Are you a researcher working on 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 or complex 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 models, such as organoids, organ-on-chip, iPSCs, etc.? During the peer review process, have you ever been asked to validate your 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 findings with animal experiments? Was it scientifically justified? We want to hear from you! Humane Society International India (HSI/India), IndiaBioscience and we are launching a 5-mins survey to understand peer reviewer expectations in India during the submission of 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 data and authors' perceptions of these requests. Take the survey here: https://lnkd.in/gpebfX-S #science #survey #invitromethods #peerreviewexperience Tuli Dey Pavithra Chavali Subha Narayan Rath Falguni Pati Prajakta Dandekar Chandragouda Patil Dr. Subhash Chander Shriyansh Srivastav Dr. Md. SABIR ALAM HARISHCHANDER ANANDARAM Arunkumar Palaniappan PhD Akbarsha Mohammad Abdulkader Abhijit Majumder Rohit Seth Kalyan Gayen Dr. Mahesh P. More PhD Surabhi Srivastava Sanjeev Kumar Mahto, PhD, MNASc, MAMS Atal Incubation Centre - CCMB
CPHMS | Centre for Predictive Human Model Systems
Biotechnology
Hyderabad, State 6,497 followers
India's first scientific & policy think-tank dedicated to making academic and industrial research human health relevant
About us
The Centre for Predictive Human Model Systems (CPHMS) is India’s first think-tank dedicated to enabling a shift from animal experimentation to human-relevant contexts using 21st century biological tools. The Centre aims to prioritise investment and research in human-centric methodologies such as organoid, organ-chips and computational biology. CPHMS is a joint initiative of AIC–CCMB and Humane Society International India (HSI/India).
- Website
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https://aic.ccmb.res.in/cphms/
External link for CPHMS | Centre for Predictive Human Model Systems
- Industry
- Biotechnology
- Company size
- 2-10 employees
- Headquarters
- Hyderabad, State
- Type
- Partnership
- Founded
- 2019
- Specialties
- Reesarch, Drug Discovery, In-vitro biology, Toxicology, Pharmacology, Microphysiological systems, and science policy
Locations
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Primary
Hyderabad, State 500013, IN
Employees at CPHMS | Centre for Predictive Human Model Systems
Updates
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Are you a researcher working on 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 or complex 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 models, such as organoids, organ-on-chip, iPSCs, etc.? During the peer review process, have you ever been asked to validate your 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 findings with animal experiments? Was it scientifically justified? We want to hear from you! Humane Society International India (HSI/India), IndiaBioscience and we are launching a 5-mins survey to understand peer reviewer expectations in India during the submission of 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 data and authors' perceptions of these requests. Take the survey here: https://lnkd.in/gpebfX-S Atal Incubation Centre - CCMB Indian Institute of Science (IISc) National Centre for Biological Sciences Indian Institute of Science Education and Research (IISER), Pune Nanomedicine Research Group, ICTMumbai Savitribai Phule Pune University Vellore Institute of Technology Centre for Cellular and Molecular Platforms (C-CAMP) National Institute of Technology Agartala NIPER Kolkata AIIMS (All India Institute of Medical Sciences, New Delhi) Manipal Institute of Management, MAHE, Manipal Indian Institute of Technology, Madras Sree Chitra Tirunal Institute for Medical Sciences and Technology Tata Institute of Fundamental Research (TIFR) Hyderabad #science #survey #invitromethods #peerreviewexperiencess
