Research Institute of Molecular Pathology (IMP)’s Post

Are  existing proteomics technologies such as #EdmanDegradation, #MassSpectrometry, and #ImmunoDetection antiquated, indirect, low-resolution, and hard to scale? “The future of measuring and characterizing the millions of “proteoforms” that are generated by #AlternativeSplicing and post-translational modification and underpin complex phenotypes lies in #SingleMoleculeProteomics technologies,” argued Jeff Nivala, Co-Director, of the Molecular Information Systems Lab at the University of Washington, at the 18th annual #sfafmeeting. Visit our website (https://lnkd.in/eFaAPYB7) listen to Jeff’s keynote presentation, which included an in-depth report of his group’s progress toward developing nanopore-based single-protein sequencing (also recently published in Nature at https://lnkd.in/eDgYWgpk), as well as a brief discussion of promising new proteomics platforms in development at Quantum-Si, Nautilus Biotechnology, Erisyon, Encodia, Glyphic Biotechnologies, Portal Biotech and Oxford Nanopore Technologies.

🧬 Exciting Breakthrough in Single-Molecule Protein Sequencing! 🔬 A new method for sequencing full-length proteins at the single-molecule level has been developed using a nanopore sensor array! 💡 This approach enables the detection of single amino acids and post-translational modifications, such as phosphorylation. Multi-pass readings and biophysical modeling further enhance accuracy, opening up new avenues for proteomic diversity analysis. 🌟 This could revolutionize our understanding of proteins and pave the way for cutting-edge research! 🚀 #ProteinSequencing #Nanopore #Biotech #Proteomics #Innovation #ScientificBreakthrough #MolecularBiology

⚡The world of proteomics is moving at lightning speed⚡ ❓“We will soon be facing a huge pile of proteomic data. The question is: what are we going to learn from it?"👉 https://lnkd.in/emefb_sw 🎙️In a interview with imec, Kris Gevaert (VIB-UGent Center for Medical Biotechnology) and Simon Devos (VIB Proteomics Core) discuss the progress and challenges in Proteomics researchers face as they strive to understand proteins at a deeper level. #VIBTechnologies

CSIR - Central Leather Research Institute is happy to share the publication of the research work by Dr. Ayyadurai N, Senior Principal Scientist from the Biochemistry & Biotechnology laboratory, and his team. The research work, titled "Biomimetic design of fibril-forming non-immunogenic collagen like proteins for tissue engineering," has been published in the International Journal of Biological Macromolecules. https://lnkd.in/gF4QE5YF CSIR India Kalarical Janardhanan Sreeram

Proteomics Market $72.9 billion by 2028 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐏𝐃𝐅 𝐁𝐫𝐨𝐜𝐡𝐮𝐫𝐞:https://lnkd.in/deXjcqCz The global proteomics market is projected to grow from $36.8 billion in 2023 to $72.9 billion by 2028, at a CAGR of 14.6%. 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞 Thermo Fisher Scientific, Inc. (US), Danaher Corporation (US), Merck KGaA (Germany), Agilent Technologies, Inc. (US), and Waters Corporation (US). 𝐎𝐭𝐡𝐞𝐫 𝐂𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐎𝐩𝐞𝐫𝐚𝐭𝐢𝐧𝐠 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐌𝐚𝐫𝐤𝐞𝐭 𝐆𝐥𝐨𝐛𝐚𝐥𝐥𝐲 Proteomics International      MRM Proteomics Inc.      PROMISE Proteomics   SCIEX   Elucidata Bruker Daltonics Hamilton Company    Cell Signaling Technology (CST) Biodesix, Inc. Octave Quanterix GenomeWeb Seer Donald Danforth Plant Science Center     Covaris Fulgent Genetics Encodia Institute for Systems Biology (ISB)     LICORbio GNF Singular Genomics SomaLogic   InterVenn Biosciences Monte Rosa Therapeutics Ultivue Juvena Therapeutics Alamar Biosciences, Inc. Canopy Biosciences Nautilus Biotechnology  Cambridge Isotope Laboratories, Inc   Ionpath Acrivon Therapeutics, Inc. Protein Metrics, LLC      Active Motif Sapient NASA GeneLab      Agricultural Research Council

