EV Biotech is a microbial cell factory (MCF) strain development company. EV Biotech distinguishes itself by the use of state-of-the-art computational modelling. Using cutting-edge scientific developments in systems biology we create computational models of bacterial strains to predict most optimal strain modifications, growth media supplementation and scale up optimization in line with the rational design strategy.
Fast-feedback loop between strain modellers and engineers increases development speed and efficiency of the MCF strain development pipeline. Preliminary models can be updated and enhanced quickly if needed, due to a close collaboration between a theoretical and experimental departments.
EV Biotech creates highly effective compound production strains on demand.
Contact us for an offer.
🔬 The Weirdest Molecules Ever Brewed in Industrial Biotech! 🍻
Ever wondered what happens when biotech meets a little creativity and a whole lot of fermentation magic? Spoiler alert: it gets weird, wild, and wonderfully innovative!
Here are some of the weirdest molecules ever produced through fermentation—proving that science can be both cool and bizarre!
🕷️Spider Silk Proteins 🕷️: Nope, not kidding! Fermentation has been used to produce spider silk proteins without spiders! This super-strong, super-light material has incredible applications—from next-gen textiles to medical sutures! This is a product EV Biotech has successfully demonstrated in the past (https://lnkd.in/dDeUiPBd).
🐋Whale Vomit (Ambergris) Compound 🐋: Traditionally, this was a rare and expensive ingredient in luxury perfumes. Now, biotech has cracked the code with fermentation to produce the same compound, saving whales and still making us smell fabulous! Amyris produces sclareol to replace Ambergris!
🍬Squalene from Sugar 🍬: Squalene, a molecule found in shark liver oil and used in cosmetics, is now being produced via fermentation from sugar. The result? A cruelty-free, vegan version that’s great for your skin and the planet! Produced with synthetic biology by Croda Pharma
👞Microbial Leather 👞: Forget cows—let's brew leather! Scientists are fermenting yeast to create microbial leather, offering an eco-friendly and ethical alternative to traditional animal leather.
🎨Natural “Unnatural” Colors 🎨: Biotech has found a way to produce natural pigments—like vibrant blues, deep purples, and neon greens—using fermentation. Some of these pigments don't even exist in nature, making them a unique, sustainable way to colour our world!
From vegan leather to whale-free vomit scents, fermentation is taking us into a whole new world of possibilities—often weirder than we could ever imagine! The future is not just bio-based; it's creatively brewed! 🌿
What’s the wildest molecule you think we should ferment next? Drop your ideas below! 👇
#Biotech#Innovation#Fermentation#IndustrialBiotech#Sustainability#WeirdScience#FutureOfMaterials#CircularEconomy#SyntheticBiology
🚀 What's Your Biggest Challenge in Metabolic Engineering? 🚀
At EV Biotech, we're all about pushing the boundaries of what's possible in metabolic engineering. With the upcoming launch of OptiStrain, our revolutionary Virtual Strain Engineering Assistant, we're excited to help researchers like you overcome the toughest obstacles in strain engineering.
But first, we want to hear from YOU! 💬
Vote in our poll below and share your specific challenges in the comments!
🔍 Question for the Experts: Drew Endy, George Church, Christina Smolke, Edward Shenderovich, Claire Skentelbery, Roel Bovenberg, Prateek M., Joshua Britton, Emily Leproust, Stef van Grieken, John Cumbers, Jay Keasling, Damien Perriman, Arvind Gupta — How do you see digital tools shaping the future of metabolic engineering? We'd love to hear your thoughts on the evolving landscape!
Your insights will help us tailor our future content and demonstrate how OptiStrain can address your needs.
OptiStrain is designed to tackle these challenges head-on, giving you the tools you need to optimize strain designs, save valuable time, and reduce costs. Don’t miss out on the future of metabolic modeling—Pre-Register Now at www.evbio.tech to be among the first to access OptiStrain!
Let's shape the future of metabolic engineering together! 💡
#MetabolicEngineering#SynBio#Biotech#StrainEngineering#OptiStrain
Last month, we explored the critical role of strain engineering in bringing bioproducts to scale and to market in an insightful webinar hosted by Synonym on ‘Optimizing Strain Performance for Commercialization.’ Together with Vectron Biosolutions AS, SynBioBeta, and Enduro.
Our discussion underscored the significance of strain development and stability in scaling biomanufacturing. It became clear that achieving economies of scale isn’t enough; optimized strains tailored for large-scale production are key to unlocking the full potential of biomanufacturing in the years ahead.