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CPHMS | Centre for Predictive Human Model Systems reposted this
I’m excited to share that I won the Best Oral Presentation Award at the International Aquatic Biotechnology Symposium (Sept 25-27, 2024) at İstanbul Üniversitesi Su Bilimleri Fakültesi, Türkiye! 🎉 It was an absolute honor to represent my lab, the National Centre for Aquatic Animal Health (NCAAH), and my university, Cochin University of Science and Technology (CUSAT), at this prestigious global event. I had the opportunity to present my PhD research on "Cell cultures from the oyster, Magallana bilineata as a platform for toxicity evaluation and transgene expression." My talk covered the challenges of developing marine invertebrate cell cultures and how we successfully created a simple, reproducible protocol for cell cultures from M. bilineata. We explored its application in detecting triclosan toxicity at environmentally relevant concentrations and showcased transgenic oncogene expression in the cell culture system. A video of beating cardiomyocyte clusters retained for a month caught the attention of many attendees, including keynote speakers. Winning the award was truly the icing on the cake! 🎉 A heartfelt thanks to Internal Quality Assurance Cell, CUSAT for the international travel grant and NCAAH for the research facilities and unwavering support. There were several talks that deeply resonated with me: Dr. Dean Jerry’s presentation on “Navigating the seas of innovation: uniting genomics, AI, and pathogen diagnostics for Sustainable Aquaculture,” especially the fascinating research on golden barramundi coloration and AI’s role in aquaculture. Dr. Kirsten Benkendorff’s talk on "Pesticide hazards for seafood health and safety," where we exchanged insights on the toxicity of pesticides in oysters (tissue vs. cell culture approaches). Dr. Luísa Custódio’s session on marine invasive algae and the regulatory frameworks around their use for bioactive compound extraction. Special congratulations to my colleague, Mr. Ambadi Kannan M.S., for his excellent presentation on "Acute streptococcosis in Oreochromis niloticus: Development of an inactivated whole-cell vaccine from Streptococcus agalactiae." His company made our exploration of Istanbul all the more enjoyable! The symposium’s social events—visits to the Basilica Cistern, the Bosphorus cruise, and the gala dinner—were truly memorable and fostered great connections with fellow attendees. I’d like to specially mention Mr. Akin, whom I met at the Symposium and who quickly became a good friend. A huge thank you to the organizers for an impeccably executed event, and a special thanks to Dr. Meriç Albay, Co-Chair of the Symposium, for his valuable support, particularly with the visa process. #AquaticBiotechnology #BestPresentationAward #Istanbul #Symposium #Research #SustainableAquaculture #MarineResearch #Genomics #Toxicology #CellCultures #CUSAT
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The 12th edition of the CPHMS newsletter is here! This issue includes a foreword by Nirnith Devireddy, CEO & Founder of InSilicoMinds, and an in-depth overview of the recent 𝗠𝗣𝗦 𝗕𝗼𝗼𝘁𝗰𝗮𝗺𝗽 in Bangalore, complete with participant insights. We also cover key takeaways from our 𝗖𝗗𝗦𝗖𝗢 & 𝗜𝗖𝗠𝗥 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝘄𝗼𝗿𝗸𝘀𝗵𝗼𝗽 at Delhi. As always, you’ll find the latest updates on new approach methods (NAMs), 𝗴𝗮𝗺𝗲-𝗰𝗵𝗮𝗻𝗴𝗶𝗻𝗴 𝗽𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀, 𝗮𝗻𝗱 𝗮 𝗰𝘂𝗿𝗮𝘁𝗲𝗱 𝗹𝗶𝘀𝘁 𝗼𝗳 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀, 𝗰𝗮𝗹𝗹𝘀, 𝘄𝗲𝗯𝗶𝗻𝗮𝗿𝘀, and 𝗰𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲𝘀. Want these updates delivered straight to your inbox? 𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝘁𝗼 𝗼𝘂𝗿 𝗺𝗮𝗶𝗹𝗶𝗻𝗴 𝗹𝗶𝘀𝘁! Featuring: Nirnith Devireddy Viraj Mehta Manjeera Gowravaram Dennis Nahon Ahmad Al-Shihabi Anagha Rajesh