Jon Kleinman’s Post

Heading to #CRYO2024? Join us for Dr. Gerald Brandacher’s keynote speech, “Taking Time Out of the Equation for Transplantation Using Nature-Inspired Cryoprotectants in a Preclinical Large Animal Model,” on the XT-ViVo®️ & TimeSeal® transplant results!   X-Therma’s XT-ViVo® is a groundbreaking non-toxic, serum- and protein-free, completely defined organ preservation solution. It consists of fully synthetic biomimetics of antifreeze proteins found in nature and bypasses the drawbacks of toxic molecules. This solution prevents damaging ice crystal formation during organ preservation at subzero temperature while supporting reduced metabolism and ischemic damage. XT-ViVo® combines with TimeSeal® – a smart transporter that received a breakthrough device designation by the US #FDA.   Dr. Brandacher’s keynote will be at 11 AM on July 25 in the Wisconsin Room.   #cryopreservation #organtransplant #nontoxic #XTViVo #TimeSeal #youhavetime #XTherma

Missed SLAS earlier this month? Make sure to download our poster! From the 3rd to 7th February, we were in Boston for the Society for Laboratory Automation and Screening (SLAS) International Conference, discussing our work with human iPSC technology for research and drug discovery. Alongside discussions on quality iPSC manufacturing, functional QC and in vitro models, we presented a poster titled "Differentiation of multiple iPSC lines to different cell types to enable cohort analysis in neurodegeneration: challenges and learnings". Listen to our Project Manager, Sian Humphreys presenting the key findings in the poster: https://hubs.la/Q02m28G90 Click here to download the poster: https://hubs.la/Q02m29CX0 #iPSCs #SLAS #biotech #StemCells #DrugDiscovery

🌟 Friday Read: Accelerating Drug Development with Spatial Biology 👉https://bit.ly/4aro6Lo Presage Biosciences, Inc.'s CIVO® platform, combined with GeoMx and CosMx technologies, effectively tracks anti-neoplastic and immune-modulating activity in the intact tumor microenvironment. This innovative approach is speeding up drug development and paving the way for more successful clinical trials.🔬 #SpatialBiology #DrugDevelopment #FridayRead This post may include information regarding CosMx™ SMI products for RNA detection, which products are not available in the Federal Republic of Germany, as further described here - https://lnkd.in/gUXh88Pr.

At Cirrus Therapeutics, every day marks a new milestone in our quest to conquer age-related macular degeneration (AMD). The team's dedication to discovery comes to life in our state-of-the-art labs where collaboration meets innovation,  forging a path to groundbreaking treatments. "Working here isn’t just about the science; it’s about creating real-world solutions that will one day improve the lives of millions globally," shares Dr. Sumeet Sarin, Project Lead at Cirrus. "The energy here is electric—we're not just studying the disease, we're actively fighting it with every experiment, every breakthrough." Cirrus, born from the pioneering spirits of Cofounders Dr. Ying Kai Chan and Dr. Andrew Dick, is championing a novel approach to treating AMD by enhancing the IRAK-M protein in retinal cells, promising a significant advancement in available therapies. ➡️ Follow us on our journey as we bring visionary science from the lab to the lives of patients around the world. #vision #AMD #DryAMD #WetAMD #optometry #ophthalmology #healthcare #innovation #science #research #termeerfellow #biotech #STEM

Designing LNPs for RNA delivery? Check out this great manuscript from Jake Brenner's team from the University of Pennsylvania on bioRxiv. This pre-print (https://lnkd.in/dpDZ3riu) describes how LNP design can attenuate LNP-associated inflammation caused by "excessive" endosomal membrane damage leading to inflammatory responses (the "endosomal escape" is a double-edged sword). Certain LNPs containing rapidly biodegradable ionizable lipids have the potential to rather induce membrane damage that can be repaired by the endosomal sorting complex required for transport (ESCRT), which leads to safer LNPs. Looking forward to seeing this published soon, well done Serena Omo-Lamai et al.

Over the past 25 years, the life science industry has witnessed an array of groundbreaking achievements that have revolutionised human health, fuelled industry expansion, and propelled innovation in #healthcare, #clinicalresearch, #biotechnology, and #medicaldevices. In this article, we look at 25 of the most transformative milestones in the #lifescience industry over this period; from decoding the human genome to the celebration of the 75th birthday of the NHS. https://buff.ly/3HdEKC8 #25YearsOfPharmiWeb

“Before 3D models, studying fibroblasts was a race against time, as the cells would lose their essential natural characteristics very quickly. 3D models enable us to preserve their function for an extended amount of time, which allows us to properly study them.” Dr. Marie Besnier, Head of Life Science at Inventia Life Science. Jumpstart your new year by discovering the recent advancements in in vitro fibrosis models and their applications in drug development in this latest blog post by our partners at PhenoVista! 📢 👏 https://lnkd.in/gpP6KXJD #Fibrosis #FibroblastBiology #Drugdevelopment #invitromodels

📚 PUBLICATION | Blood-brain barrier #organoids grown in our #Gri3D 600 µm microwells Employing receptor-mediated transcytosis (RMT) emerges as an effective approach for delivering biologic agents across the blood-brain barrier (#BBB). The recent progression in creating human BBB organoid models is a significant breakthrough, aiding in understanding RMT mechanisms and expediting the development of brain delivery technologies for #drugdevelopment. However, the existing techniques for generating organoids suffer from multiple limitations, preventing the use of #BBBorganoids as a screening tool 💡 Elena Kassianidou, Ph.D. and colleagues from Roche describe in their protocol the use of #Gri3D hydrogel-based arrays for #BBBorganoids. The plates offer a 55-fold increase in organoid yield, addressing #challenges of throughput and heterogeneity of the microtissues 🚀. Paired with a custom semi-automated imaging assay, our scalable platform fast-tracks brain delivery tech development for early-stage drug discovery. 📄 Read the full publication here: https://lnkd.in/eDg3sVsz and contact us (enquiries@sunbioscience.ch) if you want to learn more! #drugdelivery #BBBorganoids #innovation #3Dcellculture #invitromodel #highthroughput

"There is magic in every beginning." - Hermann Hesse ... or in German: "Jedem Anfang wohnt ein Zauber inne" We just started our collaboration with Genome Biologics to exclusively introduce TruCardium cardiac organoid disease models to our customers. I feel the magic of this beginning, combining the decade-long expertise of the Genome Biologics team in cardiac organoid culture and our know how in upscaling production and assay development in our Akura™ multiwell plates. This partnership marks a significant milestone in our mission to provide biologically relevant and highly reproducible solutions for cardiovascular research. The TruCardium models offer unprecedented accuracy in mimicking human heart diseases, enabling researchers to gain deeper insights and accelerate the development of novel therapies. I am confident that this innovative technology will significantly impact our customers' research capabilities and advance the field of cardiac health. I am looking forward to embark on this journey with you, Jaya Krishnan, Jonathan Ward, Filip Henzler, Madhu Lal Nag, MBS PhD, Paul Edgard Clémençon, David Fluri, Bärbel Ulmer and many more involved over here. #Cardiovascular #3Dcellculture #organoids

🔬 Organoids vs. Immortal Cell Lines 🧬 Are you curious about the latest advancements in cell culture technology? In this insightful blog post, CelVivo's Stephen Fey delves into the pros and cons of patient-derived organoids and immortal cell lines. Discover why 3D cultures might be the game-changer we need for more accurate drug testing and personalized medicine. Is it time for a shift in our research paradigms? 📖 Read more: https://lnkd.in/exMnyr7T #BiomedicalResearch #Organoids #CellCulture #Innovation #DrugDevelopment