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October issue from #CellReports. See below to learn about the cover and featured content👇 and access the full issue here: https://lnkd.in/dyDaP62X On the cover: Navigating crevasses at night is aided by spatial learning and memory, which requires forms of synaptic plasticity such as long-term potentiation (LTP). In this issue of Cell Reports, Rumian et al. describe how the different phases of LTP are mediated by distinct CaMKII functions. The picture was taken on the slopes of Cotopaxi, an active stratovolcano in Ecuador, by Ulli Bayer. Featured content: 🔵 "Metabolite regulation of #epigenetics in #cancer" Shanghai Medical College of Fudan University Authors: Pu Wang, Lei-Lei Chen, Yue Xiong, Dan Ye 🔵 "Integration of #genetic and #chromatin modification data pinpoints #autoimmune-specific remodeling of enhancer landscape in CD4+ #Tcells" EMBL European Molecular Biology Laboratory, University of Tartu, Stanford University, GSK, Universidad de Málaga Authors: Neha Daga, PhD, Nila Servaas, Kai Kisand, Dewi Moonen, Christian Arnold, PhD, Armando R., Epp Kaleviste, Kingo Kulli, Reet Kuuse, Katrin Ulst, Lars Steinmetz, Pärt Peterson, Nikolina Nakic, Judith Zaugg 🔵 "Mitotic ER-mitochondria contact enhances #mitochondrial Ca2+ influx to promote #celldivision" Peking University, Kunming University of Science and Technology Authors: Gan Zhao, Mingkang Jia, Shicong Zhu, He Ren, Guopeng Wang, Guangwei Xin, Mengjie Sun, Xiangyang Wang, Qiaoyu Lin, Qing Jiang, Chuanmao Zhang

#CellReports is now on LinkedIn! Read the latest issue below.

📅 The next February 13th,10.00-12.00, we invite you to participate in our specialized event on Emerging OMICS Techniques in Medical Research, focusing on Metabolomics, Lipidomics, and Proteomics and their applications in health research 🔬   🌟 The event will feature insights from experts in the OMICS field:   ☑ Paolo Bonini (oloBion) will introduce how innovative techniques such as metabolomics, lipidomics, and proteomics are making significant strides in biomedical research. ☑ Jacob Folz (ETH Zürich) will share insights into the application of OMICS in non-invasive and longitudinal profiles, highlighting its role in understanding the microbiome and metabolome in physiology and diseases.   ☑ Raquel Cumeras (Universitat Rovira i Virgili) will showcase the application of metabolomics techniques in oncological research.   📍 The event will take place in Parc Científic de Barcelona (Sala Dolors Aleu). Don't miss the opportunity to explore these cases and interact with the experts and other attendees during our Coffee & Snack after the presentations ☕🍪   Register now at https://wkf.ms/3RTo1c7   #BCNHealthInnovationWeek #MedicalResearch #OMICTechniques

💡 Research highlight from the Max Planck Yearbook! Do we really need both copies of the chromosomes we inherit from our mother and father? According to a fundamental principle in biology, nature does not act without a purpose. For certain genes, having one copy is actually sufficient. In these cases, the duplicate on the second chromosome can be silenced without having any impact on the organism. For other genes, however, a mutation or inactivation in just one of the two copies can trigger a serious disease. https://lnkd.in/e6b8YBb6 🔦 Background: The Max Planck Society annually publishes a scientific research report, digitally presented as a yearbook. This publication contains articles composed by varied research groups across all institutes, showcasing the diverse range of research undertaken in over 84 Max Planck Institutes. Out of these numerous reports, only a select few are highlighted and included in a refined print version. Among them is this year’s Highlight is a story by Maria Shvedunova, Meike Wiese, PhD and Asifa Akhtar. Their groundbreaking study uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each #chromosome & reveals a communication system between parental alleles but also points to potential therapeutic strategies for #diseases associated with haploinsufficient genes. Original Article in Nature Magazine: https://lnkd.in/euBD8WdB

Reflecting on a journey of discovery that began years ago, it's exhilarating to share how a bold idea after many ups and downs is transformed into reality✨ Back then, we envisioned experiments to unravel responses of intestinal epithelial cells (IECs) at the single cell level using the innovative FluidFM technology combined with advanced organoid cultures. Today, we've not only realized this vision but have also shed light on the intricate dance between host and pathogen. In a first publication on this, we show how it is possible to directly deliverer bacteria into the cytosol of IECs. With this we've been able to observe the activation of inflammasomes in real-time with high spatiotemporal resolution, offering a window into the intestines immediate response to detection of cytosolic of bacteria as well as bacterial growth dynamics in this niche. This allowed us to study aspect of both parts that would otherwise have been difficult to disentangle with conventional methods. The success of these experiments is not only a testament to our advanced technological capabilities, but also to the power of collaboration and innovation. I would like to thank all the great people involved from the Vorholt, Hardt and Sellin labs at ETH Zürich and Uppsala University. A special thanks to the amazingly talented Chantal Ernst, who I got the privilege and joy of working closely together with on this challenging journey of scientific exploration. As we continue to explore the mysteries of cellular biology, let's also celebrate the achievements we have reached and the possibilities of the future🔬 Read the full publication here: https://lnkd.in/dGEeQHFp And stay tuned, more is soon to come #Science #Innovation #Research #Biotechnology #FluidFM #Enteroids #CellBiology #Pathogens #PLOSBiology

