European Annals of Allergy and Clinical Immunology

It's a great honor to confirm, 𝗳𝗼𝗿 𝘁𝗵𝗲 𝘀𝗲𝗰𝗼𝗻𝗱 𝘆𝗲𝗮𝗿 𝗰𝗼𝗻𝘀𝗲𝗰𝘂𝘁𝗶𝘃𝗲𝗹𝘆, the achievement of the 𝕀𝕄ℙ𝔸ℂ𝕋 𝔽𝔸ℂ𝕋𝕆ℝ: 𝟮.𝟲 during the year 2023. +0.3 𝘱𝘰𝘪𝘯𝘵𝘴 𝘪𝘯 𝘤𝘰𝘮𝘱𝘢𝘳𝘪𝘴𝘰𝘯 𝘸𝘪𝘵𝘩 𝘵𝘩𝘦 2022. Thanks to everyone who recognize - every single day - our Journal as a serious product for #professional growth and #knowledge diffusion in the field of #allergy and #immunology. AAIITO Società Scientifica

𝗛𝗼𝗺𝗮 𝗦𝗮𝗱𝗿𝗶, 𝗔𝘁𝗼𝘀𝘀𝗮 𝗠𝗮𝗱𝗮𝗻𝗶𝗽𝗼𝘂𝗿, 𝗡𝗲𝗴𝗮𝗿 𝗧𝗼𝗮𝗺𝗶, 𝗠𝗮𝗵𝗺𝗼𝗼𝗱 𝗕𝗮𝗸𝗵𝘁𝗶𝗮𝗿𝗶, 𝗛𝗮𝗱𝗶 𝗠𝗼𝗻𝘁𝗮𝘇𝗲𝗿𝗹𝗼𝘁𝗳𝗲𝗹𝗮𝗵𝗶, 𝗘𝗵𝘀𝗮𝗻 𝗭𝗮𝗵𝗺𝗮𝘁𝗸𝗲𝘀𝗵, Zandifar Atefeh and marzieh tavakol suggested that #inflammation from #allergies may increase #seizure risk in children. 𝗡𝗼 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁 𝗹𝗶𝗻𝗸 𝘄𝗮𝘀 𝗳𝗼𝘂𝗻𝗱 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗮𝗹𝗹𝗲𝗿𝗴𝗶𝗰 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀 𝗮𝗻𝗱 𝘀𝗲𝗶𝘇𝘂𝗿𝗲𝘀. However, febrile #convulsions were associated with the number of 𝗰𝗼𝗺𝗼𝗿𝗯𝗶𝗱 𝗮𝗹𝗹𝗲𝗿𝗴𝗶𝗰 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀. A significant link was also found between mothers’ allergic diseases and idiopathic #epilepsy in children indicating that 𝗺𝗼𝘁𝗵𝗲𝗿𝘀’ 𝗮𝗹𝗹𝗲𝗿𝗴𝗶𝗰 𝗰𝗼𝗻𝗱𝗶𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗺𝗼𝗿𝗲 𝘀𝘁𝗿𝗼𝗻𝗴𝗹𝘆 𝗹𝗶𝗻𝗸𝗲𝗱 𝘁𝗼 𝗶𝗱𝗶𝗼𝗽𝗮𝘁𝗵𝗶𝗰 𝗲𝗽𝗶𝗹𝗲𝗽𝘀𝘆 in children than fathers’.

A 6-month study reveals insights into 𝗰𝗵𝗿𝗼𝗻𝗶𝗰 𝘀𝗽𝗼𝗻𝘁𝗮𝗻𝗲𝗼𝘂𝘀 𝘂𝗿𝘁𝗶𝗰𝗮𝗿𝗶𝗮 (CSU), challenging our understanding of this perplexing condition. Lukas Jörg, 𝗡𝗶𝗰𝗼𝗹𝗲 𝗠𝘂𝗲𝗹𝗹𝗲𝗿-𝗪𝗶𝗿𝘁𝗵, Kevin Kammermann, Odile Stalder, Werner Pichler and 𝗢𝗹𝗶𝘃𝗲𝗿 𝗛𝗮𝘂𝘀𝗺𝗮𝗻𝗻 found a paradoxical relationship between #autoantibody quantity and quality: as CSU patients' autoantibody levels surged, their functional affinity unexpectedly declined. Surprisingly, #basophil activation remained stable despite fluctuating autoantibody levels. This suggests the CU-BAT test might be superior for diagnosing #autoimmune CSU compared to antibody measurements alone. This research not only challenges assumptions but paves the way for a more nuanced understanding of CSU. It's a must-read for anyone looking to scratch beneath the surface of this complex condition!

