Kara Hansell Keehan’s Post

Review: Net water uptake as a predictive neuroimaging marker for acute ischemic stroke outcomes. (Sherief Ghozy et al.) #EuropeanRadiology Read the full review here ➡️ https://buff.ly/3HSh9ab

Check out our new translational paper in AJP Heart & Circulation that showed association between Apo-AI and HDL-C with skeletal muscle mitochondrial function in healthy adults! https://lnkd.in/gagwwayB

The National Cardiogenic Shock Initiative, developed a shock protocol that was found to improve early hemodynamics and in-hospital survival. In the study, a cardiogenic shock diagnosis was defined by the presence of at least 2 of the following: - Hypotension with SBP <90 or need for inotropes to maintain SBP >90 - Evidence of end organ hypoperfusion (elevated lactate level, cool extremities, oliguria) - Cardiac index <2.2 L/min/m2, or CPO <0.6 W Learn how VitalStream can aid in rapid diagnosis according to the protocol: https://lnkd.in/g_C-kYNW

Physiology after PDA definitive closure: Pre-closure: pulmonary overcirculation, low afterload to LV (exposed to PVR as well). Post-closure: drop in LA preload + increase in LV afterload = decreased LVO.

The kidney is a complex organ and this complexity has made it difficult to reliably study kidney function using cultured cells in the lab. Microphysiological systems (MPS) involve growing multiple types of cells together in a way that can reproduce the physiology of a functioning organ, helping us to learn more about how kidneys work and the changes that occur in chronic kidney disease. We’ve recently published research on two novel kidney MPS, find out more about them: https://lnkd.in/eJe2tXEm #WhatScienceCanDo #MicrophysiologicalSystems  

Dysautonomia International’s recent webinar, Introduction to Cardiovascular Physiology: What People with Dysautonomia Should Know By Heart, presented by Dr. Amanda Miller is now available online. This webinar provides an excellent introduction to how the autonomic nervous system controls heart rate, blood pressure, and blood flow. It also offers insight into what causes #dysautonomia symptoms and how treatments work. Watch now: https://lnkd.in/eMazAY8m

🔹Examining modulators of the optic nerve head and their role in primary open-angle glaucoma (POAG) 🔹 For November, our intricate Image of the Month was produced by Dillinger et al from the University of Regensburg. Through investigation of the optic nerve head and the molecular factors involved in ECM changes, they found a self-amplifying signalling process that may ultimately contribute to POAG pathogenesis, a devastating disease which can cause blindness. 📷 Pictured is the use of a Cy3-AffiniPure Goat Anti-Rabbit IgG (H+L) (min X Hu,Ms,Rat Sr Prot) from Jackson ImmunoResearch. Image collected and cropped by CiteAb under a CC-BY license from: Dillinger et al. (2022) Front Cell Dev Biol. https://lnkd.in/ed9uYq3j

#ILTSVanguard Article of the Week: From 'Transplantation' Interleukin-6 Levels During Normothermic Machine Perfusion Impact Postreperfusion Hemodynamics of Liver Graft Recipients: A Prospective Single-center Observational Study #LiverTransplantation https://loom.ly/bkPehi8

Oxidative DNA Damage in the Pathophysiology of Spinal Cord Injury: Seems Obvious, but Where Is the Evidence? ''Oxidative DNA damage after Spinal Cord Injury results from massive oxidative stress with limited antioxidative capacities. Mitochondrial respiration and ensuing dysfunction, together with elevated immune responses and excessive inflammation, are thought to be the primary producers of ROS in the spinal cord following injury. Due to the intrinsic limited presence and injury-induced loss of antioxidants, ROS can attack the DNA of cells, giving rise to 8-oxodG, single-strand breaks (SSBs), and double-strand breaks (DSBs). Evidence indicates that DNA damage response factors such as PCNA and PARP1 are upregulated, whereas APEX1 is downregulated''. https://lnkd.in/dzkWNWye

Inflammation + ageing = inflammaging. As we age inflammation becomes an increasing problem driving chronic disease, reducing mitochondrial function and accelerating ageing. In his recent presentation at the International College of Integrative Medicine's recent conference Rob Verkerk PhD spoke about #inflammaging and the role of some pretty amazing small molecules known as nucleotides and peptides. Want to know more? Click on the link for a fascinating read! https://lnkd.in/eTgPpXgC #nucleotides #peptides #naturalhealth