Lux Capital

Science and politics don't always mix well.... Last week, in a thought provoking op-ed for RealClearPolitics, our Josh Wolfe argues that Scientific American presidential endorsement may alienate those we need to persuade rather than change minds. The real issue: both US parties neglect long-horizon scientific research investment, CRUCIAL for peace and economic power! We urgently need the US government to invest in cutting-edge scientific discovery. This maintains our national defense, deters aggression, spawns new industries, and gives America the advantage in Great Power competition. 🧪 🧬 🔬 🇺🇸 Read the full piece here: https://lnkd.in/ekCVCbBA

A decade into their journey, the world needs Maven Clinic more than ever before. We’re excited to support the Maven team as they continue to drive innovation for women and families in this next phase of growth.

Deena Shakir of Lux Capital says every company needs an answer to AI adoption, efficiency and application https://trib.al/Ng5RNN4

We so enjoyed sponsoring and participating in Lux Capital Second Annual AI Summit today. It was a tremendous gathering of incredible leaders and talented entrepreneurs driving innovation from “Sci-Fi to Sci-Fact.” Thank you Lux team for inviting Banc of California to be part of this engaging event! #LuxAISummit #bancofcal

Small molecule optimization is complex, difficult, and expensive. At the Lux Capital AI Summit, Josh Haimson shared how Inductive Bio is transforming this process by combining unique data with cutting-edge ML models to enhance the quality and effectiveness of small molecule drug discovery. Thank you to Lux Capital and all the attendees today!

Our final conversation today at the #LuxAISummit was on AI and the future of modern war, with former SOCOM commander Tony Thomas and West Point Dean Shane Reeves. Gen. Tony Thomas: “The conversation invariably tilts to Skynet right away. I would like to disabuse us of that — that's a long way off, but it is comprehensive. In fact, as the focus has been on lethal effects and maneuver, it's absolutely about lethal maneuver, but it's [also] about maintenance, it's about logistics, it's about medical, it's about, more importantly, information ops. … AI will both be a positive player and a negative player for that in the future.” Brig. Gen. Shane Reeves: “Pick your area. If you want to talk about trying to solve the contested logistics problem in the Pacific; if you want to talk about targeting in a really complicated urban environment in Gaza or southern Lebanon; if you want to talk about collecting all the ubiquitous data that's all over the battlefield in Ukraine and trying to process it to the into the drone revolution that's taking place; or you talk about what probably Israel is trying to do right now with the Iron Dome, with missiles coming into Tel Aviv. At this moment, it's all going to be reliant on artificial intelligence … and what we have known — and we know — is that technology always wins. Technology always finds its way into the into the battle space — that's never not happened. There's a long history of this. The one I always go to is famously Pope Urban II in the end of the 11th century, realized crossbows were very effective, and they were good at piercing armor, and it was upsetting the societal norms of the time. So what did he do? He's like, ‘We're going to ban crossbows,’ right? And crossbows, anyone who used them, are excommunicated. So what does everybody do? Well, let's get a bunch of crossbows, right? And this has happened repeatedly, aircraft, submarines, balloons — you pick it — the technology finds itself into into the battle space.” Brig. Gen. Shane Reeves: “We are also increasingly recognizing that [West Point cadets] have to be AI-enabled officers. If they aren't AI-enabled, then we're going to lose. And that's just not a viable solution for us. So what did we have done? We've really aggressively stepped into this AI revolution at the military academy in lots of different ways. As mentioned, we have an academic year theme called The Human and the Machine: Leadership on the Emerging Battlefield.” … “They can take these skills with them, and they have to be AI-enabled, not just AI-comfortable, not just know about it, but they have to be able to embrace it and employ it, though, without having critical thinking skills atrophy. We still need them to be able to think through problems when all the technology perhaps goes away.”

Our last panel at the #LuxAISummit focused on AI x Bio, and included Maruan Al-Shedivat, PhD of Genesis Therapeutics, Mohammed AlQuraishi of Columbia, Alex Rives of EvolutionaryScale and Rahul Satija of NYU. Some top quotes: Mohammed: “Let me start with the long-term vision, which is probably a 20-year horizon. And to me, what that would constitute is basically a system, a computational artifact, that essentially reproduces anything you could do experimentally, right? So there's an experimental question that you need to do in the real cell. You could pose that question to the system, and essentially it gives you the same answer.” … “What I suspect is going to be true in the next few years are essentially, kind of digital twins of cellular behavior in more constrained settings…” Rahul: “I like that the theme of this, which is on the back wall, is ‘Impossible to Inevitable,’ which I think really highlights the idea of this virtual AI cell.” … “What an incredible opportunity that would be: half of my lab at NYU in the New York Genome Center is focused on doing experiments. We take cells, we perturb them in very specific ways, and then we run these very intricate measurement technologies to figure out what's happening. This costs hundreds of thousands to millions of dollars. We have PhD students, postdocs feeding the cells, making these measurements, and we're doing individual experiments at a time. The idea that we could do this at scale on a computer is absolutely transformative and incredibly exciting at the same time.” Alex:  “Nature wasn't created to be comprehensible to the unaided human intellect. What we want to do [at Evolutionary Scale] is really build tools that can … make biology programmable from first principles.” “We started with proteins, because there's an incredible wealth of data there, there's incredible impact. If you can solve that problem, [you can span] the hierarchy of biology from molecule all the way to cell to organism.”