Eosinophilic esophagitis (EoE) is a chronic 𝗲𝘀𝗼𝗽𝗵𝗮𝗴𝗲𝗮𝗹 disease linked to atopy. The study of Leonor Esteves Caldeira, Rita Limão, Rita Brás, Elisa Pedro and Célia Costa aimed to see if sensitization to airborne and food #allergens correlates with EoE severity and to evaluate clinical and laboratory characteristics. The association between age at diagnosis, disease duration, allergen sensitization, serum IgE, blood #eosinophil counts, and severe clinical symptoms impacting quality of life and and histological #disease was evaluated. Among 92 patients (83% male, 87% atopic), the average diagnosis delay was 4 years. #Sensitization to #aeroallergens was 84%, and food sensitization was 71%. Severe clinical disease was seen in 55%, and histological severity in 37%. Severe clinical disease was linked to longer disease duration before diagnosis. 𝗣𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗶𝘁𝗵 𝗳𝗼𝗼𝗱 𝗶𝗺𝗽𝗮𝗰𝘁𝗶𝗼𝗻 𝘄𝗲𝗿𝗲 𝗼𝗹𝗱𝗲𝗿 𝗮𝘁 𝗱𝗶𝗮𝗴𝗻𝗼𝘀𝗶𝘀. No significant link was found between allergen sensitization, serum IgE, blood eosinophils, and disease severity.

📣 ᴛᴏᴅᴀʏ ᴡᴇ ʜᴀᴠᴇ ʀᴇʟᴇᴀꜱᴇᴅ ᴛʜᴇ ɴᴏᴠᴇᴍʙᴇʀ ɪꜱꜱᴜᴇ! 📣 𝘼𝙧𝙚 𝙮𝙤𝙪 𝙧𝙚𝙖𝙙𝙮 𝙛𝙤𝙧 𝙩𝙝𝙚 𝙡𝙖𝙨𝙩 #𝙧𝙚𝙫𝙞𝙚𝙬 𝙤𝙛 𝙩𝙝𝙚 𝙮𝙚𝙖𝙧? 𝗔𝗹𝗲𝘅𝗮𝗻𝗱𝗲𝗿 𝗣𝗮𝗺𝗽𝘂𝗿𝗮, 𝗡𝗮𝘁𝗮𝗹𝗶𝗮 𝗘𝘀𝗮𝗸𝗼𝘃𝗮, 𝗦𝗲𝗿𝗴𝗲𝘆 𝗭𝗶𝗺𝗶𝗻, 𝗘𝘃𝗴𝗲𝗻𝗶𝗮 𝗙𝗶𝗹𝗶𝗽𝗽𝗼𝘃𝗮 reviewed the current data on potential #biomarkers of #anaphylaxis and the possibilities and perspectives for their use in future clinical practice. Anaphylaxis is a 𝘀𝗲𝘃𝗲𝗿𝗲, 𝗳𝗮𝘀𝘁-𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗶𝗻𝗴, 𝗮𝗻𝗱 𝗹𝗶𝗳𝗲-𝘁𝗵𝗿𝗲𝗮𝘁𝗲𝗻𝗶𝗻𝗴 systemic hypersensitivity reaction. These biomarkers could become crucial tools for #diagnosing, #preventing, #assessing risk, #stratifying severity, and #developing new treatments for anaphylaxis. Various immune and non-immune #mediators produced and released by 𝗲𝗳𝗳𝗲𝗰𝘁𝗼𝗿 𝗰𝗲𝗹𝗹 𝗽𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 are currently considered potential biomarkers.