Karthik Mahesh, Ph.D. Rajarshi Pal, Ph.D. Vijeta Jaiswal Kaushik Chatterjee Sujata Mohanty Sonia Gandhi Rajeev Raghuvanshi Nabendu S. Chatterjee, M.Sc, Ph.D Surat Saravanan, PhD Dr. Tausif Ahmed Bhairav Paleja Pranav Karmwar Kasinath Viswanathan PhD Anita Krishnan Ramjee Pallela Nalam Rao Thierry Poumeyrol Clive Roper BSc PhD CBiol CSci ERT FRSB Kasturi Mahadik SATHISH S Sourabh Ghosh Joel P Joseph Dr. Kirthanashri S Vasanthan Bhushan Venkatesh Amogh Kumar Shiva Prasad Pranjali S G Isha Dey Kruttika Phalnikar Tanay Bhatt Atal Incubation Centre - CCMB Humane Society International India India Animal Fund Dr. Reddy's Laboratories
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CPHMS | Centre for Predictive Human Model Systems reposted this
🌟Kore Additive Manufacturing and Medical Reconstruction Pvt Ltd at the MPS Bootcamp 2024 🌟 Module 2 - 3D Bioprinting We are excited to share highlights from the second module of the MPS Bootcamp 2024, held at the Indian Institute of Science (IISc) Bangalore in collaboration with CELLINK. This module focused on the revolutionary field of 3D Bioprinting, providing participants with hands-on experience in cutting-edge technologies like Extrusion-based and Digital Light Projection (DLP)-based 3D bioprinting techniques. With CELLINK’s cutting-edge bioprinters, participants applied their learning by printing models such as: Microfluidic devices Corneal constructs Hollow microneedle patches We also participated in interesting sessions run by professionals in the field: Overview of Extrusion and DLP-based Bioprinting Technologies – Ms. Vijeta Jaiswal, CELLINK Model Designing and Biomaterial Selection – Mr.Joel P Joseph , Indian Institute of Science (IISc) 3D Bioprinting for Biomedical Applications –. Dr. Kirthanashri S Vasanthan S Vasanthan , MCBR MAHE, one of our Scientific advisors Applications of 3D Bioprinting in Tissue Regeneration – Dr. Kaushik Chatterjee, Indian Institute of Science (IISc) Department of Bioengineering, IISc Silk-based Bioprinting – Dr. Sourabh Ghosh , Indian Institute of Technology, Delhi The module also touched on recent regulatory developments like the FDA Modernization Act 2.0 and the 2014 amendment to the Drugs and Cosmetics Rules, 1945, underscoring how 3D bioprinting is transforming personalized medicine, drug screening, and tissue engineering. Participants had the opportunity to work with four state-of-the-art bioprinters from CELLINK, each offering unique capabilities: BIO X, BIO X6, BIONOVA X and LUMEN X The 3D Bioprinting module was an enlightening experience that opened new doors for innovation in personalized medicine, tissue engineering, and drug discovery. We are grateful to CELLINK, Indian Institute of Science (IISc),CPHMS | Centre for Predictive Human Model Systems and all the expert speakers along with organisers Tejaswini D. Kasturi Mahadik Goutami Nayak for guiding us through these advanced bioprinting technologies. We are eager to integrate these insights into our ongoing projects at Kore Additive Manufacturing and Medical Reconstruction Pvt. Ltd. Stay tuned for more updates as we continue our journey through the final module on Organoids!!! Chaitanya Doshi Samruddhi Kulkarni RBK Dinesh Kumar #MPSBootcamp2024 #3DBioprinting #Bioprinting #CELLINK #MedicalInnovation #HealthcareTechnology #Biotech #AdditiveManufacturing #TissueEngineering #RegenerativeMedicine #PersonalizedMedicine #OrganOnChip #BiomedicalResearch #LifeSciences #InnovationInHealthcare #BioprintingTechnology #IIScBangalore #ScientificResearch #AdvancedManufacturing #MedicalDevices #DrugScreening #NextGenTechnology #TissueRegeneration #Biofabrication #StemCells #Biomaterials #3DPrinting
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CPHMS | Centre for Predictive Human Model Systems reposted this