Our expert panel highlighted how strain optimization can drive productivity, enhance process stability, and reduce costs in biomanufacturing.
🎥 Missed the live session? No problem! Comment below or email us at info@evbio.tech to get access to the webinar recording and discover valuable insights into the future of biomanufacturing.
A big thank you to everyone who participated live! Let’s keep pushing the boundaries of biomanufacturing together.
#bioeconomy#biomanufacturing#sustainability#innovation#webinar#strainengineering#strainoptimization#fermentation#precisionfermentation#bioproductionatscale#synbio
Topic of the day: Phenotypic instability 💔
Try as we might, microorganisms don’t always do what we design them to do. In a recent mini-review published by our very own Max Guillaume, titled “Assessing and Reducing Phenotypic Instability in Cyanobacteria,” Max discusses a rather insidious obstacle when it comes to the scale-up process of production fermentation: phenotypic instability. Phenotypic instability is a phenomenon where your production culture gradually stops producing over time, and production cannot be rescued from the same culture. The paper outlines how this can be due to the metabolic burden of production itself!
But fear not! Max also discusses how we can use genome-scale modelling and various modelling techniques, precisely what we do here at EV Biotech, to tackle and/or mitigate this challenge. Although this review is primarily focused on cyanobacteria, phenotypic instability has been observed in a variety of different organisms and the underlying principles for solving this puzzle are not inherent to one organism. This paper is also closely related to the work of our colleague Anne Hensen, who is currently focusing on modelling strain degeneration during the scale-up process.
Phenotypic instability often goes overlooked at the laboratory scale because it is usually only detectable in continuous or large-scale bioreactors, like those you see at the industrial scale. It is important to be cognizant of this phenomenon and to address it early on, because if you don’t, well, in the immortal words of Dr Ian Malcolm, “Life, uh, finds a way.”
Read the whole review here: https://lnkd.in/eck8U7TP
Curious to know more? Check out our website (https://evbio.tech/) on how EV Biotech's no-nonsense, modelling-driven DBTL approach can help you out, and reach out to us with your questions.
#biotechnology#microorganisms#scaleup#fermentation#degeneration#productivity#DBTL#modelling#CRO#industrial
☀️ The summer is upon us and while some enjoy well-deserved holidays, our strain engineering and fermentation labs are running at full speed. Today, we want to introduce you to one of our recent products of commercial interest: Amylase. ☀️
Amylase, a crucial enzyme in various industries, is predominantly produced through the fermentation of microorganisms such as fungi, yeast or bacteria. This biotechnological approach offers a sustainable and efficient method to meet the growing demand for this versatile enzyme.
🔬 Why Amylase? Amylase catalyses the breakdown of starches into simple sugars, playing a vital role in:
- Food and Beverage Industry: Enhancing bread quality, brewing beer, and producing high-fructose corn syrup.
- Dairy Industry: Amylase can break down milk into monomers which are responsible for flavors in cheese
- Textile Industry: Desizing fabrics.
- Paper Industry: Modifying starches for coating and sizing.
- Biofuel Production: Converting starches into fermentable sugars.
♻️ Circular Economy and Waste Valorization: Amylase also plays a pivotal role in the circular economy by enabling the conversion of agricultural and food waste into valuable products. Through side-stream valorisation, waste materials rich in starch can be transformed into useful sugars, reducing waste, and promoting sustainability and a circular economy.
💡 Market Insights: The global amylase market is experiencing robust growth, driven by the increasing demand for processed foods and beverages, advancements in biotechnology, and the rising trend of biofuels. In 2023, the market was valued at approximately $2.7 billion and is projected to reach $4.4 billion by 2033, growing at a CAGR of around 5.1% from 2024 to 2033 (Allied Market Research)
🔗 What else is brewing at EV Biotech? We recently announced the upcoming release of our ✨OptiStrain✨ tool, which will enable our clients to interact with our metabolic models, and design and test strain engineering strategies, before starting the work in the lab. Want to hear more? sign up here: https://lnkd.in/e5F9_tku#Biotechnology#Enzymes#Amylase#Sustainability#CircularEconomy#Innovation#WasteValorization#MicrobialFermentation
Video by: Arno de Vries
Nieuwe samenwerking EV Biotech x Researchable | Data-innovatiebureau🤝
We hebben recent de ontwerpfase met EV Biotech afgerond. In een ontwerpfase identificeren we eerst de behoeften en eisen van de organisatie en eindgebruikers, en stellen we een duidelijk en gedeeld begrip vast van wat het Minimum Viable Product omvat en wat niet (Scope van het MVP).