Rosella Gallo, Ilaria Trave, 𝗚𝗶𝘂𝗹𝗶𝗮 𝗚𝗮𝘀𝗽𝗮𝗿𝗶𝗻𝗶, 𝗥𝗶𝗰𝗰𝗮𝗿𝗱𝗼 𝗖𝗮𝘀𝘁𝗲𝗹𝗹𝗶, 𝗚𝗶𝘂𝗹𝗶𝗮 𝗠𝗲𝗿𝗹𝗼, aurora parodi, 𝗘𝗺𝗮𝗻𝘂𝗲𝗹𝗲 𝗖𝗼𝘇𝘇𝗮𝗻𝗶 discuss a rare form of chronic inducible urticaria (CIndU) known as 𝗮𝗾𝘂𝗮𝗴𝗲𝗻𝗶𝗰 𝘂𝗿𝘁𝗶𝗰𝗮𝗿𝗶𝗮 (AquaU), specifically focusing on a 𝘀𝗮𝗹𝘁-𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝘀𝘂𝗯𝘁𝘆𝗽𝗲 (SDAU). AquaU is a rare condition where contact with #water, regardless of temperature, causes #hives on the #skin. Predominantly affects young #females; most cases are sporadic. The exact cause is unknown, but hypotheses include the generation of a 𝘁𝗼𝘅𝗶𝗰 𝘀𝘂𝗯𝘀𝘁𝗮𝗻𝗰𝗲 𝗼𝗿 𝗮𝘂𝘁𝗼-𝗮𝗹𝗹𝗲𝗿𝗴𝗲𝗻 𝗳𝗿𝗼𝗺 𝘄𝗮𝘁𝗲𝗿-𝘀𝗼𝗹𝘂𝗯𝗹𝗲 𝗰𝗼𝗺𝗽𝗼𝗻𝗲𝗻𝘁𝘀 𝗶𝗻 𝘁𝗵𝗲 𝘀𝗸𝗶𝗻. The symptoms are highly pruritic urticarial #rashes triggered by #sea bathing, tap water, #swimmingpool water, and #sweat. Nine female patients diagnosed with SDAU underwent tests with tap water and a 3.5% NaCl solution. The tests helped identify the #𝘀𝗲𝗻𝘀𝗶𝘁𝗶𝘃𝗶𝘁𝘆 𝘁𝗼 𝘀𝗮𝗹𝘁𝘆 𝘄𝗮𝘁𝗲𝗿, suggesting that #salinity might be a relevant parameter for AquaU.

A 18-month-old male without a history of atopic #diseases developed a pruritic rash 𝟮𝟬 𝗺𝗶𝗻𝘂𝘁𝗲𝘀 after consuming #oatmeal with #flaxseed. 𝗦𝗸𝗶𝗻 𝗽𝗿𝗶𝗰𝗸 𝘁𝗲𝘀𝘁𝘀 revealed #sensitization to various #nuts and #seeds, including flaxseed. It is hypothesized that the child was 𝗰𝘂𝘁𝗮𝗻𝗲𝗼𝘂𝘀𝗹𝘆 𝘀𝗲𝗻𝘀𝗶𝘁𝗶𝘇𝗲𝗱 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗵𝗶𝘀 𝗺𝗼𝘁𝗵𝗲𝗿, who consumed flaxseed during #pregnancy and #lactation. 𝗔𝘃𝗼𝗶𝗱𝗮𝗻𝗰𝗲 of flaxseed 𝗶𝘀 𝗿𝗲𝗰𝗼𝗺𝗺𝗲𝗻𝗱𝗲𝗱, but the child can consume products with minimal traces. 𝗔𝗹𝗮𝗻𝗮 𝗫𝗮𝘃𝗶𝗲𝗿 𝗱𝗲 𝗔𝗹𝗺𝗲𝗶𝗱𝗮, Travis Satnarine, 𝗝𝗲𝗻𝗻𝗶𝗳𝗲𝗿 𝗚𝗲𝗯𝗯𝗶𝗮, Hugh. Sampson, Gary Kleiner and 𝗠𝗲𝗹𝗶𝘀𝘀𝗮 𝗚𝗮𝗻𝘀 concluded that with the increasing use of flaxseed for its health #benefits of high content of 𝗼𝗺𝗲𝗴𝗮-𝟯 𝗳𝗮𝘁𝘁𝘆 𝗮𝗰𝗶𝗱𝘀 𝗮𝗻𝗱 𝗹𝗮𝘅𝗮𝘁𝗶𝘃𝗲 𝗲𝗳𝗳𝗲𝗰𝘁, allergic reactions are likely to rise.