🌟 Kore Additive Manufacturing and Medical Reconstruction Pvt Ltd at the Microphysiological Systems (MPS) Bootcamp 2024! 🌟 We were thrilled to participate in the Microphysiological Systems (MPS) Bootcamp 2024, held from August 19-24, 2024, organized by the CPHMS | Centre for Predictive Human Model Systems and Atal Incubation Centre - CCMB This intensive 6-day bootcamp, hosted at Centre for Cellular and Molecular Platforms (C-CAMP) and the Indian Institute of Science (IISc), was an incredible learning opportunity for participants from industry, academia, startups, and CROs. The bootcamp was divided into 3 comprehensive modules: 1. Microfluidics 2. 3D Bioprinting 3. Organoids This post highlights our experience in the Microfluidics module, where we collaborated with Karthik Mahesh, Ph.D. (MedTech Facility at C-CAMP). Our team gained valuable hands-on knowledge in: - Direct laser writing - Stereolithography (SLA) 3D printing - PDMS-based soft lithography - Micro-milling fabrication - Microfluidics testing Our CEO Chaitanya Doshi moderated discussions on regulatory perspectives, integrating cellular components, and the future of organ-on-chip technology, during which we also learned a lot from experts like Clive Roper BSc PhD CBiol CSci ERT FRSB ,Sri Harsha Paladugu, and Thierry Poumeyrol. A heartfelt thanks to the organizers—CPHMS | Centre for Predictive Human Model Systems, Centre for Cellular and Molecular Platforms (C-CAMP), and Atal Incubation Centre—CCMB for their impeccable execution and to MedTech Facility at C-CAMP and INFAB Semiconductor Pvt Ltd for their hands-on support. The bootcamp was a fantastic opportunity to advance our knowledge of MPS and its potential applications in healthcare and biotechnology. Tejaswini D. Kasturi Mahadik Goutami Nayak SATHISH S Bhushan Venkatesh Mohamed Yousuff Caffiyar A special shout-out to RBK Dinesh Kumar and Samruddhi Kulkarni from our team, who actively participated in the camp We’re excited to bring these learnings into our future innovations! Stay tuned for updates on the next modules—3D Bioprinting and Organoids! #MPSBootcamp2024 #Microfluidics #OrganOnChip #CPHMS #CCAMP #Biotech #MedicalInnovation #HealthcareTech #AdditiveManufacturing #Fabrication #Manufacturing #3DPrinting #Biotechnology #organonchip #MicrophysiologicalSystems #Mems #chips #miniaturization #workshop #conference #bootcamp #bangalore #startups
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CPHMS | Centre for Predictive Human Model Systems reposted this
🌟 Kore Additive Manufacturing and Medical Reconstruction Pvt Ltd at the MPS Bootcamp 2024: Module 3 - Organoids! 🌟 We are thrilled to share insights from the final module of the MPS Bootcamp 2024, held in collaboration with Thermo Fisher Scientific and Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), where participants explored the fascinating world of Organoid Technology. This module focused on using organoids as advanced in vitro models for drug discovery, disease modeling, and personalized medicine. Key Highlights: Lung Organoids and Applications – Dr. Rajarshi Pal, Ph.D. Pal, co-founder of Eyestem Research, kicked off the session with a comprehensive overview of lung organoid technology and its role in studying respiratory diseases, including SARS CoV-2. His insights into how lung organoids can revolutionize respiratory research and drug screening were particularly eye-opening. Tumoroids and Cancer Research – Dr. Isha Dey Dey from Thermo Fisher Scientific delivered a captivating talk on the creation and use of tumoroids in studying cancer. She covered everything from culture techniques to growth kinetics and assays that help researchers model tumor behavior for effective drug screening. Organoids in Neuropsychiatric Disorders – Dr. Kruttika Phalnikar from Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem)- presented groundbreaking research on using organoids to study bipolar disorders and other neuropsychiatric conditions. Her work shed light on how organoids are opening new avenues for understanding brain function