EV Biotech produceert micro-organismen om producten zoals vanille en plastic op een duurzame manier te ontwikkelen. Zij doen dit in een digitaal laboratorium waarin alle celcombinaties worden getest voor het echte laboratoriumwerk start. Tijdens dit proces worden veel data gegenereerd zoals data van experimenten, chemische reacties en simulaties.
Door de data-applicatie die wij nu mogen ontwikkelen kun je het aantal fysieke lab experimenten aanzienlijk verminderen. Via de Software-as-a-Service applicatie #OptiStrain wil EV Biotech haar klanten een virtuele assistent aanbieden die onderzoekers in staat stelt om onbeperkt digitale experimenten uit te voeren, waarbij de effecten van 'knock-outs' en verschillende koolstofbronnen op groei en productie in meer dan 10 verschillende microben worden getest.
🎯 Zeer nauwkeurig door gebruik van geavanceerde modellen
🔮 Voorspelt welke genetische aanpassingen het beste werken
👍 Makkelijk te gebruiken voor iedereen
💸 Bespaart geld en versnelt ontwikkeling
📈 Wordt regelmatig bijgewerkt met nieuwe functies
Inmiddels zijn we begonnen met de ontwikkelfase en technische realisatie van deze data-innovatie. Omdat de omgang met data centraal staat in de applicaties die wij ontwikkelen, houden we rekening met de hoogste normen voor informatiebeveiliging. Ons bedrijf is #ISO27001 gecertificeerd en daarnaast hebben we ook de ISO/IEC 25010:2023 en NEN7510-normen geïmplementeerd.
Aga WegrzynLinda DijkshoornMax VerbeekFrank BlaauwReindert VisserCarmen RozendaalMandelo
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Wij bij Researchable | Data-innovatiebureau helpen organisaties met het bedenken, ontwerpen en realiseren van impactvolle softwareapplicaties waarin de omgang met data centraal staat.
#Samenwerking#InnovatieDoorData#SoftwareOntwikkeling#Researchable#EVBiotech#DatagedrevenInnovatie
🚀🚀Prelaunch announcement - SIGN UP for the launch!! 🚀🚀
Yesterday during the webinar with SynonymEnduroVectron Biosolutions ASSynBioBeta we made a big announcement! EV Biotech is thrilled to introduce OptiStrain, our cutting-edge SaaS solution designed to revolutionize the way you approach strain engineering. This digital toolbox/suite is crafted to accelerate strain engineering by integrating advanced computational tools and genome-scale modeling, providing unparalleled precision and speed in your research.
What is OptiStrain? Optistrain is a cloud-based, user-friendly platform that serves as your virtual strain engineering assistant. It enables researchers to perform unlimited digital experiments, testing the effects of knockouts and different carbon sources on growth and production in over 10+ microbes.
How Does It Work? Our platform simulates years’ worth of lab work at the click of a button, allowing you to test hypotheses, optimize strain designs, and identify the best knockouts to enhance production. By using OptiStrain, you can significantly limit the number of physical experiments needed, saving both time and costs.
Why Choose OptiStrain?
🎯 Unmatched Accuracy: Leverage genome-scale modeling for precise insights.
🔮 Predictive Power: Identify the most effective genetic modifications to boost molecule production.
👍 User-Friendly Interface: Our intuitive design makes advanced modeling accessible to everyone.
💸 Cost-Effective: Reduce experimental costs and streamline your development process.
📈 Future-Proof: StrainOptimizer is not a static tool; it evolves with continuous updates and new features to meet your growing needs.
Key Benefits:
⏩ Accelerate Your Research: Save years of lab work with our digital solutions.
🔬 Unlimited Experimentation: Test countless hypotheses to find the best strategies.
🚀 Fast and Reliable: Achieve your research goals quicker with high precision and reliability.
👩💻 Secure and IP Safe: Your experimental work remains confidential and protected.
Join the Revolution! Pre-Register Today at www.evbio.tech !
Be among the first to experience the future of metabolic modeling. Pre-register now for our exclusive launch and get a head start on transforming your research and production capabilities. Smart strain engineering can lead us to reach cost parity according to Boston Consulting Group (BCG)