𝗦𝗲𝗹𝗺𝗮 𝗬𝗲ş𝗶𝗹𝗸𝗮𝘆𝗮, 𝗞𝘂𝗿𝘁𝘂𝗹𝘂ş 𝗔𝗸𝘀𝘂, Gürgün Tuğçe Vural Solak, Özgür Akkale, 𝗢𝗻𝘂𝗿 𝗧𝗲𝗹𝗹𝗶, 𝗛𝗮𝘁𝗶𝗰𝗲 Ç𝗲𝗹𝗶𝗸 𝗧𝘂ğ𝗹𝘂, Gözde Köycü Buhari, 𝗦𝗮𝗸𝗶𝗻𝗲 𝗡𝗮𝘇𝗶𝗸 𝗕𝗮𝗵ç𝗲𝗰𝗶𝗼ğ𝗹𝘂 and Ş𝗲𝗻𝗮𝘆 𝗗𝗲𝗺𝗶𝗿 aimed to investigate: ➡ the clinical remission success of #biologics in 74 adults followed-up due to severe asthma who were treated with #mepolizumab or #omalizumab with severe #asthma; ➡ the factors associated with #remission. 𝗢𝗺𝗮𝗹𝗶𝘇𝘂𝗺𝗮𝗯 and 𝗺𝗲𝗽𝗼𝗹𝗶𝘇𝘂𝗺𝗮𝗯 provide significant clinical remission 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗿𝗲𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 in severe asthma. #FEV1% predicted is a variable that can independently predict clinical remission among severe asthmatics receiving biologic agents.

Cláudia Varandas, Leonor Esteves Caldeira et al. (*) aimed to raise awareness about hereditary #angioedema (HAE). They included a cohort of 126 patients followed in a single #Portuguese center and found a long delay in HAE #diagnosis, especially in patients without family history. The most common #triggers: ✔ #stress ✔ #trauma ✔ #infection The most common #symptoms: ✔ #cutaneous ✔ #gastrointestinal ✔ #respiratory The correct distinction between HAE and other common causes of angioedema is critical, allowing reduction of diagnostic delay, improvement of adequate management, and ultimately improving outcomes and quality of life of HAE patients. (*) 𝗦𝘂𝘀𝗮𝗻𝗮 𝗟. 𝗦𝗶𝗹𝘃𝗮, 𝗖é𝗹𝗶𝗮 𝗖𝗼𝘀𝘁𝗮, 𝗥𝗶𝘁𝗮 𝗟𝗶𝗺ã𝗼, 𝗠𝗮𝗿𝗶𝗮 𝗜𝗻ê𝘀 𝗦𝗶𝗹𝘃𝗮, 𝗔𝗻𝗮𝗯𝗲𝗹𝗮 𝗟𝗼𝗽𝗲𝘀, 𝗝𝗼𝗮𝗻𝗮 𝗖𝗮𝗶𝗮𝗱𝗼, 𝗝𝗼𝗮𝗻𝗮 𝗖𝗼𝘀𝗺𝗲, 𝗘𝘀𝘁𝗿𝗲𝗹𝗹𝗮 𝗔𝗹𝗼𝗻𝘀𝗼, 𝗝𝗼ã𝗼 𝗠𝗮𝗿𝗰𝗲𝗹𝗶𝗻𝗼, 𝗙á𝘁𝗶𝗺𝗮 𝗖𝗮𝗯𝗿𝗮𝗹 𝗗𝘂𝗮𝗿𝘁𝗲, 𝗡𝗮𝘁á𝗹𝗶𝗮 𝗣á𝗿𝗶𝘀 𝗙𝗲𝗿𝗻𝗮𝗻𝗱𝗲𝘀, 𝗠𝗮𝗿𝘁𝗮 𝗡𝗲𝘁𝗼, 𝗘𝗹𝗶𝘀𝗮 𝗣𝗲𝗱𝗿𝗼, 𝗠𝗮𝗻𝘂𝗲𝗹 𝗕𝗿𝗮𝗻𝗰𝗼 𝗙𝗲𝗿𝗿𝗲𝗶𝗿𝗮, 𝗔𝗺é𝗹𝗶𝗮 𝗦𝗽í𝗻𝗼𝗹𝗮 𝗦𝗮𝗻𝘁𝗼𝘀𝗦𝘂𝘀𝗮𝗻𝗮 𝗟. 𝗦𝗶𝗹𝘃𝗮, 𝗖é𝗹𝗶𝗮 𝗖𝗼𝘀𝘁𝗮, 𝗥𝗶𝘁𝗮 𝗟𝗶𝗺ã𝗼, 𝗠𝗮𝗿𝗶𝗮 𝗜𝗻ê𝘀 𝗦𝗶𝗹𝘃𝗮, 𝗔𝗻𝗮𝗯𝗲𝗹𝗮 𝗟𝗼𝗽𝗲𝘀, 𝗝𝗼𝗮𝗻𝗮 𝗖𝗮𝗶𝗮𝗱𝗼, 𝗝𝗼𝗮𝗻𝗮 𝗖𝗼𝘀𝗺𝗲, 𝗘𝘀𝘁𝗿𝗲𝗹𝗹𝗮 𝗔𝗹𝗼𝗻𝘀𝗼, 𝗝𝗼ã𝗼 𝗠𝗮𝗿𝗰𝗲𝗹𝗶𝗻𝗼, 𝗙á𝘁𝗶𝗺𝗮 𝗖𝗮𝗯𝗿𝗮𝗹 𝗗𝘂𝗮𝗿𝘁𝗲, 𝗡𝗮𝘁á𝗹𝗶𝗮 𝗣á𝗿𝗶𝘀 𝗙𝗲𝗿𝗻𝗮𝗻𝗱𝗲𝘀, 𝗠𝗮𝗿𝘁𝗮 𝗡𝗲𝘁𝗼, 𝗘𝗹𝗶𝘀𝗮 𝗣𝗲𝗱𝗿𝗼, 𝗠𝗮𝗻𝘂𝗲𝗹 𝗕𝗿𝗮𝗻𝗰𝗼 𝗙𝗲𝗿𝗿𝗲𝗶𝗿𝗮, 𝗔𝗺é𝗹𝗶𝗮 𝗦𝗽í𝗻𝗼𝗹𝗮 𝗦𝗮𝗻𝘁𝗼𝘀