Infrastructure is critical for running AI models effectively and efficiently, and we had an excellent pair talking about the subject during the #LuxAISummit: Vipul Ved Prakash of Together AI and Clem Delangue 🤗 of Hugging Face in conversation with Brandon Duderstadt of Nomic AI. Here are some highlighted quotes: Vipul at Together: “We can create synthetic data with more entropy, with all these different synthetic data methods. So I do see that being another exciting area, which is you don't have yield problems there. You can run experiments really quickly, and we'll see more and more of that.” Vipul at Together: “I think we need more power and more data centers. That's pretty clear. Like right now, it's way [too] difficult to find anything above 15 megawatts in North America. All these data centers have already been reserved and will not provide enough capacity for building and serving models. So I think we need more power. I also think the GPU power envelope is quite off.” Hugging Face’s Clem: “I also think that we can do some things to make AI more energy efficient today. I think this movement of only using and focusing a lot of our efforts on large generalist models is a mistake in many aspects. You don't need to take a private jet to go to work. In a similar way when you're doing like a specialized, customized use case, as I mentioned, you don't need a model that is going to tell you about the meaning of life. You can actually use a smaller model that is going to take less energy to train, take less energy to run. The world is a bit like biased right now, and a lot of the investment goes towards large, very energy-intensive models and directions, I think as a field, we can take a different direction and focus on specialized, customized, smaller models that give us a more credible path to continuing to build AI capabilities without ruining the planet.” Hugging Face’s Clem: “Usually what we see is that companies start with like using a large, generalist model behind an API, because it's easier, it's in a way safer, because that's what others are using. And after a few months, especially when it's production with users, and you start to see more users and the cost is starting to pile up, they think, ‘Okay, can we build different systems where we have more control, where we can optimize the models to run cheaper, faster, more focused on our specific use case, specific constraints?’ And that's usually when they when they start experimenting with other approaches, with taking open-source-based models and fine-tuning them, optimizing them, training them, and I think ultimately it's going to pay off for them, because it's a learning curve, right? It takes more time, it takes more investment. But at the end of the day, if you want to be an AI company, you have to be able to build AI, right?”

Grateful to Senator Mark Warner for joining the #LuxAIsummit. He has been a steady voice and has shown leadership on national security/defense, new energy sources and climate tech, and maintaining US leadership in AI. I also like his views on AI regulations.

One of the most important companies in the world for machine learning is Hugging Face, and we got a full update on the company and its activites from co-founder and CEO Clem Delangue 🤗. Here are a few highlights from the conversation at #LuxAISummit with Brandon Reeves: “We always felt like AI is a new paradigm to build software. So in a way, you have to do things differently if you want to be successful. And frankly, our goals as founders wasn't really to build a successful company.” … “If you end up building a big company that is similar to all the big companies that are out there today, I think it doesn't really move the needle. So we try to be very intentional about doing things quite differently. You [Brandon Reeves] mentioned how decentralized we are, both in terms of location, but in terms of responsibilities ownership. All team members have the freedom to develop their own products, their own projects, their own features. We have this framework where everyone can do that and progressively grow that into impactful projects. We didn't have for a very long time, product managers. We never had Community Manager, which is surprising for community platform.” “We envision a world and a field where ultimately all companies or organizations are going to do their own specialized, customized, optimized models. Right now, we're not exactly there, but my understanding is that we are pretty early in the technology cycle, and usually early in technology cycles, decision-making might not be the most rational one. It's more based on hype, or a lot of companies are basically doing what others are doing because it's safer. There's been a lot of rush in companies to adopt AI. And so it's going to be interesting to see if one thread that we're seeing that companies start by using API and then building their own models. Does this trend continue, and how it accelerates in the future?” On what’s outside text, audio and video? “One area that I'm also extremely excited about are time series. So for example, last week, NASA and IBM released on Hugging Face their climate prediction foundation model. And it's interesting because nobody talked about it [yet it’s] quite, quite a big deal. But the media is so focused and obsessed on NLP that sometimes they're missing some interesting things like that. It's a foundation model to be able to predict climate. So it's a very interesting example of AI for good, because on the topic, if you can actually improve your predictions, or make your predictions a few hours earlier, you actually have the ability to save thousands of life by, for example, telling people to evacuate regions or stuff like that.” “We're trying to advocate for regulation that fights concentration of power, because in AI, there are very strong natural tendencies for concentration of power in the hands of a few. And we're trying to do that all over the world.”