The Journal of Clinical Investigation’s Post

🧠 Delve into the fascinating world of stroke research! Discover the pivotal role of microRNA-34a in ischemic stroke, unraveling its impact on blood-brain barrier permeability and mitochondrial function. Read here to explore the latest findings and insights 🧬 https://lnkd.in/gfntrpYd #StrokeResearch #MicroRNA #BrainHealth

As  #musculardystrophyawarenessmonth approaches, this discovery led by Dr. Molkentin at #cincinnatichildrens opens an entirely new line of research to stop the muscle wasting outcome of these conditions. #mitochondria #genetherapy #duchenne #rarediseases #musculardystrophy  #cincykidsscience  https://lnkd.in/g4HGAFNM

Review: Net water uptake as a predictive neuroimaging marker for acute ischemic stroke outcomes. (Sherief Ghozy et al.) #EuropeanRadiology Read the full review here ➡️ https://buff.ly/3HSh9ab

New 3i Investigator Article Alert!! STAT3 modulates CD4+ T mitochondrial dynamics and function in aging https://lnkd.in/g6skQdGC

Aging decreases electron transport complex IIi activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site https://t.co/qZtgT0I8En #EurekaMag

Here's our theory of mitochondrial transfer in the bloodstream: - The human body has about a Trillion platelets in circulation at any given point, and recycles about 1/10 per day. - Each of which contains 4-5 mitochondria, generally "younger" (less damage in the mtDNA). - These mitochondria are ejected in small vesicles ("mitlets") before the platelet is recycled. - These mitlets are quickly absorbed by other cells nearby...white blood cells, damaged tissue, etc. - So our bodies supply about half a trillion young mitochondria per day from the bone marrow to other peripheral tissues. That's 150 trillion mitochondria per year. (And there are many other types of EVs containing mitochondria, from other sources, so this number could be much higher). There are 37 trillion cells in the body, so in theory"on average, all the cells of your body are getting drip-fed with at least 5 new mitochondria per year. But this is such a rough and unproven estimate, it's hard to know if it's true or not. But, we think it represents a system of refreshing mitochondrial throughout the body, to provide longer life span. "The Mitochondrial Cycle of the Body" Here's a summary video:

Serologically active clinically quiescent (SACQ) systemic #lupus erythematosus is heterogeneous, but hierarchical cluster analysis subgroups these patients into three distinct #phenotypes with unique flare patterns and organ damage accumulation rates: the major organ involvement subtype (cluster 1), precise SACQ subtype (cluster 2), and #renal involvement subtype (cluster 3). This stratification may guide precision therapy and improve long-term outcomes. 🔗https://lnkd.in/d4r4U2eE

Proline restores mitochondrial function and reverses aging hallmarks in senescent cells- this study highlights the role of proline in mitophagy and its potential in reversing senescence-associated mitochondrial dysfunction and aging hallmarks. https://lnkd.in/eHg5-xs7

Multiaxial analysis provides unique insight into the physiology and mechanics of the heart in the presence of ischemia and low-dose dobutamine, with potential implications in many areas, including the detection and characterization of ischemic heart disease and the use of inotropic support for low cardiac output. https://ow.ly/xa4050PHZ2I