Cleveland Clinic Lerner Research Institute’s Post

🔦 PUBLICATION UNDER THE SPOTLIGHT! Discover this groundbreaking study: "Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice" (Rosito et al., 2024) published in “Cell Death and Disease”, where our X-Light V3 Spinning Disk technology was extensively used to answer key biological questions. 🧠 The study explores the effects of dysbiosis induced by non-absorbable antibiotics on the #tumor microenvironment and mouse #metabolome. Using a mouse glioma model, they found antibiotics-induced dysbiosis alters the #gut and #brain metabolome, promotes a pro-angiogenic tumor environment, increases glioma stemness, and boosts vasculogenesis. 📖 Check out the full article here: https://lnkd.in/dMNtu382   A sincere thank you to the researchers from the Department of Physiology and Pharmacology at Sapienza Università di Roma — Dr. Maria Rosito, Dr. Giuseppina D'Alessandro, Prof. Cristina Limatola, and their team—for their outstanding contributions to this field. We are proud to support research that drives scientific progress forward! #PUTS #scientificpublication 

Check the impressive list of international speakers!

⭐TANGO2 Family Conference Speaker Spotlight!⭐ Dr. Li is a tenured Associate Professor in the Department of Medicine at Baylor College of Medicine. Her primary research objective focuses on unveiling the intricate molecular mechanisms underlying cardiac arrhythmias. The team employs genetically modified mouse models to elucidate the molecular mechanisms of common and rare forms of cardiac arrhythmias. #TANGO2ResearchFoundation #TANGO2FamilyConference2024 #TANGO2Disease

#citation Exciting findings on cytokines and chronic inflammation in #CELL 👏 ✅Researchers from Icahn School of Medicine at Mount Sinai explored the role of JAK1 in conditions like atopic dermatitis (AD) and asthma, using a human JAK1 gain-of-function variant in mice. ✅Surprisingly, this variant caused AD-like skin disease but conferred resistance to lung inflammation when limited to the stroma. ✅The study also revealed a novel role for JAK1 in vagal sensory neurons, suppressing airway inflammation. These insights suggest that JAK inhibitors could be optimized for tissue-specific precision medicine. Read more here: https://lnkd.in/gXFfcyAe Cyagen takes pride in its contribution to this groundbreaking study involving the creation of humanized mice. 🐭Explore our comprehensive humanized mouse model services here: https://lnkd.in/gBe5BuPy #cell #cellbiology #biotechnology #biotech #biotechnologie #cytokines #research #researchpaper #researchpaper #sciencecommunication #science #scienceofreading #biotechinnovation #sciencecommunity

Have you ever wondered how cells decide when to live and when to die? The intricate dance of life and death within our bodies is governed by various forms of cell death, with ferroptosis being a relatively recent discovery. This regulated process, characterized by iron-dependent lipid peroxidation, is not just a biological curiosity but holds the key to understanding and potentially treating a range of diseases, from cancer to neurodegeneration. Recent research, as highlighted in a Nature Cell Biology review, sheds light on the molecular ecosystem regulating ferroptosis. Before this study, the field faced significant challenges, such as understanding the diverse mechanisms that trigger ferroptosis and how cells defend against it. The complexity of ferroptosis, with its implications for disease and therapeutic strategies, was a puzzle with many missing pieces. This comprehensive review not only maps out the current landscape of ferroptosis research but also charts a course for future exploration. It delves into the roles of heterogeneity and plasticity in ferroptosis, the integrated antioxidant and membrane systems' role in sensitivity regulation, and the therapeutic prospects across a broad spectrum of diseases. As we stand on the brink of new medical breakthroughs, it's crucial to stay informed and engaged with the latest scientific advancements. Let's dive into the molecular intricacies of ferroptosis and explore its vast potential together. `#ScienceResearch #CellBiology #Ferroptosis #MedicalResearch #CancerTherapy #Neurodegeneration #BiomedicalScience #NatureCellBiology #InnovativeTherapies #HealthcareInnovation`

Lasted News| News medical| KMD Bioscience Friday News The discovery of a surprising way yeast used to brew beer can survive starvation could lead to new treatments for cancer. Scientists from the University of Virginia School of Medicine and collaborators from the European Molecular Biology Laboratory in Germany have jointly discovered an unprecedented adaptability that can help yeast cells enter a dormant state during nutrient deprivation. This ability to sleep under pressure reflects the ability of cancer to survive in nutrient-deprived conditions, which are accompanied by uncontrolled growth of cancer cells. By better understanding S. pombe, we can gain a better understanding of the fundamental cellular processes in both healthy and cancer cells. Dr. Ahmad Jomaa, a researcher in the Department of Molecular Physiology and Biophysics at the School of Medicine, stated that this unexpected discovery may lead to new strategies that make cancer cells more susceptible to starvation and easier to treat. https://lnkd.in/g5azgCC8 https://lnkd.in/dJnPExyr #MedicalNews #CancerResearch #YeastStudy #KMDBioscience #UVA #ScientificDiscovery #CellAdaptability #NutrientDeprivation #DormantState #SpongeYeast #CancerCells

Explore the power of in situ spatial interactomics in dissecting the intricacies of the tumor microenvironment. Join us for a webinar where we'll delve into its practical applications and insights. Presented by: Carlo Bifulco and Dr. Doroteya Raykova Navinci Diagnostics #InSituProximityLigation #ProteinProteinInteractions #SpatialInteractomics #SpatialProteomics #SpatialBiology #Webinar

🚀 Dive into groundbreaking research titled "Structure of the thrombopoietin-MPL receptor complex: A blueprint for biasing hematopoiesis", published in #Cell. 🧬 Dr. Garcia et al. from Stanford University School of Medicine utilized Tissue Cytometry to unveil insights from CD markers on bone marrow sections. 📚 Explore more through the link in the comments! #ResearchBreakthrough #TissueCytometry #ScienceInAction

World first: Monash researchers have solved the structure of a “plant-like” protein known as ‘LYCHOS’ which can detect and regulate cell growth by sensing cholesterol levels in the body, opening up an exciting new drug target for several types of cancer and neurological diseases. Published in Nature Portfolio, the Monash team used cryo‐electron microscopy to, for the first time, determine the 3D structure of LYCHOS and have shown it is a unique hybrid of a cell transporter commonly found in plants (and not humans), and a G protein-coupled receptor (GPCR). “Much like the process whereby plants move their stems and leaves toward light to receive the maximum energy for photosynthesis, the LYCHOS plant-like transporter helps human cells sense when there's enough cholesterol to start growing” - said co-lead author, Associate Professor Andrew Ellisdon. Associate Professor Ellisdon from Monash’s Biomedicine Discovery Institute and co-lead author Associate Professor Michelle Halls from the Monash Institute of Pharmaceutical Sciences spoke to Angus Dalton at The Sydney Morning Herald about what the discovery could mean for diseases perpetuated by abnormal cell growth. Integral to the research team are the study’s first authors, Dr Charlie Bayly Jones and Dr Christopher Lupton, both from the Monash BDI. Read more: https://lnkd.in/gGtfmu94 Full article: https://lnkd.in/gJN6yTJT #MonashPharm #MonashUni #Research