and mental health. Hands-On Sessions: Participants got hands-on experience in generating embryoid bodies from iPSCs and learned advanced techniques like cryosectioning and staining under the guidance of Ms. Harshini and Ms. Swati from Eyestem. Dr.Isha Dey 's session on GFP-labeled tumoroids for colorectal cancer research demonstrated the use of advanced organoid models in cancer drug screening. Skin Models – Dr. Tanay Bhatt from KoshKey Sciences led a highly interactive session on creating skin models and discussed their wide-ranging applications in cosmetic testing and dermatological research. The Organoid Technology module showcased cutting-edge research and applications that are transforming drug discovery, personalized medicine, and the future of biomedical research. We look forward to incorporating these revolutionary technologies into our work at Kore Additive Manufacturing and Medical Reconstruction Pvt. Ltd. Chaitanya Doshi Samruddhi Kulkarni RBK Dinesh Kumar CPHMS | Centre for Predictive Human Model Systems Atal Incubation Centre - CCMB Tejaswini D. Kasturi Mahadik Goutami Nayak #MPSBootcamp2024 #Organoids #ThermoFisherScientific #EyestemResearch #DBTinStem #MedicalInnovation #TissueEngineering #DrugScreening #BiomedicalResearch #PersonalizedMedicine #StemCells #KoreAdditive #AdditiveManufacturing #HealthcareTechnology #LifeSciences #ScientificResearch
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At Global Bio India 2024, Atal Incubation Centre - CCMB & CPHMS | Centre for Predictive Human Model Systems were invited to a Roundtable on 𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗕𝗶𝗼𝗺𝗮𝗻𝘂𝗳𝗮𝗰𝘁𝘂𝗿𝗶𝗻𝗴 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗚𝗹𝗼𝗯𝗮𝗹 𝗥𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗖𝗼𝗻𝘃𝗲𝗿𝗴𝗲𝗻𝗰𝗲: 𝗔 𝗨𝗻𝗶𝗳𝗶𝗲𝗱 𝗔𝗽𝗽𝗿𝗼𝗮𝗰𝗵. Partnered by Biotechnology Industry Research Assistance Council (BIRAC), CDSCO FDA India MoHFW and WHO India Office, the august gathering comprised of two dozen regulatory, industry and science & policy personnel. It proved an insightful discussion for regulatory capacities and collaborations needed for emerging technologies of stem cell biology, cell and gene therapy, and non-animal methods (organoid, organ-on-chips and computational biology). Rajeev Raghuvanshi highlighted that CDSCO had recently approved 147 biotech products, including 41 biosimilars, setting a global record. He emphasized the need for deep thinking and scientific cadre at Indian regulatory offices, converging with US FDA’s views. Sonia Gandhi emphasized that regulatory convergence remains a bottleneck for policies such as BioE3. She pointed out the lack of a regulatory knowledge-sharing platform in the country, which BIRAC is now working to establish. Deepanwita Chattopadhyay put the start-up and industry perspective in place by saying ‘uncertainty kills us’, referring to unclear regulatory perspectives creating a challenging and often non-progressive atmosphere Some notable points were raised: 👉 Communication on regulation was identified as crucial. 👉It was proposed that, similar to the US FDA, India should establish regulatory offices in various countries abroad to ensure global harmonization. 👉 It was recommended that stakeholder meetings be conducted nationwide, rather than being concentrated solely in the national capital. 👉 There was unanimous agreement on the need to build momentum in the field of NAMs, particularly around validation data. An open dialogue between the national and international regulators was emphasized as essential to fostering a better understanding of successful NAMs regulatory dossiers, ultimately paving the way for the development of guidelines. 👉 Early and frequent engagement with regulators, which offers clarity on the largely case-specific regulatory framework also identified as crucial. 👉 Participation of the WHO-controlled laboratory network in discussions on regulatory convergence is necessary. 👉 Technology developers face significant challenges in coordinating with multiple agencies for pre-clinical, CMC, and clinical work. 👉 Need for a comprehensive regulatory discussion on the smart protein landscape. More information in BIRAC's upcoming report on #GBI2024 Humane Society International India India Animal Fund Blockchain for Impact (BFI) Kasturi Mahadik IKP Knowledge Park Ramjee Pallela Nalam Rao