The sudy signed by Pedro Simão Coelho, Gonçalo Martins dos Santos, 𝗠𝗶𝗹𝗮 𝗠𝗶𝗸𝗼𝘃𝗶𝗰, 𝗝𝗼ã𝗼 𝗢𝗹𝗶𝘃𝗲𝗶𝗿𝗮, 𝗦ó𝗻𝗶𝗮 𝗥𝗼𝘀𝗮, 𝗘𝗱𝘂𝗮𝗿𝗱𝗼 𝗦𝗶𝗹𝘃𝗮 and Paula Leiria Pinto evaluates the #frequency of #drug allergies and their impact on treatment among hospitalized patients in a Lisbon hospital. It involved a retrospective analysis of 3,046 adult patients with documented drug allergies from 2018 to 2020. The study found that 𝟭𝟱.𝟰% 𝗼𝗳 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝗵𝗮𝗱 𝗮 𝗱𝗿𝘂𝗴 𝗮𝗹𝗹𝗲𝗿𝗴𝘆 𝗹𝗮𝗯𝗲𝗹, 𝗵𝗶𝗴𝗵𝗲𝗿 𝘁𝗵𝗮𝗻 𝘁𝗵𝗲 𝗴𝗲𝗻𝗲𝗿𝗮𝗹 𝗽𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻'𝘀 𝟴%. The most commonly reported allergens were #antibiotics, non-steroidal #antiinflammatory drugs, and #radiocontrast media. Drug allergy labels led to the use of second-line treatments in 14.5% of cases, 𝗶𝗻𝗰𝗿𝗲𝗮𝘀𝗶𝗻𝗴 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗰𝗼𝘀𝘁𝘀 𝗯𝘆 𝟮.𝟰 𝘁𝗶𝗺𝗲𝘀. However, many allergy records were incomplete, and some had previously tolerated the drug without adverse reactions, suggesting potential #overdiagnosis. Only 1.9% of patients were referred for allergy evaluation post-discharge, with several allergy suspicions later excluded after proper testing. The study suggests that 𝗼𝘃𝗲𝗿𝗱𝗶𝗮𝗴𝗻𝗼𝘀𝗶𝘀 𝗼𝗳 𝗱𝗿𝘂𝗴 𝗮𝗹𝗹𝗲𝗿𝗴𝗶𝗲𝘀, especially in hospitalized patients, 𝗹𝗲𝗮𝗱𝘀 𝘁𝗼 𝘂𝗻𝗻𝗲𝗰𝗲𝘀𝘀𝗮𝗿𝘆 𝗮𝘃𝗼𝗶𝗱𝗮𝗻𝗰𝗲 𝗼𝗳 𝗰𝗲𝗿𝘁𝗮𝗶𝗻 𝗱𝗿𝘂𝗴𝘀, resulting in 𝗵𝗶𝗴𝗵𝗲𝗿 #costs and potential treatment complications. Improved #communication between departments, thorough documentation, and routine allergy evaluation, are essential to enhance patient care and reduce #healthcare costs associated with drug allergy labels.