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NEW ioCells™ ALERT! We are at #ADPD2024 to launch new opti-ox™ powered, hiPSC-derived ioDisease Model Cells™ adding 16 new products to our Alzheimer’s and Parkinson’s disease panels in different CNS cell types! You can now access a toolbox of highly consistent, functional and physiologically relevant human disease models, enabling you to develop co-cultures to better represent and model complex multifactorial neurodegenerative disease in vitro. ioDisease Model Cells can be paired with genetically matched ioWild Type Cells™ and ioCRISPR-Ready Cells™ to make true comparisons and systematically interrogate healthy and diseased states of physiologically relevant cells at a scale suitable for drug target discovery and validation. Find out more: https://lnkd.in/eev7at8H #research #DrugDiscovery #AlzheimersDisease #ParkinsonsDisease #science #data #optiox #ioCells #ioDiseaseModelCells #microglia #HTS #ADPD #ADPD24

It's the last day at #ADPD2024 Lisbon! Are you in need of defined, functional, consistent and scalable human iPSC-derived cells to model neurodegenerative disease in vitro? Then, you need to talk to our scientists at booth #56 about how opti-ox™ powered ioCells™ can support your research and drug discovery. Not at AD/PD? Discover below how our ioDisease Model Cells™ can provide a physiologically relevant alternative to animal models. Explore how easily they can be paired with genetically matched controls from our ioWild Type Cells™ portfolio. Learn about our Alzheimer’s and Parkinson’s disease models: https://hubs.ly/Q02nqLMw0 #research #DrugDiscovery #AlzheimersDisease #ParkinsonsDisease #science #data #optiox #ioCells #ioDiseaseModelCells #microglia #HTS #ADPD #ADPD24

NEW DATA ALERT! Benefit from consistent, defined and scalable human iPSC-derived disease model cells to study the impact of mutations related to Alzheimer’s and Parkinson’s in human CNS cells? Explore our latest poster to see the characterisation and functional data of our ioDisease Model Cells™ for Alzheimer’s disease. https://hubs.ly/Q02pkz1Z0 The disease model cells show protein expression of key markers. The ioMicroglia™ APOE 4/4 and TREM2 R47H Het disease models also show reduced phagocytic activity compared to the genetically matched wild-type control. #research #DrugDiscovery #AlzheimersDisease #ParkinsonsDisease #microglia #glutamatergic #neurons #science #data #optiox #ioCells #ioDiseaseModelCells

New blog post! Unlocking Hope: Recent Breakthroughs in Sickle Cell Disease Research Learn about the latest advancements in SCD research and the potential for a brighter future for those affected by the disease. Read now and share with your network! #SickleCellAwareness #SCDResearch #HopeForACure

CENTOGENE is dedicated to offering rapid and reliable diagnoses – leveraging a multiomic approach to provide the most in-depth disease understanding from the very beginning. To learn more about MOx, our multiomic portfolio - now enriched with transcriptomics, and how it is leading to accelerated precision medicine in rare and neurodegenerative diseases, visit: https://lnkd.in/euKpiYsm hashtag #MOxMonday hashtag #MOx hashtag #Multiomics hashtag #Transcriptomics hashtag #MultiomicRevolution hashtag

Down regulation of DNA topoisomerase IIβ exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson's disease by Down regulating tyrosine hydroxylase https://lnkd.in/dXWqt5kr

Sharing my recently published work on alpha-synuclein modulation of TDP-43 phase separation and aggregation in stress granules. The work highlights the molecular basis of the interplay between Parkinson's disease and ALS/FTD. The paper can be accessed through this link: https://lnkd.in/exE_bTDa #Neurodgeneration #TDP43 #alphasynuclein #parkinsonsdisease #ALS #FTD

🔬 Exciting Advances in IBD Research! 🧬 A new study sheds light on the genetic, immune, and microbial factors driving Inflammatory Bowel Disease (IBD), offering hope for more targeted treatments tailored to individual patients. This breakthrough aligns perfectly with our mission at Crohn’s Colitis Cure to improve care now for those living with IBD and to be instrumental in finding a cure. At CCCure, we continue to drive innovation with initiatives like the CCCare platform and the upcoming CCCare Consumer App, empowering patients with tools that improve their care and quality of life. Read more about this exciting research here: https://lnkd.in/gBFRHfhV #IBDResearch #HealthcareInnovation #PatientEmpowerment #CrohnsDisease #UlcerativeColitis #IBDAwareness #IBDCare #PrecisionMedicine #AutoimmuneResearch

Exciting News in Sickle Cell Disease Treatment! 🌟 Sickle cell disease is a genetic disorder impacting hemoglobin, the key molecule in red blood cells that delivers oxygen to cells throughout the body. It causes red blood cells to become rigid and sticky, shaping them into sickle or crescent moons. It causes pain, fatigue, infections, and severe complications. Traditionally, treatments focused on managing symptoms. However, a groundbreaking milestone has been achieved with the FDA approval of the first CRISPR-based treatment for sickle cell disease. CRISPR, a gene-editing tool, enables precise alterations to a patient's DNA, offering a potential cure. This significant advancement opens doors to correcting the genetic mutations causing the disease and fostering the production of healthy red blood cells. A remarkable leap forward in the quest for effective and transformative treatments! 💪 #SickleCell #CRISPR #MedicalInnovation Read the full article here: https://lnkd.in/d69CMAQk

Sickle cell anemia, or sickle cell disease (SCD), is a genetic disease of the red blood cells (RBCs). A sickle cell test is a simple blood test used to determine if you have sickle cell disease (SCD) or sickle cell trait. People with SCD have red blood cells (RBCs) that are abnormally shaped. Sickle cells are shaped like a crescent moon. Normal RBCs look like doughnuts. The sickle cell test is part of routine screening performed on a baby after they’re born. However, it can be used on older children and adults when needed. Do you know your sickle cell status? #medical #bloodtest #medicallab #sicklecell