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Delving into the Human Microbiome's Mysteries with Evidilya! Embark on a journey with us into the intriguing world of the human microbiome, the complex ecosystem residing within us that is pivotal for our health and wellness. The possibilities for groundbreaking healthcare innovations through this knowledge are vast. Evidilya takes pride in being at the forefront of discovering and providing evidence in the largely unexplored realm of the human microbiome. Our innovative clinical and real-world evidence (RWE) approaches aim to reveal how these microorganisms interact with our bodies and affect various medical treatments. Our Key Research Areas: 🔬Digestive Health: We delve into the microbiome's role in digestion and nutrient absorption. Evidilya is developing interventions that could transform treatments for IBS, Crohn's disease, and colitis. 🔬Immune System Modulation: In an era where autoimmune conditions are increasing, understanding how the microbiome affects immune responses is essential. Our research focuses on creating microbiome-based therapies to enhance immune health. 🔬Mental Health Solutions: At the intersection of gut health and mental well-being, Evidilya explores how changes in the microbiome can influence mood and cognitive functions, pioneering in the promising field of psychobiotics. 🔬Chronic Disease Management: Evidilya investigates the link between our microbial companions and the management of diabetes and obesity, with the goal of devising interventions that could alter these populations for better health outcomes. 🔬Bone Health: Unveiling the gut microbiome's impact on bone density, our research investigates its role in the dynamic process of bone regeneration, crucial for maintaining bone strength. 🔬Skin Health: Evidilya studies the skin's microbiome, essential for pathogen defense, immune modulation, and skin integrity. We're exploring how balancing this microbiome can address conditions like acne, eczema, and psoriasis. ...and more Evidilya is unrelentingly devoted to pushing the boundaries of conventional research, employing thorough scientific methods and collaborating with worldwide experts. Our goal is to build a robust evidence base that not only enhances our understanding of the human microbiome but also translates this knowledge into actionable healthcare solutions. 🔬🧬 Experience this groundbreaking journey with Evidilya: contact@evidilya.com #Microbiome #HealthcareInnovation #Evidilya #MedicalResearch #FutureOfHealthcare #virtual #DCTs #ECS #LucaH #virtual

🔬The emerging field of osteomicrobiology, which explores the connection between gut microbiota and skeletal health, presents a promising avenue for preventing and treating osteoporosis. Recently, the gut microbiome has gained attention as a potential target for improving bone strength through involving microbe-derived vitamin K and short-chain fatty acids (SCFAs). It seems that SCFAs released by the gut microbiota not only have direct effects on bone remodeling, but may also affect the immune response (T cells and cytokines) that can influence the activity of osteoclasts and osteoblasts. In line with the gut-bone axis, interventions targeting gut microbiota, such as probiotics or antibiotics, have been found to affect bone remodeling and thus emerge as a novel promising therapy for osteoporosis. https://lnkd.in/dg84KqBB

🌟 Exploring the Connection Between Gut Health and Osteoporosis 🌟 Osteoporosis, the most common bone disorder, is marked by low bone mineral density and the deterioration of bone tissue, significantly increasing fracture risk. Emerging research over the past decade has highlighted the crucial role of gut microbiota in bone health and the pathology of osteoporosis. Individuals with osteoporosis or lower bone mineral density often exhibit altered gut microbiota. Studies show that gut microbiota influences bone metabolism by modulating gut function, immune response, and the endocrine system. As a result, the gut microbiota has become a novel therapeutic target for preventing bone loss and treating osteoporosis. Microbial-based functional food ingredients like probiotics, prebiotics, synbiotics, and fermented foods have been developed to alter gut microbiota composition and function, offering potential benefits to bone health. While initial results are promising, more research, including animal studies and clinical trials, is needed to fully understand the interactions between gut microbiota and bone metabolism. The gut microbiome is indirectly connected to all major organ systems and physiological processes in the body, highlighting its fundamental role in overall health. At Novel Biome, we are at the forefront of this exciting field, providing high-quality FMT (Fecal Microbiota Transplantation) products that harness the power of gut microbiota to improve health outcomes. With our commitment to safety, efficacy, and consistency, we are dedicated to advancing the potential of FMT as a key therapeutic approach for various health conditions, including osteoporosis. 🌱🦴 #GutHealth #Osteoporosis #Microbiome #BoneHealth #NovelBiome #FMT #Probiotics #Prebiotics #Synbiotics #Research #HealthcareInnovation