🔬 Unlock the Power of Lipidomics for Your Research at Rothamsted 🔬 The Rothamsted Lipidomics Facility combines cutting-edge analytical mass spectrometry with years of expertise to offer a flexible workflow tailored to your lipidomic needs. Lipids do more than store energy—they are vital regulators of nearly every cell function. By understanding lipid composition and turnover, you gain invaluable insights that can drive impactful research. Our advanced approach makes lipid analysis simple to integrate into your work, using both targeted and untargeted techniques. With highly sensitive mass spectrometry, we can deliver a comprehensive analysis of the cellular lipidome from minimal sample sizes. Need help with sample prep? We’ve got you covered - from guidance to full lipid extraction as part of our workflow. Explore how Rothamsted’s Lipidomics services can elevate your research. Visit: https://lnkd.in/eu5SRDt6 #Lipidomics #MassSpectrometry #ResearchInnovation #CellBiology #Biotechnology #ScienceForHire #ScientificServices Rothamsted Research Claire Wolstencroft Frances Mitchell

scFv antibodies-Research areas: scFv antibodies are widely used in research laboratories as probes to study protein interactions, cellular processes, and signaling pathways. They can be labeled with fluorescent dyes or enzymes for imaging or detection purposes. https://lnkd.in/gzxGaNF6 #scFv #antibodies #research #laboratories #proteininteractions #cellularprocesses #signalingpathways #fluorescentdyes #enzymes #phagedisplay #NaïvePhageDisplayLibrary #probes #science #biotechnology #molecularbiology #technology #innovation #biotechresearch #lifesciences #cellbiology #biochemistry #elisa #immunofluorescence #AlphaLifetech

Heat shock 🌡️ alters the 3D structure of proteins and impairs their function. In response, cells immediately react by shutting down 🛑 protein production and generating "first-aid" proteins. But how do they manage such a rapid response? The Simon Alberti group at the Biotechnology Center (BIOTEC) has uncovered that translation factors play a crucial role in this fast response during heat shock. They discovered that some translation factors "sense" temperature changes and shapeshift to halt protein production and initiate the formation of heat shock granules. The work is published in Molecular Cell by Cell Press. Read our news piece ➡ https://tud.link/66trm1 #HeatShock #CellBiology #LifeScience #PaperAlert

scFv antibodies-Research areas: scFv antibodies are widely used in research laboratories as probes to study protein interactions, cellular processes, and signaling pathways. They can be labeled with fluorescent dyes or enzymes for imaging or detection purposes. https://lnkd.in/gK-iQpfB #scFv #antibodies #research #laboratories #proteininteractions #cellularprocesses #signalingpathways #fluorescentdyes #enzymes #phagedisplay #NaïvePhageDisplayLibrary #probes #science #biotechnology #molecularbiology #technology #innovation #biotechresearch #lifesciences #cellbiology #biochemistry #elisa #immunofluorescence #AlphaLifetech

Targeted protein editing with an antibody-based system ABSTRACT The chemical modification of proteins is one of the major mechanisms used to regulate the properties and functions of these macromolecules in the cell. It is therefore of great interest to develop tools to exploit this type of modifications for applications in molecular biology, medicine and biotechnology. Here we present a method of using antibodies to perform post-translational covalent modifications of endogenous proteins in complex environments by exploiting proximity-driven chemistry. The method is based on the ability of antibodies to hold a weakly reactive group close to its intended site of reaction by binding the target protein on a nearby epitope. We characterise this approach by modifying the green fluorescent protein in increasingly complex environments, and illustrate its applicability by targeting the disease-associated protein beta-2 microglobulin. UPDATED PAPER: https://lnkd.in/deeYZ2vs