bit.bio’s Post

It's the last day at #ADPD2024 Lisbon! Are you in need of defined, functional, consistent and scalable human iPSC-derived cells to model neurodegenerative disease in vitro? Then, you need to talk to our scientists at booth #56 about how opti-ox™ powered ioCells™ can support your research and drug discovery. Not at AD/PD? Discover below how our ioDisease Model Cells™ can provide a physiologically relevant alternative to animal models. Explore how easily they can be paired with genetically matched controls from our ioWild Type Cells™ portfolio. Learn about our Alzheimer’s and Parkinson’s disease models: https://hubs.ly/Q02nqLMw0 #research #DrugDiscovery #AlzheimersDisease #ParkinsonsDisease #science #data #optiox #ioCells #ioDiseaseModelCells #microglia #HTS #ADPD #ADPD24

Did you know that in developing therapies for Alzheimer’s disease, researchers face significant challenges because fewer than 10% of findings from preclinical animal models can be translated to humans? Researchers can now access a toolbox of highly consistent, functional and physiologically relevant human ioDisease Model Cells™, powered by opti-ox™, enabling them to develop co-cultures to better represent and model complex multifactorial neurodegenerative disease in vitro. These cells contain disease-relevant mutations for early (APP V717I, APP KM670/671NL, PSEN1 M146L) and late (APOE 4/4 C112R, TREM2 R47H) onset Alzheimer’s and can be paired with genetically matched ioWild Type Cells™. This allows you to make true comparisons and systematically interrogate healthy and diseased states of physiologically relevant cells at a scale suitable for drug target discovery and validation. Learn how to incorporate physiologically relevant and consistent human cells into your research and drug discovery workflows. https://hubs.ly/Q02pZT9P0 #research #DrugDiscovery #AlzheimersDisease #ParkinsonsDisease #science #data #optiox #ioCells #ioDiseaseModelCells

New blog post! Unlocking Hope: Recent Breakthroughs in Sickle Cell Disease Research Learn about the latest advancements in SCD research and the potential for a brighter future for those affected by the disease. Read now and share with your network! #SickleCellAwareness #SCDResearch #HopeForACure

Down regulation of DNA topoisomerase IIβ exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson's disease by Down regulating tyrosine hydroxylase https://lnkd.in/dXWqt5kr

Sickle cell anemia, or sickle cell disease (SCD), is a genetic disease of the red blood cells (RBCs). A sickle cell test is a simple blood test used to determine if you have sickle cell disease (SCD) or sickle cell trait. People with SCD have red blood cells (RBCs) that are abnormally shaped. Sickle cells are shaped like a crescent moon. Normal RBCs look like doughnuts. The sickle cell test is part of routine screening performed on a baby after they’re born. However, it can be used on older children and adults when needed. Do you know your sickle cell status? #medical #bloodtest #medicallab #sicklecell

🔬 Exciting Advances in IBD Research! 🧬 A new study sheds light on the genetic, immune, and microbial factors driving Inflammatory Bowel Disease (IBD), offering hope for more targeted treatments tailored to individual patients. This breakthrough aligns perfectly with our mission at Crohn’s Colitis Cure to improve care now for those living with IBD and to be instrumental in finding a cure. At CCCure, we continue to drive innovation with initiatives like the CCCare platform and the upcoming CCCare Consumer App, empowering patients with tools that improve their care and quality of life. Read more about this exciting research here: https://lnkd.in/gBFRHfhV #IBDResearch #HealthcareInnovation #PatientEmpowerment #CrohnsDisease #UlcerativeColitis #IBDAwareness #IBDCare #PrecisionMedicine #AutoimmuneResearch

A recent study published in Nature has uncovered critical insights into the assembly of protein filaments in the brains of individuals suffering from  frontotemporal lobar degeneration with #TDP43 inclusions (FTLD-TDP) type C – a neurodegenerative disease. The data reveal that annexin A11 co-assembles with #TDP-43 in heteromeric amyloid filaments. This work challenges our previous understanding of amyloid assembly and may be of significance in the discovery and development of potential new therapies for #neurodegenerativediseases. Congratulations to the team of Diana Arseni, Takashi Nonaka, Max H. Jacobsen, Alexey G. Murzin, Laura Cracco, Sew Y. Peak-Chew, Holly J. Garringer, Ito Kawakami, Hisaomi Suzuki, Misumoto Onaya, Yuko Saito, Shigeo Murayama, Changiz Geula, Ruben Vidal, Kathy L. Newell, Marsel Mesulam, Bernardino Ghetti, Masato Hasegawa, and Benjamin Ryskeldi-Falcon on this important research. https://bit.ly/403t3s4

A rare genetic muscular disease called LGMD2B causes patients develop severe weakness in the legs and shoulders, typically requiring them to use wheelchairs for the rest of their lives. And, bizarrely, causes muscle to turn into fat. Nobody knows why. Discover how, by growing diseased muscle fibers from scratch in his lab, Nenad Bursac is getting closer to answers. https://lnkd.in/guKKsYyC #DukeEngineering #DukeBME #BiomedicalEngineering

A rare genetic muscular disease called LGMD2B causes patients develop severe weakness in the legs and shoulders, typically requiring them to use wheelchairs for the rest of their lives. And, bizarrely, causes muscle to turn into fat. Nobody knows why. Discover how, by growing diseased muscle fibers from scratch in his lab, Nenad Bursac is getting closer to answers. https://lnkd.in/guKKsYyC #DukeEngineering #DukeBME #BiomedicalEngineering

Delighted to be part of a very important study with Ravi Shah, Sadiya Khan, Nate Tucker, Matt Nayor and others, comparing to circulating proteome along the trajectory for heart failure and correlating it to outcomes as well as transcriptomic features using snRNAseq from myocardial tissue. Many expected pathways related to inflammation, fibrosis, but many novel potential targets that may be druggable in the future. Have a read: https://lnkd.in/eAiimf4S