Prebiotics Mitigate the Detrimental Effects of High-Fat Diet on Memory, Anxiety & Microglia Functionality: in murine models. Ageing is characterised by a progressive increase in systemic inflammation and especially #neuroinflammation. Age and #diet are well known to influence the composition and functions of the gut microbiome, which affects host physiology, brain functions and behaviour. Although multiple factors play a role in the development of neuroinflammation, microglia have emerged as a crucial target. Microglia are the only macrophage population in the central nervous system (CNS) parenchyma that plays a crucial role in maintaining homeostasis and in the immune response, which depends on the activation and subsequent deactivation of microglia. Therefore, microglial dysfunction has a major impact on neuroinflammation. The gut #microbiota has been shown to significantly influence microglia from birth to adulthood in terms of development, proliferation, and function…” In this this study researchers sort to explore the relationship between #diet and #microglia functionality specifically focusing of the impact of different dietary compositions on the gut microbiota and its potential role in modulating behaviour and regulating neuroinflammation…’ In short, as illustrated in the accompanying graphic: Was establish a link between diet, animal behaviour and the functionality of microglia. The results showed negative effects of long-term consumption of a high fat diet on ageing mice, epitomised by increased body weight, glucose intolerance, anxiety, cognitive impairment and microglia dysfunction compared to ageing mice on a control diet..Significantly, They also show that, these effects were a consequence of the changes in gut microbiota modulated by the #diet. However, by adding the #prebiotics fructo- and galacto-oligosaccharides, they were able to mitigate the deleterious effects of a long-term high-fat diet. In conclusion Consequently, we can infer that the prebiotics GOS+FOS indeed have beneficial effects on the #gut microbiota and that this effect has a positive impact on reducing #neuroinflammation and overall brain health during ageing. DYD MEDICINA INTEGRATIVA di Diana Yedid DyD medicina Integrativa "THE HUMAN GUT MICROBIOME" Read More 👇

Hey everyone! 👋 Breaking down some technical terms, a new research shows changing gut microbiome (the system of good and bad bacteria in our stomach 😌) with age, can affect our bone health. This aging increases harmful inflammatory bacteria, and decreases the beneficial ones, disrupting bone metabolism and can lead to diseases like osteoporosis! 😰 But don't worry, there is good news! 🎉 Probiotic therapy and fecal microbiota transplantation (yes, it's exactly what you're thinking 💩) have potential as preventive and treatment strategies for osteoporosis and related bone diseases. Imagine, by promoting healthy aging, maintaining ageless bones could be as easy as looking after our gut! 😊 Thought you'd find it interesting. Longevity Lily 🌸 Read the full article here for more details: https://lnkd.in/eAdfQVGe #longevitylily #longevity #agingresearch #stayyoungsociety

Dr. Ronald Klatz, MD, DO Worldhealth.net Researchers have found that digestive #enzymes, particularly trypsin, can escape the #gut and damage multiple organs, potentially accelerating #aging in rats. Blocking this enzyme temporarily prevented the harmful effects, highlighting a trade-off in which the enzymes essential for life also contribute to "autodigestion" with age. Researchers are now investigating ways to inhibit these enzymes without interrupting #digestions to protect the gut lining and explore potential applications in humans. #worldhealth #antiaging #antiagingmedicine #aging #regenerativemedicine #medicine #neuroscience #GI #clinicalresearch #health https://lnkd.in/gw_m96Kz

Understanding Vaginal Microbiome Dynamics Throughout the Menstrual Cycle - A Clinical Study #Mysummary In a new study published 2 days ago, two of The Microbiome Mavericks, Henriette Svarre Nielsen and Ina Schuppe-Koistinen explored the dynamics of the vaginal microbiome throughout the menstrual cycle. The study involved 49 healthy young women. Daily vaginal swabs were collected across a menstrual cycle and sequenced using metagenomic sequencing. There is a lot to unpack, but here is what you need to know: 🔹They identified four distinct Vaginal Community Dynamics (VCDs) based on daily transitions in community state types (CSTs): constant eubiotic, constant dysbiotic, menses-related dysbiotic, and unstable dysbiotic. 🔹The study found that the stability and composition of the vaginal microbiome were significantly influenced by menstruation and sexual activity, with notable differences in phage, i.e. virus that infect bacteria, abundance and bacterial composition across different VCDs. 🔹Women with unstable vaginal microbiomes had higher phage counts, suggesting a potential role of phages in destabilizing bacterial communities, leading to dysbiosis. 🔹The vaginal microbiome in some women could shift rapidly from day to day, especially during menstruation, which was previously underappreciated. 🔹Strains of Gardnerella spp. associated with bacteriocin genes were more prevalent in unstable VCDs, hinting at a potential mechanism for maintaining dysbiosis through competitive inhibition of other bacteria. #Mythoughts The study shows that the balance of good and bad bacteria can change daily, especially around the time of menstruation. This is a great study that all women and men should know about to keep this balance healthy, which could help prevent infections and other health issues in the future. HAPPY to hear your THOUGHTS and stay POSITIVE! #Myinspiration "Curiosity is the spark that ignites the fire of discovery, leading us to explore, learn, and grow in ways we never imagined." Link to the paper here: https://lnkd.in/e7DTf2Xv Link to The Microbiome Mavericks episode with Henriette Svarre Nielsen: https://lnkd.in/encjfKmE Stay tuned this week for the new episode with Ina Schuppe-Koistinen! #microbiome #science #biology #health #pharma #diet #nutrition #probiotics #therapeutics #startup #biotech

