Clinical, Surgery and Medicine Group Journals’ Post

#citation New research sheds light on the impact of aspirin on gut health. 🌟 A study on Cell Host & Microbe from The First Affiliated Hospital of Xi'an Jiaotong University using clinical cohorts and mouse models found that aspirin suppresses the growth of a specific gut microbe, Parabacteroides goldsteinii. Supplementing mice with this microbe or its metabolite, 7-keto-lithocholic acid (7-keto-LCA), reduced aspirin-induced damage to the intestinal barrier. Findings suggest that 7-keto-LCA promotes intestinal epithelium repair by suppressing signaling through the farnesoid X receptor (FXR), highlighting the complex interplay between aspirin, gut microbiota, and gastrointestinal homeostasis. Read more here: https://lnkd.in/gazBpena Cyagen takes pride in its contribution to this groundbreaking study with our Nr1h4=flox [Fxrᶠˡ/ᶠˡ] and PVillin-Cre mice🐭Explore our Cyagen knockout catalog models here: https://lnkd.in/gqxybj-x #gutmicrobiome #guthealth #researchexcellence #research #researchimpact #science #scienceofreading #sciencecommunication #biotechnologie #biotech #biotechinnovation #mouse #aspirin

“Although bilirubin reductase is present in almost all healthy adults, the scientists found that it’s often missing from newborns. “This absence may contribute to infant jaundice and the formation of pigmented gallstones,” says Hall. If this hypothesis is confirmed, one approach to treating infant jaundice might be to add back the bacteria through a probiotic strategy, he says. The enzyme is often lacking or missing in people with inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis, according to researchers. “The absence of bilirubin microbes may also contribute to the formation of gallstones, which has been observed in some people with inflammatory bowel disease,” says Hall. More research is needed to confirm these associations before any conclusions can be made, but the findings highlight yet another reason why our gut microbiome is so vital to human health, he adds.”- what an interesting study! #gutmicrobiome #ibd #inflammation #urinecolor #crohnsdisease #jaundice #interesting

#BioChem_MDPI #biochem #article 📕 Oxidative Stress-Induced Gastrointestinal Diseases: Biology and Nanomedicines—A Review ✍ Author: Maryam Rezvani 👉 https://buff.ly/3XbNsbt 🔥 Call for Reading 🔥 Open Access 🔥 📩 For any further questions, please feel free to contact us at biochem@mdpi.com #gastrointestinal #diseases; #oxidative stress; #nanomedicine; #stimuli-responsive #nanoparticles; reactive oxygen #species

Hesperidin- Important Bioactive From Plants! Hesperidin is a flavonoid that is commonly found in citrus fruits, particularly in the peels and membranes of oranges and lemons. Among its possible health benefits: ·     Antioxidant Properties ·     Anti-Inflammatory Effects ·     Cardioprotective ·     Blood Vessel Health ·     Immune System Support   ·     Neuroprotective Effects ·     Anti-Cancer Potential ·     Antiviral Activity ·     Anti-Allergic Effects ·     Skin Health The main area of interest for Hesperidin seems to be for its use in inflammation or conditions where inflammation is playing a key role, especially due to its combination of anti-inflammatory and antioxidant activities. Hesperidin’s anti-inflammatory activity has been observed in a number of models and physiological processes and it shows promise for benefitting cardiovascular health, neurological health, psychiatric mechanisms, lipid-lowering and insulin-sensitizing, among other uses. Research has indicated that Hesperidin enhances activities of other antioxidants and enzymes, and has been combined with other nutrients in clinical research. For example, combined with calcium it may help preserve bone health in postmenopausal women. #bioactives #medicinalplants #phytochemicals #ethnobotany #hesperidin

🔬 New Research Unveils Gut Microbiota's Role in Diabetic Nephropathy Risk In a recent study, researchers have uncovered potential causal links between specific gut microbiota compositions and the risk of developing diabetic nephropathy (DN), a major diabetic complication. 🌐 Study Insights Utilizing data from the largest genome-wide association study (GWAS) aggregated by the MiBioGen consortium and DN data from the IEU database, the study employed the inverse-variance weighting (IVW) method to explore these associations. Key findings include: Protective Microbiota: Genus Dialister shows a strong protective correlation against DN. Similar protective effects were observed in classes Gammaproteobacteria and Lentisphaeria, and phylum Proteobacteria. Risks Associated with Certain Microbiota: Conversely, genus LachnospiraceaeUCG008, order Bacteroidales, and genus Terrisporobacter were found to increase the risk of developing DN. 💡 This study not only establishes a causal relationship between the genus Dialister and a reduced risk of DN but also highlights the need for further clinical trials. These trials will aim to confirm the protective effects of probiotics containing these beneficial bacteria and elucidate the mechanisms behind their protective properties. #diabetes #microbiomeresearch #clinicaltrials https://lnkd.in/dQMDGyyb

Interplay between the Chaperone System and Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus Pathogenesis: Is Molecular Mimicry the Missing Link between Those Two Factors? https://lnkd.in/dVaRpQqa

Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach Here, the authors employ multi-omics on a cohort comprising three generations of family members, showing that fecal microbiota populations, functions, and metabolome of infants vary greatly from their maternal lineage, exhibiting a less diverse microbiota and differences in various metabolite classes including short- and branched-chain fatty acids. https://lnkd.in/eZtkvN6v

Targeting the Microbiota by Medical Professionals: Where Are We Now? Koen Venema, Beneficial Microbes Consultancy, the Netherlands, shared his insights on the topic during #TargetingMicrobiota2024. Key points covered: 🔹 Gut microbiota’s established role in health and disease 🔹 Challenges in translating microbiota insights into real-life clinical applications 🔹 Large inter-individual differences in microbiota composition, influenced by genetics, diet, and lifestyle 🔹 Functional similarities between individuals despite microbial diversity 🔹 Limited but promising applications like fecal microbiota transplantation for C. difficile infection 🔹 Need for guidance on selecting specific probiotic strains for patients Dr. Venema’s presentation provided a critical overview of the current state of microbiota-targeted approaches in medical practice. #InternationalSocietyofMicrobiota #TargetingMicrobiota #microbiomeresearch #microbiome #microbiota #guthealth