Ionis Pharmaceuticals, Inc.’s Post

At OWL Metabolomics, we believe it is crucial to bring the spotlight towards fatty liver disease, a condition affecting 115 million people worldwide. By 2030, this number is expected to skyrocket to 357 million. Often underdiagnosed due to subtle symptoms, fatty liver disease poses significant risks, including cirrhosis, liver cancer, and liver transplant. Our purpose is to raise awareness and promote preventive measures, such as our OWLiver panel the only non-invasive diagnostic test capable to detect at risk-MASH in any of its phases. Join us in this fight against fatty liver disease this #GlobalFattyLiverDay #MASH #HealthAwareness #LiverHealth #JoinTheMovement

October is Liver Cancer Awareness Month, whose focus is to increase awareness and screening opportunities for liver disease. Take the liver health quiz https://lnkd.in/eyJp666K to learn more about your risks and the appropriate follow-up measures you can take. #LiverCancerAwarenessMonth

Pancreatic cancer can be difficult to diagnose at its onset and can easily be confused with symptoms associated with other disorders and diseases. Learn the risk factors and symptoms of pancreatic cancer by visiting https://lnkd.in/gTp9abDK.

Grateful to the Kidney Cancer Association for the opportunity to present data from the first cohort of STELLAR-001 focused on patients with clear cell renal cell carcinoma. In 32 patients with heavily pretreated disease (41% with 3 prior lines of therapy) and an aggressive phenotype (38% and 34% with liver and bone metastases, respectively), objective response rate was 38% and disease control rate was 88%. Responses were seen in cabozantinib-exposed patients, and if we focus on cabozantinib-naive patients with prior TKI, response rate was 63% and 100% of patients had disease control. From my experience treating patients on the study, the toxicity profile also compares favorably to other agents in this setting. As an investigative community, we need to get behind ongoing studies of zanzalintinib to learn more about this incredibly promising compound (e.g., STELLAR-002; STELLAR-304). I've posted all slides here: https://lnkd.in/gmYC5t6v #kidneycancer #cabozantinib #zanzalintinib #XL092 #STELLAR001 #STELLAR002 #STELLAR304

#MASHAdventCalendar Day 1 🎄 🎅 Metabolic (dysfunction)-associated steatotic liver disease (#MASLD) affects a quarter of the global population. #MASH (steatohepatitis) is its most severe form and is characterized by a presence of liver fat, inflammation and ballooning, associated or not with liver fibrosis. Understanding the complexity of MASH, especially how it can lead to fibrosis progression, has become an essential requirement rather than a nice-to-have information. This understanding is key to efficiently combat serious liver-related events such as cirrhosis and liver cancer. https://lnkd.in/gGmEgSp

When diagnosing bowel problems, it’s important to differentiate between IBS, inflammatory bowel diseases and bowel cancer. Calprotectin is a biomarker that can aid in the differential diagnosis between IBD and IBS. Learn more: https://lnkd.in/eVUPNVsg #IBSAwarenessMonth #BowelCancerAwarenessMonth

70% of Oesophageal Cancer patients have symptoms for over 3 months before seeing their GP. it is vital that we, as a community, continue to raise awareness of the signs and symptoms of Oesophageal Cancer: - Difficulty Swallowing - Acid Indigestion or Heartburn that doesn’t go away - Hoarseness that persists — and isn’t due to a cold - Coughing, Burping, Belching or Hiccups that don’t subside - Progressive and unplanned Weight Loss Early detection is key. Heeding signs of ongoing digestive discomfort could save your life. Learn more here: www.ocf.ie

70% of Oesophageal Cancer patients have symptoms for over 3 months before seeing their GP. it is vital that we, as a community, continue to raise awareness of the signs and symptoms of Oesophageal Cancer: - Difficulty Swallowing - Acid Indigestion or Heartburn that doesn’t go away - Hoarseness that persists — and isn’t due to a cold - Coughing, Burping, Belching or Hiccups that don’t subside - Progressive and unplanned Weight Loss Early detection is key. Heeding signs of ongoing digestive discomfort could save your life. Learn more here: www.ocf.ie

70% of Oesophageal Cancer patients have symptoms for over 3 months before seeing their GP. it is vital that we, as a community, continue to raise awareness of the signs and symptoms of Oesophageal Cancer: - Difficulty Swallowing - Acid Indigestion or Heartburn that doesn’t go away - Hoarseness that persists — and isn’t due to a cold - Coughing, Burping, Belching or Hiccups that don’t subside - Progressive and unplanned Weight Loss Early detection is key. Heeding signs of ongoing digestive discomfort could save your life. Learn more here: www.ocf.ie

Did you know ~ half of kidney cancers are found when people are being checked for a different issue, such as a urine infection, liver problems or gut problems? Find out more by downloading the Kidney Cancer Diagnosis Factsheet here: https://lnkd.in/gp8qS_mN #KidneyCancer #KCSM