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CPHMS | Centre for Predictive Human Model Systems reposted this
Session: Non-Animal Methodologies for Drug Development and Biomedical Research at #GlobalBioIndia2024 India is at the forefront of integrating human-relevant, non-animal technologies (NAM) in biomedical research and drug development. The session will bring together national and international stakeholders from academia, industry, government, and regulatory bodies to drive innovation and enhance public health. We will explore strategies for increasing investment, fostering strategic partnerships, and promoting affordable, indigenous non-animal methodologies. Join us to commit to these initiatives and shape the future of humane and effective research practices. 📅 Date: 13 September 2024 📍 Venue: Pragati Maidan, Delhi Don’t miss this important discussion! For more details, visit globalbioindia.org. #GlobalBioIndia2024 #NonAnimalMethodologies #DrugDevelopment #BiomedicalResearch #Innovation Jitendra Kumar Shilpy Kochhar DBT BIRAC Department of Biotechnology Indian Venture and Alternate Capital Association (IVCA) TiE Delhi-NCR Invest India Startup India FICCI TWA Be Inspired Sathguru Management Consultants ABLE - Association of Biotechnology Led Enterprises Global Business Inroads (GBI) US-India Strategic Partnership Forum Indian STEPs and Business Incubators Association (ISBA)
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𝗧𝗵𝗿𝗶𝗹𝗹𝗲𝗱 𝘁𝗼 𝘀𝗲𝗲 𝗔𝗻𝗮𝗴𝗵𝗮 𝗮𝗻𝗱 𝗕𝗶𝗼𝗰𝗼𝗺𝗽𝘂𝘁𝗲 𝗿𝗲𝗰𝗼𝗴𝗻𝗶𝘇𝗲𝗱 𝘄𝗶𝘁𝗵 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝗳𝗿𝗼𝗺 𝗪𝗧𝗙𝘂𝗻𝗱! 🎉 Anagha, who was a participant in our recent MPS Bootcamp 2024, has been driving impactful work at Biocompute. Their focus on revolutionizing data storage using DNA and microfluidics is truly inspiring. With this, Anagha is set to expand her team by hiring and training new personnel in microfluidics. If you're passionate about this field, this is a fantastic opportunity to join her on this exciting journey! https://lnkd.in/gMUxd-g9 Humane Society International India Humane Society International Dr. Reddy's Laboratories India Animal Fund Atal Incubation Centre - CCMB Centre for Cellular and Molecular Biology Centre for Cellular and Molecular Platforms (C-CAMP) Department of Bioengineering, IISc CELLINK Anagha Rajesh Karthik Mahesh, Ph.D. Kasturi Mahadik Goutami Nayak Tejaswini D.
BIG BIG news to share 📢 BioCompute Inc is now backed by WTFund - India’s biggest and boldest non-dilutive grant for young founders. The WTFund is a passion project of Nikhil Kamath the super successful founder of Zerodha, Gruhas and True Beacon who started out as a first-generation entrepreneur fairly young in life, and this fund is his way of paying it forward to young entrepreneurs in India. After a rigorous selection process spanning many months, several (not-so-easy) rounds and competing with 1500+ applicants from across India, we have emerged as one of the top 9 companies for the grant. In this edition of our newsletter, I write about the evening spent with Nikhil and co, and how it felt like being in a WTF podcast but 10X better. Check it out! https://lnkd.in/dZF2cqv3 P.S. A huge shout out to my former intern Samriddhi Rastogi for nudging me to apply, that shows how much everyone at team BioCompute, regardless of how short or long their stint is, cares about the company and the mission P.S.S. We are hiring full-time in-person MEMS and microfluidics engineers, check out the JD (in the blog article) and shoot us an application