one in 2025. Grateful for this wonderful experience at CPW Liverpool. Thanks, everyone! #CPW #ionchannels #transporters #electrophysiology #patchclamp University of Liverpool, University of Leicester, The Company of Biologists, Cairn Research Ltd, Nanion Technologies, Sophion Bioscience, Campden Instruments, Scientifica, Digitimer Ltd, World Precision Instruments, LLC., Cambridge Electronic Design Ltd.