DID YOU KNOW Your Brain is responsible for normalizing all major systems, enhancing cognitive function, and increasing communication between the brain and all bodily organs and systems? Brain Total is a dietary supplement extracted from embryonic porcine brain cells and tissues. Brain Total may improve neurological responses and increase all reflex reactions and responses. Brain Total 3 ml vial causes a gentle improvement in all Ectodermal tissue organs and all systems throughout the body. Visit CellLifeusa.com to learn more. #health #physique #brain #brainhealth #antiaging #wellness

🔬🧫🧬  Oral intake of probiotics has been shown to alter the communication along the gut-brain axis, ultimately impacting brain health. 👩⚕️ Probiotics have been shown to positively impact on depression, anxiety, stress and cognition, in numerous preclinical as well as clinical studies involving self-reported rating scales. 🧬 Recently, a growing number of studies have investigated the effects of probiotics utilising neuroimaging techniques such as (functional) magnetic resonance imaging, functional near-infrared spectroscopy, magnetoencephalography and electroencephalography, amongst others, in an effort to more objectively assess the impact of probiotics on brain structure and function. 👨🔬 However, there has been no systematic assessment of the outcomes of these studies nor the techniques utilised. Therefore, we performed a systematic review on the effects of probiotic interventions on brain health assessed by neuroimaging techniques in human adults. 🧫 Of the original 1828 articles screened, 23 articles comprising 17 studies, with totally 696 healthy subjects or patients with various diseases, were ultimately included. Neuroimaging for assessment of nutritional interventions such as probiotics is a novel approach with the majority of studies being published within the last 5 years. 🎤 To find out more, meet Julia Rode from Örebro University at the 17th IPC2024 in Prague, 18-21 June 2024, see the entire programme at https://lnkd.in/ef9hv-vv and... Hit the bell 🔔🔔🔔 to stay tuned on to International Scientific Conference on #Probiotics, #Prebiotics, #Gut #Microbiota and #Health - #IPC2024 and get updated on probiotic, prebiotic #science and #microbiota #research.

Aging and Gastrointestinal #redox Balance! Jan Homolak from the University of Zagreb / Sveučilište u Zagrebu School of Medicine underscored the significance of gut redox homeostasis, a complex interplay of essential elements for a robust gut ecosystem. His paper highlighted the necessity of establishing an electrophilic tone and mucosal gradient, along with the capacity to produce reactive oxygen species, to efficiently eliminate invading microorganisms and restore barrier integrity. The study emphasized the crucial role of redox signaling pathways like NOX2 and the H2O2 pathway in maintaining physiological balance. Looking ahead, research efforts should prioritize identifying preventative and therapeutic interventions aimed at improving GI redox homeostasis. Strengthening this system not only reduces the vulnerability of the gut to harmful stimuli but also holds the potential to optimize healthspan and longevity by mitigating age-related gut dysfunctions. 🔗 Read more: https://lnkd.in/dSn8_gr9 Redox Medicine 2024, this June in Paris, will shed light on the importance of the gastrointestinal redox balance and its role in aging. 🌐 Stay Tuned on the conference website: https://lnkd.in/dkNzFQZU #RedoxMedicineSociety #RedoxMedicine2024 #biomarkers #redoxbiology #redox #antioxidants #innovation #mitochondria #inflammation #redoxbalance #gut #gutmicrobiome #gutmicrobiota #aging #ageing