🥁 “This study represents a significant scientific breakthrough, as it shifts the paradigm in the understanding of MHC Class II peptides and their recognition by CD4+ T cells. It will be directly relevant in the design of therapeutic treatments for immune diseases and cancers.” ‘Improved predictions of antigen presentation reveal new structural insights’ is one of the #SIBRemarkableOutputs 2023 👏 This work joins the yearly list of outstanding contributions from SIB Members across Switzerland to the field of #bioinformatics. 👉 Discover this shortlist of outstanding works: https://lnkd.in/ewNA9BST   #machinelearning #Tcells #CancerResearch 💡The SIB Remarkable Outputs gather on a shortlist the most outstanding works produced by SIB members each year. These contributions showcase the latest advances in the Swiss bioinformatics field and include innovative solutions to share with the life science community. BioAlps - Swiss Health Valley ELIXIR Life Sciences Switzerland (LS2) Luciano Cascione Laurent Falquet Robert Ivánek Charlotte Soneson Patricia Palagi Graf Frederique Lisacek Robert Waterhouse University of Lausanne - UNIL Julien Racle David Gfeller Vincent Zoete

🌟#notablepaper on New #ComputerTechnologies for #Bioinformatics 📚Comparison of the Capacity of Several Machine Learning Tools to Assist Immunofluorescence-Based Detection of Anti-Neutrophil Cytoplasmic Antibodies 🔗https://lnkd.in/eefg3VEj 👨🔬By Prof. Pierre Bongrand et al MDPI Aix-Marseille University APHM (Assistance Publique - Hopitaux de Marseille) Adhesion and Inflammation Lab - LAI (INSERM U1067 | CNRS UMR 7333) #artificialintelligence #immunofluorescence #vasculitis #myeloperoxdase #proteinase

🔬🌟 Exciting news! We've launched new products: mRNA & LNPs Fluorescent labelled! 🚀 Discover how these innovative tools can enhance your research in molecular biology. 💡 mRNA Fluorescent ➡ https://bit.ly/3IHe5y9 LNPs Fluorescent & Double Fluorescent ➡ https://bit.ly/3vjzKJJ Learn more about fluorescent labeling and its importance in our latest article: "mRNA and LNPs: A Guide to Fluorescent Labeling to Enhance Research." 📝 Dive into the world of mRNA and LNPs, understand the techniques, factors to consider, best practices, applications, and future perspectives. 💬 Ready to elevate your research game? Head over to our website and check out the full article now: https://bit.ly/4ciG1pI Don't miss out on the latest advancements in molecular biology! 🌐🔍 #mRNA #LNPs #FluorescentLabeling #MolecularBiology #Research 🧬🔬

RNA that doesn't age: Neuroscientists discover building blocks in nerve cells that last a life time. Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have now demonstrated that this is the case together with researchers from Germany, Austria and the U.S. Read: https://lnkd.in/eQFJNQC8 #sciencesdelavie #biotechnology #biotechnology #innovation #innovations #research #sciences #medicaments #research #drugresearch #laboratories #labs #chemistry #chemistry #biology #biologie #biopharma #rna #rnatherapeutics #arn #revolution #happy

👋🏽 Meet Marc Talló Parra, our principal researcher and co-founder. 👨🏽🔬 Marc holds a degree in Human Biology, a master’s degree in Biomedical Research, and a PhD in Biomedicine from Universitat Pompeu Fabra. 🧬 He is the coinventor of the patent that led to NoctuRNA's circRNA technology. He specialized in molecular virology and RNA biology and conducted his doctoral research on the interaction between viruses and circRNAs, exploring the translational implications of these molecules. 🏆 In 2019, he was awarded the Tech Transfer Prize from UPF, and in the same year, he received the Extraordinary Award for Best Doctoral Thesis from UPF. He has published four scientific articles in high-impact journals. 💬 In Marc's own words:  "It is exciting to see how a project that started as an innovative, crazy idea in the lab goes beyond basic research and can reach the market. With this project, I fulfilled the dream of translating our research into a therapeutic application." We are building the best team to lead the circRNA therapeutic revolution! #therapeutics #circRNA #noctuRNA #biotech