In the world of #autoimmune testing, RNP antibody results may not always be what they seem. Hear Dr. Lisa Peterson of ARUP Laboratories review RNP antigen structure, RNP antibody detection methods, and case study examples. Register for the May 7th #webinar. https://bit.ly/3U1keM1 #AutoimmuneDisease
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I design antibody to enable people live the very best version of themselves | Antibody Designer at Novo Nordisk | Health & Safety Rep. Digital Science & Innovation at Novo Nordisk
Download a dataset of ~500 antibodies with binding affinity. In the table: antibody sequence, antigen sequence. Dataset & Code: https://lnkd.in/d8EmVHPe #antibody #antibodyin #rahmab #abducation
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In the world of #autoimmune #testing, RNP antibody results may not always be what they seem. Hear Dr. Lisa Peterson of ARUP Laboratories review RNP antigen structure, RNP antibody detection methods, and case study examples. Register for the May 7th #webinar. https://bit.ly/4aEFCfR #diagnostics
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Looking to enhance your #antigenassay development? Then you should look at The Native Antigen Company's newest market leading tool! The range includes antibody pairs optimised for capture and detection, self pairing antibodies and those which have been shown to pair but have not been fully optimised. Click the link below to find your perfect match #ScienceforaSaferWorld
Enhance your antigen assay development with The Native Antigen Company's newest market-leading tool, Matched Pair Antibodies! These capture and detection antibodies are optimized for sandwich ELISA and lateral flow assay development. Find yours today by clicking the link: https://hubs.ly/Q02r1YbY0 #matchedpair #antibodies #newproductline
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Associate Dean for Oncologic Sciences, Warren Alpert Medical School, Brown University, Providence, RI
Reprogramming human B cells with custom heavy-chain antibodies https://lnkd.in/eSqZ_9j4
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The latest FDA Guidance recommends the direct detection of the CAR to determine the percentage of CAR-positive cells. Did you know that Dextramer® reagents may provide a sensitive solution for direct detection and quantification of CAR-positive cells by flow cytometry? Using Dextramer® technology, our Custom Solutions and Services team can work with you to develop custom antigen multimers for detection of CAR-T cells. Read the latest FDA Guidance for Industry released recently on “Considerations for the Development of Chimeric Antigen Receptor (CAR) T Cell Products” via the link in the comments. #CARTTherapy #fda #CellTherapy #Immunotherapy #flowcytometry
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Some of the major themes of this update relate to drug product (DP) functional quality and manufacturing consistency including: 🔎 Optimal CAR detection is direct (and functional?): "We recommend direct detection of the CAR to determine the percentage of CAR-positive cells" (Page 11) 🎯 Higher bar for cross-reactivity studies potentially including "tissue cross-reactivity studies using a monoclonal antibody or fusion protein with the same antigen recognition domain" (Page 21) ✅ CQA identification / lot acceptance criteria: "we recommend that acceptance criteria be refined to ensure batches are well-defined and consistently manufactured." (Page 6) ⚔ Minimization of recombination events (Page 3) and independent confirmation of efficacy (Page 15) for multi-CAR product. Additional points: 🚫 If pre-treated with another CAR-therapy, “evaluation of the previously administered CAR T cell levels in the cellular starting material may be appropriate” (Page 4) -- which may remain difficult for competing companies to accomplish unless target antigen multimers are used! 👋 TCR repertoire analysis of pre-transduced cells may be a benefit to ensure consistent downstream biological activity: "Thus, nonclinical evaluation may include examination of uncontrolled proliferation, in vitro and in vivo testing for T cell clonality, karyotypic analysis, TCR repertoire analysis, and specificity for viral antigens through ex vivo stimulation and recognition assay" (Page 22) #KlickmerCART #fda
The latest FDA Guidance recommends the direct detection of the CAR to determine the percentage of CAR-positive cells. Did you know that Dextramer® reagents may provide a sensitive solution for direct detection and quantification of CAR-positive cells by flow cytometry? Using Dextramer® technology, our Custom Solutions and Services team can work with you to develop custom antigen multimers for detection of CAR-T cells. Read the latest FDA Guidance for Industry released recently on “Considerations for the Development of Chimeric Antigen Receptor (CAR) T Cell Products” via the link in the comments. #CARTTherapy #fda #CellTherapy #Immunotherapy #flowcytometry
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ELISA, various antigen-antibody combinations are used, always including an enzyme-labeled antigen or antibody, and enzyme activity is measured colorimetrically. The enzyme activity is measured using a substrate that changes color when modified by the enzyme.#canada#job.
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Elecsys HBsAg II and Elecsys HBsAg II Auto Confirm Intended Use for Elecsys HBsAg II Immunoassay for the in vitro qualitative detection of hepatitis B surface antigen
Elecsys HBsAg II and Elecsys HBsAg II Auto Confirm
openexo.com
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Antibody Cross-Reactivity Antibody cross-reactivity is a phenomenon where an antibody designed to target a specific antigen also reacts with other similar antigens. This can be due to structural similarities between the primary target and other molecules, leading to unintended binding. Understanding and managing antibody cross-reactivity is crucial in both research and clinical settings to ensure specificity and accuracy. https://lnkd.in/gNByRpVQ #AntibodyCrossReactivity #AntigenRecognition #StructuralSimilarities #UnintendedBinding #Specificity #ResearchTools #ClinicalAssays #AntibodyDesign #ImmunologyResearch #KMDBioscience
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Research scholar in Biotechnology | M.sc Botany (GOLD MEDALIST)🥇 | Medicinal plants | Drug Delivery | Anticancer | Antioxidant | Antidiabetic | Antimicrobial | Biotechnology | Pharmaceuticals
Direct ELISA: ELISA, short for enzyme-linked immunosorbent assay, is a very mature method for the detection of various targets. In direct ELISA, only an enzyme-labeled primary antibody is used, meaning that secondary antibodies are not needed. The enzyme-labeled primary antibody "directly" binds to the target (antigen) that is immobilized to the plate (solid surface). Next, the enzyme linked to the primary antibody reacts with its substrate to produce a visible signal that can be measured. In this way, the antigen of interest is detected.
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Biosciences Innovation Master’s Graduate
3moomaima barkaoui